Total RNA-Seq Sequencing Report



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1. Introduction


The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serves as the template for protein synthesis. The discovery of extensive transcription of large RNA transcripts that do not code for proteins, termed long noncoding RNAs (lncRNAs) provide an important new perspective on the centrality of RNA in gene regulation. An emerging theme from multiple model systems is that lncRNAs form extensive networks of ribonucleoprotein (RNP) complexes with numerous chromatin regulators, and target these enzymatic activities to appropriate locations in the genome. Consistent with this notion, long noncoding RNAs can function as modular scaffolds to specify higher order organization in RNP complexes and in chromatin states. The importance of these modes of regulation is underscored by the newly recognized roles of long RNAs for proper gene control across all kingdoms of life.


Fig.1 Schematic diagram illustrating various classes of ncRNAs. Laurent et al. Trends Genet. 2015 May ; 31(5): 239–251


As shown in Fig.1, three hypothetical loci are shown. Protein coding exons are shown as green (locus 1) or yellow boxes (locus 3). Locus 2 signifies a pseudogene of locus 1. Regulatory regions of locus 1 are shown in purple (promoter) and magenta (enhancer). Repeats are denoted by brown boxes. Lines with arrows represent ncRNAs. CAR: chromatin-associated RNA. ceRNA: Competing endogenous. RNA ciRNA: chromatin-interlinking RNA (grey) or circular intronic RNA (green). ecircRNA: exonic circular RNA. eRNA: enhancer-associated RNA. lincRNA: long intervening non-coding RNA. ncRNA-a: activating non-coding RNAs. PALR: promoter-associated long RNA. PIN: partially intronic RNA. TIN: totally intronic RNA. TSSa-RNA: transcription start site-associated RNA. T-UCR: Transcribed Ultraconserved Regions. uaRNA: 3′UTR-derived RNAs. vlincRNA: very long intergenic non-coding RNA. The role depicted here for CARs and ciRNAs in stabilizing a chromatin loop is hypothetical.



2. Materials and Methods


2.1 Library construction and sequencing


Total RNA was extracted using Trizol reagent (Invitrogen, CA, USA) following the manufacturer's procedure. The total RNA quantity and purity were analysis of Bioanalyzer 2100 and RNA 6000 Nano LabChip Kit (Agilent, CA, USA) with RIN number >7.0. Approximately 10 ug of total RNA representing a specific adipose type was used to deplete ribosomal RNA according to the manuscript of the Epicentre Ribo-Zero Gold Kit (Illumina, San Diego, USA). Following purification, the poly(A)- or poly(A)+ RNA fractions is fragmented into small pieces using divalent cations under elevated temperature. Then the cleaved RNA fragments were reverse-transcribed to create the final cDNA library in accordance with the protocol for the mRNA-Seq sample preparation kit (Illumina, San Diego, USA), the average insert size for the paired-end libraries was 300 bp (±50 bp). And then we performed the paired-end sequencing on an Illumina Hiseq 4000 at LC Sciences following the vendor's recommended protocol.



2.2 Bioinformatics analysis


Transcripts Assembly:

Firstly, Cutadapt [1] and perl scripts in house were used to remove the reads that contained adaptor contamination, low quality bases and undetermined bases. Then sequence quality was verified using FastQC (http://www.bioinformatics.babraham.ac.uk/projects/fastqc/). We used Bowtie2 [2] and Tophat2 [3] to map reads to the genome of (____). The mapped reads of each sample were assembled using StringTie [4]. Then, all transcriptomes from (____) Samples were merged to reconstruct a comprehensive transcriptome using perl scripts and gffcompare [4]. After the final transcriptome was generated, StringTie [4] and Ballgown [5] was used to estimate the expression levels of all transcripts.


Different expression analysis of transcripts:

StringTie [4] was used to perform expression level for mRNAs and lncRNAs by calculating FPKM. The differentially expressed mRNAs and lncRNAs were selected with log2 (fold change) >1 or log2 (fold change) <-1 and with statistical significance (p value < 0.05) by R package Ballgown [5].




Bioinformatics pipeline for lncRNA (RiboZero)


Reference:

1. Martin M (2011) Cutadapt removes adapter sequences from high-throughput sequencing reads. Embnet Journal 17.

2. Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nature Methods 9: 357-359.

3. Kim D, et al. (2013) TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biology 14: R36.

4. Pertea M, et al. (2015) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nature Biotechnology 33: 290-295.

5. Frazee AC, et al. (2015) Ballgown bridges the gap between transcriptome assembly and expression analysis. Nature Biotechnology 33: 243.

6. Kong L, et al. (2007) CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Research 35: 345-349.

7. Sun L, et al. (2013) Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. Nucleic Acids Research 41: e166-e166.

8. Krzywinski M, et al. (2009) Circos: an information aesthetic for comparative genomics.Genome Research 19: 1639-1645.




3. Project information


3.1 Sample information


Species name: Human

Latin name: Homo sapiens

Specimens: tissue/whole blood


3.2 Group information


SampleCOND1
EM01_MM
EM02_MM
EM03_MM
KTY01_KK
KTY02_KK
KTY03_KK

3.3 Database


Dababase Web links Version/date
Genomeftp://ftp.ensembl.org/pub/release-90/fasta/homo_sapiens/dna/GRCh38/Ensemble v90
lncRNAftp://ftp.sanger.ac.uk/pub/gencode/Gencode_human/release_27/gencode.v27.lncRNA_transcripts.fa.gzgencode v27
Gene Orthology (GO)http://www.geneontology.org/2016.12
KEGGhttp://www.genome.jp/kegg/pathway.html2017.06

3.4 Bioinformatics software


Analysis item Software Version/date
Quality controlFastQC0.10.1
Adapter removeCutadapt1.10
MappingTophat2.0
Transcripts assemblyStringTie1.3
Differential expression analysisR package: Ballgown2016.09.29
GO and KEGG enrichment analysisPerl scripts in houseNA
Coding potentialCPC (Coding Potential Calculator)0.9
Coding potentialCNCI (Coding-Non-Coding Index)2.0


4. Results of mRNA


4.1 Quality control


SampleRaw DataValid DataValid Ratio(reads)Q20%Q30%GC content%
ReadBaseReadBase
EM01_M9109787713.66G8848192013.27G97.1399.5693.6751
EM02_M88733750.5013.31G6894008810.34G77.6999.5793.7551
EM03_M9003858613.51G6995481010.49G77.6999.5693.7551
KTY01_K87751966.5013.16G8588128412.88G97.8799.5993.7850
KTY02_K8546831012.82G8367666812.55G97.9099.6394.5550
KTY03_K93711271.5014.06G7336312011.00G78.2999.5893.8750

document location: summary/1_rawdata/ReadsQC.xlsx


4.2 Mapping


SampleValid readsMapped readsUnique Mapped readsMulti Mapped readsPE Mapped readsMapped left readsMapped right readsReads map to sense strandReads map to antisense strandNon-splice readsSplice reads
EM01_M6898486061403066(89.01%)59284876(85.94%)2118190(3.07%)28591268(41.45%)31853168(46.17%)29549898(42.84%)29588508(42.89%)29696368(43.05%)37477965(54.33%)21806911(31.61%)
EM02_M5374766847921784(89.16%)46290322(86.13%)1631462(3.04%)22337066(41.56%)24837216(46.21%)23084568(42.95%)23104056(42.99%)23186266(43.14%)29256773(54.43%)17033549(31.69%)
EM03_M5453734848627522(89.16%)46971952(86.13%)1655570(3.04%)22667090(41.56%)25201550(46.21%)23425972(42.95%)23444442(42.99%)23527510(43.14%)29686513(54.43%)17285439(31.69%)
KTY01_K6791755060691201(89.36%)59015058(86.89%)1676143(2.47%)28186846(41.50%)31625635(46.56%)29065566(42.80%)29497002(43.43%)29518056(43.46%)38092998(56.09%)20922060(30.81%)
KTY02_K6727541460947071(90.59%)59310831(88.16%)1636240(2.43%)28648791(42.58%)31402890(46.68%)29544181(43.92%)29647889(44.07%)29662942(44.09%)37119682(55.18%)22191149(32.99%)
KTY03_K5798778852278895(90.16%)50842143(87.68%)1436752(2.48%)24453727(42.17%)27069515(46.68%)25209380(43.47%)25413011(43.82%)25429132(43.85%)32811360(56.58%)18030783(31.09%)

document location: summary/1_rawdata/2_mapped_stat.xlsx


4.3 Statistics of mapped region



document location: summary/2_reference_mapping/3_mapped_region_stat.png


4.4 Localization of mRNAs on genome





document location: summary/2_reference_mapping/4_DensityDistribution/*_chromosome.jpeg


4.5 Prediction of novel transcripts


Those transcripts assembled by StringTie which are not annotated in genome annotation database are belong to novel transcripts with class code (i, j, o, u ,x).


Class code typies and definitions:

class codeDescription
jPotentially novel isoform (fragment): at least one splice junction is shared with a reference transcript
iA transfrag falling entirely within a reference intron
oGeneric exonic overlap with a reference transcript
uUnknown, intergenic transcript
xExonic overlap with reference on the opposite strand

document location:

summary/4_1_lncRNA_assembly/novel_merged.fa

summary/4_1_lncRNA_assembly/novel_merged.gtf


Tips: The Gene transfer format (GTF) is a file format used to hold information about gene structure. It is a tab-delimited text format based on the general feature format (GFF), but contains some additional conventions specific to gene information. A significant feature of the GTF that can be validated: given a sequence and a GTF file, one can check that the format is correct. This significantly reduces problems with the interchange of data between groups.


4.6 Overview of gene expression


4.6.1 Statistics of gene/transcript expression


Statistics of gene expression:

SampleExp geneMin.1st Qu.MedianMean3rd Qu.Max.Sd.Sum.
EM01_M299960.000.100.525.972.1326373.26167.30179153.22
EM02_M297360.000.120.626.152.2026355.62168.65182841.25
EM03_M297480.000.120.626.152.2026357.08168.76182971.87
KTY01_K310550.000.110.715.362.788211.8069.30166435.86
KTY02_K316940.000.100.635.532.5411062.1486.33175266.20
KTY03_K308880.000.120.805.442.848207.7469.57167879.83

Statistics of transcript expression:

SampleExp transcriptMin.1st Qu.MedianMean3rd Qu.Max.Sd.Sum.
EM01_M1107370.000.080.232.970.7921508.7288.24328707.53
EM02_M1059690.000.090.263.150.8821454.0190.76334070.66
EM03_M1062640.000.090.263.140.8721447.3290.69334067.24
KTY01_K1145260.000.080.272.841.016142.8342.65324720.31
KTY02_K1155960.000.080.252.930.926768.0850.16338956.20
KTY03_K1118190.000.090.292.911.086173.1043.13325887.89



document location:

summary/3_1_transcript_expression/1_gene_expression_statistics.xlsx

summary/3_1_transcript_expression/*_gene_expression_boxplot.png

summary/3_1_transcript_expression/1_gene_expression_statistics.xlsx

summary/3_1_transcript_expression/*_transcript_expression_boxplot.png


4.6.2 FPKM Interval (FI) of gene/transcripts expression


FI of gene expression:

Sample0-0.1 FI0.1-0.3 FI0.3-3.57 FI3.57-15 FI15-60 FI>60 FI
EM01_M7571(25.24%)5027(16.76%)12504(41.69%)3815(12.72%)823(2.74%)256(0.85%)
EM02_M6572(22.10%)5003(16.82%)13189(44.35%)3878(13.04%)832(2.80%)262(0.88%)
EM03_M6635(22.30%)4982(16.75%)13163(44.25%)3879(13.04%)828(2.78%)261(0.88%)
KTY01_K7499(24.15%)4646(14.96%)12319(39.67%)5057(16.28%)1229(3.96%)305(0.98%)
KTY02_K8113(25.60%)4717(14.88%)12474(39.36%)4895(15.44%)1188(3.75%)307(0.97%)
KTY03_K6903(22.35%)4647(15.04%)12699(41.11%)5112(16.55%)1221(3.95%)306(0.99%)

FI of transcripts expression:

Sample0-0.1 FI0.1-0.3 FI0.3-3.57 FI3.57-15 FI15-60 FI>60 FI
EM01_M33696(30.43%)28453(25.69%)40165(36.27%)6445(5.82%)1460(1.32%)518(0.47%)
EM02_M29157(27.51%)27365(25.82%)40984(38.68%)6459(6.10%)1483(1.40%)521(0.49%)
EM03_M29420(27.69%)27392(25.78%)41005(38.59%)6445(6.07%)1482(1.39%)520(0.49%)
KTY01_K32337(28.24%)27288(23.83%)43920(38.35%)8250(7.20%)2125(1.86%)606(0.53%)
KTY02_K34571(29.91%)28024(24.24%)42426(36.70%)7874(6.81%)2073(1.79%)628(0.54%)
KTY03_K29868(26.71%)26792(23.96%)44124(39.46%)8297(7.42%)2126(1.90%)612(0.55%)

document location:

summary/3_1_transcript_expression/2_gene_expression_interval.xlsx

summary/3_1_transcript_expression/2_transcript_expression_interval.xlsx


4.6.3 Density of gene/transcript expression




document location:

summary/3_1_transcript_expression/*_gene_expression_density.png

summary/3_1_transcript_expression/*_transcript_expression_density.png


4.6.4 Gene/transcript expression profiling


Gene expression profiling:

