Despite significant developments in its clinical treatment, the reported incidence and mortality of gastric cancer have exhibited marked increases. The molecular mechanisms of gastric cancer initiation and progression remain to be fully elucidated. The aim of a recent study sought to identify novel microRNAs (miRNAs/miRs) with a role in the peritoneal metastasis of gastric cancer by comparing the miRNA expression in the gastric cancer cell line GC9811 with that in its variant GC9811‑P, a sub‑cell line with a high potential for peritoneal metastasis...
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Drought is a major abiotic stress that reduces rice development and yield. miRNAs are known to mediate post-transcriptional regulation under drought stress. Although the importance of individual miRNAs has been established, the cross-talks between miRNAs and mRNAs remain unearthed. In a recent study, researchers performed microarray analysis of miRNAs and matched mRNA expression profiles of drought treated rice cultivar Nipponbare...
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Cyanobacteria have become more prevalent than other phytoplankton in freshwater assemblages during summer. In such conditions, cyanobacterial traits may reduce zooplankton fitness and the energy flow efficiency from primary producers to aquatic herbivores. Cladocerans, as the dominant zooplankton grazers in freshwater ecosystems, exhibit clonal variation in their tolerance to cyanobacteria with an increasing gradient in eutrophication history. Hitherto, research on the full modes of action (MoAs) of Daphnia clonal differences in tolerance to toxic Microcystis still remains in its infancy. Researchers recently conducted fitness and transcriptome analyses on two Daphnia clones, clone TH09 and TH14...
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Primordial germ cells (PGCs) are the precursors of adult germ cells, and among the embryonic stem-like cells in the bird embryo, only they can transmit the genetic information to the next generation. Despite the wide range of applications, very little is known about the mechanism that governs primordial germ cell self-renewal and differentiation. As a first step, a team led by researchers from the National Agricultural Research and Innovation Centre compared 12 newly established chicken PGC lines derived from two different chicken breeds, performing CCK-8 proliferation assay...
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Coronary artery occlusion results in ischemic heart tissue and subsequent death of cardiomyocytes, followed by an inflammatory response to clear the infarcted area from dead cells. Invading inflammatory cells are suggested to contribute to myocardial ischemia-reperfusion (I/R) injury and adverse remodeling. Given the importance of the inflammatory phase during cardiac wound healing, better understanding is needed to develop novel interventions. In a recent study, researchers from University Medical Center Utrecht investigated the role of the inflammatory-related miR-223 in the ischemic heart using miRNA microarray technology...
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Loss of oral barrier homeostasis leads to the development of periodontitis, the most common chronic inflammatory condition of mankind. Therefore, it is important to better understand the immune mediators acting at this unique barrier to safeguard tissue integrity. In a recent study, researchers identify a vital role for γδ T cells in constraining pathological inflammation at the oral barrier, as the absence of γδ T cells resulted in enhanced pathology during periodontitis. They show that oral barrier γδ T cells produce the reparative cytokine Amphiregulin, administration of which rescued the elevated oral pathology of tcrδ−/− mice...
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Coffea arabica L. is an important agricultural commodity, accounting for 60% of traded coffee worldwide. Nitrogen (N) is a macronutrient that is usually limiting to plant yield; however, molecular mechanisms of plant acclimation to N limitation remain largely unknown in tropical woody crops. In a recent study, researchers investigated the transcriptome of coffee roots under N starvation, analyzing poly-A+ libraries and small RNAs...
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MicroRNAs (miRNAs) play important regulatory roles in numerous biological processes, but there is no report on miRNAs of hybrid snakehead. In this study, four independent small RNA libraries were constructed from the spleen, liver kidney and muscle of hybrid snakehead. These libraries were sequenced using deep sequencing technology...
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LC Sciences
Latest studies have indicated that microRNAs (miRNAs) play important roles in defending against bacterial and viral infections in marine crustacean, whereas little is known regarding the immunological roles of crustacean miRNAs in response to parasitic infection...
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The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In a recent study, researchers aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell proliferation and apoptosis, to determine a novel therapeutic target for CA recurrence...
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