Accumulating evidence has demonstrated that voltage-gated potassium channels (Kv channels) are associated with regulating cell proliferation and apoptosis in tumor cells. A previous study proved that Kv channel blocker, 4-aminopyridine (4-AP) could inhibit cell proliferation and induce apoptosis in glioma. However, the precise mechanisms were not clear yet. Because small non-coding RNAs act as key mediators in the progression of tumors, the aim of a recent study sought to investigate the role of miRNAs in the apoptosis-promoting effect of 4-AP in glioma cells...
Read More
Intestinal infection by the zoonotic protozoan, Cryptosporidium parvum, causes significant alterations in the gene expression profile in host epithelial cells. The molecular mechanisms of how C. parvum may modulate host cell gene transcription and the pathological significance of such alterations are largely unclear...
Read More
Tumor necrosis factor (TNF) α can induce cell apoptosis and activate nuclear transcription (NF)‐κB in different cell types. Activated NF‐κB further promotes or suppresses cellular apoptosis in different cases. A recent study explored the effect of activated NF‐κB on adipocyte apoptosis induced by TNFα and which microRNAs (miRNAs) were involved in the process...
Read More
MicroRNAs (miRNAs) have been reported to play vital roles in liver regeneration. Previous studies mainly focused on the functions of intracellular miRNAs, while the functions of circulating exosomal miRNAs in liver regeneration remain largely unknown. The aim of a recent study was to identify the key exosomal miRNA that played vital roles in liver regeneration...
Read More
Breast cancer is the most commonly diagnosed cancer among females, and chemoresistance constitutes a major clinical obstacle to the treatment of this disease. MicroRNAs (miRNAs) are related to human cancer development, progression and drug resistance. To identify breast cancer chemoresistance-associated miRNAs, miRNA microarray dataset GSE71142, including five chemoresistant breast cancer tissues and five chemosensitive tissues, were analyzed from the Gene Expression Omnibus (GEO) database...
Read More
Exosomes are small vesicles of endocytic origin, which are released into the extracellular environment and mediate a variety of physiological and pathological conditions. In a recent study, a team led by researchers from McGill University show that Schistosoma mansoni releases exosome-like vesiclesin vitro...
Read More
A recent study aimed to systematically investigate the relationship between miRNA expression and the occurrence of ventricular septal defect (VSD), as well as characterize the miRNA target genes and pathways that can lead to VSD. MiRNA microarray and qRT-PCR were used to screen and validate differentially miRNA expressed in blood samples from VSD and normal infants...
Read More
Unlike most ancient microRNAs, which conservatively target homologous genes across species, microRNA827 (miR827) targets two different types of SPX (SYG1/PHO81/XPR1)-domain-containing genes, Nitrogen Limitation Adaptation (NLA) and Phosphate Transporter 5 (PHT5), in Arabidopsis thaliana and Oryza sativa to regulate phosphate (Pi) transport and storage, respectively. However, how miR827 shifted its target preference and its evolutionary history are unknown...
Read More
Auxin response factors (ARFs) encode transcriptional factors that function in the regulation of plant development processes. In a recent study, a tomato ARF gene, SlARF5, was observed to be expressed at high levels in emasculated ovaries but maintained low expression levels in pollinated ovaries...
Read More
Chronic myeloid leukemia (CML) stem/progenitor cells (SPC) express a transcriptional program characteristic of proliferation, yet can achieve and maintain quiescence. Understanding the mechanisms by which leukemic SPC maintain quiescence can help to clarify how they persist during long-term targeted treatment...
Read More