gene_idgene_nametranscript_idGOKEGGKO_ENTRYECDescriptionFPKM.EM01_MFPKM.EM02_MFPKM.EM03_MFPKM.KTY01_KFPKM.KTY02_KFPKM.KTY03_K
ENSG00000000005TNMDENST00000373031GO:0001886(endothelial cell morphogenesis);GO:0001937(negative regulation of endothelial cell proliferation);GO:0005515(protein binding);GO:0005635(nuclear envelope);GO:0005737(cytoplasm);GO:0016021(integral component of membrane);GO:0016525(negative regulation of angiogenesis);GO:0035990(tendon cell differentiation);GO:0071773(cellular response to BMP stimulus)NANANAtenomodulin [Source:HGNC Symbol;Acc:HGNC:17757]0.050.070.07000
ENSG00000002079MYH16ENST00000439784NANANANANA0.000.000.000.010.010.01
ENSG00000002587HS3ST1ENST00000002596;ENST00000514690GO:0005796(Golgi lumen);GO:0005975(carbohydrate metabolic process);GO:0006024(glycosaminoglycan biosynthetic process);GO:0008146(sulfotransferase activity);GO:0008467([heparan sulfate]-glucosamine 3-sulfotransferase 1 activity);GO:0016021(integral component of membrane);GO:0030203(glycosaminoglycan metabolic process);GO:0044281(small molecule metabolic process)NANANAheparan sulfate (glucosamine) 3-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5194]0.160.160.160.100.100.10
ENSG00000002726AOC1ENST00000493429;ENST00000467291;ENST00000622116;ENST00000360937;ENST00000619575GO:0004872(receptor activity);GO:0005261(cation channel activity);GO:0005272(sodium channel activity);GO:0005507(copper ion binding);GO:0005509(calcium ion binding);GO:0005615(extracellular space);GO:0005777(peroxisome);GO:0005886(plasma membrane);GO:0005923(bicellular tight junction);GO:0008131(primary amine oxidase activity);GO:0008144(drug binding);GO:0008201(heparin binding);GO:0008270(zinc ion binding);GO:0009308(amine metabolic process);GO:0032403(protein complex binding);GO:0035725(sodium ion transmembrane transport);GO:0035874(cellular response to copper ion starvation);GO:0042493(response to drug);GO:0042803(protein homodimerization activity);GO:0046677(response to antibiotic);GO:0048038(quinone binding);GO:0052597(diamine oxidase activity);GO:0052598(histamine oxidase activity);GO:0052599(methylputrescine oxidase activity);GO:0052600(propane-1,3-diamine oxidase activity);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome);GO:0071280(cellular response to copper ion);GO:0071420(cellular response to histamine);GO:0071504(cellular response to heparin);GO:0097185(cellular response to azide)00330(Arginine and proline metabolism);00340(Histidine metabolism);00380(Tryptophan metabolism)NANAamine oxidase, copper containing 1 [Source:HGNC Symbol;Acc:HGNC:80]0.110.080.080.230.300.25
ENSG00000002745WNT16ENST00000222462GO:0003408(optic cup formation involved in camera-type eye development);GO:0005102(receptor binding);GO:0005109(frizzled binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005615(extracellular space);GO:0005737(cytoplasm);GO:0007275(multicellular organismal development);GO:0010628(positive regulation of gene expression);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0016055(Wnt signaling pathway);GO:0030182(neuron differentiation);GO:0030216(keratinocyte differentiation);GO:0043616(keratinocyte proliferation);GO:0045165(cell fate commitment);GO:0046330(positive regulation of JNK cascade);GO:0046849(bone remodeling);GO:0060317(cardiac epithelial to mesenchymal transition);GO:0060548(negative regulation of cell death);GO:0090399(replicative senescence);GO:0090403(oxidative stress-induced premature senescence)04310(Wnt signaling pathway);04340(Hedgehog signaling pathway);04916(Melanogenesis);05200(Pathways in cancer);05217(Basal cell carcinoma)NANAwingless-type MMTV integration site family, member 16 [Source:HGNC Symbol;Acc:HGNC:16267]0.080.070.070.030.040.03
ENSG00000002746HECW1ENST00000395891;ENST00000493057;ENST00000471043;ENST00000461842GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0016874(ligase activity);GO:0042787(protein ubiquitination involved in ubiquitin-dependent protein catabolic process);GO:0061630(ubiquitin protein ligase activity);GO:0090090(negative regulation of canonical Wnt signaling pathway)NANANAHECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:22195]0.030.040.040.130.150.12
ENSG00000003137CYP26B1ENST00000001146;ENST00000461519GO:0001709(cell fate determination);GO:0001768(establishment of T cell polarity);GO:0001972(retinoic acid binding);GO:0004497(monooxygenase activity);GO:0005506(iron ion binding);GO:0005737(cytoplasm);GO:0005789(endoplasmic reticulum membrane);GO:0006766(vitamin metabolic process);GO:0006805(xenobiotic metabolic process);GO:0006954(inflammatory response);GO:0007140(male meiosis);GO:0007283(spermatogenesis);GO:0008401(retinoic acid 4-hydroxylase activity);GO:0009954(proximal/distal pattern formation);GO:0010628(positive regulation of gene expression);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0020037(heme binding);GO:0030326(embryonic limb morphogenesis);GO:0034653(retinoic acid catabolic process);GO:0042573(retinoic acid metabolic process);GO:0043587(tongue morphogenesis);GO:0044281(small molecule metabolic process);GO:0045580(regulation of T cell differentiation);GO:0048384(retinoic acid receptor signaling pathway);GO:0048385(regulation of retinoic acid receptor signaling pathway);GO:0048387(negative regulation of retinoic acid receptor signaling pathway);GO:0055114(oxidation-reduction process);GO:0060349(bone morphogenesis);GO:0061436(establishment of skin barrier);GO:0070268(cornification);GO:0071300(cellular response to retinoic acid);GO:2001037(positive regulation of tongue muscle cell differentiation)00830(Retinol metabolism)NANAcytochrome P450, family 26, subfamily B, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:20581]0.210.180.180.020.160.02
ENSG00000004660CAMKK1ENST00000348335;ENST00000158166;ENST00000573483GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004683(calmodulin-dependent protein kinase activity);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005829(cytosol);GO:0006468(protein phosphorylation);GO:0007268(synaptic transmission);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0032147(activation of protein kinase activity);GO:0045860(positive regulation of protein kinase activity)04920(Adipocytokine signaling pathway)NANAcalcium/calmodulin-dependent protein kinase kinase 1, alpha [Source:HGNC Symbol;Acc:HGNC:1469]0.290.340.330.100.090.10
ENSG00000004777ARHGAP33ENST00000314737;ENST00000221905;ENST00000601474;ENST00000591438;ENST00000586918;ENST00000587447;ENST00000593034GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0015031(protein transport);GO:0035091(phosphatidylinositol binding);GO:0043547(positive regulation of GTPase activity);GO:0051056(regulation of small GTPase mediated signal transduction)NANANARho GTPase activating protein 33 [Source:HGNC Symbol;Acc:HGNC:23085]0.250.240.230.190.210.22
ENSG00000004809SLC22A16ENST00000460159;ENST00000330550GO:0005275(amine transmembrane transporter activity);GO:0005886(plasma membrane);GO:0007275(multicellular organismal development);GO:0007283(spermatogenesis);GO:0007338(single fertilization);GO:0015101(organic cation transmembrane transporter activity);GO:0015226(carnitine transmembrane transporter activity);GO:0015695(organic cation transport);GO:0015837(amine transport);GO:0015879(carnitine transport);GO:0016021(integral component of membrane);GO:0022857(transmembrane transporter activity);GO:0030154(cell differentiation);GO:0030317(sperm motility);GO:0046717(acid secretion);GO:0055085(transmembrane transport);GO:1902603(carnitine transmembrane transport)NANANAsolute carrier family 22 (organic cation/carnitine transporter), member 16 [Source:HGNC Symbol;Acc:HGNC:20302]0.020.020.0200.010
ENSG00000004846ABCB5ENST00000404938;ENST00000443026GO:0002481(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent);GO:0002485(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent);GO:0002489(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent);GO:0002591(positive regulation of antigen processing and presentation of peptide antigen via MHC class I);GO:0005524(ATP binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0008152(metabolic process);GO:0015562(efflux transmembrane transporter activity);GO:0016021(integral component of membrane);GO:0016887(ATPase activity);GO:0030154(cell differentiation);GO:0042391(regulation of membrane potential);GO:0042626(ATPase activity, coupled to transmembrane movement of substances);GO:0048058(compound eye corneal lens development);GO:0055085(transmembrane transport)02010(ABC transporters)NANAATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:HGNC Symbol;Acc:HGNC:46]0.010.010.010.020.020.02
ENSG00000004848ARXENST00000379044GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000980(RNA polymerase II distal enhancer sequence-specific DNA binding);GO:0001206(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription);GO:0001764(neuron migration);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007411(axon guidance);GO:0021759(globus pallidus development);GO:0021772(olfactory bulb development);GO:0021800(cerebral cortex tangential migration);GO:0021831(embryonic olfactory bulb interneuron precursor migration);GO:0021846(cell proliferation in forebrain);GO:0021853(cerebral cortex GABAergic interneuron migration);GO:0030900(forebrain development);GO:0042127(regulation of cell proliferation);GO:0043565(sequence-specific DNA binding);GO:0044241(lipid digestion);GO:0046622(positive regulation of organ growth);GO:0072148(epithelial cell fate commitment)NANANAaristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060]0000.020.010.02
ENSG00000004939SLC4A1ENST00000262418;ENST00000498270GO:0003779(actin binding);GO:0005215(transporter activity);GO:0005452(inorganic anion exchanger activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0006820(anion transport);GO:0006821(chloride transport);GO:0006873(cellular ion homeostasis);GO:0008022(protein C-terminus binding);GO:0008509(anion transmembrane transporter activity);GO:0015106(bicarbonate transmembrane transporter activity);GO:0015108(chloride transmembrane transporter activity);GO:0015301(anion:anion antiporter activity);GO:0015701(bicarbonate transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016323(basolateral plasma membrane);GO:0030018(Z disc);GO:0030506(ankyrin binding);GO:0030863(cortical cytoskeleton);GO:0042803(protein homodimerization activity);GO:0043495(protein anchor);GO:0044281(small molecule metabolic process);GO:0051453(regulation of intracellular pH);GO:0055085(transmembrane transport);GO:0070062(extracellular exosome);GO:0072562(blood microparticle);GO:1902476(chloride transmembrane transport)04966(Collecting duct acid secretion)NANAsolute carrier family 4 (anion exchanger), member 1 (Diego blood group) [Source:HGNC Symbol;Acc:HGNC:11027]0.120.110.110.010.030.01
ENSG00000004948CALCRENST00000359558GO:0001669(acrosomal vesicle);GO:0004872(receptor activity);GO:0004888(transmembrane signaling receptor activity);GO:0004930(G-protein coupled receptor activity);GO:0004948(calcitonin receptor activity);GO:0005515(protein binding);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005929(cilium);GO:0007166(cell surface receptor signaling pathway);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007189(adenylate cyclase-activating G-protein coupled receptor signaling pathway);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0008565(protein transporter activity);GO:0015031(protein transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030279(negative regulation of ossification);GO:0030316(osteoclast differentiation);GO:0030424(axon);GO:0030819(positive regulation of cAMP biosynthetic process);GO:0031623(receptor internalization);GO:0032841(calcitonin binding);GO:0043005(neuron projection);GO:0043025(neuronal cell body);GO:0043488(regulation of mRNA stability);GO:0045762(positive regulation of adenylate cyclase activity);GO:0051384(response to glucocorticoid);GO:0072659(protein localization to plasma membrane)04080(Neuroactive ligand-receptor interaction);04380(Osteoclast differentiation)NANAcalcitonin receptor [Source:HGNC Symbol;Acc:HGNC:1440]0.010.010.010.030.030.04
ENSG00000005001PRSS22ENST00000161006;ENST00000570950GO:0004252(serine-type endopeptidase activity);GO:0005576(extracellular region);GO:0006508(proteolysis)NANANAprotease, serine, 22 [Source:HGNC Symbol;Acc:HGNC:14368]0.060.060.0700.010
ENSG00000005073HOXA11ENST00000006015GO:0001501(skeletal system development);GO:0001656(metanephros development);GO:0001658(branching involved in ureteric bud morphogenesis);GO:0001759(organ induction);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005667(transcription factor complex);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organismal development);GO:0007283(spermatogenesis);GO:0007338(single fertilization);GO:0007501(mesodermal cell fate specification);GO:0008584(male gonad development);GO:0009653(anatomical structure morphogenesis);GO:0009952(anterior/posterior pattern specification);GO:0009953(dorsal/ventral pattern formation);GO:0009954(proximal/distal pattern formation);GO:0010468(regulation of gene expression);GO:0010720(positive regulation of cell development);GO:0030326(embryonic limb morphogenesis);GO:0032330(regulation of chondrocyte differentiation);GO:0032332(positive regulation of chondrocyte differentiation);GO:0032993(protein-DNA complex);GO:0035115(embryonic forelimb morphogenesis);GO:0042733(embryonic digit morphogenesis);GO:0043234(protein complex);GO:0043565(sequence-specific DNA binding);GO:0045893(positive regulation of transcription, DNA-templated);GO:0048589(developmental growth);GO:0060065(uterus development);GO:0060272(embryonic skeletal joint morphogenesis);GO:0060351(cartilage development involved in endochondral bone morphogenesis)NANANAhomeobox A11 [Source:HGNC Symbol;Acc:HGNC:5101]0000.020.130.02
ENSG00000005102MEOX1ENST00000329168;ENST00000549132GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001046(core promoter sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001757(somite specification);GO:0003674(molecular_function);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0007275(multicellular organismal development);GO:0008150(biological_process);GO:0043565(sequence-specific DNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0060218(hematopoietic stem cell differentiation);GO:0061053(somite development);GO:0061056(sclerotome development);GO:0071837(HMG box domain binding)NANANAmesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013]0.020.020.02000
ENSG00000005381MPOENST00000225275;ENST00000578493;ENST00000581022GO:0001878(response to yeast);GO:0002149(hypochlorous acid biosynthetic process);GO:0002679(respiratory burst involved in defense response);GO:0003682(chromatin binding);GO:0004601(peroxidase activity);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005739(mitochondrion);GO:0005764(lysosome);GO:0006952(defense response);GO:0006979(response to oxidative stress);GO:0008201(heparin binding);GO:0019430(removal of superoxide radicals);GO:0020037(heme binding);GO:0030141(secretory granule);GO:0034374(low-density lipoprotein particle remodeling);GO:0042582(azurophil granule);GO:0042744(hydrogen peroxide catabolic process);GO:0043066(negative regulation of apoptotic process);GO:0044130(negative regulation of growth of symbiont in host);GO:0046872(metal ion binding);GO:0050832(defense response to fungus);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome)04145(Phagosome)NANAmyeloperoxidase [Source:HGNC Symbol;Acc:HGNC:7218]0.130.150.1500.040
ENSG00000005513SOX8ENST00000293894GO:0000979(RNA polymerase II core promoter sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0001649(osteoblast differentiation);GO:0001701(in utero embryonic development);GO:0001755(neural crest cell migration);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0007165(signal transduction);GO:0007283(spermatogenesis);GO:0007422(peripheral nervous system development);GO:0008134(transcription factor binding);GO:0008584(male gonad development);GO:0010628(positive regulation of gene expression);GO:0010817(regulation of hormone levels);GO:0014015(positive regulation of gliogenesis);GO:0033690(positive regulation of osteoblast proliferation);GO:0035914(skeletal muscle cell differentiation);GO:0043066(negative regulation of apoptotic process);GO:0043565(sequence-specific DNA binding);GO:0044798(nuclear transcription factor complex);GO:0045165(cell fate commitment);GO:0045444(fat cell differentiation);GO:0045662(negative regulation of myoblast differentiation);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046533(negative regulation of photoreceptor cell differentiation);GO:0046982(protein heterodimerization activity);GO:0048469(cell maturation);GO:0048484(enteric nervous system development);GO:0048709(oligodendrocyte differentiation);GO:0060009(Sertoli cell development);GO:0060018(astrocyte fate commitment);GO:0060041(retina development in camera-type eye);GO:0060221(retinal rod cell differentiation);GO:0060612(adipose tissue development);GO:0061138(morphogenesis of a branching epithelium);GO:0072034(renal vesicle induction);GO:0072197(ureter morphogenesis);GO:0072289(metanephric nephron tubule formation);GO:0090184(positive regulation of kidney development);GO:0090190(positive regulation of branching involved in ureteric bud morphogenesis)NANANASRY (sex determining region Y)-box 8 [Source:HGNC Symbol;Acc:HGNC:11203]0.030.040.04000
ENSG00000005884ITGA3ENST00000506401;ENST00000505306;ENST00000320031;ENST00000570989;ENST00000510809;ENST00000507771;ENST00000515147;ENST00000506437;ENST00000514834GO:0001764(neuron migration);GO:0001948(glycoprotein binding);GO:0001968(fibronectin binding);GO:0002020(protease binding);GO:0005178(integrin binding);GO:0005515(protein binding);GO:0005518(collagen binding);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0007155(cell adhesion);GO:0007160(cell-matrix adhesion);GO:0007229(integrin-mediated signaling pathway);GO:0007507(heart development);GO:0007596(blood coagulation);GO:0007613(memory);GO:0008305(integrin complex);GO:0009897(external side of plasma membrane);GO:0009986(cell surface);GO:0010628(positive regulation of gene expression);GO:0010634(positive regulation of epithelial cell migration);GO:0010811(positive regulation of cell-substrate adhesion);GO:0010976(positive regulation of neuron projection development);GO:0016021(integral component of membrane);GO:0016323(basolateral plasma membrane);GO:0017015(regulation of transforming growth factor beta receptor signaling pathway);GO:0019904(protein domain specific binding);GO:0030111(regulation of Wnt signaling pathway);GO:0030198(extracellular matrix organization);GO:0030324(lung development);GO:0030426(growth cone);GO:0030510(regulation of BMP signaling pathway);GO:0031345(negative regulation of cell projection organization);GO:0031527(filopodium membrane);GO:0034667(integrin alpha3-beta1 complex);GO:0034698(response to gonadotropin);GO:0035024(negative regulation of Rho protein signal transduction);GO:0035640(exploration behavior);GO:0042493(response to drug);GO:0043235(receptor complex);GO:0043236(laminin binding);GO:0043588(skin development);GO:0044708(single-organism behavior);GO:0045202(synapse);GO:0046872(metal ion binding);GO:0046982(protein heterodimerization activity);GO:0048333(mesodermal cell differentiation);GO:0048471(perinuclear region of cytoplasm);GO:0050900(leukocyte migration);GO:0060076(excitatory synapse);GO:0060135(maternal process involved in female pregnancy);GO:0070062(extracellular exosome);GO:0071438(invadopodium membrane);GO:0071944(cell periphery);GO:0072006(nephron development);GO:0090004(positive regulation of establishment of protein localization to plasma membrane);GO:0097060(synaptic membrane);GO:0097062(dendritic spine maintenance);GO:0097205(renal filtration)04510(Focal adhesion);04512(ECM-receptor interaction);04640(Hematopoietic cell lineage);04810(Regulation of actin cytoskeleton);05200(Pathways in cancer);05222(Small cell lung cancer);05410(Hypertrophic cardiomyopathy (HCM));05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));05414(Dilated cardiomyopathy)NANAintegrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) [Source:HGNC Symbol;Acc:HGNC:6139]0.410.430.430.470.500.49
ENSG00000005961ITGA2BENST00000262407;ENST00000592462;ENST00000591990GO:0002576(platelet degranulation);GO:0002687(positive regulation of leukocyte migration);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005925(focal adhesion);GO:0007155(cell adhesion);GO:0007160(cell-matrix adhesion);GO:0007229(integrin-mediated signaling pathway);GO:0007411(axon guidance);GO:0007596(blood coagulation);GO:0008305(integrin complex);GO:0009897(external side of plasma membrane);GO:0009986(cell surface);GO:0030168(platelet activation);GO:0030198(extracellular matrix organization);GO:0031092(platelet alpha granule membrane);GO:0042802(identical protein binding);GO:0046872(metal ion binding);GO:0050840(extracellular matrix binding);GO:0070051(fibrinogen binding);GO:0070062(extracellular exosome);GO:0070527(platelet aggregation);GO:0072562(blood microparticle)04510(Focal adhesion);04512(ECM-receptor interaction);04640(Hematopoietic cell lineage);04810(Regulation of actin cytoskeleton);05200(Pathways in cancer);05222(Small cell lung cancer);05410(Hypertrophic cardiomyopathy (HCM));05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));05414(Dilated cardiomyopathy)NANAintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [Source:HGNC Symbol;Acc:HGNC:6138]0.020.030.030.030.020.03
ENSG00000006025OSBPL7ENST00000007414;ENST00000583167;ENST00000578461;ENST00000580140;ENST00000584698;ENST00000580226;ENST00000585051GO:0005515(protein binding);GO:0005776(autophagosome);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006869(lipid transport);GO:0015485(cholesterol binding);GO:0071397(cellular response to cholesterol);GO:0097038(perinuclear endoplasmic reticulum);GO:1901800(positive regulation of proteasomal protein catabolic process)NANANAoxysterol binding protein-like 7 [Source:HGNC Symbol;Acc:HGNC:16387]0.420.450.440.370.350.39
ENSG00000006071ABCC8ENST00000302539;ENST00000530147GO:0005267(potassium channel activity);GO:0005524(ATP binding);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006112(energy reserve metabolic process);GO:0006810(transport);GO:0006813(potassium ion transport);GO:0007165(signal transduction);GO:0007268(synaptic transmission);GO:0008076(voltage-gated potassium channel complex);GO:0008152(metabolic process);GO:0008281(sulfonylurea receptor activity);GO:0009268(response to pH);GO:0010043(response to zinc ion);GO:0015079(potassium ion transmembrane transporter activity);GO:0016021(integral component of membrane);GO:0016887(ATPase activity);GO:0019905(syntaxin binding);GO:0030672(synaptic vesicle membrane);GO:0032496(response to lipopolysaccharide);GO:0032868(response to insulin);GO:0042383(sarcolemma);GO:0042493(response to drug);GO:0042626(ATPase activity, coupled to transmembrane movement of substances);GO:0043268(positive regulation of potassium ion transport);GO:0044281(small molecule metabolic process);GO:0044325(ion channel binding);GO:0046676(negative regulation of insulin secretion);GO:0050796(regulation of insulin secretion);GO:0055085(transmembrane transport);GO:0071310(cellular response to organic substance);GO:0071805(potassium ion transmembrane transport)02010(ABC transporters);04930(Type II diabetes mellitus)NANAATP-binding cassette, sub-family C (CFTR/MRP), member 8 [Source:HGNC Symbol;Acc:HGNC:59]00000.010
ENSG00000006116CACNG3ENST00000005284GO:0005245(voltage-gated calcium channel activity);GO:0005886(plasma membrane);GO:0005891(voltage-gated calcium channel complex);GO:0006816(calcium ion transport);GO:0007268(synaptic transmission);GO:0016021(integral component of membrane);GO:0030666(endocytic vesicle membrane);GO:0032281(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex);GO:0070588(calcium ion transmembrane transport);GO:2000311(regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity)04010(MAPK signaling pathway);04260(Cardiac muscle contraction);05410(Hypertrophic cardiomyopathy (HCM));05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));05414(Dilated cardiomyopathy)NANAcalcium channel, voltage-dependent, gamma subunit 3 [Source:HGNC Symbol;Acc:HGNC:1407]0.020.020.02000
ENSG00000006283CACNA1GENST00000354983;ENST00000416767GO:0001508(action potential);GO:0002027(regulation of heart rate);GO:0005216(ion channel activity);GO:0005245(voltage-gated calcium channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005891(voltage-gated calcium channel complex);GO:0006810(transport);GO:0006811(ion transport);GO:0007268(synaptic transmission);GO:0007411(axon guidance);GO:0008332(low voltage-gated calcium channel activity);GO:0010045(response to nickel cation);GO:0016020(membrane);GO:0034220(ion transmembrane transport);GO:0034765(regulation of ion transmembrane transport);GO:0042391(regulation of membrane potential);GO:0045956(positive regulation of calcium ion-dependent exocytosis);GO:0055085(transmembrane transport);GO:0060371(regulation of atrial cardiac muscle cell membrane depolarization);GO:0070509(calcium ion import);GO:0070588(calcium ion transmembrane transport);GO:0086010(membrane depolarization during action potential);GO:0097110(scaffold protein binding)04010(MAPK signaling pathway);04020(Calcium signaling pathway);04930(Type II diabetes mellitus)NANAcalcium channel, voltage-dependent, T type, alpha 1G subunit [Source:HGNC Symbol;Acc:HGNC:1394]0.020.020.020.010.010.01
ENSG00000006377DLX6ENST00000518156GO:0001501(skeletal system development);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005634(nucleus);GO:0006355(regulation of transcription, DNA-templated);GO:0007399(nervous system development);GO:0030326(embryonic limb morphogenesis);GO:0030855(epithelial cell differentiation);GO:0042472(inner ear morphogenesis);GO:0043565(sequence-specific DNA binding);GO:0048646(anatomical structure formation involved in morphogenesis);GO:0050679(positive regulation of epithelial cell proliferation);GO:0060021(palate development);GO:0060322(head development)NANANAdistal-less homeobox 6 [Source:HGNC Symbol;Acc:HGNC:2919]00000.020
ENSG00000006432MAP3K9ENST00000611979;ENST00000554752;ENST00000555993;ENST00000553414;ENST00000381250;ENST00000554146;ENST00000554024GO:0000165(MAPK cascade);GO:0000186(activation of MAPKK activity);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004706(JUN kinase kinase kinase activity);GO:0004708(MAP kinase kinase activity);GO:0004709(MAP kinase kinase kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005575(cellular_component);GO:0005622(intracellular);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006468(protein phosphorylation);GO:0006915(apoptotic process);GO:0007256(activation of JNKK activity);GO:0007257(activation of JUN kinase activity);GO:0008219(cell death);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0042803(protein homodimerization activity);GO:0043065(positive regulation of apoptotic process);GO:0046777(protein autophosphorylation)NANANAmitogen-activated protein kinase kinase kinase 9 [Source:HGNC Symbol;Acc:HGNC:6861]0.580.580.570.400.390.46
ENSG00000006606CCL26ENST00000394905GO:0001938(positive regulation of endothelial cell proliferation);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0006935(chemotaxis);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0007165(signal transduction);GO:0007267(cell-cell signaling);GO:0008009(chemokine activity);GO:0030335(positive regulation of cell migration);GO:0030838(positive regulation of actin filament polymerization);GO:0043547(positive regulation of GTPase activity);GO:0060326(cell chemotaxis)04060(Cytokine-cytokine receptor interaction);04062(Chemokine signaling pathway)NANAchemokine (C-C motif) ligand 26 [Source:HGNC Symbol;Acc:HGNC:10625]00000.040
ENSG00000006740ARHGAP44ENST00000379672;ENST00000580768;ENST00000538915;ENST00000584974GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005543(phospholipid binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006887(exocytosis);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0030054(cell junction);GO:0031256(leading edge membrane);GO:0043197(dendritic spine);GO:0043547(positive regulation of GTPase activity);GO:0045202(synapse);GO:0051056(regulation of small GTPase mediated signal transduction);GO:0055037(recycling endosome)NANANARho GTPase activating protein 44 [Source:HGNC Symbol;Acc:HGNC:29096]0.160.160.170.070.050.06
ENSG00000006747SCINENST00000297029GO:0001786(phosphatidylserine binding);GO:0003779(actin binding);GO:0005509(calcium ion binding);GO:0005545(1-phosphatidylinositol binding);GO:0005546(phosphatidylinositol-4,5-bisphosphate binding);GO:0005737(cytoplasm);GO:0005856(cytoskeleton);GO:0005903(brush border);GO:0005938(cell cortex);GO:0008285(negative regulation of cell proliferation);GO:0017156(calcium ion-dependent exocytosis);GO:0032330(regulation of chondrocyte differentiation);GO:0042989(sequestering of actin monomers);GO:0043065(positive regulation of apoptotic process);GO:0045010(actin nucleation);GO:0045654(positive regulation of megakaryocyte differentiation);GO:0051014(actin filament severing);GO:0051015(actin filament binding);GO:0051047(positive regulation of secretion);GO:0051127(positive regulation of actin nucleation);GO:0051693(actin filament capping);GO:0070062(extracellular exosome)04666(Fc gamma R-mediated phagocytosis);04810(Regulation of actin cytoskeleton)NANAscinderin [Source:HGNC Symbol;Acc:HGNC:21695]0.020.010.010.080.060.08
ENSG00000006788MYH13ENST00000418404GO:0000146(microfilament motor activity);GO:0003774(motor activity);GO:0003779(actin binding);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005859(muscle myosin complex);GO:0006936(muscle contraction);GO:0008152(metabolic process);GO:0009267(cellular response to starvation);GO:0016459(myosin complex);GO:0030016(myofibril);GO:0032982(myosin filament);GO:0070062(extracellular exosome)04530(Tight junction);05416(Viral myocarditis)NANAmyosin, heavy chain 13, skeletal muscle [Source:HGNC Symbol;Acc:HGNC:7571]0.010.010.010.000.000.01
ENSG00000007001UPP2ENST00000605860;ENST00000005756;ENST00000489438GO:0003824(catalytic activity);GO:0004850(uridine phosphorylase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006206(pyrimidine nucleobase metabolic process);GO:0009116(nucleoside metabolic process);GO:0009166(nucleotide catabolic process);GO:0016763(transferase activity, transferring pentosyl groups);GO:0043097(pyrimidine nucleoside salvage);GO:0044206(UMP salvage);GO:0044281(small molecule metabolic process);GO:0045098(type III intermediate filament);GO:0046108(uridine metabolic process);GO:0046135(pyrimidine nucleoside catabolic process);GO:0055086(nucleobase-containing small molecule metabolic process)00240(Pyrimidine metabolism);00983(Drug metabolism - other enzymes);01100(Metabolic pathways)NANAuridine phosphorylase 2 [Source:HGNC Symbol;Acc:HGNC:23061]0.250.190.190.990.880.78
ENSG00000007038PRSS21ENST00000450020GO:0004252(serine-type endopeptidase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0007283(spermatogenesis);GO:0008236(serine-type peptidase activity);GO:0016020(membrane);GO:0031225(anchored component of membrane)NANANAprotease, serine, 21 (testisin) [Source:HGNC Symbol;Acc:HGNC:9485]0.010.010.010.020.020.03
ENSG00000007062PROM1ENST00000447510;ENST00000505450;ENST00000513448;ENST00000508167;ENST00000510224;ENST00000511153;ENST00000508940;ENST00000514967;ENST00000504842;ENST00000513108;ENST00000502501;ENST00000514693;ENST00000512304GO:0001750(photoreceptor outer segment);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005783(endoplasmic reticulum);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005902(microvillus);GO:0005903(brush border);GO:0009986(cell surface);GO:0010842(retina layer formation);GO:0016021(integral component of membrane);GO:0016324(apical plasma membrane);GO:0031528(microvillus membrane);GO:0031982(vesicle);GO:0032420(stereocilium);GO:0042622(photoreceptor outer segment membrane);GO:0042805(actinin binding);GO:0042995(cell projection);GO:0045296(cadherin binding);GO:0045494(photoreceptor cell maintenance);GO:0060042(retina morphogenesis in camera-type eye);GO:0060219(camera-type eye photoreceptor cell differentiation);GO:0070062(extracellular exosome);GO:0072112(glomerular visceral epithelial cell differentiation);GO:0072139(glomerular parietal epithelial cell differentiation);GO:2000768(positive regulation of nephron tubule epithelial cell differentiation)NANANAprominin 1 [Source:HGNC Symbol;Acc:HGNC:9454]0.310.310.311.521.101.45
ENSG00000007129CEACAM21ENST00000618577;ENST00000407170;ENST00000482870;ENST00000457737;ENST00000187608;ENST00000401445;ENST00000632983GO:0005515(protein binding);GO:0016021(integral component of membrane)NANANAcarcinoembryonic antigen-related cell adhesion molecule 21 [Source:HGNC Symbol;Acc:HGNC:28834]0.380.390.380.380.360.39
ENSG00000007171NOS2ENST00000313735GO:0001666(response to hypoxia);GO:0001912(positive regulation of leukocyte mediated cytotoxicity);GO:0002227(innate immune response in mucosa);GO:0003958(NADPH-hemoprotein reductase activity);GO:0004517(nitric-oxide synthase activity);GO:0005102(receptor binding);GO:0005506(iron ion binding);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005777(peroxisome);GO:0005829(cytosol);GO:0006527(arginine catabolic process);GO:0006801(superoxide metabolic process);GO:0006809(nitric oxide biosynthetic process);GO:0006954(inflammatory response);GO:0007263(nitric oxide mediated signal transduction);GO:0007596(blood coagulation);GO:0007623(circadian rhythm);GO:0009617(response to bacterium);GO:0010181(FMN binding);GO:0010629(negative regulation of gene expression);GO:0016491(oxidoreductase activity);GO:0018119(peptidyl-cysteine S-nitrosylation);GO:0020037(heme binding);GO:0030863(cortical cytoskeleton);GO:0031284(positive regulation of guanylate cyclase activity);GO:0032496(response to lipopolysaccharide);GO:0034617(tetrahydrobiopterin binding);GO:0034618(arginine binding);GO:0035690(cellular response to drug);GO:0042127(regulation of cell proliferation);GO:0042177(negative regulation of protein catabolic process);GO:0042742(defense response to bacterium);GO:0042803(protein homodimerization activity);GO:0043457(regulation of cellular respiration);GO:0045776(negative regulation of blood pressure);GO:0045909(positive regulation of vasodilation);GO:0048471(perinuclear region of cytoplasm);GO:0050660(flavin adenine dinucleotide binding);GO:0050661(NADP binding);GO:0050796(regulation of insulin secretion);GO:0050829(defense response to Gram-negative bacterium);GO:0051701(interaction with host);GO:0051712(positive regulation of killing of cells of other organism);GO:0055114(oxidation-reduction process);GO:0071222(cellular response to lipopolysaccharide);GO:0071346(cellular response to interferon-gamma);GO:0090382(phagosome maturation)00330(Arginine and proline metabolism);01100(Metabolic pathways);04020(Calcium signaling pathway);04146(Peroxisome);05140(Leishmaniasis);05142(Chagas disease (American trypanosomiasis));05145(Toxoplasmosis);05146(Amoebiasis);05152(Tuberculosis);05200(Pathways in cancer);05222(Small cell lung cancer)K13240;K13241;K13242;K13253;K134271.14.13.39nitric oxide synthase 2, inducible [Source:HGNC Symbol;Acc:HGNC:7873]0.220.170.180.150.150.16
ENSG00000007264MATKENST00000619596;ENST00000395040;ENST00000310132;ENST00000588983;ENST00000587180;ENST00000590028;ENST00000591059GO:0002009(morphogenesis of an epithelium);GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004715(non-membrane spanning protein tyrosine kinase activity);GO:0005102(receptor binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005829(cytosol);GO:0006468(protein phosphorylation);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0007498(mesoderm development);GO:0008283(cell proliferation);GO:0008284(positive regulation of cell proliferation);GO:0016477(cell migration);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0030154(cell differentiation);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0038083(peptidyl-tyrosine autophosphorylation);GO:0045087(innate immune response)NANANAmegakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6906]0.690.730.720.210.220.22
ENSG00000007312CD79BENST00000392795;ENST00000006750;ENST00000559358;ENST00000349817;ENST00000558969;ENST00000583260GO:0004888(transmembrane signaling receptor activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006955(immune response);GO:0007165(signal transduction);GO:0007166(cell surface receptor signaling pathway);GO:0009897(external side of plasma membrane);GO:0016020(membrane);GO:0019815(B cell receptor complex);GO:0050853(B cell receptor signaling pathway);GO:0070062(extracellular exosome)04662(B cell receptor signaling pathway)NANACD79b molecule, immunoglobulin-associated beta [Source:HGNC Symbol;Acc:HGNC:1699]1.171.061.040.940.720.94
ENSG00000007314SCN4AENST00000578147;ENST00000581514GO:0001518(voltage-gated sodium channel complex);GO:0005216(ion channel activity);GO:0005248(voltage-gated sodium channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006811(ion transport);GO:0006814(sodium ion transport);GO:0006936(muscle contraction);GO:0016020(membrane);GO:0019228(neuronal action potential);GO:0034765(regulation of ion transmembrane transport);GO:0035725(sodium ion transmembrane transport);GO:0055085(transmembrane transport);GO:0086010(membrane depolarization during action potential)NANANAsodium channel, voltage gated, type IV alpha subunit [Source:HGNC Symbol;Acc:HGNC:10591]0.070.060.060.050.080.05
ENSG00000007350TKTL1ENST00000369915GO:0003824(catalytic activity);GO:0004802(transketolase activity);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006007(glucose catabolic process);GO:0006772(thiamine metabolic process);GO:0008152(metabolic process);GO:0046872(metal ion binding)00030(Pentose phosphate pathway);01100(Metabolic pathways)K016622.2.1.7transketolase-like 1 [Source:HGNC Symbol;Acc:HGNC:11835]0.010.010.0100.010
ENSG00000007952NOX1ENST00000372966GO:0001525(angiogenesis);GO:0003081(regulation of systemic arterial blood pressure by renin-angiotensin);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005768(endosome);GO:0005769(early endosome);GO:0005886(plasma membrane);GO:0006739(NADP metabolic process);GO:0006801(superoxide metabolic process);GO:0006954(inflammatory response);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0008217(regulation of blood pressure);GO:0008284(positive regulation of cell proliferation);GO:0010575(positive regulation of vascular endothelial growth factor production);GO:0015992(proton transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016175(superoxide-generating NADPH oxidase activity);GO:0016477(cell migration);GO:0016491(oxidoreductase activity);GO:0030054(cell junction);GO:0030171(voltage-gated proton channel activity);GO:0030198(extracellular matrix organization);GO:0034765(regulation of ion transmembrane transport);GO:0042554(superoxide anion generation);GO:0042743(hydrogen peroxide metabolic process);GO:0043020(NADPH oxidase complex);GO:0043410(positive regulation of MAPK cascade);GO:0045726(positive regulation of integrin biosynthetic process);GO:0045730(respiratory burst);GO:0046330(positive regulation of JNK cascade);GO:0046872(metal ion binding);GO:0048365(Rac GTPase binding);GO:0048661(positive regulation of smooth muscle cell proliferation);GO:0050661(NADP binding);GO:0051454(intracellular pH elevation);GO:0055114(oxidation-reduction process);GO:0071438(invadopodium membrane);GO:0071455(cellular response to hyperoxia);GO:0072592(oxygen metabolic process);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1990451(cellular stress response to acidic pH)04145(Phagosome);04380(Osteoclast differentiation);04670(Leukocyte transendothelial migration)NANANADPH oxidase 1 [Source:HGNC Symbol;Acc:HGNC:7889]0000.090.070.08
ENSG00000007968E2F2ENST00000361729;ENST00000487237GO:0000278(mitotic cell cycle);GO:0001047(core promoter binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005667(transcription factor complex);GO:0006355(regulation of transcription, DNA-templated);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0008134(transcription factor binding);GO:0051726(regulation of cell cycle);GO:0072332(intrinsic apoptotic signaling pathway by p53 class mediator);GO:1990086(lens fiber cell apoptotic process)04110(Cell cycle);05200(Pathways in cancer);05212(Pancreatic cancer);05214(Glioma);05215(Prostate cancer);05218(Melanoma);05219(Bladder cancer);05220(Chronic myeloid leukemia);05222(Small cell lung cancer);05223(Non-small cell lung cancer)NANAE2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114]0.040.040.041.130.991.15
ENSG00000008196TFAP2BENST00000393655;ENST00000489228GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000979(RNA polymerase II core promoter sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0000983(RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001105(RNA polymerase II transcription coactivator activity);GO:0001106(RNA polymerase II transcription corepressor activity);GO:0001158(enhancer sequence-specific DNA binding);GO:0001822(kidney development);GO:0003091(renal water homeostasis);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003713(transcription coactivator activity);GO:0003714(transcription corepressor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006006(glucose metabolic process);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0006915(apoptotic process);GO:0007423(sensory organ development);GO:0008284(positive regulation of cell proliferation);GO:0008285(negative regulation of cell proliferation);GO:0010842(retina layer formation);GO:0010960(magnesium ion homeostasis);GO:0030510(regulation of BMP signaling pathway);GO:0035136(forelimb morphogenesis);GO:0035137(hindlimb morphogenesis);GO:0035810(positive regulation of urine volume);GO:0035909(aorta morphogenesis);GO:0042593(glucose homeostasis);GO:0042803(protein homodimerization activity);GO:0043027(cysteine-type endopeptidase inhibitor activity involved in apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0043154(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0043525(positive regulation of neuron apoptotic process);GO:0043565(sequence-specific DNA binding);GO:0043588(skin development);GO:0045444(fat cell differentiation);GO:0045595(regulation of cell differentiation);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046982(protein heterodimerization activity);GO:0046983(protein dimerization activity);GO:0048485(sympathetic nervous system development);GO:0048856(anatomical structure development);GO:0050796(regulation of insulin secretion);GO:0055062(phosphate ion homeostasis);GO:0055074(calcium ion homeostasis);GO:0055075(potassium ion homeostasis);GO:0055078(sodium ion homeostasis);GO:0072017(distal tubule development);GO:0072044(collecting duct development);GO:0072210(metanephric nephron development);GO:0097070(ductus arteriosus closure);GO:0097275(cellular ammonia homeostasis);GO:0097276(cellular creatinine homeostasis);GO:0097277(cellular urea homeostasis)NANANAtranscription factor AP-2 beta (activating enhancer binding protein 2 beta) [Source:HGNC Symbol;Acc:HGNC:11743]0000.010.020.02
ENSG00000008197TFAP2DENST00000008391GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005667(transcription factor complex);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0042127(regulation of cell proliferation);GO:0043524(negative regulation of neuron apoptotic process);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048856(anatomical structure development);GO:0061379(inferior colliculus development)NANANAtranscription factor AP-2 delta (activating enhancer binding protein 2 delta) [Source:HGNC Symbol;Acc:HGNC:15581]00000.010
ENSG00000008277ADAM22ENST00000398204;ENST00000398209;ENST00000398203;ENST00000478920;ENST00000413139;ENST00000476330GO:0004222(metalloendopeptidase activity);GO:0005178(integrin binding);GO:0005515(protein binding);GO:0006508(proteolysis);GO:0007155(cell adhesion);GO:0007162(negative regulation of cell adhesion);GO:0007417(central nervous system development);GO:0008270(zinc ion binding);GO:0008344(adult locomotory behavior);GO:0014037(Schwann cell differentiation);GO:0016021(integral component of membrane);GO:0022011(myelination in peripheral nervous system);GO:0030424(axon);GO:0042063(gliogenesis)NANANAADAM metallopeptidase domain 22 [Source:HGNC Symbol;Acc:HGNC:201]0.240.240.230.150.130.14
ENSG00000008516MMP25ENST00000336577;ENST00000575441GO:0004222(metalloendopeptidase activity);GO:0005509(calcium ion binding);GO:0005578(proteinaceous extracellular matrix);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0006954(inflammatory response);GO:0008237(metallopeptidase activity);GO:0008270(zinc ion binding);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0031012(extracellular matrix);GO:0031225(anchored component of membrane);GO:0060022(hard palate development)NANANAmatrix metallopeptidase 25 [Source:HGNC Symbol;Acc:HGNC:14246]0.480.480.490.430.330.45
ENSG00000010310GIPRENST00000590918;ENST00000588816;ENST00000591224GO:0002029(desensitization of G-protein coupled receptor protein signaling pathway);GO:0004888(transmembrane signaling receptor activity);GO:0004930(G-protein coupled receptor activity);GO:0005886(plasma membrane);GO:0006091(generation of precursor metabolites and energy);GO:0007166(cell surface receptor signaling pathway);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007190(activation of adenylate cyclase activity);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007584(response to nutrient);GO:0009749(response to glucose);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016519(gastric inhibitory peptide receptor activity);GO:0017046(peptide hormone binding);GO:0030819(positive regulation of cAMP biosynthetic process);GO:0031018(endocrine pancreas development);GO:0032024(positive regulation of insulin secretion);GO:0038192(gastric inhibitory peptide signaling pathway);GO:0048678(response to axon injury);GO:0051592(response to calcium ion);GO:0070542(response to fatty acid)04080(Neuroactive ligand-receptor interaction)NANAgastric inhibitory polypeptide receptor [Source:HGNC Symbol;Acc:HGNC:4271]0.030.040.040.180.150.20
ENSG00000010319SEMA3GENST00000231721;ENST00000475739GO:0005515(protein binding);GO:0016020(membrane);GO:0070062(extracellular exosome)04360(Axon guidance)NANAsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G [Source:HGNC Symbol;Acc:HGNC:30400]0.560.530.530.590.550.60
