A new study published by researchers from Zhejiang University sought to investigate the mechanism underlying the promoting role of CD97 in gastric cancer cell proliferation and invasion. In their study, two types of exosomes released by gastric cancer cells with high (SGC/wt) or low (SGC/kd) CD97 expression were isolated by ultracentrifugation and identified by electron […]
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Exosome microarray
Extracellular vesicles, including exosomes, are currently being investigated to better understand their biogenesis and biological functions. There is also a rapidly growing interest in utilizing exosomes present in patient biofluids for molecular diagnostics in the clinic. Exosomes are natural shuttles of RNA and protein cargo, making them attractive as potential therapeutic delivery vehicles. Here, the […]
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High seed vigor is significant for agriculture, as low seed vigor hinders the popularization of sweet corn (Zea mays L. saccharata Sturt). To better understand the involvement and regulatory mechanism of miRNAs and how they might play a role with seed vigor, researchers from the China Jiliang University had small RNA libraries from seed non-artificial […]
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Spontaneous self-terminating atrial fibrillation (AF) is one of the most common heart rhythm disorders, yet the regulatory molecular mechanisms underlying this syndrome are rather unclear. In a recent paper published by researchers from the University of La Coruna, microRNA (miRNA) transcriptome and expression of candidate transcription factors (TFs) with potential roles in arrhythmogenesis, such as […]
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MicroRNAs have been shown to be involved in regulating plant’s response to environmental stresses, including salinity. There is no report yet on the miRNA-mediated posttranscriptional regulation of salt stress response of a grass halophyte by miRNAs which led researchers from Louisiana State University Agricultural Center to focus on this subject in their recent investigation. Using […]
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Phytochrome B (phyB), a member of the phytochrome family in rice, plays important roles in regulating a range of developmental processes and stress responses. However, little information about the mechanisms involved in the phyB-mediated light signaling pathway has been reported in rice. MicroRNAs (miRNAs) also perform important roles in plant development and stress responses. Thus, […]
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Recently, LC Sciences traveled to New Orleans to take part in the American Association of Immunologist’s annual meeting. The Immunology meeting provides a unique opportunity for researchers to network with colleagues from more than 40 countries. Meeting attendees can find out about the latest developments in their field through lectures by the world’s most prominent […]
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Immunology Workshop
MicroRNAs have proven to be an extremely important part of the gene expression regulation mechanism.  While the role of microRNAs in cancer was recognized early on, expression profiling and functional studies have now shown that microRNAs participate in the regulation of many biological systems. There is now strong evidence suggesting that miRNA signaling plays a […]
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got variants?
from GenomeWeb NEW YORK (GenomeWeb) – Aiming to simplify and improve the targeted sequencing workflow, LC Sciences is building out its VariantPro multiplexing PCR technology with an eye on a fourth quarter launch. The company is in the midst of testing the technology and recently sent out a call for beta testers to, among other […]
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Alternative splicing (AS) is an important regulatory mechanism that greatly contributes to eukaryotic transcriptome diversity. A substantial amount of evidence has demonstrated that AS complexity is relevant to eukaryotic evolution, development, adaptation, and complexity. In a recent study, published by researchers from Huazhong Agricultural University, investigators used LC Sciences RNA sequencing services to analyze AS […]
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