The antianxiety effects of ethanol appear to be a crucial factor in promoting alcohol intake. Because regulation of gene expression by microRNA (miRNA) is an important epigenetic mechanism that affects neuronal pathways and behaviors, researchers from the Jesse Brown Veterans Affairs Medical Center investigated the role of miRNAs underlying the mechanisms of ethanol-induced anxiolysis. Acute […]
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Cannabinoid administration before and after simian immunodeficiency virus (SIV)-inoculation has been shown to ameliorate disease progression and decrease inflammation in male rhesus macaques. Previous studies showed that Δ9-tetrahydrocannabinol (Δ9-THC) did not increase viral load in brain tissue or produce additive neuropsychological impairment in SIV-infected macaques. To determine if the neuroimmunomodulation of Δ9-THC involved differential microRNA […]
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Bone-marrow derived vascular precursors are an important endogenous repair reservoir for vascular repair and neovascularization. Therapies of stem/progenitor cells targeting on angiogenesis are considered hopeful solutions for tissue repair and regeneration. However, the dysfunction of patient-derived progenitor cells has been implicated in diabetes, which limits the efficacy of autologous cell therapies in the clinic. In […]
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Neurogenic neuroprotection is a promising approach for treating patients with ischemic brain lesions. In earlier studies, fastigial nucleus stimulation (FNS) has been shown to reduce the tissue damage resulting from focal cerebral ischemia. However, the mechanisms of neuroprotection induced by FNS remain unclear. MicroRNAs (miRNAs) are a newly discovered group of non-coding small RNA molecules […]
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Blood feeding in Anopheles stephensi initiates a cascade of events that modulate several physiological functions in the mosquito. The midgut epithelium activates several of its molecules, most important among these being microRNAs, which regulate some of the physiological changes by targeting diverse mRNAs. Recently, researchers from the International Centre for Genetic Engineering and Biotechnology conducted […]
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Excessive fat accretion is a crucial problem during broiler production. Abdominal fat weight (AbFW) and abdominal fat percentage (AbFP) are major phenotypic indices of fat traits. A recent study by resarchers from the Chinese Academy of Agricultural Sciences used F2 females derived from a cross between Beijing-You and Cobb-Vantress chickens. Cohorts with extreme AbFP and […]
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Metasequoia glyptostroboides is a famous redwood tree of ecological and economic importance, and requires more than 20 years of juvenile-to-adult transition before producing female and male cones. Previously, researchers from Beijing Forestry University induced reproductive buds using a hormone solution in juvenile Metasequoia trees as young as 5-to-7 years old. In their current study, hormone-treated […]
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Abscisic acid (ABA) has been proven to be involved in the regulation of climacteric fruit ripening, but a comprehensive investigation of its influence on ripening related processes is still lacking. By applying next generation sequencing services, researchers from Zhejiang University conducted a comparative analysis of the effects of exogenous ABA and NDGA (Nordihydroguaiaretic acid, an inhibitor […]
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Canola (Brassica napus) is one of the most important oil crops in the world. However, its yield has been constrained by salt stress. In a recent study by researchers from the Chinese Academy of Agricultural Science, transcriptome profiles were explored using Digital Gene Expression (DGE) at 0, 3, 12 and 24 hours after H2O (control) […]
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Endometrium receptivity is essential for successful embryo implantation in mammals. However, the lack of genetic information remains an obstacle to understanding the mechanisms underlying the development of a receptive endometrium from the pre-receptive phase in dairy goats. In a recent study by researchers from Northwest A&F University, more than 4 billion high-quality reads were generated […]
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