ENSG00000010932FMO1ENST00000402921;ENST00000617670;ENST00000433267;ENST00000469112;ENST00000354841;ENST00000459868;ENST00000469711GO:0004497(monooxygenase activity);GO:0004499(N,N-dimethylaniline monooxygenase activity);GO:0005788(endoplasmic reticulum lumen);GO:0005789(endoplasmic reticulum membrane);GO:0006082(organic acid metabolic process);GO:0006805(xenobiotic metabolic process);GO:0006970(response to osmotic stress);GO:0009404(toxin metabolic process);GO:0016021(integral component of membrane);GO:0017144(drug metabolic process);GO:0032496(response to lipopolysaccharide);GO:0043231(intracellular membrane-bounded organelle);GO:0044281(small molecule metabolic process);GO:0050660(flavin adenine dinucleotide binding);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0070995(NADPH oxidation)00982(Drug metabolism - cytochrome P450)NANAflavin containing monooxygenase 1 [Source:HGNC Symbol;Acc:HGNC:3769]0.530.510.540.330.520.28
ENSG00000011083SLC6A7ENST00000230671GO:0005328(neurotransmitter:sodium symporter activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006836(neurotransmitter transport);GO:0015824(proline transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0055085(transmembrane transport)NANANAsolute carrier family 6 (neurotransmitter transporter), member 7 [Source:HGNC Symbol;Acc:HGNC:11054]0.030.040.040.010.010.01
ENSG00000011201ANOS1ENST00000262648;ENST00000488294GO:0004867(serine-type endopeptidase inhibitor activity);GO:0005201(extracellular matrix structural constituent);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005615(extracellular space);GO:0005886(plasma membrane);GO:0006928(movement of cell or subcellular component);GO:0006935(chemotaxis);GO:0007155(cell adhesion);GO:0007411(axon guidance);GO:0008201(heparin binding);GO:0010466(negative regulation of peptidase activity);GO:0010951(negative regulation of endopeptidase activity);GO:0030414(peptidase inhibitor activity)NANANAanosmin 1 [Source:HGNC Symbol;Acc:HGNC:6211]0.330.280.290.210.180.21
ENSG00000011332DPF1ENST00000614244GO:0003676(nucleic acid binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006915(apoptotic process);GO:0007399(nervous system development);GO:0008270(zinc ion binding);GO:0046872(metal ion binding);GO:0071565(nBAF complex)NANANAD4, zinc and double PHD fingers family 1 [Source:HGNC Symbol;Acc:HGNC:20225]0000.020.020.03
ENSG00000011590ZBTB32ENST00000392197;ENST00000442282GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000228(nuclear chromosome);GO:0001817(regulation of cytokine production);GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0003714(transcription corepressor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006281(DNA repair);GO:0006366(transcription from RNA polymerase II promoter);GO:0008270(zinc ion binding);GO:0019985(translesion synthesis);GO:0030097(hemopoiesis);GO:0042098(T cell proliferation);GO:0042769(DNA damage response, detection of DNA damage);GO:0046872(metal ion binding);GO:1903507(negative regulation of nucleic acid-templated transcription)NANANAzinc finger and BTB domain containing 32 [Source:HGNC Symbol;Acc:HGNC:16763]0.050.070.060.200.250.23
ENSG00000011677GABRA3ENST00000370314;ENST00000535043;ENST00000497894GO:0004890(GABA-A receptor activity);GO:0005230(extracellular ligand-gated ion channel activity);GO:0005254(chloride channel activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0007214(gamma-aminobutyric acid signaling pathway);GO:0007268(synaptic transmission);GO:0008503(benzodiazepine receptor activity);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0034220(ion transmembrane transport);GO:0034707(chloride channel complex);GO:0045211(postsynaptic membrane);GO:0055085(transmembrane transport);GO:1902476(chloride transmembrane transport)NANANAgamma-aminobutyric acid (GABA) A receptor, alpha 3 [Source:HGNC Symbol;Acc:HGNC:4077]0000.280.230.28
ENSG00000012124CD22ENST00000598537;ENST00000595419;ENST00000599717;ENST00000599799;ENST00000595780;ENST00000596492;ENST00000593867;ENST00000601769;ENST00000085219;ENST00000544992;ENST00000270311;ENST00000594250;ENST00000613136;ENST00000593704GO:0005515(protein binding);GO:0005887(integral component of plasma membrane);GO:0007155(cell adhesion);GO:0009897(external side of plasma membrane);GO:0016021(integral component of membrane);GO:0030246(carbohydrate binding);GO:0070062(extracellular exosome)04514(Cell adhesion molecules (CAMs));04640(Hematopoietic cell lineage);04662(B cell receptor signaling pathway)NANACD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643]0.650.670.680.110.080.11
ENSG00000012171SEMA3BENST00000621029;ENST00000618865;ENST00000619119;ENST00000616701;ENST00000612509;ENST00000433753;ENST00000611418;ENST00000441915;ENST00000456560;ENST00000419007;ENST00000416295GO:0005515(protein binding);GO:0005783(endoplasmic reticulum);GO:0007267(cell-cell signaling);GO:0007411(axon guidance);GO:0016020(membrane);GO:0070062(extracellular exosome)NANANAsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B [Source:HGNC Symbol;Acc:HGNC:10724]0.510.560.560.760.600.78
ENSG00000012223LTFENST00000231751GO:0001503(ossification);GO:0001817(regulation of cytokine production);GO:0001895(retina homeostasis);GO:0002227(innate immune response in mucosa);GO:0003677(DNA binding);GO:0004252(serine-type endopeptidase activity);GO:0005506(iron ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006508(proteolysis);GO:0006811(ion transport);GO:0006959(humoral immune response);GO:0008201(heparin binding);GO:0008233(peptidase activity);GO:0019731(antibacterial humoral response);GO:0019732(antifungal humoral response);GO:0030141(secretory granule);GO:0031665(negative regulation of lipopolysaccharide-mediated signaling pathway);GO:0032680(regulation of tumor necrosis factor production);GO:0032780(negative regulation of ATPase activity);GO:0033214(iron assimilation by chelation and transport);GO:0033690(positive regulation of osteoblast proliferation);GO:0034145(positive regulation of toll-like receptor 4 signaling pathway);GO:0042581(specific granule);GO:0043066(negative regulation of apoptotic process);GO:0043123(positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0043539(protein serine/threonine kinase activator activity);GO:0044793(negative regulation by host of viral process);GO:0045071(negative regulation of viral genome replication);GO:0045669(positive regulation of osteoblast differentiation);GO:0048525(negative regulation of viral process);GO:0051092(positive regulation of NF-kappaB transcription factor activity);GO:0051701(interaction with host);GO:0052572(response to host immune response);GO:0060349(bone morphogenesis);GO:0070062(extracellular exosome);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:0090382(phagosome maturation);GO:0097013(phagocytic vesicle lumen);GO:1900159(positive regulation of bone mineralization involved in bone maturation);GO:1900229(negative regulation of single-species biofilm formation in or on host organism);GO:1902732(positive regulation of chondrocyte proliferation);GO:2000308(negative regulation of tumor necrosis factor (ligand) superfamily member 11 production);GO:2001205(negative regulation of osteoclast development)NANANAlactotransferrin [Source:HGNC Symbol;Acc:HGNC:6720]0.160.140.140.020.010.02
ENSG00000013293SLC7A14ENST00000231706GO:0003333(amino acid transmembrane transport);GO:0005765(lysosomal membrane);GO:0005887(integral component of plasma membrane);GO:0010923(negative regulation of phosphatase activity);GO:0015171(amino acid transmembrane transporter activity);GO:0015179(L-amino acid transmembrane transporter activity);GO:0015297(antiporter activity);GO:0015807(L-amino acid transport);GO:0016020(membrane);GO:1902475(L-alpha-amino acid transmembrane transport)NANANAsolute carrier family 7, member 14 [Source:HGNC Symbol;Acc:HGNC:29326]0.020.020.020.010.010.01
ENSG00000013297CLDN11ENST00000064724;ENST00000486975;ENST00000477531;ENST00000480067GO:0005198(structural molecule activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005923(bicellular tight junction);GO:0007155(cell adhesion);GO:0007283(spermatogenesis);GO:0008366(axon ensheathment);GO:0016021(integral component of membrane);GO:0016338(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules);GO:0042802(identical protein binding);GO:0043209(myelin sheath);GO:0045178(basal part of cell);GO:0070062(extracellular exosome)NANANAclaudin 11 [Source:HGNC Symbol;Acc:HGNC:8514]0.430.440.440.060.070.06
ENSG00000013588GPRC5AENST00000014914GO:0004930(G-protein coupled receptor activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0016021(integral component of membrane);GO:0030659(cytoplasmic vesicle membrane);GO:0043231(intracellular membrane-bounded organelle);GO:0070062(extracellular exosome)NANANAG protein-coupled receptor, class C, group 5, member A [Source:HGNC Symbol;Acc:HGNC:9836]0.030.030.030.020.000.01
ENSG00000013619MAMLD1ENST00000370401;ENST00000358892;ENST00000262858;ENST00000426613;ENST00000464149GO:0003674(molecular_function);GO:0005575(cellular_component);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0008584(male gonad development)NANANAmastermind-like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:2568]0.460.480.470.500.520.53
ENSG00000014257ACPPENST00000336375;ENST00000351273;ENST00000489084;ENST00000483689GO:0003993(acid phosphatase activity);GO:0005615(extracellular space);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005765(lysosomal membrane);GO:0005886(plasma membrane);GO:0006144(purine nucleobase metabolic process);GO:0006772(thiamine metabolic process);GO:0008253(5'-nucleotidase activity);GO:0009117(nucleotide metabolic process);GO:0012506(vesicle membrane);GO:0016021(integral component of membrane);GO:0016311(dephosphorylation);GO:0016791(phosphatase activity);GO:0030175(filopodium);GO:0042131(thiamine phosphate phosphatase activity);GO:0042802(identical protein binding);GO:0046085(adenosine metabolic process);GO:0051930(regulation of sensory perception of pain);GO:0052642(lysophosphatidic acid phosphatase activity);GO:0060168(positive regulation of adenosine receptor signaling pathway);GO:0070062(extracellular exosome)00740(Riboflavin metabolism)NANAacid phosphatase, prostate [Source:HGNC Symbol;Acc:HGNC:125]0.090.110.110.080.070.09
ENSG00000015133CCDC88CENST00000556726;ENST00000389857;ENST00000334448;ENST00000557455;ENST00000555995;ENST00000557507;ENST00000554051;ENST00000554872;ENST00000553437;ENST00000389856;ENST00000553403;ENST00000554165;ENST00000556767GO:0001932(regulation of protein phosphorylation);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0016055(Wnt signaling pathway);GO:0030165(PDZ domain binding);GO:0031098(stress-activated protein kinase signaling cascade);GO:0031648(protein destabilization);GO:0043621(protein self-association);GO:0051260(protein homooligomerization)NANANAcoiled-coil domain containing 88C [Source:HGNC Symbol;Acc:HGNC:19967]1.091.111.100.630.890.62
ENSG00000015413DPEP1ENST00000421184;ENST00000565249;ENST00000564281;ENST00000568281;ENST00000393092;ENST00000561484;ENST00000261615GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0006691(leukotriene metabolic process);GO:0006749(glutathione metabolic process);GO:0006805(xenobiotic metabolic process);GO:0008235(metalloexopeptidase activity);GO:0008237(metallopeptidase activity);GO:0008239(dipeptidyl-peptidase activity);GO:0008270(zinc ion binding);GO:0016324(apical plasma membrane);GO:0016805(dipeptidase activity);GO:0016999(antibiotic metabolic process);GO:0019369(arachidonic acid metabolic process);GO:0030054(cell junction);GO:0030336(negative regulation of cell migration);GO:0031225(anchored component of membrane);GO:0031528(microvillus membrane);GO:0034235(GPI anchor binding);GO:0035690(cellular response to drug);GO:0043027(cysteine-type endopeptidase inhibitor activity involved in apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0043154(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0044281(small molecule metabolic process);GO:0045177(apical part of cell);GO:0046872(metal ion binding);GO:0050667(homocysteine metabolic process);GO:0070062(extracellular exosome);GO:0070573(metallodipeptidase activity);GO:0071277(cellular response to calcium ion);GO:0071732(cellular response to nitric oxide);GO:0072340(cellular lactam catabolic process);GO:0072341(modified amino acid binding)NANANAdipeptidase 1 (renal) [Source:HGNC Symbol;Acc:HGNC:3002]0.150.160.150.340.300.38
ENSG00000016082ISL1ENST00000230658GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001102(RNA polymerase II activating transcription factor binding);GO:0001105(RNA polymerase II transcription coactivator activity);GO:0001158(enhancer sequence-specific DNA binding);GO:0001755(neural crest cell migration);GO:0003007(heart morphogenesis);GO:0003139(secondary heart field specification);GO:0003148(outflow tract septum morphogenesis);GO:0003151(outflow tract morphogenesis);GO:0003203(endocardial cushion morphogenesis);GO:0003215(cardiac right ventricle morphogenesis);GO:0003266(regulation of secondary heart field cardioblast proliferation);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0006355(regulation of transcription, DNA-templated);GO:0007507(heart development);GO:0008270(zinc ion binding);GO:0008284(positive regulation of cell proliferation);GO:0010468(regulation of gene expression);GO:0010575(positive regulation of vascular endothelial growth factor production);GO:0016922(ligand-dependent nuclear receptor binding);GO:0021520(spinal cord motor neuron cell fate specification);GO:0021522(spinal cord motor neuron differentiation);GO:0021524(visceral motor neuron differentiation);GO:0021559(trigeminal nerve development);GO:0021983(pituitary gland development);GO:0030182(neuron differentiation);GO:0030331(estrogen receptor binding);GO:0031016(pancreas development);GO:0031103(axon regeneration);GO:0031290(retinal ganglion cell axon guidance);GO:0032024(positive regulation of insulin secretion);GO:0032725(positive regulation of granulocyte macrophage colony-stimulating factor production);GO:0032729(positive regulation of interferon-gamma production);GO:0032730(positive regulation of interleukin-1 alpha production);GO:0032731(positive regulation of interleukin-1 beta production);GO:0032735(positive regulation of interleukin-12 production);GO:0032755(positive regulation of interleukin-6 production);GO:0032760(positive regulation of tumor necrosis factor production);GO:0033147(negative regulation of intracellular estrogen receptor signaling pathway);GO:0035066(positive regulation of histone acetylation);GO:0042517(positive regulation of tyrosine phosphorylation of Stat3 protein);GO:0043388(positive regulation of DNA binding);GO:0043425(bHLH transcription factor binding);GO:0043524(negative regulation of neuron apoptotic process);GO:0043565(sequence-specific DNA binding);GO:0045665(negative regulation of neuron differentiation);GO:0045766(positive regulation of angiogenesis);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048663(neuron fate commitment);GO:0048665(neuron fate specification);GO:0048762(mesenchymal cell differentiation);GO:0048880(sensory system development);GO:0048935(peripheral nervous system neuron development);GO:0048936(peripheral nervous system neuron axonogenesis);GO:0050728(negative regulation of inflammatory response);GO:0055010(ventricular cardiac muscle tissue morphogenesis);GO:0060037(pharyngeal system development);GO:0060379(cardiac muscle cell myoblast differentiation);GO:0060384(innervation);GO:0060413(atrial septum morphogenesis);GO:0060913(cardiac cell fate determination);GO:0071385(cellular response to glucocorticoid stimulus);GO:0071657(positive regulation of granulocyte colony-stimulating factor production);GO:0090074(negative regulation of protein homodimerization activity);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:1901258(positive regulation of macrophage colony-stimulating factor production)NANANAISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132]0000.000.000.00
ENSG00000016402IL20RAENST00000541547;ENST00000316649;ENST00000367748;ENST00000367746GO:0004896(cytokine receptor activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0016021(integral component of membrane);GO:0019221(cytokine-mediated signaling pathway);GO:0042015(interleukin-20 binding);GO:0045124(regulation of bone resorption);GO:2001244(positive regulation of intrinsic apoptotic signaling pathway)04060(Cytokine-cytokine receptor interaction);04630(Jak-STAT signaling pathway)NANAinterleukin 20 receptor, alpha [Source:HGNC Symbol;Acc:HGNC:6003]0.050.050.0500.110
ENSG00000016602CLCA4ENST00000370563GO:0005229(intracellular calcium activated chloride channel activity);GO:0005254(chloride channel activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006508(proteolysis);GO:0006810(transport);GO:0006821(chloride transport);GO:0008237(metallopeptidase activity);GO:0016324(apical plasma membrane);GO:0034220(ion transmembrane transport);GO:0046872(metal ion binding);GO:0055085(transmembrane transport);GO:0070062(extracellular exosome);GO:1902476(chloride transmembrane transport)04740(Olfactory transduction);04972(Pancreatic secretion)NANAchloride channel accessory 4 [Source:HGNC Symbol;Acc:HGNC:2018]0.010.010.01000
ENSG00000017483SLC38A5ENST00000595796;ENST00000619100;ENST00000480105;ENST00000440085;ENST00000413668GO:0003333(amino acid transmembrane transport);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006811(ion transport);GO:0006865(amino acid transport);GO:0015171(amino acid transmembrane transporter activity);GO:0015175(neutral amino acid transmembrane transporter activity);GO:0015187(glycine transmembrane transporter activity);GO:0015804(neutral amino acid transport);GO:0015816(glycine transport);GO:0055085(transmembrane transport)NANANAsolute carrier family 38, member 5 [Source:HGNC Symbol;Acc:HGNC:18070]0.160.170.170.420.330.44
ENSG00000018280SLC11A1ENST00000468221;ENST00000233202;ENST00000473367;ENST00000465984;ENST00000492413;ENST00000483487;ENST00000490536;ENST00000468721GO:0000060(protein import into nucleus, translocation);GO:0001818(negative regulation of cytokine production);GO:0001819(positive regulation of cytokine production);GO:0002309(T cell proliferation involved in immune response);GO:0002369(T cell cytokine production);GO:0002606(positive regulation of dendritic cell antigen processing and presentation);GO:0002827(positive regulation of T-helper 1 type immune response);GO:0003674(molecular_function);GO:0005215(transporter activity);GO:0005384(manganese ion transmembrane transporter activity);GO:0005575(cellular_component);GO:0005764(lysosome);GO:0005770(late endosome);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006826(iron ion transport);GO:0006828(manganese ion transport);GO:0006876(cellular cadmium ion homeostasis);GO:0006879(cellular iron ion homeostasis);GO:0006909(phagocytosis);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0007035(vacuolar acidification);GO:0009279(cell outer membrane);GO:0009617(response to bacterium);GO:0010008(endosome membrane);GO:0010628(positive regulation of gene expression);GO:0015707(nitrite transport);GO:0016020(membrane);GO:0030670(phagocytic vesicle membrane);GO:0031902(late endosome membrane);GO:0032147(activation of protein kinase activity);GO:0032496(response to lipopolysaccharide);GO:0032623(interleukin-2 production);GO:0032632(interleukin-3 production);GO:0032729(positive regulation of interferon-gamma production);GO:0034341(response to interferon-gamma);GO:0042060(wound healing);GO:0042116(macrophage activation);GO:0042742(defense response to bacterium);GO:0042803(protein homodimerization activity);GO:0042832(defense response to protozoan);GO:0043091(L-arginine import);GO:0045342(MHC class II biosynthetic process);GO:0045730(respiratory burst);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046915(transition metal ion transmembrane transporter activity);GO:0048002(antigen processing and presentation of peptide antigen);GO:0048255(mRNA stabilization);GO:0050766(positive regulation of phagocytosis);GO:0050829(defense response to Gram-negative bacterium);GO:0051139(metal ion:proton antiporter activity);GO:0051701(interaction with host);GO:0055072(iron ion homeostasis);GO:0055085(transmembrane transport);GO:0060586(multicellular organismal iron ion homeostasis);GO:0070574(cadmium ion transmembrane transport);GO:0070821(tertiary granule membrane);GO:0070839(divalent metal ion export);GO:0071421(manganese ion transmembrane transport);GO:0090382(phagosome maturation)04142(Lysosome);04978(Mineral absorption)NANAsolute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 [Source:HGNC Symbol;Acc:HGNC:10907]0.140.130.130.120.100.14
ENSG00000018607ZNF806ENST00000438300NANANANANA0000.010.010.01
ENSG00000018625ATP1A2ENST00000478587;ENST00000361216;ENST00000468587GO:0000166(nucleotide binding);GO:0001504(neurotransmitter uptake);GO:0002026(regulation of the force of heart contraction);GO:0002087(regulation of respiratory gaseous exchange by neurological system process);GO:0005391(sodium:potassium-exchanging ATPase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005768(endosome);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005890(sodium:potassium-exchanging ATPase complex);GO:0005901(caveola);GO:0006813(potassium ion transport);GO:0006814(sodium ion transport);GO:0006883(cellular sodium ion homeostasis);GO:0006937(regulation of muscle contraction);GO:0006940(regulation of smooth muscle contraction);GO:0006942(regulation of striated muscle contraction);GO:0008152(metabolic process);GO:0008217(regulation of blood pressure);GO:0008344(adult locomotory behavior);GO:0008542(visual learning);GO:0010107(potassium ion import);GO:0010881(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion);GO:0014704(intercalated disc);GO:0015991(ATP hydrolysis coupled proton transport);GO:0016021(integral component of membrane);GO:0019229(regulation of vasoconstriction);GO:0019829(cation-transporting ATPase activity);GO:0030007(cellular potassium ion homeostasis);GO:0030315(T-tubule);GO:0034220(ion transmembrane transport);GO:0035094(response to nicotine);GO:0035725(sodium ion transmembrane transport);GO:0036376(sodium ion export from cell);GO:0040011(locomotion);GO:0042383(sarcolemma);GO:0043005(neuron projection);GO:0043197(dendritic spine);GO:0043209(myelin sheath);GO:0045202(synapse);GO:0045822(negative regulation of heart contraction);GO:0045988(negative regulation of striated muscle contraction);GO:0046872(metal ion binding);GO:0051087(chaperone binding);GO:0051481(negative regulation of cytosolic calcium ion concentration);GO:0055085(transmembrane transport);GO:0055119(relaxation of cardiac muscle);GO:0060048(cardiac muscle contraction);GO:0071260(cellular response to mechanical stimulus);GO:0071383(cellular response to steroid hormone stimulus);GO:0086004(regulation of cardiac muscle cell contraction);GO:0086012(membrane depolarization during cardiac muscle cell action potential);GO:0086064(cell communication by electrical coupling involved in cardiac conduction);GO:1903170(negative regulation of calcium ion transmembrane transport);GO:1903280(negative regulation of calcium:sodium antiporter activity);GO:1903416(response to glycoside);GO:1903561(extracellular vesicle);GO:1990239(steroid hormone binding)04260(Cardiac muscle contraction);04960(Aldosterone-regulated sodium reabsorption);04961(Endocrine and other factor-regulated calcium reabsorption);04964(Proximal tubule bicarbonate reclamation);04970(Salivary secretion);04971(Gastric acid secretion);04972(Pancreatic secretion);04973(Carbohydrate digestion and absorption);04974(Protein digestion and absorption);04976(Bile secretion);04978(Mineral absorption)NANAATPase, Na+/K+ transporting, alpha 2 polypeptide [Source:HGNC Symbol;Acc:HGNC:800]0.110.110.120.090.100.09
ENSG00000019102VSIG2ENST00000326621;ENST00000403470GO:0005515(protein binding);GO:0005887(integral component of plasma membrane);GO:0016020(membrane)NANANAV-set and immunoglobulin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17149]1.031.031.070.030.030.04
ENSG00000019144PHLDB1ENST00000361417;ENST00000530708;ENST00000600882;ENST00000530994;ENST00000621027;ENST00000356063;ENST00000532639;ENST00000525427;ENST00000527259;ENST00000526374;ENST00000617208;ENST00000532517;ENST00000614369;ENST00000601898;ENST00000534140;ENST00000612681;ENST00000526699;ENST00000392852;ENST00000531987;ENST00000526826;ENST00000525226;ENST00000526537;ENST00000620788GO:0005515(protein binding);GO:0010470(regulation of gastrulation);GO:0010717(regulation of epithelial to mesenchymal transition);GO:0045180(basal cortex);GO:0070507(regulation of microtubule cytoskeleton organization);GO:1904261(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)NANANApleckstrin homology-like domain, family B, member 1 [Source:HGNC Symbol;Acc:HGNC:23697]0.550.580.580.220.240.24
ENSG00000019186CYP24A1ENST00000216862;ENST00000460643;ENST00000395954;ENST00000487593;ENST00000472970GO:0001649(osteoblast differentiation);GO:0005506(iron ion binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006766(vitamin metabolic process);GO:0006805(xenobiotic metabolic process);GO:0008202(steroid metabolic process);GO:0008403(25-hydroxycholecalciferol-24-hydroxylase activity);GO:0016491(oxidoreductase activity);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0020037(heme binding);GO:0030342(1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity);GO:0033280(response to vitamin D);GO:0042359(vitamin D metabolic process);GO:0042369(vitamin D catabolic process);GO:0044281(small molecule metabolic process);GO:0055114(oxidation-reduction process);GO:0070561(vitamin D receptor signaling pathway)NANANAcytochrome P450, family 24, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:2602]0000.470.320.51
ENSG00000019485PRDM11ENST00000526442;ENST00000622142;ENST00000534751;ENST00000528980GO:0003682(chromatin binding);GO:0005515(protein binding);GO:0008168(methyltransferase activity);GO:0032259(methylation)NANANAPR domain containing 11 [Source:HGNC Symbol;Acc:HGNC:13996]0.260.250.250.200.380.20
ENSG00000019505SYT13ENST00000020926GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0016079(synaptic vesicle exocytosis);GO:0016192(vesicle-mediated transport);GO:0019905(syntaxin binding);GO:0030133(transport vesicle);GO:0030276(clathrin binding);GO:0048791(calcium ion-dependent exocytosis of neurotransmitter)NANANAsynaptotagmin XIII [Source:HGNC Symbol;Acc:HGNC:14962]0.130.130.130.190.140.20
ENSG00000019549SNAI2ENST00000020945;ENST00000396822GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000790(nuclear chromatin);GO:0001078(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription);GO:0001649(osteoblast differentiation);GO:0001837(epithelial to mesenchymal transition);GO:0003198(epithelial to mesenchymal transition involved in endocardial cushion formation);GO:0003273(cell migration involved in endocardial cushion formation);GO:0003682(chromatin binding);GO:0003705(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006933(negative regulation of cell adhesion involved in substrate-bound cell migration);GO:0007219(Notch signaling pathway);GO:0007605(sensory perception of sound);GO:0009314(response to radiation);GO:0010839(negative regulation of keratinocyte proliferation);GO:0010957(negative regulation of vitamin D biosynthetic process);GO:0014032(neural crest cell development);GO:0016477(cell migration);GO:0030335(positive regulation of cell migration);GO:0032331(negative regulation of chondrocyte differentiation);GO:0032642(regulation of chemokine production);GO:0033629(negative regulation of cell adhesion mediated by integrin);GO:0035066(positive regulation of histone acetylation);GO:0035414(negative regulation of catenin import into nucleus);GO:0035921(desmosome disassembly);GO:0043066(negative regulation of apoptotic process);GO:0043473(pigmentation);GO:0043518(negative regulation of DNA damage response, signal transduction by p53 class mediator);GO:0043565(sequence-specific DNA binding);GO:0044344(cellular response to fibroblast growth factor stimulus);GO:0045600(positive regulation of fat cell differentiation);GO:0045667(regulation of osteoblast differentiation);GO:0046872(metal ion binding);GO:0050872(white fat cell differentiation);GO:0060021(palate development);GO:0060070(canonical Wnt signaling pathway);GO:0060429(epithelium development);GO:0060536(cartilage morphogenesis);GO:0060693(regulation of branching involved in salivary gland morphogenesis);GO:0070563(negative regulation of vitamin D receptor signaling pathway);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071479(cellular response to ionizing radiation);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:1900387(negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter);GO:1902230(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage);GO:2000647(negative regulation of stem cell proliferation);GO:2000810(regulation of bicellular tight junction assembly);GO:2000811(negative regulation of anoikis);GO:2001240(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)04520(Adherens junction)NANAsnail family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:11094]0.320.300.300.250.340.27
ENSG00000020633RUNX3ENST00000399916;ENST00000308873;ENST00000496967GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000790(nuclear chromatin);GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0001503(ossification);GO:0002062(chondrocyte differentiation);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0006355(regulation of transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006366(transcription from RNA polymerase II promoter);GO:0006468(protein phosphorylation);GO:0007411(axon guidance);GO:0030097(hemopoiesis);GO:0030182(neuron differentiation);GO:0031069(hair follicle morphogenesis);GO:0031175(neuron projection development);GO:0032609(interferon-gamma production);GO:0043231(intracellular membrane-bounded organelle);GO:0045595(regulation of cell differentiation);GO:0045786(negative regulation of cell cycle);GO:0048469(cell maturation);GO:0048935(peripheral nervous system neuron development);GO:0050680(negative regulation of epithelial cell proliferation);GO:2001238(positive regulation of extrinsic apoptotic signaling pathway)NANANArunt-related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473]1.261.111.140.820.720.91
ENSG00000021645NRXN3ENST00000554738;ENST00000554719;ENST00000557081;ENST00000281127;ENST00000555073;ENST00000553803;ENST00000556003GO:0001525(angiogenesis);GO:0004872(receptor activity);GO:0004888(transmembrane signaling receptor activity);GO:0005246(calcium channel regulator activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005887(integral component of plasma membrane);GO:0007158(neuron cell-cell adhesion);GO:0007165(signal transduction);GO:0007268(synaptic transmission);GO:0007269(neurotransmitter secretion);GO:0007411(axon guidance);GO:0007416(synapse assembly);GO:0007612(learning);GO:0016021(integral component of membrane);GO:0030534(adult behavior);GO:0035176(social behavior);GO:0043234(protein complex);GO:0046872(metal ion binding);GO:0050839(cell adhesion molecule binding);GO:0051965(positive regulation of synapse assembly);GO:0071625(vocalization behavior);GO:0090129(positive regulation of synapse maturation);GO:0097109(neuroligin family protein binding)04514(Cell adhesion molecules (CAMs))NANAneurexin 3 [Source:HGNC Symbol;Acc:HGNC:8010]0.010.010.010.040.270.05
ENSG00000021762OSBPL5ENST00000478260;ENST00000263650;ENST00000389989;ENST00000498536;ENST00000348039;ENST00000534491;ENST00000532951;ENST00000459995;ENST00000533234;ENST00000465323;ENST00000477622;ENST00000526122;ENST00000533721;ENST00000534157;ENST00000528124GO:0005789(endoplasmic reticulum membrane);GO:0005829(cytosol);GO:0006869(lipid transport);GO:0006893(Golgi to plasma membrane transport);GO:0008142(oxysterol binding);GO:0008203(cholesterol metabolic process);GO:0015485(cholesterol binding);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030301(cholesterol transport)NANANAoxysterol binding protein-like 5 [Source:HGNC Symbol;Acc:HGNC:16392]0.820.820.810.140.130.13
ENSG00000022355GABRA1ENST00000428797GO:0004890(GABA-A receptor activity);GO:0005230(extracellular ligand-gated ion channel activity);GO:0005254(chloride channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0007165(signal transduction);GO:0007214(gamma-aminobutyric acid signaling pathway);GO:0007268(synaptic transmission);GO:0008144(drug binding);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016917(GABA receptor activity);GO:0030054(cell junction);GO:0034220(ion transmembrane transport);GO:0034707(chloride channel complex);GO:0045211(postsynaptic membrane);GO:0051932(synaptic transmission, GABAergic);GO:0055085(transmembrane transport);GO:0071420(cellular response to histamine);GO:1902476(chloride transmembrane transport);GO:1902710(GABA receptor complex)04080(Neuroactive ligand-receptor interaction)NANAgamma-aminobutyric acid (GABA) A receptor, alpha 1 [Source:HGNC Symbol;Acc:HGNC:4075]00000.010
ENSG00000022556NLRP2ENST00000543010;ENST00000540597;ENST00000427260;ENST00000543277;ENST00000381637;ENST00000586512;ENST00000542755GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0006954(inflammatory response);GO:0032090(Pyrin domain binding);GO:0043280(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0045087(innate immune response);GO:0050718(positive regulation of interleukin-1 beta secretion)NANANANLR family, pyrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:22948]0.200.210.220.240.210.26
ENSG00000022567SLC45A4ENST00000519067;ENST00000517878;ENST00000520137;ENST00000519986;ENST00000521804GO:0006810(transport);GO:0016021(integral component of membrane)NANANAsolute carrier family 45, member 4 [Source:HGNC Symbol;Acc:HGNC:29196]0.380.250.240.520.660.50
ENSG00000026559KCNG1ENST00000371571;ENST00000506387;ENST00000433903GO:0005216(ion channel activity);GO:0005251(delayed rectifier potassium channel activity);GO:0005267(potassium channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0006811(ion transport);GO:0006813(potassium ion transport);GO:0007268(synaptic transmission);GO:0008076(voltage-gated potassium channel complex);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0034765(regulation of ion transmembrane transport);GO:0043231(intracellular membrane-bounded organelle);GO:0051260(protein homooligomerization);GO:0055085(transmembrane transport);GO:0071805(potassium ion transmembrane transport)NANANApotassium channel, voltage gated modifier subfamily G, member 1 [Source:HGNC Symbol;Acc:HGNC:6248]0.040.040.040.010.020.01
ENSG00000026652AGPAT4ENST00000366911;ENST00000320285;ENST00000437165;ENST00000436279;ENST00000366905GO:0003841(1-acylglycerol-3-phosphate O-acyltransferase activity);GO:0005515(protein binding);GO:0005789(endoplasmic reticulum membrane);GO:0006644(phospholipid metabolic process);GO:0006654(phosphatidic acid biosynthetic process);GO:0008152(metabolic process);GO:0008654(phospholipid biosynthetic process);GO:0016021(integral component of membrane);GO:0016024(CDP-diacylglycerol biosynthetic process);GO:0016746(transferase activity, transferring acyl groups);GO:0019432(triglyceride biosynthetic process);GO:0044255(cellular lipid metabolic process);GO:0044281(small molecule metabolic process);GO:0046474(glycerophospholipid biosynthetic process)00561(Glycerolipid metabolism);00564(Glycerophospholipid metabolism);01100(Metabolic pathways)NANA1-acylglycerol-3-phosphate O-acyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:20885]0.430.440.450.230.210.23
ENSG00000027644INSRRENST00000368195GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004714(transmembrane receptor protein tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005887(integral component of plasma membrane);GO:0006468(protein phosphorylation);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0030238(male sex determination);GO:0031532(actin cytoskeleton reorganization);GO:0043235(receptor complex);GO:0043548(phosphatidylinositol 3-kinase binding);GO:0043560(insulin receptor substrate binding);GO:0046777(protein autophosphorylation);GO:0071469(cellular response to alkaline pH)04810(Regulation of actin cytoskeleton);05215(Prostate cancer)NANAinsulin receptor-related receptor [Source:HGNC Symbol;Acc:HGNC:6093]0.010.020.020.010.010.01
ENSG00000027869SH2D2AENST00000368198;ENST00000368199;ENST00000392306;ENST00000468744;ENST00000486350;ENST00000495306GO:0001525(angiogenesis);GO:0005070(SH3/SH2 adaptor activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0007165(signal transduction);GO:0008283(cell proliferation);GO:0009967(positive regulation of signal transduction);GO:0017124(SH3 domain binding);GO:0030154(cell differentiation);GO:0048010(vascular endothelial growth factor receptor signaling pathway)04370(VEGF signaling pathway)NANASH2 domain containing 2A [Source:HGNC Symbol;Acc:HGNC:10821]0.490.440.440.590.500.65
ENSG00000028277POU2F2ENST00000389341;ENST00000560558;ENST00000526816;ENST00000560804;ENST00000534559;ENST00000560398;ENST00000529952;ENST00000598842;ENST00000530982;ENST00000531773;ENST00000524801;ENST00000558596GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0002335(mature B cell differentiation);GO:0002380(immunoglobulin secretion involved in immune response);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0006959(humoral immune response);GO:0019904(protein domain specific binding);GO:0043565(sequence-specific DNA binding);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048305(immunoglobulin secretion);GO:0048469(cell maturation)NANANAPOU class 2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9213]0.270.270.280.210.170.22
ENSG00000029534ANK1ENST00000289734;ENST00000314214;ENST00000265709;ENST00000524227GO:0005198(structural molecule activity);GO:0005200(structural constituent of cytoskeleton);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005829(cytosol);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0006887(exocytosis);GO:0006888(ER to Golgi vesicle-mediated transport);GO:0007010(cytoskeleton organization);GO:0007165(signal transduction);GO:0007411(axon guidance);GO:0008093(cytoskeletal adaptor activity);GO:0010638(positive regulation of organelle organization);GO:0014731(spectrin-associated cytoskeleton);GO:0016323(basolateral plasma membrane);GO:0016529(sarcoplasmic reticulum);GO:0019899(enzyme binding);GO:0030018(Z disc);GO:0030507(spectrin binding);GO:0030673(axolemma);GO:0031430(M band);GO:0031672(A band);GO:0042383(sarcolemma);GO:0043005(neuron projection);GO:0045199(maintenance of epithelial cell apical/basal polarity);GO:0045211(postsynaptic membrane);GO:0051117(ATPase binding);GO:0072661(protein targeting to plasma membrane)NANANAankyrin 1, erythrocytic [Source:HGNC Symbol;Acc:HGNC:492]0.030.040.040.060.050.06
ENSG00000029559IBSPENST00000226284GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0003674(molecular_function);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0007155(cell adhesion);GO:0016020(membrane);GO:0030198(extracellular matrix organization);GO:0031214(biomineral tissue development);GO:0031988(membrane-bounded vesicle);GO:0071363(cellular response to growth factor stimulus)NANANAintegrin-binding sialoprotein [Source:HGNC Symbol;Acc:HGNC:5341]00000.080
ENSG00000030304MUSKENST00000416899GO:0001934(positive regulation of protein phosphorylation);GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004714(transmembrane receptor protein tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006355(regulation of transcription, DNA-templated);GO:0006468(protein phosphorylation);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0007275(multicellular organismal development);GO:0007528(neuromuscular junction development);GO:0007613(memory);GO:0008582(regulation of synaptic growth at neuromuscular junction);GO:0010628(positive regulation of gene expression);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0030054(cell junction);GO:0030154(cell differentiation);GO:0030198(extracellular matrix organization);GO:0031594(neuromuscular junction);GO:0043113(receptor clustering);GO:0043235(receptor complex);GO:0043525(positive regulation of neuron apoptotic process);GO:0045202(synapse);GO:0045211(postsynaptic membrane);GO:0046777(protein autophosphorylation);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:2000541(positive regulation of protein geranylgeranylation)NANANAmuscle, skeletal, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]0.080.070.070.010.010.01
ENSG00000030419IKZF2ENST00000451136;ENST00000434687;ENST00000484040;ENST00000374319;ENST00000412444;ENST00000439848;ENST00000431520;ENST00000452786;ENST00000442445GO:0003674(molecular_function);GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0008150(biological_process);GO:0042803(protein homodimerization activity);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046872(metal ion binding);GO:0046982(protein heterodimerization activity)NANANAIKAROS family zinc finger 2 (Helios) [Source:HGNC Symbol;Acc:HGNC:13177]0.310.330.320.300.240.29
ENSG00000034053APBA2ENST00000558402;ENST00000559709;ENST00000560283;ENST00000382938GO:0001540(beta-amyloid binding);GO:0001701(in utero embryonic development);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0007268(synaptic transmission);GO:0007399(nervous system development);GO:0007626(locomotory behavior);GO:0008021(synaptic vesicle);GO:0010468(regulation of gene expression);GO:0015031(protein transport);GO:0035264(multicellular organism growth)NANANAamyloid beta (A4) precursor protein-binding, family A, member 2 [Source:HGNC Symbol;Acc:HGNC:579]0.380.400.400.100.100.12
ENSG00000034239EFCAB1ENST00000433756;ENST00000262103GO:0005509(calcium ion binding)NANANAEF-hand calcium binding domain 1 [Source:HGNC Symbol;Acc:HGNC:25678]0.060.060.06000
ENSG00000034971MYOCENST00000037502GO:0001649(osteoblast differentiation);GO:0001953(negative regulation of cell-matrix adhesion);GO:0001968(fibronectin binding);GO:0005109(frizzled binding);GO:0005515(protein binding);GO:0005578(proteinaceous extracellular matrix);GO:0005615(extracellular space);GO:0005741(mitochondrial outer membrane);GO:0005743(mitochondrial inner membrane);GO:0005758(mitochondrial intermembrane space);GO:0005783(endoplasmic reticulum);GO:0005791(rough endoplasmic reticulum);GO:0005794(Golgi apparatus);GO:0005929(cilium);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0014734(skeletal muscle hypertrophy);GO:0016023(cytoplasmic membrane-bounded vesicle);GO:0022011(myelination in peripheral nervous system);GO:0030335(positive regulation of cell migration);GO:0030971(receptor tyrosine kinase binding);GO:0031012(extracellular matrix);GO:0031175(neuron projection development);GO:0031410(cytoplasmic vesicle);GO:0032027(myosin light chain binding);GO:0033268(node of Ranvier);GO:0035024(negative regulation of Rho protein signal transduction);GO:0038031(non-canonical Wnt signaling pathway via JNK cascade);GO:0038133(ERBB2-ERBB3 signaling pathway);GO:0043408(regulation of MAPK cascade);GO:0045162(clustering of voltage-gated sodium channels);GO:0051496(positive regulation of stress fiber assembly);GO:0051497(negative regulation of stress fiber assembly);GO:0051894(positive regulation of focal adhesion assembly);GO:0051897(positive regulation of protein kinase B signaling);GO:0051901(positive regulation of mitochondrial depolarization);GO:0060348(bone development);GO:0070062(extracellular exosome);GO:1900026(positive regulation of substrate adhesion-dependent cell spreading)NANANAmyocilin, trabecular meshwork inducible glucocorticoid response [Source:HGNC Symbol;Acc:HGNC:7610]0000.010.010.01
ENSG00000035664DAPK2ENST00000261891;ENST00000559007;ENST00000557867;ENST00000612884;ENST00000558076;ENST00000561162;ENST00000559306GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004683(calmodulin-dependent protein kinase activity);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0006468(protein phosphorylation);GO:0006915(apoptotic process);GO:0010506(regulation of autophagy);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0031410(cytoplasmic vesicle);GO:0034423(autophagosome lumen);GO:0035556(intracellular signal transduction);GO:0042802(identical protein binding);GO:0042981(regulation of apoptotic process);GO:0043276(anoikis);GO:0046777(protein autophosphorylation);GO:2001242(regulation of intrinsic apoptotic signaling pathway)05200(Pathways in cancer);05219(Bladder cancer)NANAdeath-associated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:2675]0.260.290.290.200.360.21
ENSG00000035720STAP1ENST00000265404GO:0001784(phosphotyrosine binding);GO:0005068(transmembrane receptor protein tyrosine kinase adaptor activity);GO:0005070(SH3/SH2 adaptor activity);GO:0005515(protein binding);GO:0005543(phospholipid binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0010628(positive regulation of gene expression);GO:0010760(negative regulation of macrophage chemotaxis);GO:0019901(protein kinase binding);GO:0042326(negative regulation of phosphorylation);GO:0043234(protein complex);GO:0050861(positive regulation of B cell receptor signaling pathway);GO:0060100(positive regulation of phagocytosis, engulfment);GO:0071222(cellular response to lipopolysaccharide);GO:1900028(negative regulation of ruffle assembly);GO:1902227(negative regulation of macrophage colony-stimulating factor signaling pathway);GO:1903980(positive regulation of microglial cell activation);GO:1903997(positive regulation of non-membrane spanning protein tyrosine kinase activity);GO:1904151(positive regulation of microglial cell mediated cytotoxicity);GO:2000251(positive regulation of actin cytoskeleton reorganization)NANANAsignal transducing adaptor family member 1 [Source:HGNC Symbol;Acc:HGNC:24133]0.160.120.110.260.230.28
ENSG00000036448MYOM2ENST00000262113;ENST00000519518;ENST00000520072;ENST00000612167;ENST00000520298;ENST00000520779;ENST00000518513GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0006936(muscle contraction);GO:0008307(structural constituent of muscle);GO:0031430(M band);GO:0032982(myosin filament)NANANAmyomesin 2 [Source:HGNC Symbol;Acc:HGNC:7614]0.390.430.430.080.080.09
ENSG00000036530CYP46A1ENST00000554611;ENST00000261835;ENST00000380228;ENST00000554176;ENST00000556313;ENST00000556822GO:0005506(iron ion binding);GO:0005783(endoplasmic reticulum);GO:0005789(endoplasmic reticulum membrane);GO:0006699(bile acid biosynthetic process);GO:0006707(cholesterol catabolic process);GO:0006805(xenobiotic metabolic process);GO:0007399(nervous system development);GO:0008206(bile acid metabolic process);GO:0008395(steroid hydroxylase activity);GO:0016021(integral component of membrane);GO:0016125(sterol metabolic process);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0020037(heme binding);GO:0033781(cholesterol 24-hydroxylase activity);GO:0044281(small molecule metabolic process);GO:0055114(oxidation-reduction process)NANANAcytochrome P450, family 46, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:2641]0.090.090.090.070.040.06


