(A) Representative electron micrographs of EVs derived from OA chondrocytes treated with vehicle (veh) and UBX0101. (B and C) Mean size and concentration of EV enrichments released per cell in human OA chondrocytes at 1, 2, 4, and 6 days after incubation with veh or 43 μM UBX0101, measured by nanoparticle tracking analysis. (D) Heatmap and hierarchical clustering depicting statistically significant differentially expressed miRs.
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