lc sciences
Oxytocin (OT) can modulate multiple physiological functions via binding to the widely distributed oxytocin receptor (OTR). In a recent study, scientists investigated the seasonal expressions of OT, OTR and extracellular signal regulated kinase (ERK1/2) signaling pathway components in the scented gland of muskrat during the breeding and non-breeding seasons...
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Sweet potato (Impomoea batatas L.) is a globally important economic food crop with the potential to become a bioenergy and pharmaceutical crop. Thus, studying the molecular mechanism of tuberous root development and storage is very important. A recent study employed next generation high-throughput deep sequencing technology to sequence all small RNAs and the degradome of sweet potato to systematically investigate sweet potato response to chilling stress during storage...
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The loss of normal regulation of corticosteroid secretion is important in the development of cardiovascular disease. Scientists from the University of Glasgow previously showed that microRNAs regulate the terminal stages of corticosteroid biosynthesis. In a recent study, they assess microRNA regulation across the whole corticosteroid pathway using miRNA microarray technology...
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The nervous system is present in all but two animal phyla – one of them being Porifera, sponges. Sponges have no neurons and yet have organized behavior and finely tuned sensation. Furthermore, sponges have genes involved in the nervous system of other animals (informally called ‘neural’ genes)...
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MicroRNAs (miRNAs) are important for plant growth and responses to environmental stresses via post-transcriptional regulation of gene expression. Tea, which is primarily produced from one bud and two tender leaves of the tea plant (Camellia sinensis), is one of the most popular non-alcoholic beverages worldwide owing to its abundance of secondary metabolites...
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VariantPro
Leber's hereditary optic neuropathy (LHON) is a classic mitochondrial disease, associated with a rapid, pain­less, acute or sub‑acute bilateral visual loss in young adults, predominantly caused by primary and secondary mutations in mitochondrial DNA (mtDNA). mtDNA is a double‑stranded 16,569‑nucleotide pair, circular molecule, consisting of one D‑Loop region and 37 genes. There is a variance in the reported incidence of known LHON...
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microRNAs are small non-coding RNAs that are important regulators of gene expression in a range of animals, including nematodes. Scientists from the University of Glasgow have analysed a cluster of four miRNAs from the pathogenic nematode species Haemonchus contortus that are closely linked in the genome...
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LC Sciences
Ground-state pluripotency is a cell state in which pluripotency is established and maintained through efficient repression of endogenous differentiation pathways. Self-renewal and pluripotency of embryonic stem cells (ESCs) are influenced by ESC-associated microRNAs...
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The aim of a recent study sought to evaluate tadalafil-mediated effects at the molecular level on bone marrow-derived mesenchymal stem cells (MSCs) survival and their homing into infarcted hearts to promote cardiac repair and improve function...
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To determine the miRNA expression profiles of neuroblastomas with different clinical and histological characteristics, a recent study utilized 24 samples from 17 patients. Their microRNA profiles were compared using miRNA microarray technology...
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