Transcript expression profiling:

t_idclass_codechrstrandstartendt_namenum_exonslengthgene_idgene_nameGOKEGGKO_ENTRYECDescriptioncov.EM01_MFPKM.EM01_Mcov.EM02_MFPKM.EM02_Mcov.EM03_MFPKM.EM03_Mcov.KTY01_KFPKM.KTY01_Kcov.KTY02_KFPKM.KTY02_Kcov.KTY03_KFPKM.KTY03_K
1"="chr1+1186914409ENST0000045632831657MSTRG.2DDX11L1NANANANANA0.380.060.380.070.380.070.170.020.240.030.170.03
2"="chr1+1201013670ENST000004503056632MSTRG.2DDX11L1NANANANANA000000000.010.0000
3"="chr1-1440429570ENST00000488147111351MSTRG.3WASH7PNANANANANA15.532.2812.932.4313.072.4313.541.9713.301.8711.161.88
4ichr1-1459214814MSTRG.4.11223MSTRG.4WASH7PNANANANANA9.911.467.901.497.901.471.200.171.410.201.140.19
5"="chr1-1736917436ENST00000619216168MSTRG.5MIR6859-1NANANANANA9.601.414.530.855.801.081.710.252.470.351.210.20
9"="chr1-3455436081ENST0000041732431187ENSG00000237613FAM138ANANANANANA0000000.130.020.210.030.130.02
12"="chr1+6294863887ENST000004928421940ENSG00000240361OR4G11PNANANANANA0.080.010.080.020.080.01000000
13"="chr1+6909170008ENST000003351371918ENSG00000186092OR4F5GO:0004888(transmembrane signaling receptor activity);GO:0004930(G-protein coupled receptor activity);GO:0004984(olfactory receptor activity);GO:0005886(plasma membrane);GO:0007186(G-protein coupled receptor signaling pathway);GO:0016021(integral component of membrane);GO:0050907(detection of chemical stimulus involved in sensory perception);GO:0050911(detection of chemical stimulus involved in sensory perception of smell)NANANAolfactory receptor, family 4, subfamily F, member 5 [Source:HGNC Symbol;Acc:HGNC:14825]0000000.160.020.160.020.160.03
14"="chr1-89295120932ENST0000046643042748ENSG00000238009RP11-34P13.7NANANANANA4.340.643.590.683.590.675.190.754.530.644.530.76
15"="chr1-8955191105ENST0000049557621319ENSG00000239945RP11-34P13.8NANANANANA0000001.040.150000
17"="chr1-110953129173ENST000004712483629ENSG00000238009RP11-34P13.7NANANANANA0000000.120.020.120.020.120.02
18"="chr1-120725133723ENST000006105423727ENSG00000238009RP11-34P13.7NANANANANA0.150.020.150.030.150.03000.110.020.110.02
19"="chr1-129081133566ENST000004535762336ENSG00000238009RP11-34P13.7NANANANANA0000000.180.030000
20"="chr1+131025134836ENST0000044298713812ENSG00000233750CICP27NANANANANA0000003.220.47002.830.48
21"="chr1-135141135895ENST000004941491755ENSG00000268903RP11-34P13.15NANANANANA4.500.662.990.563.130.58000000
23"="chr1-139790140339ENST000004937972323MSTRG.1RP11-34P13.14NANANANANA6.710.996.591.246.611.235.290.774.940.695.060.85
24"="chr1-141474149707ENST0000048485924860MSTRG.7RP11-34P13.13NANANANANA3.190.472.460.462.520.474.920.714.890.694.620.78
25"="chr1-142808146831ENST000004909973518MSTRG.7RP11-34P13.13NANANANANA0000001.270.180.800.110.760.13
26"="chr1-146386173862ENST0000046655781301MSTRG.7RP11-34P13.13NANANANANA10.511.548.091.528.111.5113.511.9610.731.5010.811.82
28"="chr1+160446161525ENST000004964882457MSTRG.9RP11-34P13.9NANANANANA1.140.171.140.221.140.213.020.443.020.423.020.51
29"="chr1-165889168767ENST000004919623278MSTRG.7RP11-34P13.13NANANANANA0.360.050.740.140.740.140.030.000.010.000.030.00
30"="chr1+182393184158ENST000006244313718ENSG00000279928FO538757.3NANANANAProtein LOC102725121 [Source:UniProtKB/TrEMBL;Acc:A0A096LP88]0.420.060.420.080.420.080.050.010.050.010.050.01
31jchr1-184878188023MSTRG.10.171186MSTRG.10FO538757.2NANANANANA12.691.87000017.402.530.410.0613.402.26
32"="chr1-184923195411ENST0000062383491376MSTRG.10FO538757.2GO:0003779(actin binding);GO:0005769(early endosome);GO:0034314(Arp2/3 complex-mediated actin nucleation);GO:0043014(alpha-tubulin binding);GO:0071203(WASH complex)NANANAUncharacterized protein [Source:UniProtKB/TrEMBL;Acc:A0A096LP26]0.090.010000000000
33"="chr1-184925195411ENST00000623083101689MSTRG.10FO538757.2GO:0003779(actin binding);GO:0005769(early endosome);GO:0034314(Arp2/3 complex-mediated actin nucleation);GO:0043014(alpha-tubulin binding);GO:0071203(WASH complex)NANANAUncharacterized protein [Source:UniProtKB/TrEMBL;Acc:A0A096LP26]8.981.3212.662.3812.872.396.580.968.801.236.261.06
34"="chr1-184927200322ENST00000624735131608MSTRG.10FO538757.2GO:0003779(actin binding);GO:0005769(early endosome);GO:0034314(Arp2/3 complex-mediated actin nucleation);GO:0043014(alpha-tubulin binding);GO:0071203(WASH complex)NANANAUncharacterized protein [Source:UniProtKB/TrEMBL;Acc:A0A096LP26]2.190.322.580.492.570.480.700.104.430.620.620.11
35"="chr1-187891187958ENST00000612080168MSTRG.10MIR6859-2NANANANANA1.090.161.000.191.000.19000000
37"="chr1-257864264733ENST0000044211621292ENSG00000228463AP006222.2NANANANANA1.760.261.490.281.500.28000.290.0400
40"="chr1-266361297502ENST0000042458742257ENSG00000228463AP006222.2NANANANANA1.180.170.800.150.800.150.750.110.710.100.580.10
41"="chr1-287517289370ENST000003355772510ENSG00000228463AP006222.2NANANANANA0000000.150.020.150.020.150.02
42"="chr1-347982348366ENST000004582031385ENSG00000236679RPL23AP24NANANANANA0.280.040.180.030.150.030.620.090.870.120.660.11
43"="chr1-357383359681ENST000004418663676MSTRG.12RP5-857K21.15NANANANANA0.070.010.070.010.070.010.260.040.150.020.150.02
48"="chr1-365615379972ENST000004401633462MSTRG.14RP4-669L17.10NANANANANA0.550.080.550.100.550.10000000
49"="chr1-373182485208ENST000004552073413MSTRG.14RP4-669L17.10NANANANANA0000000.000.000.000.000.000.00
50"="chr1+439870440232ENST000004379051363MSTRG.15WBP1LP7NANANANANA0.140.020000000000
52"="chr1-476531497259ENST000004554643735MSTRG.14RP4-669L17.10NANANANANA2.960.433.150.593.180.592.630.380.980.142.070.35
53"="chr1-476738489710ENST000006134713727MSTRG.14RP4-669L17.10NANANANANA000000000.540.0800
54"="chr1-484832495476ENST000006018143635MSTRG.14RP4-669L17.10NANANANANA6.040.895.591.055.591.042.990.434.360.613.080.52
57"="chr1+487101489906ENST0000043272322477MSTRG.17CICP7NANANANANA0.460.070.350.070.370.071.110.161.140.161.010.17
58"="chr1-491225493241ENST0000051443621239MSTRG.18RP4-669L17.8NANANANANA2.260.331.420.271.490.283.960.584.780.673.800.64
59"="chr1-494382496665ENST000004191602607MSTRG.14RP4-669L17.10NANANANANA9.361.387.881.487.881.469.951.459.151.288.751.48
60"="chr1-494464501617ENST000004400384746MSTRG.14RP4-669L17.10NANANANANA3.240.481.660.311.660.310.810.120.720.100.810.14
61"="chr1-494876499175ENST000004237283573MSTRG.14RP4-669L17.10NANANANANA00000019.852.885.350.750.230.04
62"="chr1-497134498456ENST000005997713457MSTRG.14RP4-669L17.10NANANANANA11.291.668.531.618.681.618.051.177.381.036.531.10
63"="chr1-497240499002ENST000006014864696MSTRG.14RP4-669L17.10NANANANANA1.370.202.210.422.120.390.030.000000
64"="chr1-497275498976ENST000006169472603MSTRG.14RP4-669L17.10NANANANANA0000006.310.920.110.020.100.02
69"="chr1-585989588453ENST000004176363842ENSG00000231709RP5-857K21.1NANANANANA0.060.010.060.010.060.010.210.030.120.020.120.02
74"="chr1-601436720200ENST000004402003413ENSG00000230021RP5-857K21.4NANANANANA0.990.150.990.190.990.18000000
75"="chr1-627377629010ENST000004521763802ENSG00000223659RP5-857K21.5NANANANANA000000000.110.0200
85"="chr1+674842675265ENST000004384341424ENSG00000268663WBP1LP6NANANANANA0.120.020000000000
87"="chr1-701936720150ENST000004412453629ENSG00000230021RP5-857K21.4NANANANANA0.910.130.900.170.900.170.170.030.140.020.140.02
89"="chr1-711342720200ENST000004146882750ENSG00000230021RP5-857K21.4NANANANANA1.550.231.510.281.510.284.540.663.770.533.870.65
92"="chr1+722092724903ENST0000044078222455ENSG00000229376CICP3NANANANANA1.110.160.870.160.860.160.890.131.410.200.800.14
93"="chr1-726231728147ENST0000050664021236ENSG00000224956RP11-206L10.1NANANANANA2.670.392.120.402.120.393.360.493.790.532.970.50
94"="chr1-741813750016ENST0000041638524860MSTRG.11RP11-206L10.3NANANANANA9.911.462.000.382.060.389.081.327.401.047.611.28
96"="chr1-759032764925ENST000004176592295MSTRG.19RP11-206L10.5NANANANANA4.490.663.760.713.700.694.380.644.570.644.230.71
97"="chr1+760911761989ENST000004225282456MSTRG.20RP11-206L10.4NANANANANA0.990.150.990.190.990.183.850.563.850.542.810.47
98"="chr1-764857778626ENST0000042850471317MSTRG.19RP11-206L10.2NANANANANA16.592.4412.352.3212.322.2917.692.5717.212.4116.082.71
99"="chr1+778770784690ENST000004342643844MSTRG.21RP11-206L10.9NANANANANA2.140.322.280.432.280.420.540.080.600.080.490.08
100"="chr1+778782782191ENST000004570842566MSTRG.21RP11-206L10.9NANANANANA2.450.361.810.341.810.3411.291.6410.711.5010.451.76
101"="chr1+778930784655ENST000005898994809MSTRG.21RP11-206L10.9NANANANANA0000005.030.734.620.654.590.77
102"="chr1+778937784429ENST000006098304669MSTRG.21RP11-206L10.9NANANANANA2.200.321.690.321.690.31000000
104cchr1+784370784759ENST000005858261390MSTRG.21RP11-206L10.9NANANANANA000000001.660.2300
105"="chr1+784370784977ENST000005925471608MSTRG.21RP11-206L10.9NANANANANA000000001.060.154.150.70
108"="chr1+784370801876ENST000005857682394MSTRG.21RP11-206L10.9NANANANANA1.510.220.720.130.720.130.380.061.090.150.380.06
109"="chr1+784370804832ENST000005908485726MSTRG.21RP11-206L10.9NANANANANA000000003.210.4500
111"="chr1+784370805270ENST0000058753041024MSTRG.21RP11-206L10.9NANANANANA0000000.590.090000
112"="chr1+784370806459ENST000005930224693MSTRG.21RP11-206L10.9NANANANANA0.020.000.020.000.020.00000000
114"="chr1+784370809729ENST000005889514607MSTRG.21RP11-206L10.9NANANANANA1.230.180.800.150.800.15000000
115"="chr1+784396807321ENST0000058628871040MSTRG.21RP11-206L10.9NANANANANA2.160.321.860.351.860.343.750.540.670.093.860.65
117"="chr1-800879817712ENST000004475005872MSTRG.22RP11-206L10.8NANANANANA1.890.281.470.281.470.271.850.271.030.140.970.16
118"="chr1+804799807465ENST000004437722417MSTRG.21RP11-206L10.9NANANANANA4.090.603.460.653.460.64000000
119"="chr1+804932810060ENST000004121153581MSTRG.21RP11-206L10.9NANANANANA0.100.010.110.020.110.027.111.035.820.825.820.98
120"="chr1-805799810161ENST000005908173238MSTRG.22RP11-206L10.8NANANANANA2.670.392.260.422.260.424.570.664.470.633.620.61
121ichr1-814689814989MSTRG.23.11301MSTRG.23RP11-206L10.8NANANANANA1.400.217.811.477.811.454.410.644.900.694.410.74
122"="chr1+817371819837ENST0000032673421947MSTRG.24FAM87BNANANANANA2.820.421.910.361.990.371.270.181.430.201.040.18
123"="chr1+825138849592ENST000006249273677MSTRG.25LINC01128NANANANANA3.210.472.990.562.990.553.400.495.000.703.970.67
126"="chr1+827608859446ENST0000044511856606MSTRG.25LINC01128NANANANANA0000002.430.354.550.644.210.71
128"="chr1+827661851987ENST000006100675550MSTRG.25LINC01128NANANANANA1.350.201.040.201.190.22000000
129"="chr1+827661852090ENST000006081896824MSTRG.25LINC01128NANANANANA0000001.890.27001.290.22
130"="chr1+827667841738ENST000004417653750MSTRG.25LINC01128NANANANANA7.781.145.120.965.120.95000000
132"="chr1+827673853626ENST000004490056874MSTRG.25LINC01128NANANANANA10.621.568.151.538.171.525.610.811.860.262.760.46
133"="chr1+827699852766ENST000004165705612MSTRG.25LINC01128NANANANANA6.710.993.700.703.700.69000.880.1200
134"="chr1+827700853522ENST000006230704494MSTRG.25LINC01128NANANANANA0.410.060.430.080.440.08000000
135"="chr1+827721852090ENST000006090096767MSTRG.25LINC01128NANANANANA3.290.482.680.502.710.501.120.161.240.171.140.19
136"="chr1+827821852515ENST000006229213724MSTRG.25LINC01128NANANANANA2.180.321.410.271.470.270.520.080.510.070.600.10
137ichr1+829231830430MSTRG.27.111200MSTRG.27LINC01128NANANANANA009.201.739.201.71000000
138"="chr1+831605842020ENST000004152952894MSTRG.25LINC01128NANANANANA0.460.070.350.070.350.065.050.735.050.715.050.85
139"="chr1+851348852752ENST000004256572845MSTRG.25LINC01128NANANANANA5.150.763.930.743.930.731.910.281.410.201.770.30
140"="chr1-868071876903ENST0000044613631807MSTRG.28FAM41CNANANANANA3.210.472.790.532.960.554.460.654.670.653.640.61
145"="chr1+911435914948ENST0000044817923043ENSG00000230699RP11-54O7.1NANANANANA2.980.442.580.492.580.483.230.472.930.413.230.54
147"="chr1-916865921016ENST0000060920714152ENSG00000223764RP11-54O7.3NANANANANA0.650.100.470.090.540.10000000
150"="chr1+924880939291ENST000004201907626MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]2.570.382.580.492.580.48000000
151"="chr1+925150935793ENST000004379635387MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]0.130.020.130.030.130.02000000
160"="chr1+925741944581ENST00000622503142557MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]0.300.040.330.060.330.060.330.050.510.070.310.05
161"="chr1+930312944575ENST00000341065122191MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]8.311.225.941.125.941.10000000
162"="chr1+939275944259ENST0000045597971731MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]3.490.513.620.683.620.67000000
164"="chr1+941076942994ENST000004744614862MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]0.530.080.330.060.330.06000000
165"="chr1+942103942802ENST000004668272542MSTRG.33SAMD11GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription)NANANAsterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706]0000000.320.050000

document location:

summary/3_1_transcript_expression/4_genes_fpkm_expression.xlsx

summary/3_1_transcript_expression/5_isoforms_fpkm_expression.xlsx


Class code typies and definitions:

class codeDescription
=/0Complete match (mRNA, lncRNA etc)
cContained
jPotentially novel isoform (fragment): at least one splice junction is hared with a reference transcript
eSingle exon transfrag overlapping a reference exon and at least 10 bp of a reference intron, indicating a possible pre-mRNA fragment.
iA transfrag falling entirely within a reference intron
oGeneric exonic overlap with a reference transcript
pPossible polymerase run-on fragment (within 2Kbases of a reference transcript)
rRepeat. Currently determined by looking at the soft-masked reference sequence and applied to transcripts where at least 50% of the are lower casebases
uUnknown, intergenic transcript
xExonic overlap with reference on the opposite strand
sAn intron of the transfrag overlaps a reference intron on the opposite strand (likely due to read mapping errors)
.(.tracking file only, indicates multiple classifications)

4.7 Differential expression analysis of mRNA


4.7.1 Profiling of differentially expressed genes/transcripts


Differentially expressed genes:

