MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provide cancer-specific personalized therapy.


Key Points

  • The microRNAs (miRNAs) have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and also, fine-needle aspirate specimens.
  • Recently novel in situ hybridization techniques have been described to detect miRNAs in tissues, which enables direct miRNA and histomorphologic correlation. Identification of novel molecular miRNAs and their target oncogenomic signatures have the potential to significantly impact clinical management.
  • Incorporating miRNA expression profiling on tissue samples in the future may not only confirm diagnosis categorizing diseases and their subtypes but also may predict drug response in helping clinicians define the precise therapy to each individual.
  • Increasing the knowledge of disease progression and tumor recurrence might also improve the development of personalized therapies.
  • The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that will allow designing cancer- specific personalized therapy.

LC Sciences

 

Reference
Sethi S, Sethi S, Bluth MH. (2018) Clinical Implication of MicroRNAs in Molecular Pathology: An Update for 2018. Clin Lab Med 38(2):237-251. [abstract]

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