- Dong G. (2013) MicroRNAs Profiling Reveals a Potential Link between the SDG8 Methyltransferase and Brassinosteroid-Regulated Gene Expression in Arabidopsis. Journal of Data Mining in Genomics & Proteomics 4(5),
MicroRNAs are a class of short non-coding RNAs (17-27 nucleotides) found in animals and plants. MicroRNAs play important roles in post-transcriptional regulation of gene expression by complementing the target mRNAs and causing translational repression or target mRNA degradation . Studies have shown that thousands of human protein-coding genes are regulated by microRNAs , impacting many important biological processes, from development to physiology to stress response. In plants, microRNAs have been implicated in multiple essential biological processes, such as leaf morphogenesis and polarity, flower development, hormone signaling and metabolism, and stress responses . MicroRNA genes are transcribed by RNA polymerases II, generating precursors that undergo a series of cleavage events to form mature microRNA . MicroRNA biogenesis and its expression regulation are highly complicated . Although the biological importance of microRNAs is well demonstrated in a wide range of cellular processes, how microRNA expression and abundance are regulated is not fully understood.