gene_idgene_nametranscript_idGOKEGGKO_ENTRYECDescriptionFPKM.KTY01_KFPKM.KTY02_KFPKM.KTY03_KFPKM.EM01_MFPKM.EM02_MFPKM.EM03_Mfclog2(fc)pvalqvalregulationsignificant
ENSG00000042088TDP1ENST00000555880GO:0000012(single strand break repair);GO:0003690(double-stranded DNA binding);GO:0003697(single-stranded DNA binding);GO:0004527(exonuclease activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006281(DNA repair);GO:0006302(double-strand break repair);GO:0008081(phosphoric diester hydrolase activity);GO:0017005(3'-tyrosyl-DNA phosphodiesterase activity);GO:0090305(nucleic acid phosphodiester bond hydrolysis)NANANAtyrosyl-DNA phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:18884]1.652.001.970.540.560.572.871.520.040.14upyes
ENSG00000090975PITPNM2ENST00000542749GO:0005509(calcium ion binding);GO:0005622(intracellular);GO:0006810(transport);GO:0008152(metabolic process);GO:0008289(lipid binding);GO:0012505(endomembrane system);GO:0016021(integral component of membrane);GO:0043231(intracellular membrane-bounded organelle);GO:0046872(metal ion binding)NANANAphosphatidylinositol transfer protein, membrane-associated 2 [Source:HGNC Symbol;Acc:HGNC:21044]0.530.450.502.072.032.050.47-1.090.190.35downno
ENSG00000121211MND1ENST00000240488GO:0003677(DNA binding);GO:0005634(nucleus);GO:0006310(DNA recombination);GO:0051321(meiotic cell cycle)NANANAmeiotic nuclear divisions 1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:24839]1.771.521.660.120.070.072.471.310.030.13upyes
ENSG00000137841PLCB2ENST00000456256GO:0004435(phosphatidylinositol phospholipase C activity);GO:0004629(phospholipase C activity);GO:0004871(signal transducer activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006629(lipid metabolic process);GO:0006644(phospholipid metabolic process);GO:0007165(signal transduction);GO:0007202(activation of phospholipase C activity);GO:0007268(synaptic transmission);GO:0008081(phosphoric diester hydrolase activity);GO:0008152(metabolic process);GO:0016042(lipid catabolic process);GO:0035556(intracellular signal transduction);GO:0043647(inositol phosphate metabolic process);GO:0044281(small molecule metabolic process);GO:0050913(sensory perception of bitter taste)00562(Inositol phosphate metabolism);01100(Metabolic pathways);04020(Calcium signaling pathway);04062(Chemokine signaling pathway);04070(Phosphatidylinositol signaling system);04270(Vascular smooth muscle contraction);04310(Wnt signaling pathway);04540(Gap junction);04720(Long-term potentiation);04724(Glutamatergic synapse);04725(Cholinergic synapse);04730(Long-term depression);04742(Taste transduction);04912(GnRH signaling pathway);04916(Melanogenesis);04961(Endocrine and other factor-regulated calcium reabsorption);04970(Salivary secretion);04971(Gastric acid secretion);04972(Pancreatic secretion);04973(Carbohydrate digestion and absorption);05010(Alzheimer's disease);05016(Huntington's disease);05142(Chagas disease (American trypanosomiasis));05143(African trypanosomiasis);05146(Amoebiasis)K01116;K05857;K05858;K05859;K05860;K05861;K190063.1.4.11phospholipase C, beta 2 [Source:HGNC Symbol;Acc:HGNC:9055]0.640.610.701.751.751.740.21-2.260.200.36downno
ENSG00000139354GAS2L3ENST00000266754GO:0000226(microtubule cytoskeleton organization);GO:0003779(actin binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005856(cytoskeleton);GO:0005874(microtubule);GO:0007050(cell cycle arrest);GO:0008017(microtubule binding);GO:0015629(actin cytoskeleton);GO:0015630(microtubule cytoskeleton);GO:0030036(actin cytoskeleton organization)NANANAgrowth arrest-specific 2 like 3 [Source:HGNC Symbol;Acc:HGNC:27475]1.231.251.230.300.300.303.571.830.170.33upno
ENSG00000143110C1orf162ENST00000369718GO:0016021(integral component of membrane)NANANAchromosome 1 open reading frame 162 [Source:HGNC Symbol;Acc:HGNC:28344]0.570.510.552.042.222.230.13-2.940.020.09downyes
ENSG00000149548CCDC15ENST00000344762GO:0005813(centrosome)NANANAcoiled-coil domain containing 15 [Source:HGNC Symbol;Acc:HGNC:25798]1.721.451.630.520.560.551.350.440.600.73upno
ENSG00000162396PARS2ENST00000371279GO:0000166(nucleotide binding);GO:0004812(aminoacyl-tRNA ligase activity);GO:0004827(proline-tRNA ligase activity);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005759(mitochondrial matrix);GO:0006418(tRNA aminoacylation for protein translation);GO:0006433(prolyl-tRNA aminoacylation);GO:0010467(gene expression)00970(Aminoacyl-tRNA biosynthesis)NANAprolyl-tRNA synthetase 2, mitochondrial (putative) [Source:HGNC Symbol;Acc:HGNC:30563]7.936.497.9300.010.011.730.790.290.46upno
ENSG00000174175SELPENST00000367788GO:0001530(lipopolysaccharide binding);GO:0001948(glycoprotein binding);GO:0002576(platelet degranulation);GO:0002687(positive regulation of leukocyte migration);GO:0002691(regulation of cellular extravasation);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006954(inflammatory response);GO:0007155(cell adhesion);GO:0007157(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules);GO:0007159(leukocyte cell-cell adhesion);GO:0007596(blood coagulation);GO:0008201(heparin binding);GO:0009897(external side of plasma membrane);GO:0010572(positive regulation of platelet activation);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0014070(response to organic cyclic compound);GO:0016020(membrane);GO:0016337(single organismal cell-cell adhesion);GO:0030168(platelet activation);GO:0030246(carbohydrate binding);GO:0031088(platelet dense granule membrane);GO:0031092(platelet alpha granule membrane);GO:0032496(response to lipopolysaccharide);GO:0033623(regulation of integrin activation);GO:0033691(sialic acid binding);GO:0042806(fucose binding);GO:0043208(glycosphingolipid binding);GO:0045785(positive regulation of cell adhesion);GO:0048306(calcium-dependent protein binding);GO:0050829(defense response to Gram-negative bacterium);GO:0050900(leukocyte migration);GO:0050901(leukocyte tethering or rolling);GO:0070492(oligosaccharide binding)04514(Cell adhesion molecules (CAMs));05144(Malaria);05150(Staphylococcus aureus infection)NANAselectin P (granule membrane protein 140kDa, antigen CD62) [Source:HGNC Symbol;Acc:HGNC:10721]0.200.190.191.861.881.870.36-1.460.000.02downyes
ENSG00000174326SLC16A11ENST00000308009GO:0005789(endoplasmic reticulum membrane);GO:0006629(lipid metabolic process);GO:0008028(monocarboxylic acid transmembrane transporter activity);GO:0015293(symporter activity);GO:0015718(monocarboxylic acid transport);GO:0016021(integral component of membrane);GO:0034220(ion transmembrane transport);GO:0055085(transmembrane transport)NANANAsolute carrier family 16, member 11 [Source:HGNC Symbol;Acc:HGNC:23093]3.542.813.531.281.111.130.67-0.580.630.76downno
ENSG00000174371EXO1ENST00000366548GO:0002455(humoral immune response mediated by circulating immunoglobulin);GO:0003677(DNA binding);GO:0003824(catalytic activity);GO:0004518(nuclease activity);GO:0004523(RNA-DNA hybrid ribonuclease activity);GO:0004527(exonuclease activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006281(DNA repair);GO:0006298(mismatch repair);GO:0006310(DNA recombination);GO:0008409(5'-3' exonuclease activity);GO:0016446(somatic hypermutation of immunoglobulin genes);GO:0016788(hydrolase activity, acting on ester bonds);GO:0035312(5'-3' exodeoxyribonuclease activity);GO:0043566(structure-specific DNA binding);GO:0045145(single-stranded DNA 5'-3' exodeoxyribonuclease activity);GO:0045190(isotype switching);GO:0046872(metal ion binding);GO:0048256(flap endonuclease activity);GO:0051321(meiotic cell cycle);GO:0051908(double-stranded DNA 5'-3' exodeoxyribonuclease activity);GO:0090305(nucleic acid phosphodiester bond hydrolysis);GO:0090502(RNA phosphodiester bond hydrolysis, endonucleolytic)03430(Mismatch repair)NANAexonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3511]2.402.212.340.020.030.031.580.660.220.39upno
ENSG00000196302RP11-497H16.5ENST00000508439NANANANANA1.842.101.734.314.264.351.520.610.190.35upno
ENSG00000197272IL27ENST00000356897GO:0005102(receptor binding);GO:0005125(cytokine activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0006954(inflammatory response);GO:0009617(response to bacterium);GO:0042129(regulation of T cell proliferation);GO:0045078(positive regulation of interferon-gamma biosynthetic process);GO:0045087(innate immune response);GO:0045523(interleukin-27 receptor binding);GO:0045625(regulation of T-helper 1 cell differentiation);GO:0050688(regulation of defense response to virus)NANANAinterleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157]0.420.440.483.193.243.220.25-1.980.010.06downyes
ENSG00000202538RNU4-2ENST00000365668NANANANANA00018.9118.6918.740.05-4.250.000.00downyes
ENSG00000227077AC107983.4ENST00000442562NANANANANA4.06000000.04-4.590.750.84downno
ENSG00000237039AC018738.2ENST00000441378NANANANANA2.57000000.08-3.600.750.84downno
ENSG00000268089GABRQENST00000598523GO:0004888(transmembrane signaling receptor activity);GO:0004890(GABA-A receptor activity);GO:0005230(extracellular ligand-gated ion channel activity);GO:0005254(chloride channel activity);GO:0005326(neurotransmitter transporter activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0006836(neurotransmitter transport);GO:0007165(signal transduction);GO:0007268(synaptic transmission);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0034220(ion transmembrane transport);GO:0034707(chloride channel complex);GO:0043235(receptor complex);GO:0045211(postsynaptic membrane);GO:0055085(transmembrane transport);GO:1902476(chloride transmembrane transport)NANANAgamma-aminobutyric acid (GABA) A receptor, theta [Source:HGNC Symbol;Acc:HGNC:14454]2.381.892.410000.77-0.380.550.70downno
MSTRG.10002EIF2AK4ENST00000558557GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004694(eukaryotic translation initiation factor 2alpha kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005622(intracellular);GO:0006446(regulation of translational initiation);GO:0006468(protein phosphorylation);GO:0009267(cellular response to starvation);GO:0010998(regulation of translational initiation by eIF2 alpha phosphorylation);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0017148(negative regulation of translation);GO:0022626(cytosolic ribosome);GO:0030968(endoplasmic reticulum unfolded protein response);GO:0042803(protein homodimerization activity);GO:0043558(regulation of translational initiation in response to stress)04141(Protein processing in endoplasmic reticulum);05160(Hepatitis C);05162(Measles);05164(Influenza A)NANAeukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687]6.456.286.526.756.866.8210.453.390.210.38upno
MSTRG.10005SRP14ENST00000267884GO:0003723(RNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005786(signal recognition particle, endoplasmic reticulum targeting);GO:0005829(cytosol);GO:0006412(translation);GO:0006613(cotranslational protein targeting to membrane);GO:0006614(SRP-dependent cotranslational protein targeting to membrane);GO:0008312(7S RNA binding);GO:0010467(gene expression);GO:0030942(endoplasmic reticulum signal peptide binding);GO:0042493(response to drug);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0045047(protein targeting to ER);GO:0045171(intercellular bridge);GO:0048500(signal recognition particle);GO:0070062(extracellular exosome)03060(Protein export)NANAsignal recognition particle 14kDa (homologous Alu RNA binding protein) [Source:HGNC Symbol;Acc:HGNC:11299]14.6420.4014.8910.3410.6810.7121.384.420.050.16upno
MSTRG.10010BUB1BENST00000287598GO:0000278(mitotic cell cycle);GO:0000776(kinetochore);GO:0000777(condensed chromosome kinetochore);GO:0000778(condensed nuclear chromosome kinetochore);GO:0000940(condensed chromosome outer kinetochore);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005680(anaphase-promoting complex);GO:0005737(cytoplasm);GO:0005815(microtubule organizing center);GO:0005829(cytosol);GO:0006468(protein phosphorylation);GO:0006915(apoptotic process);GO:0007067(mitotic nuclear division);GO:0007091(metaphase/anaphase transition of mitotic cell cycle);GO:0007093(mitotic cell cycle checkpoint);GO:0007094(mitotic spindle assembly checkpoint);GO:0007264(small GTPase mediated signal transduction);GO:0008283(cell proliferation);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0031145(anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0034501(protein localization to kinetochore);GO:0048471(perinuclear region of cytoplasm);GO:0051233(spindle midzone);GO:0051301(cell division);GO:0051436(negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle);GO:0051439(regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle);GO:0071459(protein localization to chromosome, centromeric region)04110(Cell cycle)NANABUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149]1.661.711.620.070.070.0711.073.470.000.01upyes
MSTRG.10016KNSTRNENST00000608100GO:0000070(mitotic sister chromatid segregation);GO:0000776(kinetochore);GO:0000777(condensed chromosome kinetochore);GO:0000922(spindle pole);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0007051(spindle organization);GO:0007059(chromosome segregation);GO:0015630(microtubule cytoskeleton);GO:0035371(microtubule plus-end);GO:0051301(cell division);GO:0051988(regulation of attachment of spindle microtubules to kinetochore);GO:0072686(mitotic spindle)NANANAkinetochore-localized astrin/SPAG5 binding protein [Source:HGNC Symbol;Acc:HGNC:30767]4.262.834.381.041.101.090.02-5.640.070.18downno
MSTRG.10017IVDENST00000487418GO:0003995(acyl-CoA dehydrogenase activity);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005759(mitochondrial matrix);GO:0006552(leucine catabolic process);GO:0008152(metabolic process);GO:0008470(isovaleryl-CoA dehydrogenase activity);GO:0009083(branched-chain amino acid catabolic process);GO:0016627(oxidoreductase activity, acting on the CH-CH group of donors);GO:0031966(mitochondrial membrane);GO:0034641(cellular nitrogen compound metabolic process);GO:0044281(small molecule metabolic process);GO:0050660(flavin adenine dinucleotide binding);GO:0055114(oxidation-reduction process)00280(Valine, leucine and isoleucine degradation);01100(Metabolic pathways)NANAisovaleryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:6186]5.495.675.5112.2517.8517.810.12-3.030.370.55downno
MSTRG.10022RPUSD2ENST00000315616GO:0001522(pseudouridine synthesis);GO:0003723(RNA binding);GO:0005575(cellular_component);GO:0008150(biological_process);GO:0009451(RNA modification);GO:0009982(pseudouridine synthase activity);GO:0044822(poly(A) RNA binding)NANANARNA pseudouridylate synthase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24180]4.714.254.651.651.661.641.100.140.700.81upno
MSTRG.10026CASC5ENST00000399668GO:0000278(mitotic cell cycle);GO:0000777(condensed chromosome kinetochore);GO:0001669(acrosomal vesicle);GO:0001675(acrosome assembly);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006334(nucleosome assembly);GO:0007067(mitotic nuclear division);GO:0007264(small GTPase mediated signal transduction);GO:0008608(attachment of spindle microtubules to kinetochore);GO:0010923(negative regulation of phosphatase activity);GO:0034080(CENP-A containing nucleosome assembly);GO:0034501(protein localization to kinetochore);GO:0051301(cell division);GO:0070062(extracellular exosome);GO:0071173(spindle assembly checkpoint)NANANAcancer susceptibility candidate 5 [Source:HGNC Symbol;Acc:HGNC:24054]3.994.464.060.600.600.606.522.700.000.01upyes
MSTRG.10047CHP1ENST00000334660GO:0000139(Golgi membrane);GO:0001578(microtubule bundle formation);GO:0001933(negative regulation of protein phosphorylation);GO:0004860(protein kinase inhibitor activity);GO:0005215(transporter activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005783(endoplasmic reticulum);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0005975(carbohydrate metabolic process);GO:0006469(negative regulation of protein kinase activity);GO:0006611(protein export from nucleus);GO:0006813(potassium ion transport);GO:0007264(small GTPase mediated signal transduction);GO:0008017(microtubule binding);GO:0010923(negative regulation of phosphatase activity);GO:0015459(potassium channel regulator activity);GO:0015630(microtubule cytoskeleton);GO:0017156(calcium ion-dependent exocytosis);GO:0019900(kinase binding);GO:0022406(membrane docking);GO:0030133(transport vesicle);GO:0030203(glycosaminoglycan metabolic process);GO:0030212(hyaluronan metabolic process);GO:0030214(hyaluronan catabolic process);GO:0031122(cytoplasmic microtubule organization);GO:0031397(negative regulation of protein ubiquitination);GO:0031953(negative regulation of protein autophosphorylation);GO:0032088(negative regulation of NF-kappaB transcription factor activity);GO:0032417(positive regulation of sodium:proton antiporter activity);GO:0042308(negative regulation of protein import into nucleus);GO:0044281(small molecule metabolic process);GO:0048306(calcium-dependent protein binding);GO:0050821(protein stabilization);GO:0051222(positive regulation of protein transport);GO:0051259(protein oligomerization);GO:0051453(regulation of intracellular pH);GO:0060050(positive regulation of protein glycosylation);GO:0061024(membrane organization);GO:0061025(membrane fusion);GO:0070062(extracellular exosome);GO:0070885(negative regulation of calcineurin-NFAT signaling cascade);GO:0071468(cellular response to acidic pH);GO:0090314(positive regulation of protein targeting to membrane);GO:1901214(regulation of neuron death)04010(MAPK signaling pathway);04020(Calcium signaling pathway);04114(Oocyte meiosis);04210(Apoptosis);04310(Wnt signaling pathway);04360(Axon guidance);04370(VEGF signaling pathway);04650(Natural killer cell mediated cytotoxicity);04660(T cell receptor signaling pathway);04662(B cell receptor signaling pathway);04720(Long-term potentiation);04724(Glutamatergic synapse);05010(Alzheimer's disease);05014(Amyotrophic lateral sclerosis (ALS));05152(Tuberculosis)NANAcalcineurin-like EF-hand protein 1 [Source:HGNC Symbol;Acc:HGNC:17433]43.5236.9943.3727.1426.6826.830.40-1.310.150.30downno
MSTRG.10049OIP5ENST00000220514GO:0000775(chromosome, centromeric region);GO:0000785(chromatin);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006334(nucleosome assembly);GO:0007067(mitotic nuclear division);GO:0007154(cell communication);GO:0010369(chromocenter);GO:0015030(Cajal body);GO:0034080(CENP-A containing nucleosome assembly);GO:0051301(cell division)NANANAOpa interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:20300]3.133.703.180.430.410.419.453.240.010.05upyes
MSTRG.1005PPAP2BENST00000459962GO:0001568(blood vessel development);GO:0001702(gastrulation with mouth forming second);GO:0001933(negative regulation of protein phosphorylation);GO:0003824(catalytic activity);GO:0004721(phosphoprotein phosphatase activity);GO:0005178(integrin binding);GO:0005515(protein binding);GO:0005789(endoplasmic reticulum membrane);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005912(adherens junction);GO:0006629(lipid metabolic process);GO:0006644(phospholipid metabolic process);GO:0006665(sphingolipid metabolic process);GO:0007155(cell adhesion);GO:0008195(phosphatidate phosphatase activity);GO:0008354(germ cell migration);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016311(dephosphorylation);GO:0016337(single organismal cell-cell adhesion);GO:0030111(regulation of Wnt signaling pathway);GO:0030148(sphingolipid biosynthetic process);GO:0034109(homotypic cell-cell adhesion);GO:0042392(sphingosine-1-phosphate phosphatase activity);GO:0042577(lipid phosphatase activity);GO:0044281(small molecule metabolic process);GO:0044328(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration);GO:0044329(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion);GO:0044330(canonical Wnt signaling pathway involved in positive regulation of wound healing);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0060020(Bergmann glial cell differentiation);GO:0060070(canonical Wnt signaling pathway);GO:0070062(extracellular exosome);GO:1902068(regulation of sphingolipid mediated signaling pathway)00561(Glycerolipid metabolism);00564(Glycerophospholipid metabolism);00565(Ether lipid metabolism);00600(Sphingolipid metabolism);01100(Metabolic pathways);04666(Fc gamma R-mediated phagocytosis);04975(Fat digestion and absorption)NANAphosphatidic acid phosphatase type 2B [Source:HGNC Symbol;Acc:HGNC:9229]6.085.616.028.068.248.200.23-2.150.000.02downyes
MSTRG.10050NUSAP1ENST00000559596;ENST00000414849GO:0000070(mitotic sister chromatid segregation);GO:0000281(mitotic cytokinesis);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005694(chromosome);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005819(spindle);GO:0005874(microtubule);GO:0005876(spindle microtubule);GO:0007076(mitotic chromosome condensation);GO:0008017(microtubule binding);GO:0040001(establishment of mitotic spindle localization);GO:0044822(poly(A) RNA binding);GO:0045840(positive regulation of mitotic nuclear division)NANANAnucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538]8.659.058.881.291.241.224.352.120.030.11upyes
MSTRG.10052NDUFAF1ENST00000260361GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005747(mitochondrial respiratory chain complex I);GO:0006120(mitochondrial electron transport, NADH to ubiquinone);GO:0006461(protein complex assembly);GO:0051082(unfolded protein binding)NANANANADH dehydrogenase (ubiquinone) complex I, assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:18828]4.974.715.035.585.995.930.26-1.930.010.08downyes
MSTRG.10053RTF1ENST00000389629GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0001711(endodermal cell fate commitment);GO:0001832(blastocyst growth);GO:0003677(DNA binding);GO:0003697(single-stranded DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0006352(DNA-templated transcription, initiation);GO:0016055(Wnt signaling pathway);GO:0016570(histone modification);GO:0016593(Cdc73/Paf1 complex);GO:0019827(stem cell maintenance);GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter);GO:0044822(poly(A) RNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0051571(positive regulation of histone H3-K4 methylation);GO:0080182(histone H3-K4 trimethylation)NANANARtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:28996]6.435.886.462.934.624.610.18-2.440.410.58downno
MSTRG.10055RPAP1ENST00000304330GO:0003677(DNA binding);GO:0003899(DNA-directed RNA polymerase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006366(transcription from RNA polymerase II promoter)NANANARNA polymerase II associated protein 1 [Source:HGNC Symbol;Acc:HGNC:24567]3.613.363.752.202.252.230.67-0.590.040.14downno
MSTRG.10056VPS39ENST00000318006GO:0005515(protein binding);GO:0005765(lysosomal membrane);GO:0006886(intracellular protein transport);GO:0016192(vesicle-mediated transport);GO:0030897(HOPS complex);GO:0031902(late endosome membrane)NANANAvacuolar protein sorting 39 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:20593]5.254.935.193.933.954.011.200.260.630.75upno
MSTRG.10070EHD4ENST00000220325;ENST00000612090GO:0003676(nucleic acid binding);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005525(GTP binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005783(endoplasmic reticulum);GO:0005886(plasma membrane);GO:0006907(pinocytosis);GO:0016020(membrane);GO:0030100(regulation of endocytosis);GO:0031901(early endosome membrane);GO:0032456(endocytic recycling);GO:0048471(perinuclear region of cytoplasm);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051260(protein homooligomerization);GO:0055038(recycling endosome membrane);GO:0070062(extracellular exosome);GO:0071363(cellular response to growth factor stimulus)04144(Endocytosis)NANAEH-domain containing 4 [Source:HGNC Symbol;Acc:HGNC:3245]4.523.734.592.352.352.340.36-1.480.070.19downno
MSTRG.10074TMEM87AENST00000389834GO:0016021(integral component of membrane)NANANAtransmembrane protein 87A [Source:HGNC Symbol;Acc:HGNC:24522]3.913.743.963.373.513.480.72-0.480.010.06downno
MSTRG.10075CAPN3ENST00000357568GO:0001896(autolysis);GO:0003824(catalytic activity);GO:0004198(calcium-dependent cysteine-type endopeptidase activity);GO:0004871(signal transducer activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006461(protein complex assembly);GO:0006508(proteolysis);GO:0006915(apoptotic process);GO:0007165(signal transduction);GO:0007517(muscle organ development);GO:0008233(peptidase activity);GO:0008234(cysteine-type peptidase activity);GO:0008307(structural constituent of muscle);GO:0014718(positive regulation of satellite cell activation involved in skeletal muscle regeneration);GO:0014850(response to muscle activity);GO:0030016(myofibril);GO:0030018(Z disc);GO:0030239(myofibril assembly);GO:0030315(T-tubule);GO:0031402(sodium ion binding);GO:0031432(titin binding);GO:0032947(protein complex scaffold);GO:0033234(negative regulation of protein sumoylation);GO:0043066(negative regulation of apoptotic process);GO:0043122(regulation of I-kappaB kinase/NF-kappaB signaling);GO:0043234(protein complex);GO:0045214(sarcomere organization);GO:0045661(regulation of myoblast differentiation);GO:0045862(positive regulation of proteolysis);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0046716(muscle cell cellular homeostasis);GO:0050790(regulation of catalytic activity);GO:0051092(positive regulation of NF-kappaB transcription factor activity);GO:0051281(positive regulation of release of sequestered calcium ion into cytosol);GO:0051592(response to calcium ion);GO:0055103(ligase regulator activity);GO:0061061(muscle structure development);GO:0070315(G1 to G0 transition involved in cell differentiation);GO:0071277(cellular response to calcium ion);GO:0071472(cellular response to salt stress);GO:0072657(protein localization to membrane);GO:0097264(self proteolysis)NANANAcalpain 3, (p94) [Source:HGNC Symbol;Acc:HGNC:1480]1.271.241.303.053.033.041.090.120.960.98upno
MSTRG.10079SNAP23ENST00000249647GO:0002553(histamine secretion by mast cell);GO:0005484(SNAP receptor activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0006887(exocytosis);GO:0006892(post-Golgi vesicle-mediated transport);GO:0006903(vesicle targeting);GO:0015031(protein transport);GO:0016082(synaptic vesicle priming);GO:0019905(syntaxin binding);GO:0031201(SNARE complex);GO:0031410(cytoplasmic vesicle);GO:0031629(synaptic vesicle fusion to presynaptic membrane);GO:0042581(specific granule);GO:0042582(azurophil granule);GO:0042629(mast cell granule);GO:0043005(neuron projection);GO:0045202(synapse);GO:0061024(membrane organization);GO:0061025(membrane fusion);GO:0070062(extracellular exosome)04130(SNARE interactions in vesicular transport)NANAsynaptosomal-associated protein, 23kDa [Source:HGNC Symbol;Acc:HGNC:11131]5.174.935.022.772.732.810.26-1.930.100.22downno
MSTRG.10089UBR1ENST00000290650GO:0000151(ubiquitin ligase complex);GO:0000502(proteasome complex);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006511(ubiquitin-dependent protein catabolic process);GO:0008270(zinc ion binding);GO:0016567(protein ubiquitination);GO:0016874(ligase activity);GO:0030163(protein catabolic process);GO:0032007(negative regulation of TOR signaling);GO:0061630(ubiquitin protein ligase activity);GO:0070728(leucine binding);GO:0071233(cellular response to leucine);GO:0071596(ubiquitin-dependent protein catabolic process via the N-end rule pathway)NANANAubiquitin protein ligase E3 component n-recognin 1 [Source:HGNC Symbol;Acc:HGNC:16808]5.895.505.923.863.773.760.88-0.180.660.78downno
MSTRG.1009PRKAA2ENST00000371244GO:0003682(chromatin binding);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004679(AMP-activated protein kinase activity);GO:0004712(protein serine/threonine/tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006112(energy reserve metabolic process);GO:0006355(regulation of transcription, DNA-templated);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0006468(protein phosphorylation);GO:0006633(fatty acid biosynthetic process);GO:0006695(cholesterol biosynthetic process);GO:0006853(carnitine shuttle);GO:0006914(autophagy);GO:0006950(response to stress);GO:0006996(organelle organization);GO:0007005(mitochondrion organization);GO:0007050(cell cycle arrest);GO:0007165(signal transduction);GO:0008286(insulin receptor signaling pathway);GO:0008610(lipid biosynthetic process);GO:0010467(gene expression);GO:0010468(regulation of gene expression);GO:0010508(positive regulation of autophagy);GO:0014850(response to muscle activity);GO:0016055(Wnt signaling pathway);GO:0016241(regulation of macroautophagy);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0031588(AMP-activated protein kinase complex);GO:0031669(cellular response to nutrient levels);GO:0032007(negative regulation of TOR signaling);GO:0035174(histone serine kinase activity);GO:0035404(histone-serine phosphorylation);GO:0035556(intracellular signal transduction);GO:0035690(cellular response to drug);GO:0042149(cellular response to glucose starvation);GO:0042304(regulation of fatty acid biosynthetic process);GO:0042593(glucose homeostasis);GO:0042752(regulation of circadian rhythm);GO:0043066(negative regulation of apoptotic process);GO:0044255(cellular lipid metabolic process);GO:0044281(small molecule metabolic process);GO:0045821(positive regulation of glycolytic process);GO:0046872(metal ion binding);GO:0047322([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity);GO:0048511(rhythmic process);GO:0050405([acetyl-CoA carboxylase] kinase activity);GO:0055089(fatty acid homeostasis);GO:0061024(membrane organization);GO:0071380(cellular response to prostaglandin E stimulus);GO:2000505(regulation of energy homeostasis)04140(Regulation of autophagy);04150(mTOR signaling pathway);04910(Insulin signaling pathway);04920(Adipocytokine signaling pathway);05410(Hypertrophic cardiomyopathy (HCM))NANAprotein kinase, AMP-activated, alpha 2 catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9377]9.829.559.790.820.800.805.082.350.000.02upyes
MSTRG.10094CCNDBP1ENST00000566515GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0007049(cell cycle);GO:0051726(regulation of cell cycle)NANANAcyclin D-type binding-protein 1 [Source:HGNC Symbol;Acc:HGNC:1587]4.243.874.222.732.762.77215.997.750.030.11upyes
MSTRG.1011C8AENST00000361249GO:0001848(complement binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005579(membrane attack complex);GO:0005615(extracellular space);GO:0006955(immune response);GO:0006956(complement activation);GO:0006957(complement activation, alternative pathway);GO:0006958(complement activation, classical pathway);GO:0016020(membrane);GO:0019835(cytolysis);GO:0030449(regulation of complement activation);GO:0032403(protein complex binding);GO:0045087(innate immune response);GO:0070062(extracellular exosome);GO:0072562(blood microparticle)04610(Complement and coagulation cascades);05020(Prion diseases);05146(Amoebiasis);05322(Systemic lupus erythematosus)NANAcomplement component 8, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:1352]80.4163.6680.60212.62215.06214.670.04-4.520.010.07downyes
MSTRG.10110MFAP1ENST00000267812GO:0001527(microfibril);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0008150(biological_process);GO:0030198(extracellular matrix organization);GO:0044822(poly(A) RNA binding)NANANAmicrofibrillar-associated protein 1 [Source:HGNC Symbol;Acc:HGNC:7032]5.556.405.432.562.562.556.582.720.010.06upyes
MSTRG.10111WDR76ENST00000263795GO:0005515(protein binding)NANANAWD repeat domain 76 [Source:HGNC Symbol;Acc:HGNC:25773]3.202.963.250.270.260.261.520.610.250.42upno
MSTRG.10117PDIA3ENST00000300289GO:0002474(antigen processing and presentation of peptide antigen via MHC class I);GO:0002479(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent);GO:0003756(protein disulfide isomerase activity);GO:0004197(cysteine-type endopeptidase activity);GO:0004629(phospholipase C activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005634(nucleus);GO:0005783(endoplasmic reticulum);GO:0005788(endoplasmic reticulum lumen);GO:0005790(smooth endoplasmic reticulum);GO:0005925(focal adhesion);GO:0006457(protein folding);GO:0006508(proteolysis);GO:0006606(protein import into nucleus);GO:0006621(protein retention in ER lumen);GO:0007165(signal transduction);GO:0008152(metabolic process);GO:0009986(cell surface);GO:0015036(disulfide oxidoreductase activity);GO:0016853(isomerase activity);GO:0018279(protein N-linked glycosylation via asparagine);GO:0034975(protein folding in endoplasmic reticulum);GO:0034976(response to endoplasmic reticulum stress);GO:0042470(melanosome);GO:0042590(antigen processing and presentation of exogenous peptide antigen via MHC class I);GO:0043209(myelin sheath);GO:0043687(post-translational protein modification);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0045454(cell redox homeostasis);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome);GO:2001238(positive regulation of extrinsic apoptotic signaling pathway)04141(Protein processing in endoplasmic reticulum);04612(Antigen processing and presentation)NANAprotein disulfide isomerase family A, member 3 [Source:HGNC Symbol;Acc:HGNC:4606]93.1096.6793.4848.0049.2349.352.341.230.030.13upyes
MSTRG.10119HYPKENST00000381359;ENST00000249786;ENST00000445816;ENST00000402131;ENST00000403425;ENST00000409614;ENST00000442995GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm)NANANAhuntingtin interacting protein K [Source:HGNC Symbol;Acc:HGNC:18418]15.9117.5215.6510.6110.8510.832.901.540.050.16upno
MSTRG.10122CASC4ENST00000299957;ENST00000345795GO:0005794(Golgi apparatus);GO:0016021(integral component of membrane)NANANAcancer susceptibility candidate 4 [Source:HGNC Symbol;Acc:HGNC:24892]4.564.334.475.996.116.110.71-0.490.140.28downno
MSTRG.10127CTDSPL2ENST00000260327GO:0004721(phosphoprotein phosphatase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006470(protein dephosphorylation);GO:0016311(dephosphorylation);GO:0016791(phosphatase activity);GO:0030514(negative regulation of BMP signaling pathway);GO:0046827(positive regulation of protein export from nucleus)NANANACTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 [Source:HGNC Symbol;Acc:HGNC:26936]3.113.223.082.021.411.416.612.720.230.40upno
MSTRG.10131EIF3JENST00000261868GO:0001731(formation of translation preinitiation complex);GO:0002181(cytoplasmic translation);GO:0003743(translation initiation factor activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005852(eukaryotic translation initiation factor 3 complex);GO:0006412(translation);GO:0006413(translational initiation);GO:0006446(regulation of translational initiation);GO:0010467(gene expression);GO:0016282(eukaryotic 43S preinitiation complex);GO:0033290(eukaryotic 48S preinitiation complex);GO:0044267(cellular protein metabolic process)03013(RNA transport)NANAeukaryotic translation initiation factor 3, subunit J [Source:HGNC Symbol;Acc:HGNC:3270]10.8511.1310.824.524.344.343.271.710.030.12upyes
MSTRG.10133SPG11ENST00000261866GO:0005515(protein binding);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0016021(integral component of membrane);GO:0031410(cytoplasmic vesicle);GO:0070062(extracellular exosome)NANANAspastic paraplegia 11 (autosomal recessive) [Source:HGNC Symbol;Acc:HGNC:11226]10.6910.4010.798.748.728.721.670.740.460.62upno
MSTRG.10137B2MENST00000558401;ENST00000559720;ENST00000544417;ENST00000561424;ENST00000559916;ENST00000349264;ENST00000559907;ENST00000561139GO:0000139(Golgi membrane);GO:0001895(retina homeostasis);GO:0001916(positive regulation of T cell mediated cytotoxicity);GO:0001948(glycoprotein binding);GO:0002237(response to molecule of bacterial origin);GO:0002474(antigen processing and presentation of peptide antigen via MHC class I);GO:0002479(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent);GO:0002480(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent);GO:0002481(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0005737(cytoplasm);GO:0005788(endoplasmic reticulum lumen);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0006955(immune response);GO:0009897(external side of plasma membrane);GO:0012507(ER to Golgi transport vesicle membrane);GO:0016020(membrane);GO:0016032(viral process);GO:0019221(cytokine-mediated signaling pathway);GO:0030670(phagocytic vesicle membrane);GO:0031901(early endosome membrane);GO:0031905(early endosome lumen);GO:0033077(T cell differentiation in thymus);GO:0042026(protein refolding);GO:0042493(response to drug);GO:0042590(antigen processing and presentation of exogenous peptide antigen via MHC class I);GO:0042612(MHC class I protein complex);GO:0042802(identical protein binding);GO:0045087(innate immune response);GO:0046686(response to cadmium ion);GO:0050690(regulation of defense response to virus by virus);GO:0050776(regulation of immune response);GO:0055072(iron ion homeostasis);GO:0060333(interferon-gamma-mediated signaling pathway);GO:0070062(extracellular exosome);GO:1900121(negative regulation of receptor binding)NANANAbeta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914]64.3955.1365.1774.8083.6583.510.12-3.030.010.06downyes
MSTRG.10138TRIM69ENST00000560141GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0006915(apoptotic process);GO:0008270(zinc ion binding);GO:0016567(protein ubiquitination);GO:0016607(nuclear speck);GO:0016874(ligase activity);GO:0043231(intracellular membrane-bounded organelle)NANANAtripartite motif containing 69 [Source:HGNC Symbol;Acc:HGNC:17857]1.361.111.471.931.961.970.12-3.080.010.08downyes
MSTRG.10140SORD2PENST00000558556NANANANANA1.081.551.156.356.396.393.931.970.250.41upno
MSTRG.10144SORDENST00000267814GO:0003939(L-iditol 2-dehydrogenase activity);GO:0005615(extracellular space);GO:0005739(mitochondrion);GO:0005829(cytosol);GO:0005975(carbohydrate metabolic process);GO:0006000(fructose metabolic process);GO:0006006(glucose metabolic process);GO:0006060(sorbitol metabolic process);GO:0006062(sorbitol catabolic process);GO:0006970(response to osmotic stress);GO:0008270(zinc ion binding);GO:0009725(response to hormone);GO:0016020(membrane);GO:0016491(oxidoreductase activity);GO:0030246(carbohydrate binding);GO:0030317(sperm motility);GO:0031514(motile cilium);GO:0031667(response to nutrient levels);GO:0031966(mitochondrial membrane);GO:0042493(response to drug);GO:0042802(identical protein binding);GO:0044281(small molecule metabolic process);GO:0046370(fructose biosynthetic process);GO:0046686(response to cadmium ion);GO:0046688(response to copper ion);GO:0051160(L-xylitol catabolic process);GO:0051164(L-xylitol metabolic process);GO:0051287(NAD binding);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome)NANANAsorbitol dehydrogenase [Source:HGNC Symbol;Acc:HGNC:11184]9.6011.379.7746.3946.7646.610.81-0.310.670.79downno
MSTRG.10155GATMENST00000396659;ENST00000558362;ENST00000558336;ENST00000558916;ENST00000558163;ENST00000558537;ENST00000561148;ENST00000558118GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0005758(mitochondrial intermembrane space);GO:0006600(creatine metabolic process);GO:0006601(creatine biosynthetic process);GO:0006979(response to oxidative stress);GO:0007584(response to nutrient);GO:0010033(response to organic substance);GO:0015067(amidinotransferase activity);GO:0015068(glycine amidinotransferase activity);GO:0016813(hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines);GO:0034641(cellular nitrogen compound metabolic process);GO:0042246(tissue regeneration);GO:0043434(response to peptide hormone);GO:0044281(small molecule metabolic process);GO:0046689(response to mercury ion);GO:0070062(extracellular exosome);GO:1990402(embryonic liver development)00260(Glycine, serine and threonine metabolism);00330(Arginine and proline metabolism);01100(Metabolic pathways)NANAglycine amidinotransferase (L-arginine:glycine amidinotransferase) [Source:HGNC Symbol;Acc:HGNC:4175]25.8087.1925.77254.13253.20253.366131.4312.580.070.18upno
MSTRG.10168SQRDLENST00000260324GO:0000096(sulfur amino acid metabolic process);GO:0000098(sulfur amino acid catabolic process);GO:0005743(mitochondrial inner membrane);GO:0016491(oxidoreductase activity);GO:0034641(cellular nitrogen compound metabolic process);GO:0044281(small molecule metabolic process);GO:0048038(quinone binding);GO:0055114(oxidation-reduction process);GO:0070221(sulfide oxidation, using sulfide:quinone oxidoreductase);GO:0070224(sulfide:quinone oxidoreductase activity);GO:0070813(hydrogen sulfide metabolic process)NANANAsulfide quinone reductase-like (yeast) [Source:HGNC Symbol;Acc:HGNC:20390]11.5910.2411.539.909.979.870.29-1.770.100.23downno
MSTRG.1017C8BENST00000371237;ENST00000535057;ENST00000543257;ENST00000465658GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005579(membrane attack complex);GO:0005615(extracellular space);GO:0006955(immune response);GO:0006956(complement activation);GO:0006957(complement activation, alternative pathway);GO:0006958(complement activation, classical pathway);GO:0016020(membrane);GO:0019835(cytolysis);GO:0030449(regulation of complement activation);GO:0032403(protein complex binding);GO:0045087(innate immune response);GO:0070062(extracellular exosome);GO:1903561(extracellular vesicle)04610(Complement and coagulation cascades);05020(Prion diseases);05146(Amoebiasis);05322(Systemic lupus erythematosus)NANAcomplement component 8, beta polypeptide [Source:HGNC Symbol;Acc:HGNC:1353]22.4419.9522.55188.76189.58190.070.04-4.570.000.03downyes
MSTRG.10171MYEF2ENST00000267836GO:0000166(nucleotide binding);GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0014902(myotube differentiation);GO:0030182(neuron differentiation);GO:0044822(poly(A) RNA binding)NANANAmyelin expression factor 2 [Source:HGNC Symbol;Acc:HGNC:17940]1.701.311.670.070.080.081.690.750.190.35upno
MSTRG.10179DUTENST00000331200;ENST00000558472;ENST00000455976GO:0000287(magnesium ion binding);GO:0004170(dUTP diphosphatase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0006139(nucleobase-containing compound metabolic process);GO:0006206(pyrimidine nucleobase metabolic process);GO:0006226(dUMP biosynthetic process);GO:0006260(DNA replication);GO:0016787(hydrolase activity);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0046080(dUTP metabolic process);GO:0046081(dUTP catabolic process);GO:0046134(pyrimidine nucleoside biosynthetic process);GO:0055086(nucleobase-containing small molecule metabolic process);GO:0070062(extracellular exosome)00240(Pyrimidine metabolism);01100(Metabolic pathways)K015203.6.1.23deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078]7.857.287.903.924.234.210.82-0.290.290.47downno
MSTRG.10180FBN1ENST00000316623GO:0001501(skeletal system development);GO:0001527(microfibril);GO:0001656(metanephros development);GO:0001822(kidney development);GO:0005178(integrin binding);GO:0005201(extracellular matrix structural constituent);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005604(basement membrane);GO:0005615(extracellular space);GO:0007507(heart development);GO:0009653(anatomical structure morphogenesis);GO:0022617(extracellular matrix disassembly);GO:0030023(extracellular matrix constituent conferring elasticity);GO:0030198(extracellular matrix organization);GO:0031012(extracellular matrix);GO:0032403(protein complex binding);GO:0035582(sequestering of BMP in extracellular matrix);GO:0035583(sequestering of TGFbeta in extracellular matrix);GO:0043010(camera-type eye development);GO:0048048(embryonic eye morphogenesis);GO:0048050(post-embryonic eye morphogenesis);GO:0070062(extracellular exosome);GO:0071560(cellular response to transforming growth factor beta stimulus);GO:0090287(regulation of cellular response to growth factor stimulus);GO:1990314(cellular response to insulin-like growth factor stimulus)NANANAfibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603]1.911.731.954.684.684.670.24-2.080.000.04downyes
MSTRG.10188EID1ENST00000530028GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003714(transcription corepressor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0007049(cell cycle);GO:0016235(aggresome);GO:0030154(cell differentiation);GO:0035034(histone acetyltransferase regulator activity);GO:0035035(histone acetyltransferase binding);GO:0035065(regulation of histone acetylation);GO:0045892(negative regulation of transcription, DNA-templated)NANANAEP300 interacting inhibitor of differentiation 1 [Source:HGNC Symbol;Acc:HGNC:1191]19.4121.7419.3516.2724.7824.730.56-0.850.820.89downno
MSTRG.10194COPS2ENST00000388901;ENST00000299259GO:0003714(transcription corepressor activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006366(transcription from RNA polymerase II promoter);GO:0007165(signal transduction);GO:0008180(COP9 signalosome);GO:0008283(cell proliferation);GO:0010388(cullin deneddylation);GO:0035914(skeletal muscle cell differentiation);GO:0045892(negative regulation of transcription, DNA-templated);GO:1903507(negative regulation of nucleic acid-templated transcription)NANANACOP9 signalosome subunit 2 [Source:HGNC Symbol;Acc:HGNC:30747]6.225.406.102.512.882.880.50-1.000.170.32downno
MSTRG.10196GALK2ENST00000559883;ENST00000559963GO:0004335(galactokinase activity);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005975(carbohydrate metabolic process);GO:0006012(galactose metabolic process);GO:0033858(N-acetylgalactosamine kinase activity);GO:0046835(carbohydrate phosphorylation)00052(Galactose metabolism);00520(Amino sugar and nucleotide sugar metabolism);01100(Metabolic pathways)NANAgalactokinase 2 [Source:HGNC Symbol;Acc:HGNC:4119]2.162.272.221.901.811.835.432.440.040.13upyes
MSTRG.1020OMA1ENST00000371226;ENST00000456980;ENST00000419242GO:0002024(diet induced thermogenesis);GO:0004222(metalloendopeptidase activity);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006006(glucose metabolic process);GO:0006508(proteolysis);GO:0006515(misfolded or incompletely synthesized protein catabolic process);GO:0006629(lipid metabolic process);GO:0006950(response to stress);GO:0007005(mitochondrion organization);GO:0010637(negative regulation of mitochondrial fusion);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0031966(mitochondrial membrane);GO:0034982(mitochondrial protein processing);GO:0042407(cristae formation);GO:0046872(metal ion binding);GO:0097009(energy homeostasis)NANANAOMA1 zinc metallopeptidase [Source:HGNC Symbol;Acc:HGNC:29661]3.072.653.062.152.152.150.62-0.680.140.29downno
MSTRG.10210SLC27A2ENST00000267842GO:0000038(very long-chain fatty acid metabolic process);GO:0001561(fatty acid alpha-oxidation);GO:0001676(long-chain fatty acid metabolic process);GO:0003824(catalytic activity);GO:0004467(long-chain fatty acid-CoA ligase activity);GO:0005102(receptor binding);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005777(peroxisome);GO:0005778(peroxisomal membrane);GO:0005779(integral component of peroxisomal membrane);GO:0005783(endoplasmic reticulum);GO:0005788(endoplasmic reticulum lumen);GO:0005789(endoplasmic reticulum membrane);GO:0006635(fatty acid beta-oxidation);GO:0006699(bile acid biosynthetic process);GO:0008152(metabolic process);GO:0008206(bile acid metabolic process);GO:0015245(fatty acid transporter activity);GO:0015908(fatty acid transport);GO:0016021(integral component of membrane);GO:0019899(enzyme binding);GO:0030176(integral component of endoplasmic reticulum membrane);GO:0031957(very long-chain fatty acid-CoA ligase activity);GO:0042760(very long-chain fatty acid catabolic process);GO:0044255(cellular lipid metabolic process);GO:0044281(small molecule metabolic process);GO:0044539(long-chain fatty acid import);GO:0050197(phytanate-CoA ligase activity);GO:0070062(extracellular exosome);GO:0070251(pristanate-CoA ligase activity);GO:0097089(methyl-branched fatty acid metabolic process)03320(PPAR signaling pathway);04146(Peroxisome)K01897;K150136.2.1.3solute carrier family 27 (fatty acid transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:10996]5.047.584.9433.6133.7633.984.212.070.210.37upno
MSTRG.10212GABPB1ENST00000560825GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006351(transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006996(organelle organization);GO:0007005(mitochondrion organization);GO:0044212(transcription regulatory region DNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046982(protein heterodimerization activity)NANANAGA binding protein transcription factor, beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:4074]1.761.641.630.511.351.3510.913.450.190.35upno
MSTRG.10222TRPM7ENST00000560955GO:0001726(ruffle);GO:0003779(actin binding);GO:0004674(protein serine/threonine kinase activity);GO:0005216(ion channel activity);GO:0005262(calcium channel activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005623(cell);GO:0005886(plasma membrane);GO:0006468(protein phosphorylation);GO:0006811(ion transport);GO:0006812(cation transport);GO:0006816(calcium ion transport);GO:0010961(cellular magnesium ion homeostasis);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016301(kinase activity);GO:0016340(calcium-dependent cell-matrix adhesion);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0017022(myosin binding);GO:0031032(actomyosin structure organization);GO:0034220(ion transmembrane transport);GO:0046777(protein autophosphorylation);GO:0046872(metal ion binding);GO:0055085(transmembrane transport);GO:0070266(necroptotic process);GO:0070588(calcium ion transmembrane transport)NANANAtransient receptor potential cation channel, subfamily M, member 7 [Source:HGNC Symbol;Acc:HGNC:17994]5.995.715.896.926.836.880.13-2.960.030.12downyes
MSTRG.10224SPPL2AENST00000261854GO:0004190(aspartic-type endopeptidase activity);GO:0005515(protein binding);GO:0005765(lysosomal membrane);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0006509(membrane protein ectodomain proteolysis);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030660(Golgi-associated vesicle membrane);GO:0031293(membrane protein intracellular domain proteolysis);GO:0031902(late endosome membrane);GO:0033619(membrane protein proteolysis);GO:0042500(aspartic endopeptidase activity, intramembrane cleaving);GO:0042803(protein homodimerization activity);GO:0050776(regulation of immune response);GO:0070062(extracellular exosome);GO:0071458(integral component of cytoplasmic side of endoplasmic reticulum membrane);GO:0071556(integral component of lumenal side of endoplasmic reticulum membrane)NANANAsignal peptide peptidase like 2A [Source:HGNC Symbol;Acc:HGNC:30227]8.639.468.737.747.607.622.171.110.030.12upyes
MSTRG.10228AP4E1ENST00000261842GO:0005488(binding);GO:0005905(coated pit);GO:0006886(intracellular protein transport);GO:0006892(post-Golgi vesicle-mediated transport);GO:0016192(vesicle-mediated transport);GO:0030117(membrane coat);GO:0031904(endosome lumen);GO:0032588(trans-Golgi network membrane);GO:0061024(membrane organization)04142(Lysosome)NANAadaptor-related protein complex 4, epsilon 1 subunit [Source:HGNC Symbol;Acc:HGNC:573]3.193.073.171.461.401.391.610.690.110.25upno
MSTRG.10239TMOD3ENST00000308580GO:0003779(actin binding);GO:0005523(tropomyosin binding);GO:0005856(cytoskeleton);GO:0005865(striated muscle thin filament);GO:0006936(muscle contraction);GO:0007015(actin filament organization);GO:0030016(myofibril);GO:0030036(actin cytoskeleton organization);GO:0030239(myofibril assembly);GO:0048821(erythrocyte development);GO:0051694(pointed-end actin filament capping);GO:1901992(positive regulation of mitotic cell cycle phase transition)NANANAtropomodulin 3 (ubiquitous) [Source:HGNC Symbol;Acc:HGNC:11873]5.044.945.073.183.203.211.190.260.000.04upno
MSTRG.10248LEO1ENST00000299601GO:0001711(endodermal cell fate commitment);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005730(nucleolus);GO:0006351(transcription, DNA-templated);GO:0006378(mRNA polyadenylation);GO:0010390(histone monoubiquitination);GO:0016055(Wnt signaling pathway);GO:0016593(Cdc73/Paf1 complex);GO:0019827(stem cell maintenance);GO:0031442(positive regulation of mRNA 3'-end processing);GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter);GO:0033523(histone H2B ubiquitination);GO:0045638(negative regulation of myeloid cell differentiation);GO:0045944(positive regulation of transcription from RNA polymerase II promoter)NANANALeo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:30401]18.4816.6718.316.476.646.601.160.210.640.76upno
MSTRG.10249MAPK6ENST00000261845GO:0000165(MAPK cascade);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004707(MAP kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006468(protein phosphorylation);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0019901(protein kinase binding);GO:0046982(protein heterodimerization activity)NANANAmitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879]32.5631.1332.558.198.108.112.601.380.010.07upyes
MSTRG.10256BCL2L10ENST00000260442GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0005741(mitochondrial outer membrane);GO:0005829(cytosol);GO:0006919(activation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0007283(spermatogenesis);GO:0007292(female gamete generation);GO:0008630(intrinsic apoptotic signaling pathway in response to DNA damage);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0031965(nuclear membrane);GO:0042803(protein homodimerization activity);GO:0042981(regulation of apoptotic process);GO:0043065(positive regulation of apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0046982(protein heterodimerization activity);GO:0097192(extrinsic apoptotic signaling pathway in absence of ligand);GO:2001240(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand);GO:2001243(negative regulation of intrinsic apoptotic signaling pathway)NANANABCL2-like 10 (apoptosis facilitator) [Source:HGNC Symbol;Acc:HGNC:993]0.020.020.022.332.172.160.36-1.460.040.13downyes
MSTRG.10258GNB5ENST00000358784GO:0001750(photoreceptor outer segment);GO:0001917(photoreceptor inner segment);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005886(plasma membrane);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007603(phototransduction, visible light);GO:0008152(metabolic process);GO:0016056(rhodopsin mediated signaling pathway);GO:0022400(regulation of rhodopsin mediated signaling pathway);GO:0031682(G-protein gamma-subunit binding);GO:0043209(myelin sheath);GO:0051087(chaperone binding);GO:1901386(negative regulation of voltage-gated calcium channel activity)04062(Chemokine signaling pathway);04724(Glutamatergic synapse);04725(Cholinergic synapse)NANAguanine nucleotide binding protein (G protein), beta 5 [Source:HGNC Symbol;Acc:HGNC:4401]3.763.233.860.650.660.661.540.630.490.65upno
MSTRG.10263MYO5CENST00000261839GO:0003774(motor activity);GO:0003779(actin binding);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0008152(metabolic process);GO:0016459(myosin complex);GO:0070062(extracellular exosome)NANANAmyosin VC [Source:HGNC Symbol;Acc:HGNC:7604]6.516.246.611.121.111.132.781.480.000.03upyes
MSTRG.10271FAM214AENST00000534964GO:0005515(protein binding)NANANAfamily with sequence similarity 214, member A [Source:HGNC Symbol;Acc:HGNC:25609]2.292.372.304.464.464.500.99-0.010.980.99downno
MSTRG.10276ONECUT1ENST00000305901GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001228(RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001889(liver development);GO:0001952(regulation of cell-matrix adhesion);GO:0002064(epithelial cell development);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005634(nucleus);GO:0006006(glucose metabolic process);GO:0006355(regulation of transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006366(transcription from RNA polymerase II promoter);GO:0007219(Notch signaling pathway);GO:0007492(endoderm development);GO:0009653(anatomical structure morphogenesis);GO:0030154(cell differentiation);GO:0030183(B cell differentiation);GO:0030335(positive regulation of cell migration);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0031016(pancreas development);GO:0031018(endocrine pancreas development);GO:0042384(cilium assembly);GO:0045165(cell fate commitment);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048536(spleen development)04950(Maturity onset diabetes of the young)NANAone cut homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8138]3.332.792.645.934.254.292.291.200.680.79upno
MSTRG.10278WDR72ENST00000567224;ENST00000614174GO:0005515(protein binding);GO:0005737(cytoplasm)NANANAWD repeat domain 72 [Source:HGNC Symbol;Acc:HGNC:26790]0.551.470.547.337.387.3814.923.900.120.26upno
MSTRG.10286RSL24D1ENST00000260443GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005840(ribosome);GO:0006412(translation);GO:0042254(ribosome biogenesis)NANANAribosomal L24 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18479]12.9414.1613.183.083.273.265.742.520.030.13upyes
MSTRG.10287RAB27AENST00000336787GO:0001750(photoreceptor outer segment);GO:0003924(GTPase activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005622(intracellular);GO:0005764(lysosome);GO:0005770(late endosome);GO:0005794(Golgi apparatus);GO:0006605(protein targeting);GO:0006886(intracellular protein transport);GO:0006887(exocytosis);GO:0006904(vesicle docking involved in exocytosis);GO:0006913(nucleocytoplasmic transport);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0007596(blood coagulation);GO:0008152(metabolic process);GO:0009306(protein secretion);GO:0010628(positive regulation of gene expression);GO:0015031(protein transport);GO:0016020(membrane);GO:0016192(vesicle-mediated transport);GO:0016324(apical plasma membrane);GO:0019003(GDP binding);GO:0019882(antigen processing and presentation);GO:0019904(protein domain specific binding);GO:0030141(secretory granule);GO:0030318(melanocyte differentiation);GO:0030425(dendrite);GO:0030667(secretory granule membrane);GO:0031489(myosin V binding);GO:0032400(melanosome localization);GO:0032402(melanosome transport);GO:0032482(Rab protein signal transduction);GO:0032585(multivesicular body membrane);GO:0033093(Weibel-Palade body);GO:0036257(multivesicular body organization);GO:0042470(melanosome);GO:0043316(cytotoxic T cell degranulation);GO:0043320(natural killer cell degranulation);GO:0043473(pigmentation);GO:0044267(cellular protein metabolic process);GO:0045921(positive regulation of exocytosis);GO:0048489(synaptic vesicle transport);GO:0050766(positive regulation of phagocytosis);GO:0051875(pigment granule localization);GO:0051904(pigment granule transport);GO:0070062(extracellular exosome);GO:0070382(exocytic vesicle);GO:0071985(multivesicular body sorting pathway);GO:0097278(complement-dependent cytotoxicity);GO:1903307(positive regulation of regulated secretory pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903435(positive regulation of constitutive secretory pathway);GO:1990182(exosomal secretion)NANANARAB27A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9766]1.701.521.782.762.752.750.13-2.990.530.68downno
MSTRG.10292CCPG1ENST00000442196;ENST00000310958;ENST00000569205GO:0003674(molecular_function);GO:0005515(protein binding);GO:0007049(cell cycle);GO:0008284(positive regulation of cell proliferation);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0045787(positive regulation of cell cycle);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:2001106(regulation of Rho guanyl-nucleotide exchange factor activity)NANANAcell cycle progression 1 [Source:HGNC Symbol;Acc:HGNC:24227]4.335.995.924.734.914.922.301.200.550.69upno
MSTRG.10297NEDD4ENST00000508342;ENST00000506154;ENST00000508075;ENST00000557845GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000151(ubiquitin ligase complex);GO:0000785(chromatin);GO:0002250(adaptive immune response);GO:0003151(outflow tract morphogenesis);GO:0003197(endocardial cushion development);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005938(cell cortex);GO:0006513(protein monoubiquitination);GO:0006622(protein targeting to lysosome);GO:0007041(lysosomal transport);GO:0007528(neuromuscular junction development);GO:0010766(negative regulation of sodium ion transport);GO:0010768(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0016020(membrane);GO:0016327(apicolateral plasma membrane);GO:0016567(protein ubiquitination);GO:0016874(ligase activity);GO:0019089(transmission of virus);GO:0019221(cytokine-mediated signaling pathway);GO:0019871(sodium channel inhibitor activity);GO:0019904(protein domain specific binding);GO:0030948(negative regulation of vascular endothelial growth factor receptor signaling pathway);GO:0031175(neuron projection development);GO:0031623(receptor internalization);GO:0031698(beta-2 adrenergic receptor binding);GO:0032801(receptor catabolic process);GO:0034644(cellular response to UV);GO:0034765(regulation of ion transmembrane transport);GO:0042110(T cell activation);GO:0042391(regulation of membrane potential);GO:0042787(protein ubiquitination involved in ubiquitin-dependent protein catabolic process);GO:0042921(glucocorticoid receptor signaling pathway);GO:0043130(ubiquitin binding);GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway);GO:0044111(development involved in symbiotic interaction);GO:0045732(positive regulation of protein catabolic process);GO:0046824(positive regulation of nucleocytoplasmic transport);GO:0048471(perinuclear region of cytoplasm);GO:0048514(blood vessel morphogenesis);GO:0048814(regulation of dendrite morphogenesis);GO:0050807(regulation of synapse organization);GO:0050815(phosphoserine binding);GO:0050816(phosphothreonine binding);GO:0050847(progesterone receptor signaling pathway);GO:0051592(response to calcium ion);GO:0061630(ubiquitin protein ligase activity);GO:0070062(extracellular exosome);GO:0070063(RNA polymerase binding);GO:0070064(proline-rich region binding);GO:0070534(protein K63-linked ubiquitination);GO:1901016(regulation of potassium ion transmembrane transporter activity);GO:2000650(negative regulation of sodium ion transmembrane transporter activity)04120(Ubiquitin mediated proteolysis);04144(Endocytosis)NANAneural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727]19.2319.2319.568.268.028.002.121.080.020.11upyes
MSTRG.103CEP104ENST00000378230GO:0005488(binding);GO:0005814(centriole)NANANAcentrosomal protein 104kDa [Source:HGNC Symbol;Acc:HGNC:24866]5.354.525.393.203.083.080.46-1.120.210.37downno
MSTRG.1030MYSM1ENST00000472487GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0003713(transcription coactivator activity);GO:0004843(ubiquitin-specific protease activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006338(chromatin remodeling);GO:0006351(transcription, DNA-templated);GO:0008237(metallopeptidase activity);GO:0015630(microtubule cytoskeleton);GO:0030334(regulation of cell migration);GO:0032403(protein complex binding);GO:0035522(monoubiquitinated histone H2A deubiquitination);GO:0042393(histone binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046872(metal ion binding);GO:0051797(regulation of hair follicle development)NANANAMyb-like, SWIRM and MPN domains 1 [Source:HGNC Symbol;Acc:HGNC:29401]6.815.466.572.662.542.561.330.410.860.91upno
MSTRG.10316ZNF280DENST00000267807GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0046872(metal ion binding)NANANAzinc finger protein 280D [Source:HGNC Symbol;Acc:HGNC:25953]1.991.981.952.632.632.611.460.540.380.55upno
MSTRG.1032JUNENST00000371222GO:0000228(nuclear chromosome);GO:0000790(nuclear chromatin);GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0000980(RNA polymerase II distal enhancer sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001102(RNA polymerase II activating transcription factor binding);GO:0001190(RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription);GO:0001525(angiogenesis);GO:0001774(microglial cell activation);GO:0001836(release of cytochrome c from mitochondria);GO:0001889(liver development);GO:0001938(positive regulation of endothelial cell proliferation);GO:0002224(toll-like receptor signaling pathway);GO:0002755(MyD88-dependent toll-like receptor signaling pathway);GO:0002756(MyD88-independent toll-like receptor signaling pathway);GO:0003151(outflow tract morphogenesis);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0003690(double-stranded DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003705(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity);GO:0003713(transcription coactivator activity);GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005667(transcription factor complex);GO:0005719(nuclear euchromatin);GO:0005829(cytosol);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0007179(transforming growth factor beta receptor signaling pathway);GO:0007184(SMAD protein import into nucleus);GO:0007568(aging);GO:0007612(learning);GO:0007623(circadian rhythm);GO:0008134(transcription factor binding);GO:0008284(positive regulation of cell proliferation);GO:0008285(negative regulation of cell proliferation);GO:0009314(response to radiation);GO:0009612(response to mechanical stimulus);GO:0009987(cellular process);GO:0010033(response to organic substance);GO:0010941(regulation of cell death);GO:0014070(response to organic cyclic compound);GO:0017053(transcriptional repressor complex);GO:0019899(enzyme binding);GO:0030224(monocyte differentiation);GO:0031103(axon regeneration);GO:0031953(negative regulation of protein autophosphorylation);GO:0032496(response to lipopolysaccharide);GO:0032870(cellular response to hormone stimulus);GO:0034097(response to cytokine);GO:0034134(toll-like receptor 2 signaling pathway);GO:0034138(toll-like receptor 3 signaling pathway);GO:0034142(toll-like receptor 4 signaling pathway);GO:0034146(toll-like receptor 5 signaling pathway);GO:0034162(toll-like receptor 9 signaling pathway);GO:0034166(toll-like receptor 10 signaling pathway);GO:0035026(leading edge cell differentiation);GO:0035497(cAMP response element binding);GO:0035666(TRIF-dependent toll-like receptor signaling pathway);GO:0035994(response to muscle stretch);GO:0038095(Fc-epsilon receptor signaling pathway);GO:0038123(toll-like receptor TLR1:TLR2 signaling pathway);GO:0038124(toll-like receptor TLR6:TLR2 signaling pathway);GO:0042127(regulation of cell proliferation);GO:0042493(response to drug);GO:0042542(response to hydrogen peroxide);GO:0043065(positive regulation of apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0043392(negative regulation of DNA binding);GO:0043524(negative regulation of neuron apoptotic process);GO:0043525(positive regulation of neuron apoptotic process);GO:0043547(positive regulation of GTPase activity);GO:0043565(sequence-specific DNA binding);GO:0043922(negative regulation by host of viral transcription);GO:0043923(positive regulation by host of viral transcription);GO:0044212(transcription regulatory region DNA binding);GO:0044822(poly(A) RNA binding);GO:0045087(innate immune response);GO:0045597(positive regulation of cell differentiation);GO:0045657(positive regulation of monocyte differentiation);GO:0045740(positive regulation of DNA replication);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048146(positive regulation of fibroblast proliferation);GO:0048661(positive regulation of smooth muscle cell proliferation);GO:0051090(regulation of sequence-specific DNA binding transcription factor activity);GO:0051365(cellular response to potassium ion starvation);GO:0051403(stress-activated MAPK cascade);GO:0051591(response to cAMP);GO:0051726(regulation of cell cycle);GO:0051899(membrane depolarization);GO:0060395(SMAD protein signal transduction);GO:0070412(R-SMAD binding);GO:0071277(cellular response to calcium ion);GO:0071837(HMG box domain binding);GO:1990441(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress);GO:2000144(positive regulation of DNA-templated transcription, initiation)04010(MAPK signaling pathway);04012(ErbB signaling pathway);04310(Wnt signaling pathway);04380(Osteoclast differentiation);04510(Focal adhesion);04620(Toll-like receptor signaling pathway);04660(T cell receptor signaling pathway);04662(B cell receptor signaling pathway);04722(Neurotrophin signaling pathway);04912(GnRH signaling pathway);05120(Epithelial cell signaling in Helicobacter pylori infection);05140(Leishmaniasis);05142(Chagas disease (American trypanosomiasis));05164(Influenza A);05200(Pathways in cancer);05210(Colorectal cancer);05211(Renal cell carcinoma);05323(Rheumatoid arthritis)NANAjun proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6204]50.5344.0551.4371.2471.5171.740.18-2.450.010.08downyes
MSTRG.10323TCF12ENST00000557843;ENST00000560887;ENST00000543579;ENST00000343827GO:0000790(nuclear chromatin);GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005667(transcription factor complex);GO:0005737(cytoplasm);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006366(transcription from RNA polymerase II promoter);GO:0006955(immune response);GO:0007517(muscle organ development);GO:0008134(transcription factor binding);GO:0010628(positive regulation of gene expression);GO:0035326(enhancer binding);GO:0035497(cAMP response element binding);GO:0042803(protein homodimerization activity);GO:0043425(bHLH transcription factor binding);GO:0044212(transcription regulatory region DNA binding);GO:0045666(positive regulation of neuron differentiation);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046332(SMAD binding);GO:0046982(protein heterodimerization activity);GO:0046983(protein dimerization activity);GO:0070888(E-box binding);GO:0071837(HMG box domain binding);GO:0090575(RNA polymerase II transcription factor complex)NANANAtranscription factor 12 [Source:HGNC Symbol;Acc:HGNC:11623]4.234.064.043.994.164.180.36-1.470.420.59downno
MSTRG.10333AQP9ENST00000558772;ENST00000219919;ENST00000536493GO:0005215(transporter activity);GO:0005275(amine transmembrane transporter activity);GO:0005345(purine nucleobase transmembrane transporter activity);GO:0005350(pyrimidine nucleobase transmembrane transporter activity);GO:0005372(water transmembrane transporter activity);GO:0005623(cell);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006833(water transport);GO:0006863(purine nucleobase transport);GO:0006955(immune response);GO:0006970(response to osmotic stress);GO:0007588(excretion);GO:0008152(metabolic process);GO:0009992(cellular water homeostasis);GO:0010033(response to organic substance);GO:0015166(polyol transmembrane transporter activity);GO:0015204(urea transmembrane transporter activity);GO:0015250(water channel activity);GO:0015254(glycerol channel activity);GO:0015288(porin activity);GO:0015722(canalicular bile acid transport);GO:0015791(polyol transport);GO:0015793(glycerol transport);GO:0015837(amine transport);GO:0015855(pyrimidine nucleobase transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016323(basolateral plasma membrane);GO:0030104(water homeostasis);GO:0034220(ion transmembrane transport);GO:0043231(intracellular membrane-bounded organelle);GO:0046689(response to mercury ion);GO:0046942(carboxylic acid transport);GO:0046943(carboxylic acid transmembrane transporter activity);GO:0055085(transmembrane transport);GO:0071320(cellular response to cAMP);GO:0071918(urea transmembrane transport);GO:0072531(pyrimidine-containing compound transmembrane transport)NANANAaquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643]23.4518.0523.2567.82150.60150.580.00-9.740.170.32downno
MSTRG.10359SLTMENST00000380516GO:0000166(nucleotide binding);GO:0003676(nucleic acid binding);GO:0005654(nucleoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006915(apoptotic process);GO:0044822(poly(A) RNA binding)NANANASAFB-like, transcription modulator [Source:HGNC Symbol;Acc:HGNC:20709]5.155.175.194.114.014.003.281.710.050.15upyes
MSTRG.10364CCNB2ENST00000288207GO:0000086(G2/M transition of mitotic cell cycle);GO:0000278(mitotic cell cycle);GO:0001701(in utero embryonic development);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005813(centrosome);GO:0005829(cytosol);GO:0007067(mitotic nuclear division);GO:0007077(mitotic nuclear envelope disassembly);GO:0015630(microtubule cytoskeleton);GO:0016020(membrane);GO:0040007(growth);GO:0043029(T cell homeostasis);GO:0048538(thymus development);GO:0051301(cell division);GO:0051726(regulation of cell cycle)04110(Cell cycle);04114(Oocyte meiosis);04115(p53 signaling pathway);04914(Progesterone-mediated oocyte maturation)NANAcyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580]4.725.924.810.050.070.0759.135.890.000.05upyes
MSTRG.10367MYO1EENST00000288235GO:0000146(microfilament motor activity);GO:0001570(vasculogenesis);GO:0001701(in utero embryonic development);GO:0001822(kidney development);GO:0003094(glomerular filtration);GO:0003774(motor activity);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005856(cytoskeleton);GO:0005903(brush border);GO:0005911(cell-cell junction);GO:0005912(adherens junction);GO:0006807(nitrogen compound metabolic process);GO:0006897(endocytosis);GO:0008152(metabolic process);GO:0015629(actin cytoskeleton);GO:0016459(myosin complex);GO:0030048(actin filament-based movement);GO:0030097(hemopoiesis);GO:0032836(glomerular basement membrane development);GO:0035091(phosphatidylinositol binding);GO:0035166(post-embryonic hemopoiesis);GO:0042623(ATPase activity, coupled);GO:0045334(clathrin-coated endocytic vesicle);GO:0048008(platelet-derived growth factor receptor signaling pathway);GO:0051015(actin filament binding);GO:0070062(extracellular exosome);GO:0072015(glomerular visceral epithelial cell development)NANANAmyosin IE [Source:HGNC Symbol;Acc:HGNC:7599]12.7310.9512.726.196.336.350.50-0.990.080.20downno
MSTRG.1038HOOK1ENST00000371208;ENST00000466803GO:0003779(actin binding);GO:0005515(protein binding);GO:0005874(microtubule);GO:0007032(endosome organization);GO:0007040(lysosome organization);GO:0007275(multicellular organismal development);GO:0007286(spermatid development);GO:0008333(endosome to lysosome transport);GO:0015031(protein transport);GO:0015630(microtubule cytoskeleton);GO:0030897(HOPS complex);GO:0042802(identical protein binding);GO:0045022(early endosome to late endosome transport);GO:0070695(FHF complex)NANANAhook microtubule-tethering protein 1 [Source:HGNC Symbol;Acc:HGNC:19884]24.4323.7524.118.148.348.222.211.140.010.06upyes
MSTRG.10382BNIP2ENST00000607373GO:0001824(blastocyst development);GO:0005096(GTPase activator activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005635(nuclear envelope);GO:0005737(cytoplasm);GO:0005814(centriole);GO:0005829(cytosol);GO:0006915(apoptotic process);GO:0031616(spindle pole centrosome);GO:0042692(muscle cell differentiation);GO:0042802(identical protein binding);GO:0043066(negative regulation of apoptotic process);GO:0043231(intracellular membrane-bounded organelle);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0045666(positive regulation of neuron differentiation);GO:0048471(perinuclear region of cytoplasm);GO:0051057(positive regulation of small GTPase mediated signal transduction);GO:0051146(striated muscle cell differentiation);GO:0051149(positive regulation of muscle cell differentiation);GO:0051297(centrosome organization)NANANABCL2/adenovirus E1B 19kDa interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:1083]2.372.162.423.063.333.332176.1311.090.030.13upyes
MSTRG.10385ANXA2ENST00000451270;ENST00000421017GO:0001525(angiogenesis);GO:0001726(ruffle);GO:0001765(membrane raft assembly);GO:0001934(positive regulation of protein phosphorylation);GO:0002091(negative regulation of receptor internalization);GO:0004859(phospholipase inhibitor activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005544(calcium-dependent phospholipid binding);GO:0005546(phosphatidylinositol-4,5-bisphosphate binding);GO:0005604(basement membrane);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005768(endosome);GO:0005769(early endosome);GO:0005811(lipid particle);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005938(cell cortex);GO:0006900(membrane budding);GO:0007589(body fluid secretion);GO:0008092(cytoskeletal protein binding);GO:0009986(cell surface);GO:0016020(membrane);GO:0016323(basolateral plasma membrane);GO:0017137(Rab GTPase binding);GO:0019834(phospholipase A2 inhibitor activity);GO:0019897(extrinsic component of plasma membrane);GO:0030199(collagen fibril organization);GO:0030496(midbody);GO:0030546(receptor activator activity);GO:0031012(extracellular matrix);GO:0031340(positive regulation of vesicle fusion);GO:0031902(late endosome membrane);GO:0031982(vesicle);GO:0032804(negative regulation of low-density lipoprotein particle receptor catabolic process);GO:0035749(myelin sheath adaxonal region);GO:0036035(osteoclast development);GO:0042383(sarcolemma);GO:0042470(melanosome);GO:0042730(fibrinolysis);GO:0043086(negative regulation of catalytic activity);GO:0043220(Schmidt-Lanterman incisure);GO:0043234(protein complex);GO:0044354(macropinosome);GO:0044548(S100 protein binding);GO:0044822(poly(A) RNA binding);GO:0045121(membrane raft);GO:0048146(positive regulation of fibroblast proliferation);GO:0048306(calcium-dependent protein binding);GO:0048471(perinuclear region of cytoplasm);GO:0051099(positive regulation of binding);GO:0051290(protein heterotetramerization);GO:0070062(extracellular exosome);GO:0072661(protein targeting to plasma membrane);GO:1900121(negative regulation of receptor binding);GO:1990667(PCSK9-AnxA2 complex);GO:2000273(positive regulation of receptor activity)NANANAannexin A2 [Source:HGNC Symbol;Acc:HGNC:537]26.6628.2425.346.015.695.7615.373.940.000.01upyes
MSTRG.10388VPS13CENST00000249837;ENST00000395898GO:0005622(intracellular);GO:0005623(cell);GO:0006623(protein targeting to vacuole);GO:0019898(extrinsic component of membrane);GO:0045053(protein retention in Golgi apparatus);GO:0070062(extracellular exosome)NANANAvacuolar protein sorting 13 homolog C (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23594]13.2911.1413.168.558.288.270.44-1.180.240.40downno
MSTRG.10393RORAENST00000335670;ENST00000261523;ENST00000449337;ENST00000560300GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0001046(core promoter sequence-specific DNA binding);GO:0001222(transcription corepressor binding);GO:0001223(transcription coactivator binding);GO:0001525(angiogenesis);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003707(steroid hormone receptor activity);GO:0004879(ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0006805(xenobiotic metabolic process);GO:0006809(nitric oxide biosynthetic process);GO:0007623(circadian rhythm);GO:0008013(beta-catenin binding);GO:0008134(transcription factor binding);GO:0008142(oxysterol binding);GO:0008270(zinc ion binding);GO:0008589(regulation of smoothened signaling pathway);GO:0010467(gene expression);GO:0010575(positive regulation of vascular endothelial growth factor production);GO:0010906(regulation of glucose metabolic process);GO:0019218(regulation of steroid metabolic process);GO:0021702(cerebellar Purkinje cell differentiation);GO:0021930(cerebellar granule cell precursor proliferation);GO:0030522(intracellular receptor signaling pathway);GO:0032922(circadian regulation of gene expression);GO:0036315(cellular response to sterol);GO:0042692(muscle cell differentiation);GO:0042752(regulation of circadian rhythm);GO:0042753(positive regulation of circadian rhythm);GO:0043030(regulation of macrophage activation);GO:0043124(negative regulation of I-kappaB kinase/NF-kappaB signaling);GO:0043401(steroid hormone mediated signaling pathway);GO:0043565(sequence-specific DNA binding);GO:0045599(negative regulation of fat cell differentiation);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046068(cGMP metabolic process);GO:0050728(negative regulation of inflammatory response);GO:0060850(regulation of transcription involved in cell fate commitment);GO:0070328(triglyceride homeostasis);GO:0071347(cellular response to interleukin-1);GO:0071356(cellular response to tumor necrosis factor);GO:0071456(cellular response to hypoxia);GO:0072539(T-helper 17 cell differentiation);GO:0098531(direct ligand regulated sequence-specific DNA binding transcription factor activity);GO:2000188(regulation of cholesterol homeostasis)04710(Circadian rhythm - mammal)NANARAR-related orphan receptor A [Source:HGNC Symbol;Acc:HGNC:10258]1.341.541.303.023.043.051.330.410.340.51upno
MSTRG.10395CYCSP38ENST00000559840NANANANANA00002.021.990.01-6.980.470.63downno
MSTRG.1040FGGYENST00000413489GO:0003674(molecular_function);GO:0005575(cellular_component);GO:0005737(cytoplasm);GO:0005975(carbohydrate metabolic process);GO:0016301(kinase activity);GO:0016773(phosphotransferase activity, alcohol group as acceptor);GO:0046835(carbohydrate phosphorylation);GO:0070050(neuron cellular homeostasis)NANANAFGGY carbohydrate kinase domain containing [Source:HGNC Symbol;Acc:HGNC:25610]1.751.431.752.042.212.230.19-2.430.020.11downyes
MSTRG.10404RPS27LENST00000439025GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005840(ribosome);GO:0006281(DNA repair);GO:0006412(translation);GO:0006919(activation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0006974(cellular response to DNA damage stimulus);GO:0008494(translation activator activity);GO:0008656(cysteine-type endopeptidase activator activity involved in apoptotic process);GO:0031571(mitotic G1 DNA damage checkpoint);GO:0042771(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator);GO:0044822(poly(A) RNA binding);GO:0045727(positive regulation of translation);GO:0046872(metal ion binding)03010(Ribosome)NANAribosomal protein S27-like [Source:HGNC Symbol;Acc:HGNC:18476]2.002.542.012.912.872.890.46-1.110.700.80downno
MSTRG.10405TPM1ENST00000358278;ENST00000559556;ENST00000404484;ENST00000560959GO:0001701(in utero embryonic development);GO:0001725(stress fiber);GO:0003065(positive regulation of heart rate by epinephrine);GO:0003779(actin binding);GO:0005200(structural constituent of cytoskeleton);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005856(cytoskeleton);GO:0005862(muscle thin filament tropomyosin);GO:0006928(movement of cell or subcellular component);GO:0006936(muscle contraction);GO:0006937(regulation of muscle contraction);GO:0007010(cytoskeleton organization);GO:0008016(regulation of heart contraction);GO:0008092(cytoskeletal protein binding);GO:0008307(structural constituent of muscle);GO:0030016(myofibril);GO:0030017(sarcomere);GO:0030049(muscle filament sliding);GO:0030336(negative regulation of cell migration);GO:0031529(ruffle organization);GO:0031941(filamentous actin);GO:0032059(bleb);GO:0032587(ruffle membrane);GO:0032781(positive regulation of ATPase activity);GO:0034614(cellular response to reactive oxygen species);GO:0042060(wound healing);GO:0045214(sarcomere organization);GO:0045785(positive regulation of cell adhesion);GO:0051496(positive regulation of stress fiber assembly);GO:0055010(ventricular cardiac muscle tissue morphogenesis);GO:0060048(cardiac muscle contraction)04260(Cardiac muscle contraction);05410(Hypertrophic cardiomyopathy (HCM));05414(Dilated cardiomyopathy)NANAtropomyosin 1 (alpha) [Source:HGNC Symbol;Acc:HGNC:12010]1.962.951.992.602.292.2812.263.620.210.37upno
MSTRG.10408RAB8BENST00000321437;ENST00000559927GO:0003924(GTPase activity);GO:0005102(receptor binding);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005622(intracellular);GO:0005739(mitochondrion);GO:0005768(endosome);GO:0005778(peroxisomal membrane);GO:0005886(plasma membrane);GO:0006886(intracellular protein transport);GO:0006904(vesicle docking involved in exocytosis);GO:0006913(nucleocytoplasmic transport);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0008021(synaptic vesicle);GO:0008152(metabolic process);GO:0009306(protein secretion);GO:0015031(protein transport);GO:0016020(membrane);GO:0016079(synaptic vesicle exocytosis);GO:0017157(regulation of exocytosis);GO:0019003(GDP binding);GO:0019882(antigen processing and presentation);GO:0030140(trans-Golgi network transport vesicle);GO:0030667(secretory granule membrane);GO:0030670(phagocytic vesicle membrane);GO:0030911(TPR domain binding);GO:0031346(positive regulation of cell projection organization);GO:0031410(cytoplasmic vesicle);GO:0032482(Rab protein signal transduction);GO:0032869(cellular response to insulin stimulus);GO:0034332(adherens junction organization);GO:0045046(protein import into peroxisome membrane);GO:0045335(phagocytic vesicle);GO:0048210(Golgi vesicle fusion to target membrane);GO:0048471(perinuclear region of cytoplasm);GO:0051286(cell tip);GO:0051461(positive regulation of corticotropin secretion);GO:0070062(extracellular exosome);GO:0072659(protein localization to plasma membrane)NANANARAB8B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30273]1.910.510.524.012.442.500.58-0.800.910.95downno


