Agricultural Genomics
Hybrid crops produce higher yields than their inbred parents due to heterosis. For high purity of hybrid seeds, it is critical to eliminate self-pollination. Manual or mechanical removal of male parts (such as detasseling in maize) is labor-intensive, fuel and time-consuming, and can cause physical damage to female plants, resulting in significant seed yield reductions....
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Tibetan minipig is an important animal model for human diseases. The anterior pituitary is the master gland responsible for growth, reproduction, and metabolism and is regulated by thousands of miRNAs/mRNAs molecules. However, little is known about miRNAs and their relationships with mRNAs in Tibetan minipig anterior pituitary. Using microarray and mRNA-Sequencing, researchers recently identified 203 miRNAs and 12,040 mRNA transcripts from the anterior pituitary of Tibetan minipigs...
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Ricolinostat (ACY-1215), a first-in-class selective HDAC6 inhibitor, exhibits antitumor effects alone or in combination with other drugs in various cancers. However, its efficacy in esophageal cancer remains unclear. In a recent study, researchers found that the high expression of HDAC6 was associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) tissues...
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Salmonella enteritidis (SE) is a foodborne pathogen that negatively affects both animal and human health. Controlling poultry SE infection will have great practical significance for human public health, as poultry are considered to be important sources and carriers of the disease. In a recent study, the splenic transcriptomes of challenged-susceptible (S), challenged-resistant (R) and non-challenged (C) chicks (3-days old, specific-pathogen-free White Leghorn) were characterized in order to identify the immune-related gene markers and pathways...
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Paulownia witches’ broom (PaWB), caused by phytoplasma, is an important disease of Paulownia. To further identify the key miRNAs associated with the formation of PaWB symptoms, a team of scientists recently used miRNA and degradome sequencing to explore important miRNAs–target regulation in healthy and diseased Paulownia tomentosa...
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LC Sciences
With such large numbers of variants now identified through rapidly increasing use of next generation sequencing (NGS), it has become important to determine the functionality of these variants to assess their clinical diagnostic, prognostic, or therapeutic potential...
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Current antidepressant treatments to anxiety and depression remain inadequate, burdened by a significant percentage of misuse and drug side-effects, due to unclear mechanisms of actions of antidepressants. To better understand the regulatory roles of antidepressant fluoxetine-related drug reactions, a team of researchers investigated changes of expression levels of hippocampal microRNAs (miRNAs) using miRNA microarray technology after administration of fluoxetine in normal adult mice...
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Previous work has explored link between mitochondrial biology and fungal pathogenicity in F1Fo-ATP synthase in Candida albicans. In recent work, researchers have detailed the more specific roles of the F1Fo-ATP synthase β subunit, a key protein subunit of F1Fo-ATP synthase...
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In a recent study, researchers from South-West University “Neofit Rilski”explored the influence of light irradiation on the sediment microbial fuel cell's (SMFCs) electrical outputs. The experiments at both natural and artificial illumination firmly show that current grows up during the photoperiods. The intensity the current increases was shown to depend on the duration of the photoperiod as well as on the wavelength of the monochromatic light source applied...
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The corpora allata (CA) are a pair of endocrine glands with neural connections to the brain and close association with another neuroendocrine organ, the corpora cardiaca (CC). The CA from adult female Aedes aegypti mosquitoes synthesize fluctuating levels of juvenile hormone (JH), which have been linked to the ovarian development and are influenced by nutritional signals. In a recent study, researchers from the University of Queensland investigated the potential involvement of microRNAs (miRNAs), a type of small non-coding RNAs, in the regulation of gene expression in CA-CC complexes during mosquito reproductive development...
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