Differentially expressed transcripts:

t_idclass_codechrstrandstartendt_namenum_exonslengthgene_idgene_nameGOKEGGKO_ENTRYECDescriptioncov.KTY01_KFPKM.KTY01_Kcov.KTY02_KFPKM.KTY02_Kcov.KTY03_KFPKM.KTY03_Kcov.EM01_MFPKM.EM01_Mcov.EM02_MFPKM.EM02_Mcov.EM03_MFPKM.EM03_Mfclog2(fc)pvalqvalregulationsignificant
199"="chr1+10201231056116ENST00000379370367323MSTRG.35AGRNGO:0001523(retinoid metabolic process);GO:0002162(dystroglycan binding);GO:0005200(structural constituent of cytoskeleton);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005604(basement membrane);GO:0005605(basal lamina);GO:0005615(extracellular space);GO:0005737(cytoplasm);GO:0005796(Golgi lumen);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006024(glycosaminoglycan biosynthetic process);GO:0006027(glycosaminoglycan catabolic process);GO:0007009(plasma membrane organization);GO:0007165(signal transduction);GO:0007213(G-protein coupled acetylcholine receptor signaling pathway);GO:0007268(synaptic transmission);GO:0007411(axon guidance);GO:0007528(neuromuscular junction development);GO:0007603(phototransduction, visible light);GO:0008582(regulation of synaptic growth at neuromuscular junction);GO:0009986(cell surface);GO:0010469(regulation of receptor activity);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0030198(extracellular matrix organization);GO:0030203(glycosaminoglycan metabolic process);GO:0030204(chondroitin sulfate metabolic process);GO:0030548(acetylcholine receptor regulator activity);GO:0031012(extracellular matrix);GO:0033691(sialic acid binding);GO:0035374(chondroitin sulfate binding);GO:0043113(receptor clustering);GO:0043202(lysosomal lumen);GO:0043236(laminin binding);GO:0043395(heparan sulfate proteoglycan binding);GO:0043525(positive regulation of neuron apoptotic process);GO:0043547(positive regulation of GTPase activity);GO:0044281(small molecule metabolic process);GO:0045162(clustering of voltage-gated sodium channels);GO:0045202(synapse);GO:0045213(neurotransmitter receptor metabolic process);GO:0045887(positive regulation of synaptic growth at neuromuscular junction);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0050808(synapse organization);GO:0051491(positive regulation of filopodium assembly);GO:0070062(extracellular exosome)04512(ECM-receptor interaction)NANAagrin [Source:HGNC Symbol;Acc:HGNC:329]69.1710.0580.8411.3460.2110.1583.7912.3266.5312.5367.1612.463.031.600.020.06upyes
254"="chr1-12113261214132ENST0000037923671068MSTRG.36TNFRSF4GO:0005031(tumor necrosis factor-activated receptor activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0006968(cellular defense response);GO:0009897(external side of plasma membrane);GO:0009986(cell surface);GO:0030890(positive regulation of B cell proliferation);GO:0033209(tumor necrosis factor-mediated signaling pathway);GO:0042098(T cell proliferation);GO:0042981(regulation of apoptotic process);GO:0043433(negative regulation of sequence-specific DNA binding transcription factor activity);GO:0045859(regulation of protein kinase activity);GO:0045892(negative regulation of transcription, DNA-templated);GO:0050710(negative regulation of cytokine secretion);GO:0051024(positive regulation of immunoglobulin secretion)04060(Cytokine-cytokine receptor interaction)NANAtumor necrosis factor receptor superfamily, member 4 [Source:HGNC Symbol;Acc:HGNC:11918]21.963.1917.112.4017.923.022.470.362.180.412.180.400.25-1.990.010.04downyes
257"="chr1-12169081232001ENST0000036000171956MSTRG.37SDF4GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005770(late endosome);GO:0005794(Golgi apparatus);GO:0005796(Golgi lumen);GO:0005886(plasma membrane);GO:0009650(UV protection);GO:0016020(membrane);GO:0017156(calcium ion-dependent exocytosis);GO:0021549(cerebellum development);GO:0032059(bleb);GO:0042802(identical protein binding);GO:0045444(fat cell differentiation);GO:0045471(response to ethanol);GO:0070062(extracellular exosome);GO:0070625(zymogen granule exocytosis)NANANAstromal cell derived factor 4 [Source:HGNC Symbol;Acc:HGNC:24188]144.4420.98156.1121.89127.4121.48235.5334.63184.2434.69187.4834.790.90-0.160.530.65downno
264"="chr1+12322651235041ENST0000037919812777MSTRG.38B3GALT6GO:0000139(Golgi membrane);GO:0005797(Golgi medial cisterna);GO:0005975(carbohydrate metabolic process);GO:0006024(glycosaminoglycan biosynthetic process);GO:0006486(protein glycosylation);GO:0008378(galactosyltransferase activity);GO:0008499(UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity);GO:0015012(heparan sulfate proteoglycan biosynthetic process);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030203(glycosaminoglycan metabolic process);GO:0030204(chondroitin sulfate metabolic process);GO:0030206(chondroitin sulfate biosynthetic process);GO:0032580(Golgi cisterna membrane);GO:0035250(UDP-galactosyltransferase activity);GO:0044281(small molecule metabolic process);GO:0047220(galactosylxylosylprotein 3-beta-galactosyltransferase activity)00532(Glycosaminoglycan biosynthesis - chondroitin sulfate);00534(Glycosaminoglycan biosynthesis - heparan sulfate);01100(Metabolic pathways)NANAUDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 [Source:HGNC Symbol;Acc:HGNC:17978]0036.105.06000000007352734607.2232.780.000.02upyes
377"="chr1+13247671328897ENST0000034393832190MSTRG.54CPTPGO:0005543(phospholipid binding);GO:0005548(phospholipid transporter activity);GO:0005640(nuclear outer membrane);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006665(sphingolipid metabolic process);GO:0006687(glycosphingolipid metabolic process);GO:0010008(endosome membrane);GO:0017089(glycolipid transporter activity);GO:0044281(small molecule metabolic process);GO:0046836(glycolipid transport);GO:0051861(glycolipid binding);GO:1902387(ceramide 1-phosphate binding);GO:1902388(ceramide 1-phosphate transporter activity);GO:1902389(ceramide 1-phosphate transport)NANANAceramide-1-phosphate transfer protein [Source:HGNC Symbol;Acc:HGNC:28116]29.144.2332.654.5825.234.2558.248.5645.678.6046.328.601.180.240.240.38upno
380"="chr1-13352761349112ENST00000378891152926MSTRG.41DVL1GO:0001505(regulation of neurotransmitter levels);GO:0001932(regulation of protein phosphorylation);GO:0001933(negative regulation of protein phosphorylation);GO:0001934(positive regulation of protein phosphorylation);GO:0005109(frizzled binding);GO:0005515(protein binding);GO:0005829(cytosol);GO:0005874(microtubule);GO:0006366(transcription from RNA polymerase II promoter);GO:0006469(negative regulation of protein kinase activity);GO:0007269(neurotransmitter secretion);GO:0007409(axonogenesis);GO:0007411(axon guidance);GO:0007528(neuromuscular junction development);GO:0010976(positive regulation of neuron projection development);GO:0015630(microtubule cytoskeleton);GO:0016023(cytoplasmic membrane-bounded vesicle);GO:0016328(lateral plasma membrane);GO:0019899(enzyme binding);GO:0019901(protein kinase binding);GO:0021915(neural tube development);GO:0022007(convergent extension involved in neural plate elongation);GO:0030136(clathrin-coated vesicle);GO:0030177(positive regulation of Wnt signaling pathway);GO:0030424(axon);GO:0030425(dendrite);GO:0030426(growth cone);GO:0031122(cytoplasmic microtubule organization);GO:0031410(cytoplasmic vesicle);GO:0032091(negative regulation of protein binding);GO:0032436(positive regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0034504(protein localization to nucleus);GO:0035176(social behavior);GO:0035372(protein localization to microtubule);GO:0035556(intracellular signal transduction);GO:0042802(identical protein binding);GO:0043025(neuronal cell body);GO:0043113(receptor clustering);GO:0045202(synapse);GO:0045893(positive regulation of transcription, DNA-templated);GO:0048365(Rac GTPase binding);GO:0048668(collateral sprouting);GO:0048675(axon extension);GO:0048813(dendrite morphogenesis);GO:0050808(synapse organization);GO:0060029(convergent extension involved in organogenesis);GO:0060070(canonical Wnt signaling pathway);GO:0060071(Wnt signaling pathway, planar cell polarity pathway);GO:0060134(prepulse inhibition);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:0090103(cochlea morphogenesis);GO:0090179(planar cell polarity pathway involved in neural tube closure);GO:0090263(positive regulation of canonical Wnt signaling pathway)04310(Wnt signaling pathway);04330(Notch signaling pathway);05200(Pathways in cancer);05217(Basal cell carcinoma)NANAdishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084]41.616.0456.527.9338.716.5356.258.2744.678.4147.938.909.183.200.060.13upno
381"="chr1-13352761349350ENST00000378888153239MSTRG.41DVL1GO:0001505(regulation of neurotransmitter levels);GO:0001932(regulation of protein phosphorylation);GO:0001933(negative regulation of protein phosphorylation);GO:0001934(positive regulation of protein phosphorylation);GO:0005109(frizzled binding);GO:0005515(protein binding);GO:0005829(cytosol);GO:0005874(microtubule);GO:0006366(transcription from RNA polymerase II promoter);GO:0006469(negative regulation of protein kinase activity);GO:0007269(neurotransmitter secretion);GO:0007409(axonogenesis);GO:0007411(axon guidance);GO:0007528(neuromuscular junction development);GO:0010976(positive regulation of neuron projection development);GO:0015630(microtubule cytoskeleton);GO:0016023(cytoplasmic membrane-bounded vesicle);GO:0016328(lateral plasma membrane);GO:0019899(enzyme binding);GO:0019901(protein kinase binding);GO:0021915(neural tube development);GO:0022007(convergent extension involved in neural plate elongation);GO:0030136(clathrin-coated vesicle);GO:0030177(positive regulation of Wnt signaling pathway);GO:0030424(axon);GO:0030425(dendrite);GO:0030426(growth cone);GO:0031122(cytoplasmic microtubule organization);GO:0031410(cytoplasmic vesicle);GO:0032091(negative regulation of protein binding);GO:0032436(positive regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0034504(protein localization to nucleus);GO:0035176(social behavior);GO:0035372(protein localization to microtubule);GO:0035556(intracellular signal transduction);GO:0042802(identical protein binding);GO:0043025(neuronal cell body);GO:0043113(receptor clustering);GO:0045202(synapse);GO:0045893(positive regulation of transcription, DNA-templated);GO:0048365(Rac GTPase binding);GO:0048668(collateral sprouting);GO:0048675(axon extension);GO:0048813(dendrite morphogenesis);GO:0050808(synapse organization);GO:0060029(convergent extension involved in organogenesis);GO:0060070(canonical Wnt signaling pathway);GO:0060071(Wnt signaling pathway, planar cell polarity pathway);GO:0060134(prepulse inhibition);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:0090103(cochlea morphogenesis);GO:0090179(planar cell polarity pathway involved in neural tube closure);GO:0090263(positive regulation of canonical Wnt signaling pathway)04310(Wnt signaling pathway);04330(Notch signaling pathway);05200(Pathways in cancer);05217(Basal cell carcinoma)NANAdishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084]30.594.4448.886.8523.734.0015.982.3510.431.9610.882.02379.858.570.000.02upyes
391"="chr1-13526911358535ENST00000309212102273MSTRG.42MXRA8GO:0003674(molecular_function);GO:0005515(protein binding);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0060857(establishment of glial blood-brain barrier);GO:0070062(extracellular exosome)NANANAmatrix-remodelling associated 8 [Source:HGNC Symbol;Acc:HGNC:7542]3.870.561.030.153.480.5919.572.8813.762.5914.502.690.01-6.810.010.05downyes
399"="chr1-13737301375157ENST0000033837031072MSTRG.43AURKAIP1GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006996(organelle organization);GO:0032543(mitochondrial translation);GO:0043231(intracellular membrane-bounded organelle);GO:0045839(negative regulation of mitotic nuclear division);GO:0045862(positive regulation of proteolysis);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination)NANANAaurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]40.445.8725.153.5333.535.6510.511.556.981.316.991.300.02-5.460.060.13downno
400"="chr1-13737301375495ENST0000033833841047MSTRG.43AURKAIP1GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006996(organelle organization);GO:0032543(mitochondrial translation);GO:0043231(intracellular membrane-bounded organelle);GO:0045839(negative regulation of mitotic nuclear division);GO:0045862(positive regulation of proteolysis);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination)NANANAaurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]78.5211.4193.8813.1669.5011.7264.709.5154.2610.2254.3710.094.532.180.090.18upno
402"="chr1-13737371375173ENST000003788534875MSTRG.43AURKAIP1GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006996(organelle organization);GO:0032543(mitochondrial translation);GO:0043231(intracellular membrane-bounded organelle);GO:0045839(negative regulation of mitotic nuclear division);GO:0045862(positive regulation of proteolysis);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination)NANANAaurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114]96.4014.00101.9314.2982.0213.83122.0917.9593.3817.5893.5717.361.160.220.470.61upno
410"="chr1-13864951399312ENST00000400809112305MSTRG.44CCNL2GO:0000079(regulation of cyclin-dependent protein serine/threonine kinase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005730(nucleolus);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0016607(nuclear speck);GO:0019901(protein kinase binding);GO:0030054(cell junction);GO:0043231(intracellular membrane-bounded organelle)NANANAcyclin L2 [Source:HGNC Symbol;Acc:HGNC:20570]6.120.896.830.964.670.7933.774.966.391.2021.624.014.772.250.830.88upno
435"="chr1-14019081407313ENST000003448434721MSTRG.46MRPL20GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0005761(mitochondrial ribosome);GO:0005840(ribosome);GO:0006412(translation);GO:0006996(organelle organization);GO:0019843(rRNA binding);GO:0032543(mitochondrial translation);GO:0044822(poly(A) RNA binding);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination)NANANAmitochondrial ribosomal protein L20 [Source:HGNC Symbol;Acc:HGNC:14478]198.6428.85285.3140.01177.1829.87214.8631.59165.7031.20167.5331.0943.105.430.000.02upyes
456"="chr1+14356711442882ENST0000047699334511MSTRG.48VWA1GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005604(basement membrane);GO:0005614(interstitial matrix);GO:0005615(extracellular space);GO:0030198(extracellular matrix organization);GO:0042802(identical protein binding);GO:0048266(behavioral response to pain);GO:0070062(extracellular exosome)NANANAvon Willebrand factor A domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30910]42.376.1541.315.7935.065.9155.838.2143.468.1844.048.170.50-1.010.050.12downno
466"="chr1+15121511534685ENST00000378756162492MSTRG.55ATAD3AGO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0016021(integral component of membrane);GO:0016049(cell growth);GO:0042645(mitochondrial nucleoid);GO:0043066(negative regulation of apoptotic process)NANANAATPase family, AAA domain containing 3A [Source:HGNC Symbol;Acc:HGNC:25567]36.145.2554.777.6841.767.0425.713.7819.093.6019.193.5622.244.480.140.25upno
476"="chr1-15416731574869ENST0000029138651290MSTRG.56SSU72GO:0004721(phosphoprotein phosphatase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006378(mRNA polyadenylation);GO:0006397(mRNA processing);GO:0008420(CTD phosphatase activity);GO:0070940(dephosphorylation of RNA polymerase II C-terminal domain)NANANASSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:25016]68.259.91117.0816.4289.9215.1661.689.0747.548.9548.378.9843.225.430.220.36upno
535"="chr1-16357381659012ENST00000611150192350MSTRG.63CDK11BGO:0004672(protein kinase activity);GO:0005524(ATP binding);GO:0006468(protein phosphorylation);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0051301(cell division)NANANAcyclin-dependent kinase 11B [Source:HGNC Symbol;Acc:HGNC:1729]00000011.941.7512.192.3013.002.410.20-2.320.340.48downno
583"="chr1-17512321778470ENST00000341426123235MSTRG.60NADKGO:0003951(NAD+ kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005829(cytosol);GO:0006741(NADP biosynthetic process);GO:0006766(vitamin metabolic process);GO:0006767(water-soluble vitamin metabolic process);GO:0008152(metabolic process);GO:0016310(phosphorylation);GO:0019674(NAD metabolic process);GO:0044281(small molecule metabolic process);GO:0046034(ATP metabolic process);GO:0046872(metal ion binding)00760(Nicotinate and nicotinamide metabolism);01100(Metabolic pathways)K008582.7.1.23NAD kinase [Source:HGNC Symbol;Acc:HGNC:29831]76.2111.07104.6414.6766.4011.20129.7519.08102.0119.21103.0819.1315.033.910.010.03upyes
607"="chr1-17879871794197ENST0000046189332438MSTRG.61GNB1GO:0001664(G-protein coupled receptor binding);GO:0001750(photoreceptor outer segment);GO:0001917(photoreceptor inner segment);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005765(lysosomal membrane);GO:0005834(heterotrimeric G-protein complex);GO:0005886(plasma membrane);GO:0006112(energy reserve metabolic process);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007191(adenylate cyclase-activating dopamine receptor signaling pathway);GO:0007200(phospholipase C-activating G-protein coupled receptor signaling pathway);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007213(G-protein coupled acetylcholine receptor signaling pathway);GO:0007265(Ras protein signal transduction);GO:0007268(synaptic transmission);GO:0007596(blood coagulation);GO:0007603(phototransduction, visible light);GO:0008283(cell proliferation);GO:0010659(cardiac muscle cell apoptotic process);GO:0016020(membrane);GO:0016056(rhodopsin mediated signaling pathway);GO:0022400(regulation of rhodopsin mediated signaling pathway);GO:0030168(platelet activation);GO:0030425(dendrite);GO:0030507(spectrin binding);GO:0031702(type 1 angiotensin receptor binding);GO:0032403(protein complex binding);GO:0042622(photoreceptor outer segment membrane);GO:0043209(myelin sheath);GO:0044281(small molecule metabolic process);GO:0044297(cell body);GO:0050909(sensory perception of taste);GO:0051020(GTPase binding);GO:0060041(retina development in camera-type eye);GO:0070062(extracellular exosome);GO:0071377(cellular response to glucagon stimulus);GO:0071380(cellular response to prostaglandin E stimulus);GO:0071456(cellular response to hypoxia);GO:0071870(cellular response to catecholamine stimulus);GO:0097381(photoreceptor disc membrane);GO:1903561(extracellular vesicle)04062(Chemokine signaling pathway);04724(Glutamatergic synapse);04725(Cholinergic synapse);04742(Taste transduction);04744(Phototransduction)NANAguanine nucleotide binding protein (G protein), beta polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:4396]1.890.272.860.401.740.2920.162.9617.933.3818.093.360.72-0.470.720.80downno
608"="chr1-17890611818386ENST0000047135471512MSTRG.61GNB1GO:0001664(G-protein coupled receptor binding);GO:0001750(photoreceptor outer segment);GO:0001917(photoreceptor inner segment);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005765(lysosomal membrane);GO:0005834(heterotrimeric G-protein complex);GO:0005886(plasma membrane);GO:0006112(energy reserve metabolic process);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007191(adenylate cyclase-activating dopamine receptor signaling pathway);GO:0007200(phospholipase C-activating G-protein coupled receptor signaling pathway);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007213(G-protein coupled acetylcholine receptor signaling pathway);GO:0007265(Ras protein signal transduction);GO:0007268(synaptic transmission);GO:0007596(blood coagulation);GO:0007603(phototransduction, visible light);GO:0008283(cell proliferation);GO:0010659(cardiac muscle cell apoptotic process);GO:0016020(membrane);GO:0016056(rhodopsin mediated signaling pathway);GO:0022400(regulation of rhodopsin mediated signaling pathway);GO:0030168(platelet activation);GO:0030425(dendrite);GO:0030507(spectrin binding);GO:0031702(type 1 angiotensin receptor binding);GO:0032403(protein complex binding);GO:0042622(photoreceptor outer segment membrane);GO:0043209(myelin sheath);GO:0044281(small molecule metabolic process);GO:0044297(cell body);GO:0050909(sensory perception of taste);GO:0051020(GTPase binding);GO:0060041(retina development in camera-type eye);GO:0070062(extracellular exosome);GO:0071377(cellular response to glucagon stimulus);GO:0071380(cellular response to prostaglandin E stimulus);GO:0071456(cellular response to hypoxia);GO:0071870(cellular response to catecholamine stimulus);GO:0097381(photoreceptor disc membrane);GO:1903561(extracellular vesicle)04062(Chemokine signaling pathway);04724(Glutamatergic synapse);04725(Cholinergic synapse);04742(Taste transduction);04744(Phototransduction)NANAguanine nucleotide binding protein (G protein), beta polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:4396]1.350.202.790.391.460.2535.915.2825.844.8726.104.841.250.320.620.73upno
655"="chr1+21047162185393ENST00000400920152009MSTRG.69PRKCZGO:0000226(microtubule cytoskeleton organization);GO:0001954(positive regulation of cell-matrix adhesion);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004697(protein kinase C activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005635(nuclear envelope);GO:0005737(cytoplasm);GO:0005768(endosome);GO:0005815(microtubule organizing center);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005911(cell-cell junction);GO:0005923(bicellular tight junction);GO:0005938(cell cortex);GO:0006468(protein phosphorylation);GO:0006954(inflammatory response);GO:0007165(signal transduction);GO:0007166(cell surface receptor signaling pathway);GO:0007179(transforming growth factor beta receptor signaling pathway);GO:0007596(blood coagulation);GO:0007616(long-term memory);GO:0008284(positive regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0015459(potassium channel regulator activity);GO:0016020(membrane);GO:0016324(apical plasma membrane);GO:0016363(nuclear matrix);GO:0016477(cell migration);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018105(peptidyl-serine phosphorylation);GO:0019901(protein kinase binding);GO:0019904(protein domain specific binding);GO:0030010(establishment of cell polarity);GO:0030054(cell junction);GO:0030168(platelet activation);GO:0031252(cell leading edge);GO:0031333(negative regulation of protein complex assembly);GO:0031532(actin cytoskeleton reorganization);GO:0031584(activation of phospholipase D activity);GO:0031941(filamentous actin);GO:0032148(activation of protein kinase B activity);GO:0032753(positive regulation of interleukin-4 production);GO:0032869(cellular response to insulin stimulus);GO:0034613(cellular protein localization);GO:0035556(intracellular signal transduction);GO:0035748(myelin sheath abaxonal region);GO:0043066(negative regulation of apoptotic process);GO:0043203(axon hillock);GO:0043231(intracellular membrane-bounded organelle);GO:0043234(protein complex);GO:0043274(phospholipase binding);GO:0043560(insulin receptor substrate binding);GO:0045121(membrane raft);GO:0045179(apical cortex);GO:0045630(positive regulation of T-helper 2 cell differentiation);GO:0046326(positive regulation of glucose import);GO:0046627(negative regulation of insulin receptor signaling pathway);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0046872(metal ion binding);GO:0047496(vesicle transport along microtubule);GO:0048010(vascular endothelial growth factor receptor signaling pathway);GO:0048471(perinuclear region of cytoplasm);GO:0050732(negative regulation of peptidyl-tyrosine phosphorylation);GO:0050806(positive regulation of synaptic transmission);GO:0051092(positive regulation of NF-kappaB transcription factor activity);GO:0051222(positive regulation of protein transport);GO:0051291(protein heterooligomerization);GO:0051346(negative regulation of hydrolase activity);GO:0051899(membrane depolarization);GO:0060081(membrane hyperpolarization);GO:0060291(long-term synaptic potentiation);GO:0070062(extracellular exosome);GO:0070374(positive regulation of ERK1 and ERK2 cascade);GO:0070528(protein kinase C signaling);GO:0071889(14-3-3 protein binding);GO:0072659(protein localization to plasma membrane);GO:1990138(neuron projection extension);GO:2000463(positive regulation of excitatory postsynaptic membrane potential);GO:2000553(positive regulation of T-helper 2 cell cytokine production);GO:2000664(positive regulation of interleukin-5 secretion);GO:2000667(positive regulation of interleukin-13 secretion);GO:2001181(positive regulation of interleukin-10 secretion)04062(Chemokine signaling pathway);04144(Endocytosis);04530(Tight junction);04910(Insulin signaling pathway);04930(Type II diabetes mellitus)NANAprotein kinase C, zeta [Source:HGNC Symbol;Acc:HGNC:9412]00000021.203.1215.652.9515.962.960.27-1.860.020.06downyes
713"="chr1+23918332403749ENST0000063083771349MSTRG.78RER1GO:0003674(molecular_function);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005794(Golgi apparatus);GO:0006890(retrograde vesicle-mediated transport, Golgi to ER);GO:0007528(neuromuscular junction development);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0030173(integral component of Golgi membrane);GO:0033130(acetylcholine receptor binding);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090004(positive regulation of establishment of protein localization to plasma membrane)NANANAretention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309]85.3712.4085.0311.9274.2712.5247.957.0537.667.0938.427.130.98-0.030.780.85downno
714"="chr1+23918332405444ENST0000060589573044MSTRG.78RER1GO:0003674(molecular_function);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005794(Golgi apparatus);GO:0006890(retrograde vesicle-mediated transport, Golgi to ER);GO:0007528(neuromuscular junction development);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0030173(integral component of Golgi membrane);GO:0033130(acetylcholine receptor binding);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090004(positive regulation of establishment of protein localization to plasma membrane)NANANAretention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309]86.6912.5984.0111.7874.1612.5050.957.4940.057.5440.667.550.75-0.410.010.04downno
722"="chr1-24048192412571ENST0000044751361997MSTRG.79PEX10GO:0005515(protein binding);GO:0005622(intracellular);GO:0005777(peroxisome);GO:0005778(peroxisomal membrane);GO:0005779(integral component of peroxisomal membrane);GO:0007031(peroxisome organization);GO:0008022(protein C-terminus binding);GO:0008270(zinc ion binding);GO:0016558(protein import into peroxisome matrix)04146(Peroxisome)NANAperoxisomal biogenesis factor 10 [Source:HGNC Symbol;Acc:HGNC:8851]48.167.0046.706.5540.386.8118.742.7615.062.8415.072.801.120.160.540.66upno
739"="chr1-25085332526628ENST00000378466192677MSTRG.80PANK4GO:0004594(pantothenate kinase activity);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0015937(coenzyme A biosynthetic process);GO:0016310(phosphorylation)00770(Pantothenate and CoA biosynthesis);01100(Metabolic pathways)K00867;K00896;K03525;K096802.7.1.33pantothenate kinase 4 [Source:HGNC Symbol;Acc:HGNC:19366]19.692.8624.093.3816.632.8011.091.633.020.573.110.5837.635.230.370.52upno
782"="chr1+25867752591468ENST0000041991672749MSTRG.83FAM213BGO:0001516(prostaglandin biosynthetic process);GO:0005737(cytoplasm);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0016616(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor);GO:0019369(arachidonic acid metabolic process);GO:0019371(cyclooxygenase pathway);GO:0043209(myelin sheath);GO:0044281(small molecule metabolic process);GO:0047017(prostaglandin-F synthase activity);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome)NANANAfamily with sequence similarity 213, member B [Source:HGNC Symbol;Acc:HGNC:28390]19.012.7620.672.9018.743.166.781.005.601.055.471.011.570.650.540.66upno
849"="chr1+36250023630127ENST0000037834452414MSTRG.87TPRG1LGO:0003674(molecular_function);GO:0008021(synaptic vesicle);GO:0008150(biological_process);GO:0030054(cell junction);GO:0042802(identical protein binding);GO:0070062(extracellular exosome)NANANAtumor protein p63 regulated 1-like [Source:HGNC Symbol;Acc:HGNC:27007]68.8410.0015.132.1256.919.60124.6518.3294.9917.8996.2417.860.00-23.310.000.02downyes
853"="chr1-36307673650073ENST00000270708121665MSTRG.95WRAP73GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005813(centrosome)NANANAWD repeat containing, antisense to TP73 [Source:HGNC Symbol;Acc:HGNC:12759]43.186.2742.856.0136.426.1414.422.1212.992.4512.002.231.310.390.690.78upno
889"="chr1+37727883775982ENST000004448704546MSTRG.91SMIM1GO:0016021(integral component of membrane);GO:0070062(extracellular exosome)NANANAsmall integral membrane protein 1 (Vel blood group) [Source:HGNC Symbol;Acc:HGNC:44204]38.555.6038.325.3736.276.1119.982.9414.182.6714.712.730.85-0.230.840.89downno
892"="chr1-37785583796504ENST0000037825174310MSTRG.92LRRC47GO:0003723(RNA binding);GO:0004826(phenylalanine-tRNA ligase activity);GO:0005515(protein binding);GO:0044822(poly(A) RNA binding)NANANAleucine rich repeat containing 47 [Source:HGNC Symbol;Acc:HGNC:29207]96.4114.0084.9911.9281.9613.8254.698.0443.318.1644.008.160.26-1.950.000.02downyes
897"="chr1-38120813857199ENST00000378230226424MSTRG.103CEP104GO:0005488(binding);GO:0005814(centriole)NANANAcentrosomal protein 104kDa [Source:HGNC Symbol;Acc:HGNC:24866]43.666.3438.315.3737.886.3925.623.7719.293.6319.603.640.27-1.880.050.11downyes
973"="chr1+60461146098855ENST00000458166141336MSTRG.107KCNAB2GO:0002244(hematopoietic progenitor cell differentiation);GO:0004033(aldo-keto reductase (NADP) activity);GO:0005249(voltage-gated potassium channel activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005874(microtubule);GO:0005886(plasma membrane);GO:0006813(potassium ion transport);GO:0007268(synaptic transmission);GO:0008076(voltage-gated potassium channel complex);GO:0014069(postsynaptic density);GO:0015459(potassium channel regulator activity);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0030424(axon);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0043679(axon terminus);GO:0044224(juxtaparanode region of axon);GO:0045202(synapse);GO:0050905(neuromuscular process);GO:0055114(oxidation-reduction process);GO:0070995(NADPH oxidation);GO:0071805(potassium ion transmembrane transport);GO:1901379(regulation of potassium ion transmembrane transport);GO:1990031(pinceau fiber);GO:2000008(regulation of protein localization to cell surface)NANANApotassium channel, voltage gated subfamily A regulatory beta subunit 2 [Source:HGNC Symbol;Acc:HGNC:6229]00000030.324.4622.984.3323.134.290.20-2.330.000.02downyes
983"="chr1-61850206199612ENST0000023487542078MSTRG.108RPL22GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay);GO:0003723(RNA binding);GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005840(ribosome);GO:0005925(focal adhesion);GO:0006412(translation);GO:0006413(translational initiation);GO:0006414(translational elongation);GO:0006415(translational termination);GO:0006614(SRP-dependent cotranslational protein targeting to membrane);GO:0008201(heparin binding);GO:0010467(gene expression);GO:0016032(viral process);GO:0019058(viral life cycle);GO:0019083(viral transcription);GO:0022625(cytosolic large ribosomal subunit);GO:0030529(ribonucleoprotein complex);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0046632(alpha-beta T cell differentiation);GO:0070062(extracellular exosome)03010(Ribosome)NANAribosomal protein L22 [Source:HGNC Symbol;Acc:HGNC:10315]208.3530.27262.3536.79196.4933.13110.5716.25122.7823.12124.4223.094.312.110.620.73upno
987"="chr1-61867236199553ENST000004653874508MSTRG.108RPL22GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay);GO:0003723(RNA binding);GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005840(ribosome);GO:0005925(focal adhesion);GO:0006412(translation);GO:0006413(translational initiation);GO:0006414(translational elongation);GO:0006415(translational termination);GO:0006614(SRP-dependent cotranslational protein targeting to membrane);GO:0008201(heparin binding);GO:0010467(gene expression);GO:0016032(viral process);GO:0019058(viral life cycle);GO:0019083(viral transcription);GO:0022625(cytosolic large ribosomal subunit);GO:0030529(ribonucleoprotein complex);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0046632(alpha-beta T cell differentiation);GO:0070062(extracellular exosome)03010(Ribosome)NANAribosomal protein L22 [Source:HGNC Symbol;Acc:HGNC:10315]15.332.2319.962.8013.842.3350.177.387.951.508.061.49101.546.670.620.73upno
1001"="chr1-62211936235940ENST0000034381354771MSTRG.111ICMTGO:0001701(in utero embryonic development);GO:0001889(liver development);GO:0003880(protein C-terminal carboxyl O-methyltransferase activity);GO:0004671(protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity);GO:0005783(endoplasmic reticulum);GO:0005789(endoplasmic reticulum membrane);GO:0006464(cellular protein modification process);GO:0006479(protein methylation);GO:0006481(C-terminal protein methylation);GO:0006612(protein targeting to membrane);GO:0008104(protein localization);GO:0008140(cAMP response element binding protein binding);GO:0008284(positive regulation of cell proliferation);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0035264(multicellular organism growth);GO:0046498(S-adenosylhomocysteine metabolic process);GO:0046499(S-adenosylmethioninamine metabolic process);GO:0046578(regulation of Ras protein signal transduction)NANANAisoprenylcysteine carboxyl methyltransferase [Source:HGNC Symbol;Acc:HGNC:5350]56.758.2456.427.9146.527.8442.316.2232.496.1233.016.131.080.120.810.87upno
1011"="chr1-62642736360707ENST0000037784591432MSTRG.112ACOT7GO:0000062(fatty-acyl-CoA binding);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005829(cytosol);GO:0009062(fatty acid catabolic process);GO:0015937(coenzyme A biosynthetic process);GO:0016290(palmitoyl-CoA hydrolase activity);GO:0036042(long-chain fatty acyl-CoA binding);GO:0036114(medium-chain fatty-acyl-CoA catabolic process);GO:0036116(long-chain fatty-acyl-CoA catabolic process);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0044297(cell body);GO:0047617(acyl-CoA hydrolase activity);GO:0051792(medium-chain fatty acid biosynthetic process);GO:0052689(carboxylic ester hydrolase activity);GO:0070062(extracellular exosome);GO:1900535(palmitic acid biosynthetic process)01040(Biosynthesis of unsaturated fatty acids)NANAacyl-CoA thioesterase 7 [Source:HGNC Symbol;Acc:HGNC:24157]20.653.0016.932.3716.872.8430.794.5324.534.6225.164.670.10-3.320.000.02downyes
1012"="chr1-62642736385813ENST0000037785591614MSTRG.112ACOT7GO:0000062(fatty-acyl-CoA binding);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005829(cytosol);GO:0009062(fatty acid catabolic process);GO:0015937(coenzyme A biosynthetic process);GO:0016290(palmitoyl-CoA hydrolase activity);GO:0036042(long-chain fatty acyl-CoA binding);GO:0036114(medium-chain fatty-acyl-CoA catabolic process);GO:0036116(long-chain fatty-acyl-CoA catabolic process);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0044297(cell body);GO:0047617(acyl-CoA hydrolase activity);GO:0051792(medium-chain fatty acid biosynthetic process);GO:0052689(carboxylic ester hydrolase activity);GO:0070062(extracellular exosome);GO:1900535(palmitic acid biosynthetic process)01040(Biosynthesis of unsaturated fatty acids)NANAacyl-CoA thioesterase 7 [Source:HGNC Symbol;Acc:HGNC:24157]57.178.3053.897.5649.838.400.240.040.240.040.240.042.871.520.000.02upyes
1041"="chr1+64503746451949ENST000004754793360MSTRG.119ESPNGO:0003779(actin binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005903(brush border);GO:0007605(sensory perception of sound);GO:0007626(locomotory behavior);GO:0017124(SH3 domain binding);GO:0030046(parallel actin filament bundle assembly);GO:0031941(filamentous actin);GO:0032420(stereocilium);GO:0032421(stereocilium bundle);GO:0032426(stereocilium bundle tip);GO:0051015(actin filament binding);GO:0051017(actin filament bundle assembly);GO:0051491(positive regulation of filopodium assembly);GO:0051494(negative regulation of cytoskeleton organization)NANANAespin [Source:HGNC Symbol;Acc:HGNC:13281]00000011.771.7312.022.2611.282.090.23-2.130.280.42downno
1045"="chr1+64605086461370ENST000004685612664MSTRG.119ESPNGO:0003779(actin binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005903(brush border);GO:0007605(sensory perception of sound);GO:0007626(locomotory behavior);GO:0017124(SH3 domain binding);GO:0030046(parallel actin filament bundle assembly);GO:0031941(filamentous actin);GO:0032420(stereocilium);GO:0032421(stereocilium bundle);GO:0032426(stereocilium bundle tip);GO:0051015(actin filament binding);GO:0051017(actin filament bundle assembly);GO:0051491(positive regulation of filopodium assembly);GO:0051494(negative regulation of cytoskeleton organization)NANANAespin [Source:HGNC Symbol;Acc:HGNC:13281]00000020.823.0616.003.0116.333.030.25-1.980.000.01downyes
1078"="chr1-65213476554535ENST00000377705126649MSTRG.114NOL9GO:0000448(cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA));GO:0000460(maturation of 5.8S rRNA);GO:0003723(RNA binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0006396(RNA processing);GO:0016020(membrane);GO:0016310(phosphorylation);GO:0051731(polynucleotide 5'-hydroxyl-kinase activity)NANANAnucleolar protein 9 [Source:HGNC Symbol;Acc:HGNC:26265]38.265.5636.165.0732.905.5516.532.4312.622.3812.952.400.76-0.400.260.40downno
1094"="chr1+65853026589280ENST0000048236072484MSTRG.118ZBTB48GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0046872(metal ion binding)NANANAzinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930]2.170.322.390.342.420.4113.762.0211.972.2512.092.240.29-1.810.150.26downno
1105"="chr1+66136856624033ENST0000037764843681MSTRG.124PHF13GO:0000278(mitotic cell cycle);GO:0003682(chromatin binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0007059(chromosome segregation);GO:0007076(mitotic chromosome condensation);GO:0008270(zinc ion binding);GO:0016568(chromatin modification);GO:0035064(methylated histone binding);GO:0051301(cell division)NANANAPHD finger protein 13 [Source:HGNC Symbol;Acc:HGNC:22983]23.903.4741.385.8034.395.809.111.340.300.060.300.06394.848.630.390.53upno
1118"="chr1-66341686701924ENST00000377577163311MSTRG.126DNAJC11GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0070062(extracellular exosome)NANANADnaJ (Hsp40) homolog, subfamily C, member 11 [Source:HGNC Symbol;Acc:HGNC:25570]101.3914.7395.7113.4287.8114.8150.947.4938.847.3139.477.320.64-0.640.200.33downno
1124"="chr1-66538096701804ENST000004850735613MSTRG.126DNAJC11GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0070062(extracellular exosome)NANANADnaJ (Hsp40) homolog, subfamily C, member 11 [Source:HGNC Symbol;Acc:HGNC:25570]3.360.493.540.503.320.5615.772.3212.692.3913.232.450.34-1.570.060.13downno
1146"="chr1+68530956872045ENST000004722832384MSTRG.129CAMTA1GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated)NANANAcalmodulin binding transcription activator 1 [Source:HGNC Symbol;Acc:HGNC:18806]00000013.401.9712.502.3512.502.320.24-2.090.180.30downno
1162"="chr1+77727077779806ENST000004703575954MSTRG.127VAMP3GO:0000149(SNARE binding);GO:0001921(positive regulation of receptor recycling);GO:0005484(SNAP receptor activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006461(protein complex assembly);GO:0006887(exocytosis);GO:0006904(vesicle docking involved in exocytosis);GO:0006906(vesicle fusion);GO:0008021(synaptic vesicle);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0016192(vesicle-mediated transport);GO:0016324(apical plasma membrane);GO:0017075(syntaxin-1 binding);GO:0017156(calcium ion-dependent exocytosis);GO:0030054(cell junction);GO:0030136(clathrin-coated vesicle);GO:0030141(secretory granule);GO:0030665(clathrin-coated vesicle membrane);GO:0031201(SNARE complex);GO:0031410(cytoplasmic vesicle);GO:0034446(substrate adhesion-dependent cell spreading);GO:0035493(SNARE complex assembly);GO:0042147(retrograde transport, endosome to Golgi);GO:0043001(Golgi to plasma membrane protein transport);GO:0043005(neuron projection);GO:0043229(intracellular organelle);GO:0043231(intracellular membrane-bounded organelle);GO:0055037(recycling endosome);GO:0061025(membrane fusion);GO:1903531(negative regulation of secretion by cell)04130(SNARE interactions in vesicular transport);04145(Phagosome)NANAvesicle-associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644]27.564.0024.363.4223.693.998.841.305.020.945.371.000.73-0.450.820.88downno
1178"="chr1-78430837853512ENST0000037751671601MSTRG.142UTS2GO:0001666(response to hypoxia);GO:0003105(negative regulation of glomerular filtration);GO:0005102(receptor binding);GO:0005179(hormone activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0006936(muscle contraction);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007268(synaptic transmission);GO:0008217(regulation of blood pressure);GO:0010459(negative regulation of heart rate);GO:0010460(positive regulation of heart rate);GO:0010763(positive regulation of fibroblast migration);GO:0010841(positive regulation of circadian sleep/wake cycle, wakefulness);GO:0032224(positive regulation of synaptic transmission, cholinergic);GO:0032967(positive regulation of collagen biosynthetic process);GO:0033574(response to testosterone);GO:0035811(negative regulation of urine volume);GO:0035814(negative regulation of renal sodium excretion);GO:0042312(regulation of vasodilation);GO:0042493(response to drug);GO:0045597(positive regulation of cell differentiation);GO:0045766(positive regulation of angiogenesis);GO:0045776(negative regulation of blood pressure);GO:0045777(positive regulation of blood pressure);GO:0045909(positive regulation of vasodilation);GO:0046005(positive regulation of circadian sleep/wake cycle, REM sleep);GO:0046676(negative regulation of insulin secretion);GO:0048146(positive regulation of fibroblast proliferation)NANANAurotensin 2 [Source:HGNC Symbol;Acc:HGNC:12636]20.963.0519.032.6719.473.280000000.85-0.230.720.80downno
1187"="chr1+79542917985052ENST000004933737624MSTRG.143PARK7GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)05012(Parkinson's disease)NANAparkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369]32.854.7738.655.4231.605.332.910.432.230.422.670.508.683.120.050.12upno
1189"="chr1+79616637985279ENST000003386397949MSTRG.143PARK7GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)05012(Parkinson's disease)NANAparkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369]492.8871.60531.6374.55417.6870.42290.7442.74224.4042.26227.1442.153.121.640.000.02upyes
1191"="chr1+79617017985281ENST000003774936795MSTRG.143PARK7GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)05012(Parkinson's disease)NANAparkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369]22.593.2825.273.5420.733.493.040.451.540.291.540.296.792.760.110.20upno
1193"="chr1+79618947985250ENST000003774917977MSTRG.143PARK7GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)05012(Parkinson's disease)NANAparkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369]47.736.9348.196.7644.147.445.790.855.160.975.130.951.890.920.310.45upno
1199"="chr1-80044048026283ENST000004748743479MSTRG.146ERRFI1GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006950(response to stress);GO:0007175(negative regulation of epidermal growth factor-activated receptor activity);GO:0017124(SH3 domain binding);GO:0019900(kinase binding);GO:0019901(protein kinase binding);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031267(small GTPase binding);GO:0031953(negative regulation of protein autophosphorylation);GO:0032691(negative regulation of interleukin-1 beta production);GO:0032869(cellular response to insulin stimulus);GO:0032966(negative regulation of collagen biosynthetic process);GO:0036120(cellular response to platelet-derived growth factor stimulus);GO:0042059(negative regulation of epidermal growth factor receptor signaling pathway);GO:0042536(negative regulation of tumor necrosis factor biosynthetic process);GO:0043547(positive regulation of GTPase activity);GO:0043589(skin morphogenesis);GO:0045616(regulation of keratinocyte differentiation);GO:0048286(lung alveolus development);GO:0060426(lung vasculature development);GO:0060428(lung epithelium development);GO:0061469(regulation of type B pancreatic cell proliferation);GO:0070373(negative regulation of ERK1 and ERK2 cascade);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071474(cellular hyperosmotic response);GO:0071549(cellular response to dexamethasone stimulus);GO:1903243(negative regulation of cardiac muscle hypertrophy in response to stress)NANANAERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185]3.630.533.150.443.160.5316.022.3513.112.4713.112.430.20-2.340.000.02downyes
1200"="chr1-80117198026308ENST0000037748243104MSTRG.146ERRFI1GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006950(response to stress);GO:0007175(negative regulation of epidermal growth factor-activated receptor activity);GO:0017124(SH3 domain binding);GO:0019900(kinase binding);GO:0019901(protein kinase binding);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031267(small GTPase binding);GO:0031953(negative regulation of protein autophosphorylation);GO:0032691(negative regulation of interleukin-1 beta production);GO:0032869(cellular response to insulin stimulus);GO:0032966(negative regulation of collagen biosynthetic process);GO:0036120(cellular response to platelet-derived growth factor stimulus);GO:0042059(negative regulation of epidermal growth factor receptor signaling pathway);GO:0042536(negative regulation of tumor necrosis factor biosynthetic process);GO:0043547(positive regulation of GTPase activity);GO:0043589(skin morphogenesis);GO:0045616(regulation of keratinocyte differentiation);GO:0048286(lung alveolus development);GO:0060426(lung vasculature development);GO:0060428(lung epithelium development);GO:0061469(regulation of type B pancreatic cell proliferation);GO:0070373(negative regulation of ERK1 and ERK2 cascade);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071474(cellular hyperosmotic response);GO:0071549(cellular response to dexamethasone stimulus);GO:1903243(negative regulation of cardiac muscle hypertrophy in response to stress)NANANAERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185]116.1616.87135.0418.9498.3016.57423.6262.28333.9762.89340.2463.141.190.250.570.69upno
1202"="chr1-80134278015633ENST0000046706722097MSTRG.146ERRFI1GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006950(response to stress);GO:0007175(negative regulation of epidermal growth factor-activated receptor activity);GO:0017124(SH3 domain binding);GO:0019900(kinase binding);GO:0019901(protein kinase binding);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031267(small GTPase binding);GO:0031953(negative regulation of protein autophosphorylation);GO:0032691(negative regulation of interleukin-1 beta production);GO:0032869(cellular response to insulin stimulus);GO:0032966(negative regulation of collagen biosynthetic process);GO:0036120(cellular response to platelet-derived growth factor stimulus);GO:0042059(negative regulation of epidermal growth factor receptor signaling pathway);GO:0042536(negative regulation of tumor necrosis factor biosynthetic process);GO:0043547(positive regulation of GTPase activity);GO:0043589(skin morphogenesis);GO:0045616(regulation of keratinocyte differentiation);GO:0048286(lung alveolus development);GO:0060426(lung vasculature development);GO:0060428(lung epithelium development);GO:0061469(regulation of type B pancreatic cell proliferation);GO:0070373(negative regulation of ERK1 and ERK2 cascade);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071474(cellular hyperosmotic response);GO:0071549(cellular response to dexamethasone stimulus);GO:1903243(negative regulation of cardiac muscle hypertrophy in response to stress)NANANAERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185]78.0811.3468.299.5866.8311.27211.6431.11161.2730.37163.4230.330.06-4.030.010.03downyes
1256"="chr1-88610028878690ENST00000234590121783MSTRG.149ENO1GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome)00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation)K016894.2.1.11enolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350]3576.75519.563029.23424.773097.99522.33706.47103.86561.99105.83570.22105.820.36-1.470.010.03downyes
1257"="chr1-88610058871297ENST0000046492092266MSTRG.149ENO1GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome)00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation)NANAenolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350]89.3612.986.600.9367.8411.447.731.146.251.186.321.170.00-32.460.000.02downyes
1262"="chr1-88713528878676ENST000004923433826MSTRG.149ENO1GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome)00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation)NANAenolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350]26.953.9212.611.7720.963.5311.611.719.001.709.071.680.00-8.890.010.03downyes
1263"="chr1-88748568879249ENST000004898672732MSTRG.149ENO1GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome)00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation)NANAenolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350]0.770.1134.954.900.390.074.750.705.551.057.751.44510315261.3328.930.020.06upyes
1305"="chr1+92347759271337ENST0000037740359146MSTRG.176H6PDGO:0004345(glucose-6-phosphate dehydrogenase activity);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005788(endoplasmic reticulum lumen);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006098(pentose-phosphate shunt);GO:0006739(NADP metabolic process);GO:0017057(6-phosphogluconolactonase activity);GO:0030246(carbohydrate binding);GO:0043231(intracellular membrane-bounded organelle);GO:0047936(glucose 1-dehydrogenase [NAD(P)] activity);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0097305(response to alcohol)00030(Pentose phosphate pathway);01100(Metabolic pathways)K01504;K02564;K01057;K074043.5.99.6;3.1.1.31hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:HGNC Symbol;Acc:HGNC:4795]96.0613.9530.784.3280.3613.5511.551.7016.603.1314.732.730.00-17.790.000.02downyes
1306"="chr1+92398449267898ENST0000060247755590MSTRG.176H6PDGO:0004345(glucose-6-phosphate dehydrogenase activity);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005788(endoplasmic reticulum lumen);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006098(pentose-phosphate shunt);GO:0006739(NADP metabolic process);GO:0017057(6-phosphogluconolactonase activity);GO:0030246(carbohydrate binding);GO:0043231(intracellular membrane-bounded organelle);GO:0047936(glucose 1-dehydrogenase [NAD(P)] activity);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0097305(response to alcohol)00030(Pentose phosphate pathway);01100(Metabolic pathways)K01504;K02564;K01057;K074043.5.99.6;3.1.1.31hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:HGNC Symbol;Acc:HGNC:4795]13.271.9357.598.0810.681.8097.2514.3039.407.4263.9811.871354978.1720.370.010.05upyes
1317"="chr1+95889229604954ENST0000034030563851MSTRG.181TMEM201GO:0005515(protein binding);GO:0005521(lamin binding);GO:0005637(nuclear inner membrane);GO:0007097(nuclear migration);GO:0010761(fibroblast migration);GO:0016021(integral component of membrane);GO:0031965(nuclear membrane);GO:0051015(actin filament binding)NANANAtransmembrane protein 201 [Source:HGNC Symbol;Acc:HGNC:33719]13.671.9925.853.6211.992.025.310.784.050.764.130.77399.198.640.000.02upyes
1324"="chr1+96517459728919ENST00000377346245203MSTRG.184PIK3CDGO:0001779(natural killer cell differentiation);GO:0001782(B cell homeostasis);GO:0001816(cytokine production);GO:0002250(adaptive immune response);GO:0002551(mast cell chemotaxis);GO:0002679(respiratory burst involved in defense response);GO:0005488(binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005942(phosphatidylinositol 3-kinase complex);GO:0006468(protein phosphorylation);GO:0006644(phospholipid metabolic process);GO:0006661(phosphatidylinositol biosynthetic process);GO:0006954(inflammatory response);GO:0007165(signal transduction);GO:0007166(cell surface receptor signaling pathway);GO:0007173(epidermal growth factor receptor signaling pathway);GO:0008543(fibroblast growth factor receptor signaling pathway);GO:0010628(positive regulation of gene expression);GO:0010818(T cell chemotaxis);GO:0014065(phosphatidylinositol 3-kinase signaling);GO:0016303(1-phosphatidylinositol-3-kinase activity);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0016773(phosphotransferase activity, alcohol group as acceptor);GO:0030101(natural killer cell activation);GO:0030168(platelet activation);GO:0030217(T cell differentiation);GO:0030335(positive regulation of cell migration);GO:0030593(neutrophil chemotaxis);GO:0035004(phosphatidylinositol 3-kinase activity);GO:0035005(1-phosphatidylinositol-4-phosphate 3-kinase activity);GO:0035747(natural killer cell chemotaxis);GO:0035754(B cell chemotaxis);GO:0036092(phosphatidylinositol-3-phosphate biosynthetic process);GO:0038095(Fc-epsilon receptor signaling pathway);GO:0042110(T cell activation);GO:0042113(B cell activation);GO:0042629(mast cell granule);GO:0043303(mast cell degranulation);GO:0044281(small molecule metabolic process);GO:0045087(innate immune response);GO:0046854(phosphatidylinositol phosphorylation);GO:0046934(phosphatidylinositol-4,5-bisphosphate 3-kinase activity);GO:0048011(neurotrophin TRK receptor signaling pathway);GO:0048015(phosphatidylinositol-mediated signaling);GO:0048872(homeostasis of number of cells);GO:0050832(defense response to fungus);GO:0050852(T cell receptor signaling pathway);GO:0050853(B cell receptor signaling pathway);GO:0060374(mast cell differentiation);GO:0072672(neutrophil extravasation)00562(Inositol phosphate metabolism);04012(ErbB signaling pathway);04062(Chemokine signaling pathway);04070(Phosphatidylinositol signaling system);04150(mTOR signaling pathway);04210(Apoptosis);04370(VEGF signaling pathway);04380(Osteoclast differentiation);04510(Focal adhesion);04620(Toll-like receptor signaling pathway);04630(Jak-STAT signaling pathway);04650(Natural killer cell mediated cytotoxicity);04660(T cell receptor signaling pathway);04662(B cell receptor signaling pathway);04664(Fc epsilon RI signaling pathway);04666(Fc gamma R-mediated phagocytosis);04670(Leukocyte transendothelial migration);04722(Neurotrophin signaling pathway);04725(Cholinergic synapse);04810(Regulation of actin cytoskeleton);04910(Insulin signaling pathway);04914(Progesterone-mediated oocyte maturation);04930(Type II diabetes mellitus);04960(Aldosterone-regulated sodium reabsorption);04973(Carbohydrate digestion and absorption);05100(Bacterial invasion of epithelial cells);05142(Chagas disease (American trypanosomiasis));05145(Toxoplasmosis);05146(Amoebiasis);05160(Hepatitis C);05162(Measles);05164(Influenza A);05200(Pathways in cancer);05210(Colorectal cancer);05211(Renal cell carcinoma);05212(Pancreatic cancer);05213(Endometrial cancer);05214(Glioma);05215(Prostate cancer);05218(Melanoma);05220(Chronic myeloid leukemia);05221(Acute myeloid leukemia);05222(Small cell lung cancer);05223(Non-small cell lung cancer)NANAphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977]14.322.0810.761.5111.681.9726.933.9621.013.9621.403.970.06-4.120.000.02downyes
1343"="chr1-98501099910336ENST0000040090451206MSTRG.182CTNNBIP1GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0001658(branching involved in ureteric bud morphogenesis);GO:0002528(regulation of vascular permeability involved in acute inflammatory response);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0008013(beta-catenin binding);GO:0009952(anterior/posterior pattern specification);GO:0016055(Wnt signaling pathway);GO:0030178(negative regulation of Wnt signaling pathway);GO:0030877(beta-catenin destruction complex);GO:0031333(negative regulation of protein complex assembly);GO:0032091(negative regulation of protein binding);GO:0043392(negative regulation of DNA binding);GO:0043433(negative regulation of sequence-specific DNA binding transcription factor activity);GO:0045657(positive regulation of monocyte differentiation);GO:0045669(positive regulation of osteoblast differentiation);GO:0048662(negative regulation of smooth muscle cell proliferation);GO:0060633(negative regulation of transcription initiation from RNA polymerase II promoter);GO:0070016(armadillo repeat domain binding);GO:0072201(negative regulation of mesenchymal cell proliferation)04310(Wnt signaling pathway)NANAcatenin, beta interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16913]28.184.0926.603.7324.844.1910.811.598.981.699.181.700.62-0.700.110.21downno
1348"="chr1-99289399943329ENST0000037722382281MSTRG.191LZICGO:0008013(beta-catenin binding);GO:0010212(response to ionizing radiation)NANANAleucine zipper and CTNNBIP1 domain containing [Source:HGNC Symbol;Acc:HGNC:17497]30.294.4032.814.6024.584.1413.441.9812.722.4012.722.362.571.360.430.57upno
1354"="chr1+99434289985498ENST0000037720553781MSTRG.194NMNAT1GO:0000309(nicotinamide-nucleotide adenylyltransferase activity);GO:0003824(catalytic activity);GO:0004515(nicotinate-nucleotide adenylyltransferase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006766(vitamin metabolic process);GO:0006767(water-soluble vitamin metabolic process);GO:0009058(biosynthetic process);GO:0009435(NAD biosynthetic process);GO:0016779(nucleotidyltransferase activity);GO:0019674(NAD metabolic process);GO:0044281(small molecule metabolic process)00760(Nicotinate and nicotinamide metabolism);01100(Metabolic pathways)K009692.7.7.18nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17877]2.600.3818.992.6616.382.764.120.613.320.633.330.62609.539.250.380.53upno
1355"="chr1+99434299983669ENST0000046268661818MSTRG.194NMNAT1GO:0000309(nicotinamide-nucleotide adenylyltransferase activity);GO:0003824(catalytic activity);GO:0004515(nicotinate-nucleotide adenylyltransferase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006766(vitamin metabolic process);GO:0006767(water-soluble vitamin metabolic process);GO:0009058(biosynthetic process);GO:0009435(NAD biosynthetic process);GO:0016779(nucleotidyltransferase activity);GO:0019674(NAD metabolic process);GO:0044281(small molecule metabolic process)00760(Nicotinate and nicotinamide metabolism);01100(Metabolic pathways)K009692.7.7.18nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17877]20.082.9200000000000.00-11.630.420.56downno
1362"="chr1+999721610016020ENST000002944354636MSTRG.190RBP7GO:0005215(transporter activity);GO:0005501(retinoid binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0006810(transport);GO:0008289(lipid binding);GO:0016918(retinal binding);GO:0019841(retinol binding)NANANAretinol binding protein 7, cellular [Source:HGNC Symbol;Acc:HGNC:30316]28.674.1625.023.5123.393.948.331.227.471.417.471.390.43-1.230.160.28downno
1363"="chr1+1003283210180367ENST00000253251274772MSTRG.197UBE4BGO:0000151(ubiquitin ligase complex);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006511(ubiquitin-dependent protein catabolic process);GO:0008626(granzyme-mediated apoptotic signaling pathway);GO:0009411(response to UV);GO:0016567(protein ubiquitination);GO:0016874(ligase activity);GO:0019899(enzyme binding);GO:0034450(ubiquitin-ubiquitin ligase activity);GO:0042787(protein ubiquitination involved in ubiquitin-dependent protein catabolic process);GO:0043161(proteasome-mediated ubiquitin-dependent protein catabolic process)04120(Ubiquitin mediated proteolysis);04141(Protein processing in endoplasmic reticulum)NANAubiquitination factor E4B [Source:HGNC Symbol;Acc:HGNC:12500]95.1113.8286.5212.1381.7213.7842.486.2433.226.2633.806.270.45-1.150.010.05downyes
1377"="chr1+1021080510308597ENST00000377093217565MSTRG.202KIF1BGO:0003777(microtubule motor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005871(kinesin complex);GO:0005874(microtubule);GO:0005875(microtubule associated complex);GO:0006915(apoptotic process);GO:0007018(microtubule-based movement);GO:0007270(neuron-neuron synaptic transmission);GO:0007274(neuromuscular synaptic transmission);GO:0008017(microtubule binding);GO:0008089(anterograde axon cargo transport);GO:0008152(metabolic process);GO:0008574(ATP-dependent microtubule motor activity, plus-end-directed);GO:0016192(vesicle-mediated transport);GO:0016887(ATPase activity);GO:0019894(kinesin binding);GO:0030659(cytoplasmic vesicle membrane);GO:0030705(cytoskeleton-dependent intracellular transport);GO:0031410(cytoplasmic vesicle);GO:0043005(neuron projection);GO:0047497(mitochondrion transport along microtubule)NANANAkinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636]5.080.7413.361.874.500.7613.762.0220.793.9120.483.8070.986.150.370.52upno
1378"="chr1+1021080510377937ENST00000263934476816MSTRG.202KIF1BGO:0003777(microtubule motor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005871(kinesin complex);GO:0005874(microtubule);GO:0005875(microtubule associated complex);GO:0006915(apoptotic process);GO:0007018(microtubule-based movement);GO:0007270(neuron-neuron synaptic transmission);GO:0007274(neuromuscular synaptic transmission);GO:0008017(microtubule binding);GO:0008089(anterograde axon cargo transport);GO:0008152(metabolic process);GO:0008574(ATP-dependent microtubule motor activity, plus-end-directed);GO:0016192(vesicle-mediated transport);GO:0016887(ATPase activity);GO:0019894(kinesin binding);GO:0030659(cytoplasmic vesicle membrane);GO:0030705(cytoskeleton-dependent intracellular transport);GO:0031410(cytoplasmic vesicle);GO:0043005(neuron projection);GO:0047497(mitochondrion transport along microtubule)NANANAkinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636]13.932.0230.464.2712.062.033.840.564.150.783.960.731456.4310.510.020.06upyes
1396"="chr1+1039908010420144ENST00000270776131885MSTRG.201PGDGO:0004616(phosphogluconate dehydrogenase (decarboxylating) activity);GO:0005634(nucleus);GO:0005829(cytosol);GO:0005975(carbohydrate metabolic process);GO:0006098(pentose-phosphate shunt);GO:0009051(pentose-phosphate shunt, oxidative branch);GO:0019322(pentose biosynthetic process);GO:0019521(D-gluconate metabolic process);GO:0044281(small molecule metabolic process);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome)00030(Pentose phosphate pathway);00480(Glutathione metabolism);01100(Metabolic pathways)NANAphosphogluconate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8891]163.4923.75194.3227.25141.8323.9187.3412.8468.3512.8769.1312.839.103.190.000.02upyes
1419"="chr1-1046246810472488ENST0000037703651403MSTRG.205DFFAGO:0000790(nuclear chromatin);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006309(apoptotic DNA fragmentation);GO:0006915(apoptotic process);GO:0006921(cellular component disassembly involved in execution phase of apoptosis);GO:0007165(signal transduction);GO:0012501(programmed cell death);GO:0043065(positive regulation of apoptotic process);GO:0070242(thymocyte apoptotic process);GO:1900118(negative regulation of execution phase of apoptosis);GO:1902511(negative regulation of apoptotic DNA fragmentation)NANANADNA fragmentation factor, 45kDa, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:2772]29.334.2622.073.0925.214.2521.233.1210.221.9210.111.880.16-2.640.560.69downno
1445"="chr1+1101240011026420ENST0000024018565367MSTRG.212TARDBPGO:0000166(nucleotide binding);GO:0001205(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001933(negative regulation of protein phosphorylation);GO:0003676(nucleic acid binding);GO:0003690(double-stranded DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003723(RNA binding);GO:0003730(mRNA 3'-UTR binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005726(perichromatin fibrils);GO:0005737(cytoplasm);GO:0006366(transcription from RNA polymerase II promoter);GO:0006397(mRNA processing);GO:0008380(RNA splicing);GO:0010629(negative regulation of gene expression);GO:0016607(nuclear speck);GO:0030264(nuclear fragmentation involved in apoptotic nuclear change);GO:0032024(positive regulation of insulin secretion);GO:0034976(response to endoplasmic reticulum stress);GO:0035061(interchromatin granule);GO:0042802(identical protein binding);GO:0043922(negative regulation by host of viral transcription);GO:0044822(poly(A) RNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0051726(regulation of cell cycle);GO:0070935(3'-UTR-mediated mRNA stabilization);GO:0071765(nuclear inner membrane organization)NANANATAR DNA binding protein [Source:HGNC Symbol;Acc:HGNC:11571]2.030.292.990.422.850.4838.765.7030.735.7930.805.720.28-1.850.230.36downno
1479"="chr1-1102652311047223ENST00000400897112439MSTRG.213MASP2GO:0001855(complement component C4b binding);GO:0001867(complement activation, lectin pathway);GO:0004252(serine-type endopeptidase activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0006508(proteolysis);GO:0006956(complement activation);GO:0006958(complement activation, classical pathway);GO:0008233(peptidase activity);GO:0045087(innate immune response);GO:0048306(calcium-dependent protein binding);GO:0070062(extracellular exosome)04610(Complement and coagulation cascades);05150(Staphylococcus aureus infection)NANAmannan-binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902]002.640.370096.6414.2173.4513.8373.6413.673.821.930.010.04upyes
1485"="chr1-1104479811047233ENST000004008985726MSTRG.213MASP2GO:0001855(complement component C4b binding);GO:0001867(complement activation, lectin pathway);GO:0004252(serine-type endopeptidase activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0006508(proteolysis);GO:0006956(complement activation);GO:0006958(complement activation, classical pathway);GO:0008233(peptidase activity);GO:0045087(innate immune response);GO:0048306(calcium-dependent protein binding);GO:0070062(extracellular exosome)04610(Complement and coagulation cascades);05150(Staphylococcus aureus infection)NANAmannan-binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902]0063.258.8700152.3622.40147.8527.84149.2227.6977764525931.2336.180.010.04upyes
1487"="chr1-1105458911060024ENST0000037695781266MSTRG.211SRMGO:0003824(catalytic activity);GO:0004766(spermidine synthase activity);GO:0005829(cytosol);GO:0006595(polyamine metabolic process);GO:0008152(metabolic process);GO:0008295(spermidine biosynthetic process);GO:0016740(transferase activity);GO:0034641(cellular nitrogen compound metabolic process);GO:0042803(protein homodimerization activity);GO:0044281(small molecule metabolic process)00270(Cysteine and methionine metabolism);00330(Arginine and proline metabolism);00410(beta-Alanine metabolism);00480(Glutathione metabolism);01100(Metabolic pathways)K007972.5.1.16spermidine synthase [Source:HGNC Symbol;Acc:HGNC:11296]78.3811.3976.5410.7367.5211.3827.504.0425.724.8425.724.770.80-0.310.830.88downno
1493"="chr1-1106661811099881ENST00000376936252808MSTRG.214EXOSC10GO:0000166(nucleotide binding);GO:0000176(nuclear exosome (RNase complex));GO:0000178(exosome (RNase complex));GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay);GO:0000460(maturation of 5.8S rRNA);GO:0000956(nuclear-transcribed mRNA catabolic process);GO:0003676(nucleic acid binding);GO:0003824(catalytic activity);GO:0004532(exoribonuclease activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0006139(nucleobase-containing compound metabolic process);GO:0006396(RNA processing);GO:0008408(3'-5' exonuclease activity);GO:0009048(dosage compensation by inactivation of X chromosome);GO:0016020(membrane);GO:0035327(transcriptionally active chromatin);GO:0044237(cellular metabolic process);GO:0044822(poly(A) RNA binding);GO:0071028(nuclear mRNA surveillance);GO:0071034(CUT catabolic process);GO:0071035(nuclear polyadenylation-dependent rRNA catabolic process);GO:0071044(histone mRNA catabolic process);GO:0071048(nuclear retention of unspliced pre-mRNA at the site of transcription);GO:0090503(RNA phosphodiester bond hydrolysis, exonucleolytic)03018(RNA degradation)NANAexosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138]74.4810.8290.5512.7066.3211.1858.518.6046.418.7447.058.736.382.670.010.04upyes
1508"="chr1-1110653511262507ENST00000361445588677MSTRG.220MTORGO:0000139(Golgi membrane);GO:0000724(double-strand break repair via homologous recombination);GO:0001030(RNA polymerase III type 1 promoter DNA binding);GO:0001031(RNA polymerase III type 2 promoter DNA binding);GO:0001032(RNA polymerase III type 3 promoter DNA binding);GO:0001156(TFIIIC-class transcription factor binding);GO:0001934(positive regulation of protein phosphorylation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0004674(protein serine/threonine kinase activity);GO:0005488(binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005741(mitochondrial outer membrane);GO:0005764(lysosome);GO:0005765(lysosomal membrane);GO:0005789(endoplasmic reticulum membrane);GO:0005829(cytosol);GO:0005942(phosphatidylinositol 3-kinase complex);GO:0005979(regulation of glycogen biosynthetic process);GO:0006109(regulation of carbohydrate metabolic process);GO:0006207('de novo' pyrimidine nucleobase biosynthetic process);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0006468(protein phosphorylation);GO:0006950(response to stress);GO:0007050(cell cycle arrest);GO:0007165(signal transduction);GO:0007173(epidermal growth factor receptor signaling pathway);GO:0007281(germ cell development);GO:0007584(response to nutrient);GO:0008144(drug binding);GO:0008286(insulin receptor signaling pathway);GO:0008543(fibroblast growth factor receptor signaling pathway);GO:0010467(gene expression);GO:0010507(negative regulation of autophagy);GO:0010592(positive regulation of lamellipodium assembly);GO:0010628(positive regulation of gene expression);GO:0010831(positive regulation of myotube differentiation);GO:0012505(endomembrane system);GO:0016020(membrane);GO:0016049(cell growth);GO:0016242(negative regulation of macroautophagy);GO:0016301(kinase activity);GO:0016310(phosphorylation);GO:0016605(PML body);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0016773(phosphotransferase activity, alcohol group as acceptor);GO:0018105(peptidyl-serine phosphorylation);GO:0018107(peptidyl-threonine phosphorylation);GO:0019904(protein domain specific binding);GO:0030030(cell projection organization);GO:0030163(protein catabolic process);GO:0030425(dendrite);GO:0030838(positive regulation of actin filament polymerization);GO:0031295(T cell costimulation);GO:0031529(ruffle organization);GO:0031641(regulation of myelination);GO:0031669(cellular response to nutrient levels);GO:0031929(TOR signaling);GO:0031931(TORC1 complex);GO:0031932(TORC2 complex);GO:0031998(regulation of fatty acid beta-oxidation);GO:0032095(regulation of response to food);GO:0032868(response to insulin);GO:0032956(regulation of actin cytoskeleton organization);GO:0032991(macromolecular complex);GO:0034605(cellular response to heat);GO:0038095(Fc-epsilon receptor signaling pathway);GO:0040007(growth);GO:0043022(ribosome binding);GO:0043025(neuronal cell body);GO:0043087(regulation of GTPase activity);GO:0043200(response to amino acid);GO:0043610(regulation of carbohydrate utilization);GO:0045087(innate immune response);GO:0045670(regulation of osteoclast differentiation);GO:0045727(positive regulation of translation);GO:0045792(negative regulation of cell size);GO:0045859(regulation of protein kinase activity);GO:0045945(positive regulation of transcription from RNA polymerase III promoter);GO:0046777(protein autophosphorylation);GO:0046889(positive regulation of lipid biosynthetic process);GO:0046983(protein dimerization activity);GO:0048010(vascular endothelial growth factor receptor signaling pathway);GO:0048011(neurotrophin TRK receptor signaling pathway);GO:0048015(phosphatidylinositol-mediated signaling);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051219(phosphoprotein binding);GO:0051496(positive regulation of stress fiber assembly);GO:0051534(negative regulation of NFAT protein import into nucleus);GO:0051897(positive regulation of protein kinase B signaling);GO:0055006(cardiac cell development);GO:0071456(cellular response to hypoxia);GO:1900034(regulation of cellular response to heat);GO:1903147(negative regulation of mitochondrion degradation)04012(ErbB signaling pathway);04150(mTOR signaling pathway);04910(Insulin signaling pathway);04920(Adipocytokine signaling pathway);04930(Type II diabetes mellitus);05200(Pathways in cancer);05214(Glioma);05215(Prostate cancer);05221(Acute myeloid leukemia)NANAmechanistic target of rapamycin (serine/threonine kinase) [Source:HGNC Symbol;Acc:HGNC:3942]95.2413.83108.2415.1882.5113.9162.499.1954.6710.3055.3110.263.081.620.270.42upno
1531"="chr1-1164836711654682ENST0000035428761560MSTRG.227FBXO2GO:0001540(beta-amyloid binding);GO:0001948(glycoprotein binding);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0006464(cellular protein modification process);GO:0006508(proteolysis);GO:0006511(ubiquitin-dependent protein catabolic process);GO:0006516(glycoprotein catabolic process);GO:0008285(negative regulation of cell proliferation);GO:0016567(protein ubiquitination);GO:0019005(SCF ubiquitin ligase complex);GO:0030246(carbohydrate binding);GO:0030433(ER-associated ubiquitin-dependent protein catabolic process);GO:0031090(organelle membrane);GO:0031146(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0031396(regulation of protein ubiquitination);GO:0043197(dendritic spine);GO:0070062(extracellular exosome)04120(Ubiquitin mediated proteolysis);04141(Protein processing in endoplasmic reticulum)NANAF-box protein 2 [Source:HGNC Symbol;Acc:HGNC:13581]2.760.402.840.402.760.4723.323.4316.793.1616.833.120.29-1.780.130.23downno
1546"="chr1+1166412411674354ENST0000037675361520MSTRG.228FBXO6GO:0000077(DNA damage checkpoint);GO:0001948(glycoprotein binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0006281(DNA repair);GO:0006508(proteolysis);GO:0006516(glycoprotein catabolic process);GO:0006986(response to unfolded protein);GO:0016567(protein ubiquitination);GO:0019005(SCF ubiquitin ligase complex);GO:0030246(carbohydrate binding);GO:0030433(ER-associated ubiquitin-dependent protein catabolic process);GO:0031146(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0061630(ubiquitin protein ligase activity)04141(Protein processing in endoplasmic reticulum)NANAF-box protein 6 [Source:HGNC Symbol;Acc:HGNC:13585]33.634.8943.986.1730.665.1712.401.829.741.8310.701.9917.604.140.020.06upyes
1567"="chr1+1173615511750765ENST0000031434051107MSTRG.230AGTRAPGO:0000139(Golgi membrane);GO:0001666(response to hypoxia);GO:0004945(angiotensin type II receptor activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005789(endoplasmic reticulum membrane);GO:0005886(plasma membrane);GO:0005938(cell cortex);GO:0008217(regulation of blood pressure);GO:0016021(integral component of membrane);GO:0030659(cytoplasmic vesicle membrane);GO:0038166(angiotensin-activated signaling pathway);GO:0043231(intracellular membrane-bounded organelle)NANANAangiotensin II receptor-associated protein [Source:HGNC Symbol;Acc:HGNC:13539]58.518.5036.475.1129.434.969.721.436.981.316.981.300.25-1.980.680.77downno
1612"="chr1-1191959111926423ENST0000037657232815MSTRG.231KIAA2013GO:0016020(membrane);GO:0016021(integral component of membrane)NANANAKIAA2013 [Source:HGNC Symbol;Acc:HGNC:28513]113.1516.44139.3219.5498.2216.56174.8825.71151.2728.48153.5128.493.651.870.260.40upno
1619"="chr1+1193475311975537ENST00000196061192940MSTRG.238PLOD1GO:0001666(response to hypoxia);GO:0005506(iron ion binding);GO:0005783(endoplasmic reticulum);GO:0005789(endoplasmic reticulum membrane);GO:0006464(cellular protein modification process);GO:0008198(ferrous iron binding);GO:0008475(procollagen-lysine 5-dioxygenase activity);GO:0008544(epidermis development);GO:0016491(oxidoreductase activity);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0016706(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors);GO:0017185(peptidyl-lysine hydroxylation);GO:0030198(extracellular matrix organization);GO:0030867(rough endoplasmic reticulum membrane);GO:0031418(L-ascorbic acid binding);GO:0032870(cellular response to hormone stimulus);GO:0042277(peptide binding);GO:0042803(protein homodimerization activity);GO:0046947(hydroxylysine biosynthetic process);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome)00310(Lysine degradation)NANAprocollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:9081]236.9134.41258.1536.20204.0734.41174.8025.70138.3626.05140.1126.002.381.250.010.04upyes
1624"="chr1+1198018112013514ENST00000444836184531MSTRG.239MFN2GO:0001825(blastocyst formation);GO:0003924(GTPase activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005739(mitochondrion);GO:0005741(mitochondrial outer membrane);GO:0005829(cytosol);GO:0006626(protein targeting to mitochondrion);GO:0006914(autophagy);GO:0006915(apoptotic process);GO:0006986(response to unfolded protein);GO:0007006(mitochondrial membrane organization);GO:0007596(blood coagulation);GO:0008053(mitochondrial fusion);GO:0008152(metabolic process);GO:0015630(microtubule cytoskeleton);GO:0016021(integral component of membrane);GO:0031306(intrinsic component of mitochondrial outer membrane);GO:0031625(ubiquitin protein ligase binding);GO:0034497(protein localization to pre-autophagosomal structure);GO:0046580(negative regulation of Ras protein signal transduction);GO:0048593(camera-type eye morphogenesis);GO:0048662(negative regulation of smooth muscle cell proliferation);GO:0051646(mitochondrion localization)NANANAmitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877]15.722.2828.704.0214.652.476.050.895.871.105.821.08197.407.620.030.08upyes
1626"="chr1+1198031212013508ENST00000235329194539MSTRG.239MFN2GO:0001825(blastocyst formation);GO:0003924(GTPase activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005739(mitochondrion);GO:0005741(mitochondrial outer membrane);GO:0005829(cytosol);GO:0006626(protein targeting to mitochondrion);GO:0006914(autophagy);GO:0006915(apoptotic process);GO:0006986(response to unfolded protein);GO:0007006(mitochondrial membrane organization);GO:0007596(blood coagulation);GO:0008053(mitochondrial fusion);GO:0008152(metabolic process);GO:0015630(microtubule cytoskeleton);GO:0016021(integral component of membrane);GO:0031306(intrinsic component of mitochondrial outer membrane);GO:0031625(ubiquitin protein ligase binding);GO:0034497(protein localization to pre-autophagosomal structure);GO:0046580(negative regulation of Ras protein signal transduction);GO:0048593(camera-type eye morphogenesis);GO:0048662(negative regulation of smooth muscle cell proliferation);GO:0051646(mitochondrion localization)NANANAmitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877]86.2912.53101.6214.2575.6812.76125.0618.3996.3918.1597.4418.082.981.580.000.02upyes
1633"="chr1+1201946612032045ENST00000235332101573MSTRG.240MIIPGO:0005515(protein binding)NANANAmigration and invasion inhibitory protein [Source:HGNC Symbol;Acc:HGNC:25715]39.655.7639.395.5234.595.8320.903.0719.843.7420.143.740.63-0.670.680.78downno
1652"="chr1+1216700312209228ENST00000376259103683MSTRG.243TNFRSF1BGO:0005031(tumor necrosis factor-activated receptor activity);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005634(nucleus);GO:0005886(plasma membrane);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0007166(cell surface receptor signaling pathway);GO:0007568(aging);GO:0008630(intrinsic apoptotic signaling pathway in response to DNA damage);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030424(axon);GO:0031625(ubiquitin protein ligase binding);GO:0032496(response to lipopolysaccharide);GO:0033209(tumor necrosis factor-mediated signaling pathway);GO:0043025(neuronal cell body);GO:0043196(varicosity);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0050728(negative regulation of inflammatory response);GO:0050779(RNA destabilization);GO:0051044(positive regulation of membrane protein ectodomain proteolysis);GO:0071222(cellular response to lipopolysaccharide);GO:0071363(cellular response to growth factor stimulus);GO:0097191(extrinsic apoptotic signaling pathway)04060(Cytokine-cytokine receptor interaction);04920(Adipocytokine signaling pathway);05014(Amyotrophic lateral sclerosis (ALS))NANAtumor necrosis factor receptor superfamily, member 1B [Source:HGNC Symbol;Acc:HGNC:11917]38.595.6127.523.8630.395.1281.0711.9265.7112.3766.7712.390.01-6.080.000.02downyes
1659"="chr1+1223006712512047ENST000006130996916245MSTRG.246VPS13DGO:0005515(protein binding);GO:0005622(intracellular);GO:0005623(cell);GO:0006623(protein targeting to vacuole);GO:0019898(extrinsic component of membrane);GO:0045053(protein retention in Golgi apparatus);GO:0070062(extracellular exosome)NANANAvacuolar protein sorting 13 homolog D (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23595]30.864.4824.073.3732.625.505.470.804.290.815.411.000.06-4.110.110.21downno
1677"="chr1-1256791012617731ENST0000061666161722MSTRG.249DHRS3GO:0000166(nucleotide binding);GO:0001523(retinoid metabolic process);GO:0003151(outflow tract morphogenesis);GO:0004745(retinol dehydrogenase activity);GO:0005789(endoplasmic reticulum membrane);GO:0007601(visual perception);GO:0007603(phototransduction, visible light);GO:0008152(metabolic process);GO:0009055(electron carrier activity);GO:0016021(integral component of membrane);GO:0016491(oxidoreductase activity);GO:0030278(regulation of ossification);GO:0042572(retinol metabolic process);GO:0042622(photoreceptor outer segment membrane);GO:0048387(negative regulation of retinoic acid receptor signaling pathway);GO:0052650(NADP-retinol dehydrogenase activity);GO:0055114(oxidation-reduction process);GO:0060021(palate development);GO:0060349(bone morphogenesis);GO:0060411(cardiac septum morphogenesis)00830(Retinol metabolism);01100(Metabolic pathways)NANAdehydrogenase/reductase (SDR family) member 3 [Source:HGNC Symbol;Acc:HGNC:17693]216.4931.45333.6746.79190.0332.04504.0174.10398.8775.11403.4174.8649.495.630.010.03upyes
1870"="chr1-1557235315585110ENST0000037582672500MSTRG.271AGMATGO:0005739(mitochondrion);GO:0006595(polyamine metabolic process);GO:0008295(spermidine biosynthetic process);GO:0008783(agmatinase activity);GO:0016813(hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines);GO:0033388(putrescine biosynthetic process from arginine);GO:0034641(cellular nitrogen compound metabolic process);GO:0044281(small molecule metabolic process);GO:0046872(metal ion binding);GO:0070062(extracellular exosome);GO:0097055(agmatine biosynthetic process)NAK014803.5.3.11agmatine ureohydrolase (agmatinase) [Source:HGNC Symbol;Acc:HGNC:18407]100.8914.66136.6619.1686.0914.52214.9331.60167.8831.61169.8131.5112.313.620.010.03upyes
1876"="chr1+1561750015669044ENST000004809451010625MSTRG.274DDI2GO:0004190(aspartic-type endopeptidase activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006508(proteolysis)NANANADNA-damage inducible 1 homolog 2 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:24578]63.619.2466.289.2954.429.1891.7213.4870.5613.2971.6913.300.82-0.290.110.21downno
1884"="chr1+1568433215734769ENST00000375799204122MSTRG.275PLEKHM2GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0007030(Golgi organization);GO:0019894(kinesin binding);GO:0032880(regulation of protein localization)NANANApleckstrin homology domain containing, family M (with RUN domain) member 2 [Source:HGNC Symbol;Acc:HGNC:29131]19.022.7628.974.0617.172.9039.135.7531.185.8731.755.8918.174.180.010.05upyes
1885"="chr1+1568439015734769ENST00000375793194004MSTRG.275PLEKHM2GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0007030(Golgi organization);GO:0019894(kinesin binding);GO:0032880(regulation of protein localization)NANANApleckstrin homology domain containing, family M (with RUN domain) member 2 [Source:HGNC Symbol;Acc:HGNC:29131]24.773.6017.132.4021.033.554.300.632.230.422.170.400.10-3.250.220.35downno
1970"="chr1-1612433716156087ENST00000358432173964MSTRG.287EPHA2GO:0001501(skeletal system development);GO:0001525(angiogenesis);GO:0001568(blood vessel development);GO:0001570(vasculogenesis);GO:0001649(osteoblast differentiation);GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004714(transmembrane receptor protein tyrosine kinase activity);GO:0005003(ephrin receptor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005622(intracellular);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005925(focal adhesion);GO:0006468(protein phosphorylation);GO:0007155(cell adhesion);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0007275(multicellular organismal development);GO:0007411(axon guidance);GO:0008630(intrinsic apoptotic signaling pathway in response to DNA damage);GO:0009986(cell surface);GO:0010591(regulation of lamellipodium assembly);GO:0014028(notochord formation);GO:0016021(integral component of membrane);GO:0016032(viral process);GO:0016477(cell migration);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0021915(neural tube development);GO:0030182(neuron differentiation);GO:0030216(keratinocyte differentiation);GO:0030316(osteoclast differentiation);GO:0031256(leading edge membrane);GO:0031258(lamellipodium membrane);GO:0032587(ruffle membrane);GO:0033598(mammary gland epithelial cell proliferation);GO:0033628(regulation of cell adhesion mediated by integrin);GO:0036342(post-anal tail morphogenesis);GO:0043491(protein kinase B signaling);GO:0043535(regulation of blood vessel endothelial cell migration);GO:0045765(regulation of angiogenesis);GO:0046849(bone remodeling);GO:0048013(ephrin receptor signaling pathway);GO:0048320(axial mesoderm formation);GO:0048570(notochord morphogenesis);GO:0051898(negative regulation of protein kinase B signaling);GO:0060035(notochord cell development);GO:0060326(cell chemotaxis);GO:0060444(branching involved in mammary gland duct morphogenesis);GO:0070309(lens fiber cell morphogenesis);GO:0070372(regulation of ERK1 and ERK2 cascade);GO:0070848(response to growth factor);GO:0090004(positive regulation of establishment of protein localization to plasma membrane);GO:0090630(activation of GTPase activity)04360(Axon guidance)NANAEPH receptor A2 [Source:HGNC Symbol;Acc:HGNC:3386]14.232.0714.732.0712.342.0898.3414.4698.8618.62100.3518.620.09-3.430.250.39downno
2002"="chr1+1636726516398142ENST0000049235433401MSTRG.293SZRD1NANANANASUZ RNA binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30232]16.532.402.860.4015.612.633.690.542.880.542.990.550.00-15.550.000.02downyes
2014"="chr1+1644067216460078ENST0000033713282070MSTRG.298NECAP2GO:0005622(intracellular);GO:0005886(plasma membrane);GO:0005905(coated pit);GO:0006897(endocytosis);GO:0015031(protein transport);GO:0016020(membrane);GO:0030125(clathrin vesicle coat)NANANANECAP endocytosis associated 2 [Source:HGNC Symbol;Acc:HGNC:25528]20.683.0033.554.7118.543.1390.4813.3070.8713.3571.8813.3420.314.340.010.04upyes
2021"="chr1+1644074316460077ENST0000049209591787MSTRG.298NECAP2GO:0005622(intracellular);GO:0005886(plasma membrane);GO:0005905(coated pit);GO:0006897(endocytosis);GO:0015031(protein transport);GO:0016020(membrane);GO:0030125(clathrin vesicle coat)NANANANECAP endocytosis associated 2 [Source:HGNC Symbol;Acc:HGNC:25528]20.102.9221.082.9618.223.070.860.130.900.170.890.172.821.490.050.12upno
2076"="chr1-1666678516666948ENST000003847821164MSTRG.303RNU1-3NANANANANA224.5332.62257.4936.11194.0632.72000000114.746.840.000.01upyes
2089"="chr1+1674051616740679ENST000003846591164MSTRG.309RNU1-4NANANANANA224.2232.57255.2135.79193.5832.64000000105.156.720.000.01upyes

document location:

summary/3_2_transcript_differential_expression/*VS*/Gene_differential_expression.xlsx

summary/3_2_transcript_differential_expression/*VS*/Transcript_differential_expression.xlsx


4.7.2 Volcano of differentially expressed genes/transcripts




document location:

summary/3_2_transcript_differential_expression/*VS*/*_Genes_volcano.png

summary/3_2_transcript_differential_expression/*VS*/*_Transcript_volcano.png


4.7.3 Heatmap of differentially expressed genes/transcripts




document location:

summary/3_2_transcript_differential_expression/*VS*/*_genes_heatmap.png

summary/3_2_transcript_differential_expression/*VS*/*_transcripts_heatmap.png


4.7.4 GO enrichment analysis of differentially expressed genes


Gene ontology (GO) (http://www.geneontology.org) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis.

GO is part of a larger classification effort, the Open Biomedical Ontologies (OBO).

Although gene nomenclature itself aims to maintain and develop controlled vocabulary of gene and gene products, the Gene Ontology extends the effort by using markup language to make the data (not only of the genes and their products but also of all their attributes) machine readable, and to do so in a way that is unified across all species (whereas gene nomenclature conventions vary by biologic taxon).


Significant GO terms::

GO_IDGO_TermGO_functionGO_classGenesS gene numberTS gene numberB gene numberTB gene numberpvalue
GO:0006415translational terminationbiological_process8ETF1;GSPT2;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;UBA526121208470870.00
GO:0006414translational elongationbiological_process8EEF1A1;EEF1B2;EEF1D;EEF1G;ELOF1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;TCEA2;UBA526521209470870.00
GO:0006614SRP-dependent cotranslational protein targeting to membranebiological_process9DDOST;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SEC11A;SRP54;SRP9;SSR1;SSR2;TRAM1;UBA5267212010270870.00
GO:0006413translational initiationbiological_process8ABCF1;DDX3Y;EIF2B2;EIF2D;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF3L;EIF4A2;EIF4E2;EIF4H;EIF5B;PABPC1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;UBA5277212012870870.00
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decaybiological_process11CASC3;EIF3E;ETF1;GSPT2;PABPC1;PARN;PPP2CA;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;UBA52;UPF2;WIBG68212010970870.00
GO:0070062extracellular exosomecellular_component7ABCB1;ABCB4;ACACA;ACAT2;ACLY;ACMSD;ACOT13;ACP1;ACP5;ACSL4;ACSM1;ACTA2;ACTN4;ADAM9;ADGRE5;ADH6;AEBP1;AFM;AGA;AHSG;AK2;AK4;AKR1B10;AKR7A2;ALCAM;ALDH1A3;ALDH1L1;ALDH2;ALDH6A1;ALDH7A1;ALDOB;ANGPTL1;ANGPTL2;ANGPTL6;ANXA2;ANXA7;AP1S1;AP2M1;APMAP;APOA2;APOC3;APOM;ARF6;ARG1;ARHGEF12;ARPC2;ARPC5L;ARSD;ASL;ASPA;ATAD2;ATP5J2;ATP6V1B2;ATP6V1C1;AXL;AZGP1;B2M;B3GNT2;BAIAP2;BASP1;BAX;BCAM;BDH2;BHMT2;BOLA2B;BPNT1;BST1;BST2;BTN2A1;C1QA;C1QB;C1QC;C1RL;C1S;C3;C6;C7;C8A;C8B;CA2;CADM1;CAD;CALM1;CANX;CAP1;CAPG;CAPZA2;CASC5;CAT;CCT2;CCT3;CCT4;CCT6A;CCT7;CD2AP;CD55;CD63;CD74;CD81;CDK1;CETP;CFD;CFI;CH507-152C13.3;CHMP2B;CIB1;CLDN2;CLDN3;CMPK1;CMTM6;COL18A1;COL1A2;COL6A1;COL6A2;COTL1;COX4I1;COX5A;CPB2;CPN2;CP;CREG1;CRISPLD2;CRYAA;CSE1L;CSNK2B;CSRP1;CST3;CSTA;CTSA;CTSC;CTSD;CTSF;CTSH;CTSL;CTSZ;CTTN;CXCR4;CYB5R1;CYB5R3;CYFIP2;CYSTM1;DAB2;DAD1;DBI;DCXR;DDC;DEFB1;DLST;DNAJB1;DNAJC7;DPP7;DPT;DPYSL2;DSG1;DUSP3;ECHDC1;ECHS1;EEF1A1;EEF1G;EFEMP1;EFNA1;EFR3A;EIF3E;EIF3H;EIF3I;ELFN1;ENO3;ENOPH1;ENPEP;F11;F12;FABP1;FAM129B;FAM151A;FAM171A1;FAM20A;FAM20C;FAM3C;FBLN2;FBN1;FBP1;FCGR3A;FCN2;FETUB;FGB;FGG;FIBP;FKBP1A;FKBP4;FLNA;FN1;FNBP1L;FOLH1;FRK;FSCN1;FTL;FUCA1;FUCA2;FZD4;G6PD;GALNT2;GANAB;GARS;GAS6;GDF15;GDI2;GFPT1;GGH;GIPC2;GLO1;GLRX3;GLYAT;GNA11;GNA13;GNAI1;GNAI2;GNAS;GNAZ;GNB1;GNG5;GOT2;GPC1;GPC3;GPT;GPX1;GRB2;GSR;GSS;GSTO1;H2AFX;H2AFY;H3F3A;H3F3B;HAGH;HBA1;HBA2;HBB;HDDC2;HEBP1;HINT3;HIST1H2AC;HIST1H2AI;HIST1H2AK;HIST1H2BC;HIST1H2BG;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H2AC;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HLA-B;HLA-DRB1;HLA-DRB5;HNRNPA1;HNRNPD;HNRNPK;HNRNPM;HPD;HPX;HRSP12;HSP90AA1;HSP90B1;HSPA8;HSPE1;HSPG2;IARS;ICAM1;IDH1;IDH2;IFT20;IGF2R;IGFALS;IGFBP2;IGFBP3;IGFBP7;IGHA1;IGSF8;IMPDH2;IRF6;ISOC1;IST1;ITGAV;ITGB5;ITM2C;JUP;KDELR2;KRT7;LAD1;LAMA2;LAMB2;LAMC1;LAMP1;LAMP2;LAMTOR1;LASP1;LBP;LCP1;LGALS3BP;LGALS8;LGMN;LIN7A;LIN7C;LIPA;LSP1;LTBP3;LTBP4;LUM;LYPLA1;LYPLA2;LYVE1;MAL2;MAN1A2;MAN1C1;MAN2B1;MAOB;MAPK1;MARC2;MARCKS;MAT2B;MDH2;MEP1A;METTL7A;MGAT4A;MGRN1;MGST3;MITD1;MME;MMRN2;MOGS;MON2;MPDU1;MRGPRF;MSRA;MTHFD1;MUC13;MXRA8;MYH11;MYH9;MYO5C;NAMPT;NAPG;NCL;NDRG2;NDUFA13;NDUFA4;NDUFB9;NEDD4;NPNT;NRAS;NSF;NUDT1;NUDT5;OAF;OLA1;ORM1;PA2G4;PABPC1L;PABPC1;PAH;PARD6B;PARK7;PBLD;PCK1;PCK2;PCMT1;PCNA;PCOLCE2;PCOLCE;PCYOX1;PDCD2;PDCD6IP;PDDC1;PDHB;PDIA3;PDIA6;PDZK1;PEF1;PFDN2;PFKL;PGD;PGLS;PGM1;PGRMC1;PIGR;PITPNB;PLAUR;PLAU;PLCB1;PLP2;PLS1;PLSCR4;PLVAP;PM20D2;PPA1;PPAP2B;PPIB;PPL;PPP1CA;PPP2CA;PPP2CB;PPP2R1B;PRDX1;PRDX3;PRDX6;PRELP;PRKCZ;PROZ;PRSS23;PRSS8;PSMA2;PSMA3;PSMA7;PSMB1;PSMB5;PSMB8;PSMD13;PTBP1;PTER;PTH1R;PTPN6;PTPRD;PVRL2;PVR;PXDN;PYGB;PZP;QDPR;QSOX1;RAB11A;RAB11B;RAB13;RAB14;RAB7A;RAB8A;RACGAP1;RARS;RBKS;RBL2;RDX;RHEB;RHOBTB3;RHOB;RHOC;RHOF;RHOG;RNASE1;RNASET2;RPE;RPL10A;RPL11;RPL12;RPL14;RPL23A;RPL23;RPL24;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL37A;RPL3;RPL4;RPL7A;RPL7;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS13;RPS16;RPS17;RPS18;RPS19;RPS25;RPS26;RPS27A;RPS29;RPS3A;RPS3;RPS4X;RPS5;RPS7;RPS8;RPS9;RPSA;RRM1;RSU1;S100A11;S100A16;S100A8;SAA1;SAA2;SAMM50;SARS;SCAMP3;SCP2;SEC11A;SEC13;SELENBP1;SEMA5A;SERPINA1;SERPINB6;SERPINF1;SERPING1;SERPINH1;SERPINI1;SH3BP4;SHISA5;SHMT1;SLC1A4;SLC25A25;SLC25A5;SLC44A2;SLC46A3;SMPDL3A;SNRPB;SNRPE;SNX12;SNX18;SOD1;SOD2;SPINK1;SPON2;SPP1;SPPL2A;SPR;SPTAN1;SRP9;SSBP1;ST14;STEAP4;STK26;STMN1;STOM;STX12;STX3;TBC1D4;TBCA;TCP1;TGM2;THBS4;THY1;TINAGL1;TKT;TM7SF3;TMBIM1;TMC6;TMPRSS2;TNFAIP3;TOM1L2;TOM1;TOMM40;TOR3A;TPM3;TPRG1L;TRMT112;TSPAN3;TSPAN8;TSPO;TSTA3;TTYH3;TUBA1B;TUBB2A;TUBB6;UBA52;UBAC1;UBE2D2;UBE2G1;UBE2K;UBE2M;UBE2N;UBL3;UEVLD;UGDH;UGT2B7;UQCR10;UXS1;VASN;VCL;VDAC1;VIL1;VMO1;VPS4A;VSIG4;WARS;WWP1;XPC;XPNPEP2;YBX1;YWHAZ;ZNF4455972120162870870.00
GO:0019083viral transcriptionbiological_process9NUP205;NUP50;NUPL1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SEH1L;UBA5263212010270870.00
GO:0006412translationbiological_process7ABCF1;DDOST;EEF1A1;EEF1B2;EEF1D;EEF1G;EIF2B2;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF4A2;EIF4H;EIF5B;EPRS;ETF1;FARSB;GSPT2;HARS;IGF2BP3;MRPL13;MRPL14;MRPL16;MRPL18;MRPL20;MRPL24;MRPL34;MRPL36;MRPL51;MRPS12;PABPC1;PABPC4;QARS;RBM3;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS6KB2;RPS7;RPS8;RPS9;RPSA;RRBP1;RSL24D1;SARS;SEC11A;SRP54;SRP9;SSR1;SSR2;TRAM1;UBA52;WARS112212022270870.00
GO:0022627cytosolic small ribosomal subunitcellular_component12EIF2D;HBA1;HBA2;MCTS1;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA2921203670870.00
GO:0022625cytosolic large ribosomal subunitcellular_component11RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;UBA523621205070870.00
GO:0044267cellular protein metabolic processbiological_process6ADAMTSL4;ALG8;ARFGAP1;ARSD;B3GNT2;BLM;BRCA1;CANX;CBX4;CCT2;CCT3;CCT4;CCT6A;CCT7;CDKN2A;CFP;CTDSP2;CTSA;CTSZ;DAD1;DDOST;DNAJB11;DOLK;DOLPP1;DPH2;EDEM1;EEF1A1;EEF1B2;EEF1D;EEF1G;EIF2B2;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF4A2;EIF4H;EIF5B;ENPEP;ETF1;EXOC4;EXOC6;EXOC8;EXTL3;GALNT2;GANAB;GAS6;GFPT1;GNPNAT1;GRPEL2;GSPT2;HDGF;HERPUD1;HSP90B1;IGF1;IGFALS;IGFBP2;IGFBP3;IGFBP4;KDELR3;LMNA;MAN1A2;MAN1C1;MBTPS2;MCFD2;MGAT4A;MLEC;MME;MMP2;MOGS;MUC13;NPL;NUP205;NUP50;NUPL1;PABPC1;PDIA3;PDIA6;PFDN2;PFDN6;PIAS1;PIGC;PIGK;PIGM;PLA2G7;PLAUR;PMPCA;PMPCB;PPP2R5B;PROZ;RAD21;REN;RFT1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SAMM50;SEC11A;SEC13;SEC23A;SEC24D;SEH1L;SLC17A5;SLC25A6;SMC3;SMC5;SMC6;SRP54;SRP9;SSR1;SSR2;STAG1;SUMO1;TBCA;TBCB;TCP1;TIMM13;TOMM40;TRAM1;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6;TUSC3;UBA52;VKORC1;XPC188212044470870.00
GO:0019058viral life cyclebiological_process6CHMP2B;NUP205;NUP50;NUPL1;PDCD6IP;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SEH1L;SLC25A6;UBA52;VPS37A;VPS4A68212012670870.00
GO:0005840ribosomecellular_component9ABCF1;CANX;MRPL13;MRPL14;MRPL16;MRPL18;MRPL20;MRPL24;MRPL34;MRPL36;MRPL44;MRPL54;MRPS12;MRPS27;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS7;RPS8;RPS9;RPSA;RRBP1;RSL24D1;UBA5275212014570870.00
GO:0003735structural constituent of ribosomemolecular_function4MRPL13;MRPL14;MRPL16;MRPL18;MRPL20;MRPL24;MRPL34;MRPL36;MRPL51;MRPS12;MRPS35;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;RSL24D1;UBA5272212013970870.00
GO:0005576extracellular regioncellular_component3ACTN4;ADAM9;ADAMTS2;ADAMTSL2;AFM;AHSG;AOAH;APOA2;APOA5;APOC3;APOL1;APOL2;APOL6;APOM;ATG4C;AZGP1;B2M;BMPER;BOLA3;C19orf80;C1QA;C1QB;C1QC;C1QTNF1;C1S;C3;C4BPA;C6;C7;C8A;C8B;CALM1;CALU;CAPZA2;CCL21;CCL4;CCL5;CD163;CD55;CETP;CFD;CFI;CFP;CHST9;CLEC4M;COL18A1;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;COLEC10;COLEC11;CPN2;CP;CRISPLD2;CST3;CTGF;CTSD;CTSL;CXCL14;CYR61;DBH;DCN;DEFB1;DKK1;EFEMP1;EFNA1;EGFL7;EMC10;EPHA3;EREG;ESM1;F11;F12;F2R;FAM180A;FAM3C;FBLN2;FBN1;FCN2;FCN3;FGB;FGFR3;FGG;FLNA;FMOD;FN1;FOLR2;GAS6;GDF15;GNAS;H3F3A;H3F3B;HAMP;HBA1;HBA2;HBB;HEBP1;HGF;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HPX;HSP90AA1;HSP90B1;HSPG2;ICOS;IGF1;IGFALS;IGFBP2;IGFBP3;IGFBP4;IGFBP7;IGHA1;IGSF1;KIAA0100;LAMA2;LAMB2;LAMC1;LAMC3;LBP;LIPG;LTBP3;LTBP4;LUM;MASP1;MET;MFAP1;MMP2;MMRN1;NGFR;NOTCH1;NOTCH4;NPIPB15;NPNT;NPW;NTS;ORM1;PCCA;PCOLCE2;PKDCC;PLA2G7;PLAU;PLEK;PLGLB1;PLGLB2;PLTP;PLXNB1;PON2;PRELP;PROZ;PRSS8;PZP;REN;RNASET2;S100A8;SAA1;SAA2;SERPINA1;SERPINF1;SERPING1;SIGLEC1;SOD1;SPINT2;SPP1;ST14;SVEP1;TFPI;THBS2;THBS4;THEM6;TINAGL1;TNFRSF1B;TUFT1;UTS2;VCL;VWA8182212045170870.00
GO:0031012extracellular matrixcellular_component3ADAMTS16;ADAMTS2;ADAMTSL2;ADAMTSL4;AEBP1;ANXA2;ASPN;CFP;COL18A1;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;CPXM2;CTSD;CYR61;DCN;DPT;EFEMP1;EGFL7;FBLN2;FBN1;FKBP1A;FMOD;FN1;HNRNPM;HSP90B1;HSPG2;IGFBP7;LAMA2;LAMB2;LAMC1;LGALS3BP;LTBP3;LTBP4;LUM;MATN2;MMP14;MMP15;MMP2;NPNT;PCOLCE;PRELP;PXDN;RPSA;SERPINF1;SOD1;THBS2;THBS4;TINAGL15121209770870.00
GO:0005615extracellular spacecellular_component5ACTA2;ACTN4;ADAM9;ADGRE5;AEBP1;AFM;AFP;AHSG;ANGPTL1;ANGPTL2;ANXA2;APOA2;APOA5;APOC3;APOL1;APOM;ARG1;AXL;AZGP1;B2M;BMPER;C1QC;C1QTNF1;C1RL;C3;C4BPA;C8A;C8B;CA2;CAT;CCL21;CCL4;CCL5;CD36;CECR1;CETP;CFD;CFI;CFP;CMTM4;CMTM6;COL18A1;COL1A1;COL1A2;COL3A1;COL6A2;CPB2;CPXM2;CP;CRHBP;CST3;CSTA;CTGF;CTSC;CTSD;CTSF;CTSH;CTSL;CTSZ;CXCL14;DCN;DEFB1;DKK1;DLK1;DPT;DPYSL3;EEF1A1;EFEMP1;EGFL7;ENG;ENO3;EREG;F11;F12;FAM20C;FBN1;FETUB;FGB;FGG;FMOD;FN1;FUCA2;GAS6;GDF15;GGH;GNL3;GPC1;GPC3;HAMP;HDGF;HGF;HIST1H2BC;HIST1H2BG;HMGB2;HPX;HSPA8;HSPG2;ICAM1;IGF1;IGFALS;IGFBP2;IGFBP3;IGFBP4;IGFBP7;IGHA1;IK;IL27;IL33;IRF2BPL;KDSR;LAMC1;LBP;LCP1;LGALS3BP;LGALS8;LIME1;LIPG;LTBP4;LTB;LUM;MANF;MASP1;MEP1A;METRN;MMP2;MMRN2;MRPL18;MTUS1;MUC13;NAMPT;NENF;ORM1;PCOLCE;PIGR;PLA2G7;PLAU;PLTP;PMPCA;PPP1R1A;PRDX1;PRDX6;PRKAG2;PRSS8;PTGIS;PVR;PXDN;PZP;QSOX1;RAB11FIP4;RAMP1;RDX;REN;RNASET2;RPL39;S100A11;S100A8;SAA1;SAA2;SELENBP1;SELP;SERPINA1;SERPINB6;SERPINF1;SERPING1;SERPINI1;SMPDL3A;SOD1;SPINK1;SPON2;SPP1;SRPX2;ST14;STOM;TFPI;THBS4;THNSL2;TINAGL1;UTS2;VASN;VNN3;YWHAZ;ZSWIM5182212047170870.00
GO:0019843rRNA bindingmolecular_function7DDX21;MRPL16;MRPL20;RPF2;RPL11;RPL23A;RPL37;RPL8;RPL9;RPS11;RPS18;RPS4X;RPS4Y1;RPS91421201870870.00
GO:0015935small ribosomal subunitcellular_component11DAP3;MRPS12;RPS16;RPS18;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS29;RPS3;RPS4X;RPS5;RPS9;RPSA1621202270870.00
GO:0007095mitotic G2 DNA damage checkpointbiological_process13BLM;CCNA2;CDK1;CDK5RAP3;FOXN3;NBN;SYF2;TAOK382120870870.00
GO:0005925focal adhesioncellular_component6ACTN4;ADAM9;ADGRE5;ALCAM;ARF6;ARPC2;ARPC5L;B2M;CAP1;CAT;CD81;CD99;CSRP1;CTTN;DAB2;ENG;FGFR3;FLNA;GDI2;GNA13;HACD3;HNRNPK;HSP90B1;HSPA8;HSPG2;ICAM1;IGF2R;ILK;ITGA6;ITGAV;ITGB5;JUP;LASP1;LCP1;LIMA1;LIMS2;LRP1;MAPK1;MARCKS;MME;MMP14;MPZL1;MRC2;MYH9;NPM1;PABPC1;PDCD6IP;PDIA3;PLAUR;PLAU;PPFIA1;PPIB;PTK7;PVRL2;PVR;RDX;REXO2;RHOB;RHOG;RPL10A;RPL12;RPL13A;RPL18;RPL19;RPL23;RPL27;RPL30;RPL31;RPL37A;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS13;RPS16;RPS17;RPS18;RPS19;RPS29;RPS3A;RPS3;RPS4X;RPS5;RPS7;RPS8;RPS9;RSU1;SLC4A2;SNTB1;SYNPO2;TADA1;TES;TGM2;THY1;TNS1;TRPV4;TSPAN4;VCL;YWHAZ107212026270870.00
GO:0005581collagen trimercellular_component3C1QA;C1QB;C1QC;C1QTNF1;COL18A1;COL1A1;COL1A2;COL3A1;COL6A2;COLEC10;COLEC11;FCN2;FCN3;MARCO;MSR1;RPS181621202470870.00
GO:0005604basement membranecellular_component6ANXA2;COL18A1;CST3;FBN1;FN1;GSTO1;HSPG2;ITGA6;LAD1;LAMA2;LAMB2;LAMC1;LAMC3;MATN2;MMRN2;NPNT;P3H2;RPSA;SERPINF1;SMC3;THBS2;THBS4;USH2A2321204070870.00
GO:0010467gene expressionbiological_process6AIMP2;ANP32A;CARS2;CASC3;CCNC;CDC5L;CLNS1A;CNOT11;COX4I1;COX5A;COX6B1;COX6C;COX7A2L;COX7C;CREBBP;CSTF3;CTGF;CWC15;DDOST;DHX9;EEF1A1;EEF1B2;EEF1D;EEF1G;EIF2B2;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF4A2;EIF4H;EIF5B;EPRS;ETF1;EXOSC1;EXOSC5;EZH2;FARSB;G6PD;GARS;GLS2;GLS;GSPT2;GSR;GTF2E2;GTF2H1;H3F3A;H3F3B;HARS;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HNF4G;HNRNPA1;HNRNPD;HNRNPH1;HNRNPH2;HNRNPK;HNRNPM;HNRNPUL1;HNRNPU;HSPA8;IARS2;IARS;IGF2BP3;IPO8;LARS;LSM4;LSM7;LTB;MED16;MED20;MED30;NELFCD;NELFE;NOTCH1;NOTCH4;NR1H4;NR1I3;NR2F1;NR2F6;NR3C1;NR5A2;NRBP1;NUP205;NUP50;NUPL1;P2RX7;PABPC1;PAPOLA;PARN;POLR2G;POLR2I;POLR3C;PPA1;PPARD;PPP2CA;PRDX1;PRKAA2;PRKAG2;PSMA2;PSMA3;PSMA7;PSMB10;PSMB1;PSMB5;PSMB8;PSMC3;PSMC4;PSMD13;PTBP1;QARS;RARS;RHEB;RNMT;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;RQCD1;SARS;SEC11A;SEH1L;SET;SF3B1;SIN3A;SLBP;SNRNP40;SNRPA1;SNRPA;SNRPB2;SNRPB;SNRPE;SNRPF;SNRPG;SRP54;SRP9;SRSF3;SRSF4;SSR1;SSR2;TAF1D;TAF2;TAF4;TRAM1;U2AF2;UBA52;UBE2D1;UPF2;WARS;XPO5;YBX1;YWHAZ;ZNF143;ZNRD1218212060370870.00
GO:0005887integral component of plasma membranecellular_component7ABCA1;ABCB4;ADGRE5;ADRA1A;APOM;AQP3;AXL;BCAM;BST2;BTN2A1;C1QTNF1;C3AR1;C5AR1;CD163;CD1D;CD36;CD55;CD63;CD81;CD83;CD99;CLCN5;CLDN3;CLEC1B;CLEC4M;DCBLD2;DEGS1;EBP;EFNA1;ENPEP;EPHA3;EREG;F2RL1;F2R;FADS2;FAM26F;FAM47E-STBD1;FCER1G;FGFR3;FLVCR1;FOLH1;FZD4;GCGR;GPC1;GPC3;HLA-B;HLA-DPA1;HNRNPM;ICAM1;ICOS;IGF2R;IL17RC;ITGAV;KTN1;LAMP1;LAPTM5;LDLR;LGR4;LINC00116;LRP1;LY6E;LYVE1;MARCO;MEP1A;MET;MFSD2A;MME;MMP14;MMP15;MPP1;MPZL1;MRC1;MRGPRF;MSR1;NGFR;NOTCH4;NPY1R;P2RX7;P2RY13;PALM;PERP;PIGR;PLAUR;PLXNB1;PODXL2;PTAFR;PTH1R;PTK7;PTPRB;PTPRC;PTPRD;RAMP1;RAMP3;SELP;SEMA6A;SGCE;SLC10A1;SLC16A2;SLC16A3;SLC17A2;SLC17A3;SLC17A4;SLC17A5;SLC19A1;SLC1A4;SLC22A1;SLC22A3;SLC25A13;SLC25A5;SLC26A6;SLC28A1;SLC2A10;SLC4A2;ST14;STAB1;STAB2;STEAP4;STOM;TENM2;THY1;TM2D1;TM4SF5;TMPRSS2;TNFRSF21;TSPAN13;TUSC3;TYROBP;VIPR1128212033270870.00
GO:0005578proteinaceous extracellular matrixcellular_component5ADAMTS16;ADAMTS2;ADAMTSL2;ADAMTSL3;ADAMTSL4;ASPN;COL1A1;COL3A1;COL6A1;COL6A2;CRISPLD2;CTGF;CYR61;DCN;DPT;EFEMP1;FBLN2;FBN1;FMOD;FN1;GPC1;GPC3;HSPG2;LAMC1;LAMC3;LGALS3BP;LTBP4;LUM;MATN2;MMP2;NPNT;PRELP;PXDN;SERPINA1;SPOCK2;SPON2;TFIP11;THBS23821208070870.00
GO:0007155cell adhesionbiological_process4ACKR3;ADAM9;ADGRE5;ALCAM;ARF6;AZGP1;BCAM;CADM1;CCL4;CD24;CD36;CD4;CD99;CDH5;CHST10;CIB1;COL18A1;COL6A1;COL6A2;CTGF;CYR61;DPT;DSG1;EGFL7;EMP2;ENG;EPHA3;FEZ1;FN1;GAS6;HES1;ICAM1;IGFALS;IGFBP7;ITGA6;ITGA9;ITGAV;ITGB5;JUP;LAMA2;LAMB2;LAMC1;LAMC3;LGALS3BP;LYVE1;MMRN1;MPDZ;MYH9;PKN2;PPAP2B;PTK7;PVR;RHOB;RPSA;SDC3;SELP;SEMA5A;SIGLEC11;SPON2;SPP1;SRPX;SSX2IP;STAB1;STAB2;SVEP1;THBS2;THBS4;THEMIS2;TINAGL1;TNFRSF12A;TPM3;TROAP;VCL73212017770870.00
GO:0006898receptor-mediated endocytosisbiological_process8AP1S1;APOL1;CAP1;CD163;CD36;CETP;CFI;COL1A1;COL1A2;COL3A1;COLEC11;CTTN;FTL;HBA1;HBA2;HBB;HPX;HSP90AA1;HSP90B1;IGF2R;IGHA1;LDLR;LGALS3BP;LRP1;LRP3;MARCO;MASP1;MRC1;MSR1;PI4KB;RABEPK;SAA1;STAB1;STAB2;TINAGL1;TMPRSS23621207770870.00
GO:0003723RNA bindingmolecular_function6ASCC1;BRCA1;CASC3;CDKN2AIP;CRNKL1;CSTF3;CWC15;DDX10;DDX21;DDX3Y;DDX60;DKC1;EIF2D;EIF2S2;EIF4E2;EIF4H;ETF1;EXOSC1;EXOSC5;EZH2;FAM103A1;FARSB;HBP1;HNRNPA1;HNRNPD;HNRNPH1;HNRNPH2;HNRNPK;HNRNPM;HNRNPUL1;HNRNPU;HSP90B1;IGF2BP3;ILF2;IMP3;IMPDH2;LSM7;MCTS1;MPHOSPH6;MRPL44;NCL;NELFE;NIFK;NOP56;NOP9;NPM1;PABPC1L;PABPC1;PABPC4;PAPOLA;PARN;PDCD4;PNPT1;PPARGC1A;PPP1R8;PPP5C;PTBP1;PURB;PUS3;QKI;RAD51AP1;RBM39;RBM3;RBMS1;RNASET2;RNMT;RPL10A;RPL11;RPL14;RPL18;RPL19;RPL21;RPL24;RPL27A;RPL28;RPL30;RPL31;RPL34;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS16;RPS18;RPS25;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS9;RPUSD1;RPUSD3;SARS;SLBP;SNRPA;SNRPE;SNRPF;SNRPG;SON;SRP9;SRSF3;TARBP1;U2AF2;UHMK1;UPF2;WDHD1;XPO5;YBX1118212031270870.00
GO:0090307mitotic spindle assemblybiological_process9BIRC5;CHEK2;FLNA;KIF11;MYBL2;NEK2;RAB11A;RACGAP1821201070870.00
GO:0004888transmembrane signaling receptor activitymolecular_function5ADGRE5;ADGRG7;BCAM;CD4;CLDN3;CLEC1B;EBP;ENG;FCER1G;FZD4;GCGR;ICAM1;LGR4;LILRB5;LYVE1;MARCO;MRC1;NGFR;PLXNB1;PTH1R;SEMA6A;VIPR12221204270870.00
GO:0042542response to hydrogen peroxidebiological_process7ADAM9;BAD;CASP3;COL1A1;DUSP1;GNAO1;GPX1;HBA1;HBA2;HBB;JUN;PARK7;PPP1R15B;PPP2CB;PRDX3;SOD1;SOD2;STK26;TXNIP1921203570870.00
GO:0048678response to axon injurybiological_process6AIF1;ARG1;BAX;CST3;DPYSL3;FGFR3;MATN2;NTS;SOD1;SOD2;TSPO1121201770870.00
GO:0007186G-protein coupled receptor signaling pathwaybiological_process8ABCA1;ACKR3;ADGRE5;ADGRG7;ADRA1A;APOC3;ARHGEF12;C3AR1;C3;C5AR1;CALM1;CCL21;CCL5;CXCR4;DEFB1;F2RL1;F2R;FPR3;FZD4;GCGR;GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ;GNB1;GNG5;GPSM2;LGR4;MRGPRF;NPW;NPY1R;P2RY13;PREX1;PTAFR;PTH1R;PTPN6;RAMP1;RAMP3;RASD1;SORT1;TM2D1;VAV1;VIPR1;ZNF21947212011170870.00
GO:0006956complement activationbiological_process5C1QA;C1QB;C1QC;C1S;C3;C6;C7;C8A;C8B;CFD;CFP;FCN2;FCN3;MASP11421202470870.00
GO:0033630positive regulation of cell adhesion mediated by integrinbiological_process6ADAM9;CCL21;CD24;CIB1;PTPN6;SYK62120770870.00
GO:0050853B cell receptor signaling pathwaybiological_process8LIME1;MAPK1;PIK3CD;PTPN6;PTPRC;SYK62120770870.00
GO:0015701bicarbonate transportbiological_process8CA2;HBA1;HBA2;HBB;SLC26A6;SLC4A262120770870.00
GO:0032776DNA methylation on cytosinebiological_process12H3F3A;H3F3B;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4921201370870.00
GO:0005520insulin-like growth factor bindingmolecular_function6CTGF;CYR61;ESM1;IGF2R;IGFALS;IGFBP2;IGFBP3;IGFBP4;IGFBP7921201370870.00
GO:0008283cell proliferationbiological_process4ANXA7;ASCC3;BAD;BAX;BIN1;BOP1;BST2;BUB1B;BUB1;CD74;CD81;CDC25C;CDC27;CDK5RAP3;CENPF;CITED2;CKS1B;CKS2;CNOT11;CREBBP;CREG1;CSE1L;CYR61;DAB2;DKC1;DLGAP5;ECD;ENPEP;EPS15;FSCN1;GAS6;GNAI2;GNB1;GNL3;GPX1;HDGF;HHEX;IGF1;IGFBP4;IGSF8;ILK;KIF15;LIPA;LIPG;LRP1;MAPRE2;MCM7;MET;MORF4L1;NAA60;NBN;PA2G4;PAK1IP1;PCNA;PDZK1;PELO;PES1;PIM1;PPARD;PPP1R8;PRDX1;PTPN6;PURB;RPL23A;RPS27;SERPINF1;SYK;TSPO;XRCC5;ZMYND1170212017870870.00
GO:0005687U4 snRNPcellular_component9DDX39B;PRPF31;SNRPB;SNRPE;SNRPF;SNRPG;SNRPN72120970870.00
GO:0007204positive regulation of cytosolic calcium ion concentrationbiological_process12ADRA1A;C1QTNF1;C3AR1;C5AR1;CD55;CXCR4;F2RL1;F2R;GNA13;GNB1;PTH1R;SAA1;SWAP70;TRPV4;UTS21521202770870.00
GO:0006958complement activation, classical pathwaybiological_process10C1QA;C1QB;C1QC;C1RL;C1S;C3;C4BPA;C6;C7;C8A;C8B;CD55;CFI;SERPING11421202570870.01
GO:0005178integrin bindingmolecular_function6ACTN4;ADAM9;ANXA7;COL3A1;CTGF;CYR61;EMP2;ESM1;FBN1;FN1;ICAM1;IGF1;ILK;ITGA6;ITGB5;LAMB2;LTBP4;MMP14;NPNT;PPAP2B;SYK;THBS4;THY1;TSPAN4;TSPAN82521205370870.01
GO:0000786nucleosomecellular_component12H1FX;H2AFX;H2AFY;H3F3A;H3F3B;HIST1H2AC;HIST1H2AI;HIST1H2AK;HIST1H2BC;HIST1H2BG;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H2AC;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H41821203570870.01
GO:0000775chromosome, centromeric regioncellular_component12BIRC5;BUB1;CDCA8;CENPB;CENPF;CENPN;CENPQ;CENPW;HELLS;HJURP;MAD2L1;NDC80;NUF2;OIP5;PPP2CA;PPP2CB;RAD21;SMC3;STAG1;TNKS;WDHD12121204370870.01
GO:0005044scavenger receptor activitymolecular_function5ACKR3;CD163;CFI;LGALS3BP;MARCO;MSR1;STAB1;STAB2;TINAGL1;TMPRSS21021201670870.01
GO:0050776regulation of immune responsebiological_process5B2M;C3;CD81;FCER1G;FCGR2B;FCGR3A;FKBP1A;HLA-B;ICAM1;IFITM1;PTPRD;PVRL2;PVR;SPPL2A;TYROBP1521202870870.01
GO:0032432actin filament bundlecellular_component11FLNA;LCP1;MICALL2;VIL142120470870.01
GO:0032133chromosome passenger complexcellular_component12AURKA;AURKB;BIRC5;CDCA842120470870.01
GO:0050732negative regulation of peptidyl-tyrosine phosphorylationbiological_process10PRKCZ;PTPN6;PTPRC;SPINK142120470870.01
GO:2001046positive regulation of integrin-mediated signaling pathwaybiological_process10CD63;EMP2;FLNA;LIMS242120470870.01
GO:0005833hemoglobin complexcellular_component11CYB5R3;HBA1;HBA2;HBB42120470870.01
GO:0097208alveolar lamellar bodycellular_component13CTSH;LAMP1;RAB14;RAB7A42120470870.01
GO:0005834heterotrimeric G-protein complexcellular_component7GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ;GNB1;GNG5921201470870.01
GO:0042744hydrogen peroxide catabolic processbiological_process6CAT;GPX1;HBA1;HBA2;HBB;PRDX1;PRDX3;PRDX6;PXDN921201470870.01
GO:0016020membranecellular_component3ABCB1;ABCB4;ABCF1;ACLY;ACSL4;ADGRE5;ADGRG7;ADRA1A;AGPAT1;AGPAT6;AIMP2;AMFR;ANKLE2;ANXA2;ANXA7;AP1S1;AP3B1;AP3D1;APMAP;APOL2;AQP3;ARF6;ARHGEF12;ASCC3;ASPH;AVEN;B2M;B3GALT6;B3GNT2;B9D1;BAX;BCL2L10;BET1L;BIN1;BST2;BTN3A3;BUB1;BZW1;BZW2;C8A;C8B;CAD;CALU;CANX;CAPZA2;CAST;CAT;CCNB1;CCNB2;CD163;CD302;CD36;CD68;CD74;CD81;CDC5L;CDH5;CDK1;CDK5RAP3;CEP55;CFI;CHST10;CIB1;CISD2;CLCN5;CLEC4M;CLPTM1L;CMTM4;CMTM6;CNNM3;COL6A1;COPZ1;COX4I1;CSE1L;CSNK1G2;CTAGE5;CTSA;CTSC;CYB5R1;CYB5R3;CYC1;CYFIP2;CYP20A1;CYP51A1;DAD1;DBH;DCXR;DDOST;DDX1;DDX21;DDX24;DDX3Y;DEGS1;DHCR7;DHRS7;DHX9;DISP1;DLST;DNAJB11;DNAJB6;DNAJC7;DOLPP1;DPYSL2;DRG2;DSG1;DYNLL2;EDEM1;EEF1A1;EEF1G;EFNA1;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3L;EIF4ENIF1;EIF4H;ELOVL5;EML4;ENO3;ENPP7;ENTPD8;EPRS;EPS15;ERGIC3;ERH;EXOC4;EXOC8;F11;FADS1;FADS2;FAM120A;FAM151A;FAM47E-STBD1;FARSB;FCER1G;FIBP;FKBP1A;FKBP8;FLNA;FOLH1;FOLR2;FTL;FZD4;G6PC;G6PD;GALNT2;GANAB;GAS2;GCGR;GCNT2;GDI2;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNB1;GNG5;GNL3;GNPAT;GOLGB1;GOLT1B;GOPC;GPC1;GPC3;GRB2;GTF2I;GTPBP4;HBA1;HBA2;HEATR1;HERPUD1;HGF;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H4B;HIST4H4;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HMHA1;HMMR;HNRNPA1;HNRNPH1;HNRNPH2;HNRNPK;HNRNPM;HNRNPU;HOMER1;HSD11B1;HSP90AA1;HSP90B1;HSPA8;HSPE1;IARS;ICAM1;IFITM1;IGF2R;IGSF1;IGSF8;ILF2;ILK;IMPDH2;ITGA9;ITGAV;JUP;KCNAB2;KCND3;KDSR;KIAA2018;KIF11;KIF14;KIF15;KIF4A;KPNA2;KTN1;LAMC3;LAMP1;LAMP2;LARP4B;LDLR;LGALS3BP;LGALS8;LIN7A;LMBRD1;LMNB1;LONP2;LPCAT3;LPPR2;LRRC1;LRRC8A;LSP1;LTB;LYVE1;MAL2;MAMDC4;MAN1A2;MAN1C1;MAP3K13;MARCH6;MARCKS;MARCO;MBTPS2;MCM4;MCM5;MCM7;MDH2;MED16;MEP1A;METTL7A;MET;MFSD5;MGAT4A;MGRN1;MGST3;MLEC;MME;MOGS;MOSPD2;MPDU1;MPP1;MRC2;MSH2;MSR1;MSRA;MTHFD1;MTMR7;MYH9;NCAPD2;NCAPG2;NCAPG;NCAPH2;NCL;NDC1;NDC80;NEDD4;NELFCD;NENF;NIPSNAP1;NOP56;NOP58;NOTCH1;NOTCH4;NPM1;NPNT;NR3C1;NRAS;NRBP1;NSMF;NUF2;NUP205;NUS1;OCIAD1;OGFR;OLA1;ORAI3;ORC6;OSBP;P2RX7;P4HA1;PA2G4;PABPC1;PAF1;PALM;PARP14;PDCD6IP;PEF1;PES1;PEX2;PFKL;PGRMC1;PHLPP1;PI4KB;PIGK;PLAU;PLEK;PLP2;PLXNB1;PNPT1;PPAP2B;PPAPDC2;PPIB;PPP2CA;PPP5C;PRDX6;PRKCZ;PSMC3;PSMC4;PSMD13;PTAFR;PTBP1;PTDSS1;PTDSS2;PTH1R;PTK7;PTPN6;PYGB;RAB11A;RAB11B;RAB12;RAB13;RAB14;RAB32;RAB7A;RAB8A;RAD21;RARS;RASD1;RHEB;RHOB;RHOC;RHOF;RHOG;RIPK4;RNF5;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL18;RPL19;RPL21;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL35A;RPL35;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS23;RPS24;RPS26;RPS27A;RPS3;RPS4X;RPS4Y1;RPS5;RPS6KC1;RPS7;RPS8;RPS9;RPSA;RQCD1;RRBP1;SCD;SCN9A;SCP2;SDC2;SDC3;SEC11A;SELENBP1;SELP;SEMA5A;SEMA6A;SERINC3;SFXN3;SGCE;SIRT3;SLC10A1;SLC15A3;SLC16A2;SLC16A3;SLC17A2;SLC17A4;SLC17A5;SLC19A1;SLC1A4;SLC22A1;SLC22A3;SLC25A5;SLC26A6;SLC27A3;SLC27A4;SLC28A1;SLC35B2;SLC35C1;SLC39A1;SLC39A7;SLC39A8;SLC4A2;SLCO2B1;SNX15;SNX1;SPG7;SPPL2A;SPRED2;SPTAN1;SRD5A2;SREBF2;SRPX;ST14;STARD10;STMN1;STOM;STX12;STX18;STX3;SVEP1;TMEM14A;TMPO;TMPRSS2;TNFRSF1B;TOM1;TOMM34;TRPM7;TRPM8;TRPV4;TSPAN13;TTK;UBR4;UGT2B7;ULK3;VDAC1;VIPR1;WDR11;XAB2;XPNPEP2;XRCC5;XRCC64832120148770870.01
GO:0043588skin developmentbiological_process8ADAMTS2;ARRDC3;COL1A1;COL3A1;DBI;GNAS;IRF6;ITGA6;JUP;LTB;NGFR;SLC27A41221202170870.01
GO:0002244hematopoietic progenitor cell differentiationbiological_process7ANLN;CITED2;DHTKD1;ESCO2;GPATCH4;KCNAB2;PAPD4;PLEK;PTPN6;SIN3A;SRSF4;TOP2A;WDR7;ZFAT1421202670870.01
GO:0071276cellular response to cadmium ionbiological_process8CYP1A2;MT1F;MT1G;MT1H;MT1X;OGG1;PPP5C;SOD1821201270870.01
GO:0030532small nuclear ribonucleoprotein complexcellular_component8LSM4;SF3B1;SNRPA1;SNRPB;SNRPE;SNRPF;SNRPG;SNRPN821201270870.01
GO:0016032viral processbiological_process5ACKR3;AP1S1;AP2M1;AP2S1;APOA2;B2M;BAX;BIN1;BUB1;CCNA2;CD1D;CD4;CDC25C;CHMP2B;CREBBP;CXCR4;EIF4A2;EIF4H;FBXW7;FCGR2B;FDPS;FKBP8;GRB2;GTF2E2;GTF2H1;H2AFX;HLA-B;HNRNPA1;HNRNPK;HPX;HSPA8;KPNA2;KRT7;LAMP1;LDLR;LMBRD1;MAPK1;MPDZ;NELFCD;NELFE;NFKBIA;NPM1;NUP205;NUP50;NUPL1;PDCD6IP;PDCL3;POLR2G;POLR2I;PRMT6;PSMA2;PSMA3;PSMA7;PSMB10;PSMB1;PSMB5;PSMB8;PSMC3;PSMC4;PSMD13;PVR;RAB11FIP4;RAD23A;RBX1;RNMT;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;RSAD2;SEH1L;SEPT6;SET;SLC25A5;SLC25A6;SRPK1;STAT2;SYK;TAF2;TAF4;TRAM1;TRIM22;TRIM25;UBA52;UBR4;VDAC1;VPRBP;VPS37A;VPS4A;XRCC5;XRCC6;ZMYND11146212041570870.01
GO:0009897external side of plasma membranecellular_component6ABCA1;ALCAM;B2M;BCAM;CD24;CD36;CD4;CD74;CD83;DLK1;ENG;ENPEP;FCER1G;FCGR3A;FGB;FGG;GSR;HLA-DRB1;ICAM1;ICOS;ITGA6;ITGAV;LAMP1;LDLR;NGFR;P2RX7;PTPRC;SELP;STAB2;THY1;TMEM123;TRPM83221207470870.01
GO:0031683G-protein beta/gamma-subunit complex bindingmolecular_function6GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ721201070870.01
GO:0019001guanyl nucleotide bindingmolecular_function7GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ721201070870.01
GO:0043277apoptotic cell clearancebiological_process6AXL;CD36;GAS6;ITGAV;LRP1;MARCO;TGM2721201070870.01
GO:0010719negative regulation of epithelial to mesenchymal transitionbiological_process12EFNA1;FOXA1;LDLRAD4;PBLD;PPP2CA;SDHAF2;VASN721201070870.01
GO:0071294cellular response to zinc ionbiological_process8MT1F;MT1G;MT1H;MT1M;MT1X;MT2A;TSPO721201070870.01
GO:0007339binding of sperm to zona pellucidabiological_process8CCT2;CCT3;CCT4;CCT7;CLGN;FETUB;TCP1721201070870.01
GO:0006334nucleosome assemblybiological_process12ASF1A;CASC5;CENPH;CENPN;CENPQ;CENPW;H1FX;H2AFX;H2AFY;H3F3A;H3F3B;HIST1H2BC;HIST1H2BG;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HJURP;HMGB2;MCM2;NAA60;NPM1;OIP5;SET;SMYD3;TSPYL12921206670870.01
GO:0006475internal protein amino acid acetylationbiological_process10ASL;EHHADH;HAT1;MDH2;PCK152120670870.01
GO:0045954positive regulation of natural killer cell mediated cytotoxicitybiological_process7CADM1;LAMP1;PVRL2;PVR;VAV152120670870.01
GO:0034101erythrocyte homeostasisbiological_process5AXL;KLF2;PRDX1;RPS17;RPS2452120670870.01
GO:0042119neutrophil activationbiological_process7CCL5;CXCR4;F2RL1;KMT2E;PREX152120670870.01
GO:0002009morphogenesis of an epitheliumbiological_process6CA2;FGFR3;HHEX;RIPK4;TIMELESS;VCL62120870870.01
GO:0005686U2 snRNPcellular_component9CCDC97;SNRPA1;SNRPB2;SNRPB;SNRPE;SNRPN62120870870.01
GO:0006268DNA unwinding involved in DNA replicationbiological_process11MCM2;MCM4;MCM6;MCM7;TOP2A;TOP2B62120870870.01
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathwaybiological_process10GCGR;GNA11;GNAI1;GNAO1;GNAZ;PTH1R62120870870.01
GO:0004601peroxidase activitymolecular_function6HBA1;HBA2;HBB;MGST3;PRDX1;PXDN62120870870.01
GO:0010466negative regulation of peptidase activitybiological_process10CAST;CST3;CSTA;GPC3;SPINK1;TFPI62120870870.01
GO:0031616spindle pole centrosomecellular_component10AURKA;AURKB;BNIP2;DLGAP5;NPM1;TBCCD162120870870.01
GO:0005832chaperonin-containing T-complexcellular_component11CCT2;CCT3;CCT4;CCT6A;CCT7;TCP162120870870.01
GO:0000228nuclear chromosomecellular_component11BIRC5;BLM;H2AFY;H3F3A;H3F3B;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H4B;HIST4H4;JUN;MSH2;NCAPD2;RAD21;TOP2A1521202970870.01
GO:0051084'de novo' posttranslational protein foldingbiological_process9CCT2;CCT3;CCT4;CCT6A;CCT7;PFDN2;PFDN6;TBCA;TBCB;TCP1;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB61521202970870.01
GO:0009612response to mechanical stimulusbiological_process5CCNB1;CITED2;COL1A1;COL3A1;DCN;ETS1;FOSB;IGFBP2;JUN;MMP14;P2RX7;PIEZO2;RCAN1;TRPV4;TXNIP1521202970870.01
GO:0004930G-protein coupled receptor activitymolecular_function6ACKR3;ADGRE5;ADGRG7;ADRA1A;C3AR1;C5AR1;CXCR4;F2RL1;F2R;FPR3;FZD4;GCGR;LGR4;MRGPRF;NPY1R;P2RY13;PTAFR;PTH1R;TM2D1;VIPR12021204270870.01
GO:0030529ribonucleoprotein complexcellular_component7ACTN4;BOP1;BRCA1;CASC3;DDX1;DHX9;EPRS;HNRNPA1;HNRNPD;HNRNPH2;HNRNPUL1;HNRNPU;HSPA8;ILF2;NCL;NPM1;PA2G4;PABPC1;PABPC4;RPL13A;RPL27;RPL4;RPL7A;RPL7;RPLP0;RPS3A;RPS3;RPS4X;RPS5;RPS7;RPS8;RPS9;SLBP;SLIRP;SNRPA1;YBX13621208670870.01
GO:0001731formation of translation preinitiation complexbiological_process9EIF2D;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF3L;MCTS11021201770870.01
GO:0034446substrate adhesion-dependent cell spreadingbiological_process9AKIP1;AXL;EFNA1;FN1;FZD4;ILK;ITGAV;KIF14;LAMC1;MICALL21021201770870.01
GO:0007267cell-cell signalingbiological_process6ADGRE5;ADRA1A;BST2;C1QA;CCL21;CCL4;CCL5;CTGF;CXCL14;CYR61;EFNA1;ENPEP;EREG;FADS1;GDF15;GRAP;GRB2;IK;LTB;MPZL1;NAMPT;SEMA5A;SRD5A2;STAB12421205370870.01
GO:0030666endocytic vesicle membranecellular_component12AP2M1;AP2S1;CD163;CD36;CD74;HLA-DPA1;HLA-DRB1;HLA-DRB5;LRP1;MARCO;MSR1;NOSTRIN;RPS27A;STAB1;STAB2;UBA521621203270870.01
GO:0048146positive regulation of fibroblast proliferationbiological_process6ANXA2;CCNA2;CCNB1;CD74;CDK4;CDKN1A;E2F1;EREG;FN1;FOSL2;GAS6;IGF1;JUN;NGFR;NRAS;UTS21621203270870.01
GO:0045335phagocytic vesiclecellular_component12ABCA1;CD36;ITGAV;ITGB5;LAMP1;RAB11A;RAB11B;RAB14;RAB32;RAB7A;RAB8A;STX121221202270870.01
GO:0070527platelet aggregationbiological_process7BLOC1S4;CSRP1;FGB;FGG;FIBP;FLNA;GAS6;GNAS;HBB;ILK;MYH9;PLEK;PTPN6;VCL1421202770870.01
GO:0044255cellular lipid metabolic processbiological_process5ABCA1;ABCB4;ACACA;ACACB;ACADL;ACADS;ACLY;ACOX2;ACSL4;AGPAT1;AGPAT6;ALAS1;AMACR;APOA2;APOA5;C19orf80;CD36;CRAT;CREBBP;CTGF;ECHS1;ELOVL2;ELOVL5;ELOVL6;FABP1;FADS1;G0S2;GNPAT;GPD2;HADHA;HADH;HMGCR;HMGCS1;IDH1;PCCA;PRKAA2;PRKAG2;SCP2;SIN3A;SLC25A20;TNFRSF21;TRIB342212010470870.01
GO:0030658transport vesicle membranecellular_component12CD74;DBH;HLA-DPA1;HLA-DRB1;HLA-DRB5;ICA1;RAB11FIP5;RAB13;SPRED2921201570870.01
GO:0036464cytoplasmic ribonucleoprotein granulecellular_component9DDX3Y;DHX9;HNRNPU;NCL;PABPC1;RPL28;RPL6;RPLP0;RPS4X921201570870.01
GO:0008289lipid bindingmolecular_function4AP2M1;APOA2;APOA5;APOC3;APOL1;APOL2;APOL6;ATP5G3;BAD;BAX;C3;CD36;CD55;CETP;DBI;EPN2;FABP1;FAM21A;FNBP1L;LBP;OSBPL11;PITPNB;PLTP;PPARD;PPP5C;RUFY1;STARD10;STARD13;STARD5;STARD7;UNC119B3121207370870.01

document location: summary/3_2_transcript_differential_expression/*VS*/1_GO_Enrichment/*VS*_GO_enrichment_Gene.xlsx


Barplot of enriched GO terms:



document location: summary/3_2_transcript_differential_expression/*VS*/1_GO_Enrichment/*VS*_GO_enrichment.png


Scatterplot of GO enrichment:



document location: summary/3_2_transcript_differential_expression/*VS*/1_GO_Enrichment/*VS*_GO_enrichment_scatterplot.png


4.7.5 KEGG enrichment analysis of differentially expressed genes


KEGG (Kyoto Encyclopedia of Genes and Genomes) (http://www.kegg.jp/) is a collection of databases dealing with genomes, biological pathways, diseases, drugs, and chemical substances. KEGG is utilized for bioinformatics research and education, including data analysis in genomics, metagenomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug development.


Significant KEGG pathways::

pathway_idpathway_nameGenesS gene numberTS gene numberB gene numberTB gene numberpvalue
ko03010RibosomeMRPL13;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL39;RPL3;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPS10;RPS11;RPS13;RPS16;RPS17;RPS18;RPS21;RPS23;RPS24;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS5;RPS7;RPS8;RPS9;RPSA;UBA52508476725330.00
ko05150Staphylococcus aureus infectionC1QA;C1QB;C1QC;C1S;C3AR1;C3;C5AR1;CFI;DSG1;FCGR2B;FCGR3A;FGG;FPR3;HLA-DPA1;HLA-DRB1;HLA-DRB5;ICAM1;MASP1;PTAFR;SELP208473225330.00
ko05322Systemic lupus erythematosusC1QA;C1QB;C1QC;C1S;C3;C6;C7;C8A;C8B;FCGR2B;FCGR3A;H2AFX;H2AFY;H3F3A;H3F3B;HIST1H2AC;HIST1H2AI;HIST1H4J;HIST2H2AC;HLA-DPA1;HLA-DRB1;HLA-DRB5;SNRPB238474025330.00
ko05020Prion diseasesBAX;C1QA;C1QB;C1QC;C6;C7;C8A;C8B;LAMC1;MAPK1;NOTCH1;SOD1;STIP1138471925330.00
ko05144MalariaCD36;CD81;HBA1;HBA2;HBB;HGF;LRP1;MET;MYD88;SDC2;SELP;THBS2;THBS4138472025330.00
ko00380Tryptophan metabolismAADAT;ACMSD;ALDH1B1;ALDH2;ALDH7A1;CYP1A2;DDC;ECHS1;EHHADH;GCDH;HADHA;HADH;INMT;MAOB;OGDHL;WARS168472825330.01
ko04610Complement and coagulation cascadesC1QA;C1QB;C1QC;C1S;C3AR1;C3;C4BPA;C5AR1;C6;C7;C8A;C8B;CD55;CFD;CFI;CPB2;F11;F12;F2R;FGG;MASP1;PLAUR;PLAU;SERPINA1;SERPING1;TFPI268475225330.01
ko04080Neuroactive ligand-receptor interactionADRA1A;C3AR1;C5AR1;F2RL1;F2R;FPR3;GCGR;NPY1R;NR3C1;P2RY13;PTAFR;PTH1R;TSPO;VIPR1148472425330.01
ko04512ECM-receptor interactionCD36;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;FN1;HMMR;HSPG2;ITGA6;ITGAV;LAMA2;LAMB2;LAMC1;LAMC3;SDC2;SPP1;THBS2;THBS4198473625330.01
ko04514Cell adhesion molecules (CAMs)ALCAM;CADM1;CD4;CD99;CDH5;CLDN2;CLDN3;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ICAM1;ICOS;ITGA6;ITGAV;MPZL1;PTPRC;PVRL2;PVR;SDC2;SELP;SIGLEC1238474725330.02
ko00360Phenylalanine metabolismALDH1A3;DDC;GOT2;HPD;MAOB;PAH;PRDX678471025330.02
ko00040Pentose and glucuronate interconversionsALDH1B1;ALDH2;DCXR;RPE;UGDH;UGT2A3;UGT2B11;UGT2B4;UGT2B798471525330.03
ko00053Ascorbate and aldarate metabolismALDH1B1;ALDH2;ALDH7A1;UGDH;UGT2A3;UGT2B11;UGT2B4;UGT2B788471325330.03
ko00471D-Glutamine and D-glutamate metabolismGLS2;GLS;GLUD13847325330.04
ko03320PPAR signaling pathwayACADL;ACOX2;ACSL4;APOA2;APOA5;APOC3;CD36;DBI;EHHADH;FABP1;FADS2;ILK;PCK1;PCK2;PLTP;PPARD;SCD;SCP2;SLC27A4;SLC27A5208474225330.04
ko04320Dorso-ventral axis formationETS1;ETS2;GRB2;MAPK1;NOTCH1;NOTCH468471025330.08
ko04672Intestinal immune network for IgA productionCXCR4;HLA-DPA1;HLA-DRB1;HLA-DRB5;ICOS;PIGR68471025330.08
ko00350Tyrosine metabolismADH1C;ADH4;ADH6;ALDH1A3;DBH;DDC;GOT2;GSTZ1;HPD;MAOB;WBSCR22118472225330.08
ko04110Cell cycleANAPC11;ANAPC1;BUB1B;BUB1;CCNA2;CCNB1;CCNB2;CDC20;CDC23;CDC25C;CDC27;CDK1;CDK4;CDKN1A;CDKN2A;CHEK2;CREBBP;DBF4;E2F1;GADD45A;GADD45B;MAD2L1;MCM2;MCM4;MCM5;MCM6;MCM7;ORC6;PCNA;PTTG1;RAD21;RBL2;SMC3;STAG1;TTK;YWHAZ368478825330.08
ko05142Chagas disease (American trypanosomiasis)AKT3;C1QA;C1QB;C1QC;C3;GNAI1;GNAI2;GNAO1;GNAS;JUN;MAPK1;MAPK8;MYD88;NFKBIA;PIK3CD;PLCB1;PPP2CB;PPP2R1B188474025330.08
ko05143African trypanosomiasisAPOL1;F2RL1;HBA1;HBA2;HBB;ICAM1;MYD88;PLCB188471525330.09
ko00071Fatty acid metabolismACADL;ACADS;ACSL4;ADH1C;ADH4;ADH6;ALDH1B1;ALDH2;ALDH7A1;ECHS1;EHHADH;GCDH;HADHA;HADH148473025330.09
ko04914Progesterone-mediated oocyte maturationAKT3;ANAPC11;ANAPC1;BUB1;CCNA2;CCNB1;CCNB2;CDC23;CDC25C;CDC27;CDK1;GNAI1;GNAI2;HSP90AA1;IGF1;MAD2L1;MAPK1;MAPK8;PIK3CD198474325330.09
ko03440Homologous recombinationBLM;EME1;MUS81;NBN;RAD54B;RPA2;SSBP178471325330.10
ko00010Glycolysis / GluconeogenesisADH1C;ADH4;ADH6;ALDH1A3;ALDH1B1;ALDH2;ALDH7A1;ALDOB;DLAT;ENO3;FBP1;PCK1;PCK2;PDHB;PFKL;PGM1168473625330.11
ko00300Lysine biosynthesisAADAT;ALDH7A12847225330.11
ko00620Pyruvate metabolismACACB;ACYP2;ALDH1B1;ALDH2;ALDH7A1;DLAT;GLO1;HAGH;LDHD;PCK1;PCK2;PDHB128472625330.12
ko00020Citrate cycle (TCA cycle)ACLY;ACO2;DLAT;DLST;IDH1;OGDHL;PCK1;PCK2;PDHB;SDHA108472125330.13
ko04145PhagosomeATP6V0B;ATP6V1B2;ATP6V1C1;C3;CANX;CD36;CLEC4M;COLEC11;CTSL;FCGR2B;FCGR3A;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ITGAV;LAMP1;LAMP2;MARCO;MRC2;MSR1;RAB7A;STX12;STX18;THBS2;THBS4;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6328478025330.13
ko01040Biosynthesis of unsaturated fatty acidsELOVL2;ELOVL5;ELOVL6;FADS1;FADS2;HADHA;PECR;SCD88471625330.13
ko05146AmoebiasisARG1;C8A;C8B;CASP3;COL1A1;COL1A2;COL3A1;FN1;GNAS;LAMA2;LAMB2;LAMC1;LAMC3;PIK3CD;PLCB1;RAB7A;SERPINB6;VCL188474225330.13
ko04114Oocyte meiosisANAPC11;ANAPC1;AURKA;BUB1;CALM1;CCNB1;CCNB2;CDC20;CDC23;CDC25C;CDC27;CDK1;FBXW11;IGF1;MAD2L1;MAPK1;PPP1CA;PPP2CB;PPP2R1B;PPP2R5B;PTTG1;SMC3;YWHAZ238475625330.14
ko03030DNA replicationMCM2;MCM4;MCM5;MCM6;MCM7;PCNA;POLE3;RFC2;RFC4;RPA2;SSBP1118472425330.14
ko00030Pentose phosphate pathwayALDOB;FBP1;G6PD;PFKL;PGD;PGLS;PGM1;RPE;TKT98471925330.15
ko05145ToxoplasmosisAKT3;BAD;BIRC2;CASP3;GNAI1;GNAI2;GNAO1;HLA-DPA1;HLA-DRB1;HLA-DRB5;HSPA8;ITGA6;LAMA2;LAMB2;LAMC1;LAMC3;LDLR;MAPK1;MAPK8;NFKBIA;PIK3CD218475125330.15
ko05218MelanomaAKT3;BAD;CDK4;CDKN1A;CDKN2A;E2F1;HGF;IGF1;MAPK1;MET;NRAS;PIK3CD128472725330.16
ko00982Drug metabolism - cytochrome P450ADH1C;ADH4;ADH6;ALDH1A3;CYP1A2;FMO4;GSTA4;GSTM1;GSTO1;GSTZ1;MAOB;UGT2A3;UGT2B11;UGT2B4;UGT2B7158473525330.16
ko05152TuberculosisAKT3;ARHGEF12;ATP6V0B;BAD;BAX;C3;CALM1;CASP3;CD74;CLEC4M;CREBBP;CTSD;FCER1G;FCGR2B;FCGR3A;HLA-DPA1;HLA-DRB1;HLA-DRB5;IRAK2;LAMP1;LAMP2;LBP;LSP1;MAPK1;MAPK8;MRC2;MYD88;PLK3;RAB7A;RFX5;SYK318477925330.16
ko05310AsthmaFCER1G;HLA-DPA1;HLA-DRB1;HLA-DRB54847725330.17
ko04940Type I diabetes mellitusHLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ICA168471225330.18
ko04730Long-term depressionGNAI1;GNAI2;GNAO1;GNAS;GNAZ;IGF1;MAPK1;NRAS;PLCB1;PPP2CB;PPP2R1B118472525330.18
ko00650Butanoate metabolismACADS;ACSM1;ACSM2A;AKR1B10;ECHS1;EHHADH;HADHA;HADH;PDHB98472025330.19
ko00330Arginine and proline metabolismALDH18A1;ALDH1B1;ALDH2;ALDH7A1;ARG1;ASL;DAO;GLS2;GLS;GLUD1;GOT2;MAOB;P4HA1;PRODH;PYCRL;SAT1168473925330.20
ko00980Metabolism of xenobiotics by cytochrome P450ADH1C;ADH4;ADH6;ALDH1A3;CYP1A2;GSTA4;GSTM1;GSTO1;GSTZ1;UGT2A3;UGT2B11;UGT2B4;UGT2B7138473125330.20
ko05320Autoimmune thyroid diseaseHLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E58471025330.21
ko05330Allograft rejectionHLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E58471025330.21
ko05332Graft-versus-host diseaseHLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E58471025330.21
ko04612Antigen processing and presentationCANX;CD4;CD74;CTSL;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;HSP90AA1;HSPA8;LGMN;PDIA3;RFX5148473425330.22
ko00510N-Glycan biosynthesisALG8;DAD1;DDOST;DOLK;DOLPP1;GANAB;MGAT4A;MOGS;RFT1;RPN2;TUSC3118472625330.22
ko00340Histidine metabolismALDH1A3;ALDH1B1;ALDH2;ALDH7A1;DDC;MAOB;UROC1;WBSCR2288471825330.23
ko04964Proximal tubule bicarbonate reclamationCA2;GLS2;GLS;GLUD1;PCK1;PCK268471325330.24
ko04115p53 signaling pathwayBAX;CASP3;CCNB1;CCNB2;CDK1;CDK4;CDKN1A;CDKN2A;CHEK2;GADD45A;GADD45B;IGF1;IGFBP3;SHISA5148473525330.26
ko00400Phenylalanine, tyrosine and tryptophan biosynthesisGOT2;PAH2847325330.26
ko04742Taste transductionGNAS;GNB12847325330.26
ko05222Small cell lung cancerAKT3;BIRC2;CDK4;CKS1B;E2F1;FN1;ITGA6;ITGAV;LAMA2;LAMB2;LAMC1;LAMC3;NFKBIA;PIAS1;PIK3CD158473825330.26
ko04540Gap junctionCDK1;GNAI1;GNAI2;GNAS;GRB2;MAPK1;NRAS;PLCB1;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6138473325330.29
ko04662B cell receptor signaling pathwayAKT3;CD81;FCGR2B;GRB2;IFITM1;JUN;MAPK1;NFKBIA;NRAS;PIK3CD;PTPN6;SYK;VAV1138473325330.29
ko00640Propanoate metabolismACACB;ALDH1B1;ALDH2;ALDH6A1;ALDH7A1;ECHS1;EHHADH;HADHA;PCCA98472225330.30
ko05223Non-small cell lung cancerAKT3;BAD;CDK4;CDKN2A;E2F1;GRB2;MAPK1;NRAS;PIK3CD;STK4108472525330.31
ko00062Fatty acid elongation in mitochondriaECHS1;HADHA;HADH3847625330.32
ko00410beta-Alanine metabolismALDH1A3;ALDH1B1;ALDH2;ALDH7A1;ECHS1;EHHADH;HADHA78471725330.33
ko00472D-Arginine and D-ornithine metabolismDAO1847125330.33
ko04510Focal adhesionAKT3;ARHGAP35;BAD;BIRC2;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;DIAPH1;FLNA;FN1;GRB2;HGF;IGF1;ILK;ITGA6;ITGAV;JUN;LAMA2;LAMB2;LAMC1;LAMC3;MAPK1;MAPK8;MET;PIK3CD;PPP1CA;SHC2;SPP1;THBS2;THBS4;VAV1;VCL348479525330.35
ko03015mRNA surveillance pathwayCASC3;CSTF3;DDX39B;ETF1;GSPT2;NXT1;PABPC1L;PABPC1;PABPC4;PAPOLA;PPP2CB;PPP2R1B;PPP2R5B;RNMT;UPF2;WIBG168474325330.35
ko00910Nitrogen metabolismCA2;GLS2;GLS;GLUD14847925330.35
ko00290Valine, leucine and isoleucine biosynthesisIARS2;IARS;LARS;PDHB4847925330.35
ko05014Amyotrophic lateral sclerosis (ALS)BAD;BAX;CASP3;CAT;GPX1;SOD1;TNFRSF1B;TOMM40L;TOMM4098472325330.35
ko00260Glycine, serine and threonine metabolismALAS1;ALDH7A1;CBS;DAO;DMGDH;GCAT;GNMT;MAOB;SARDH;SHMT1108472625330.36
ko04974Protein digestion and absorptionCOL18A1;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;CPB2;MEP1A;MME;SLC36A1;XPNPEP2118472925330.37
ko00310Lysine degradationAADAT;ALDH1B1;ALDH2;ALDH7A1;DLST;ECHS1;EHHADH;GCDH;HADHA;HADH;KMT2E;OGDHL128473225330.37
ko00970Aminoacyl-tRNA biosynthesisCARS2;EPRS;FARSB;GARS;HARS;IARS2;IARS;LARS;QARS;RARS;SARS;WARS128473225330.37
ko05214GliomaAKT3;CALM1;CDK4;CDKN1A;CDKN2A;E2F1;GRB2;IGF1;MAPK1;NRAS;PIK3CD;SHC2128473225330.37
ko00250Alanine, aspartate and glutamate metabolismASL;CAD;GFPT1;GLS2;GLS;GLUD1;GOT2;GPT88472125330.40
ko04530Tight junctionAKT3;CDK4;CLDN2;CLDN3;CSNK2A2;CSNK2B;CTTN;EXOC4;GNAI1;GNAI2;MPDZ;MYH11;MYH9;NRAS;PARD6B;PPP2CB;PPP2R1B;PRKCZ;RAB13;SPTAN1208475625330.41
ko04744PhototransductionCALM1;GNB12847425330.41
ko00232Caffeine metabolismCYP1A2;NAT22847425330.41
ko04260Cardiac muscle contractionCOX4I1;COX6A2;COX6B1;COX6C;COX7A2L;COX7A2;CYC1;TPM3;UQCR1098472425330.41
ko00520Amino sugar and nucleotide sugar metabolismAMDHD2;CYB5R1;CYB5R3;GALK2;GFPT1;GNPNAT1;NPL;PGM1;TSTA3;UGDH;UXS1118473025330.42
ko04920Adipocytokine signaling pathwayACACB;ACSL4;AKT3;CD36;MAPK8;NFKBIA;PCK1;PCK2;PPARGC1A;PRKAA2;PRKAG2;TNFRSF1B128473325330.42
ko00100Steroid biosynthesisCYP51A1;DHCR7;LIPA;MSMO1;SQLE58471325330.45
ko03430Mismatch repairMSH2;PCNA;RFC2;RFC4;RPA2;SSBP168471625330.46
ko00860Porphyrin and chlorophyll metabolismALAS1;CP;EPRS;FTL;UGT2A3;UGT2B11;UGT2B4;UGT2B788472225330.46
ko00983Drug metabolism - other enzymesCES1;GMPS;IMPDH2;NAT2;TYMP;UGT2A3;UGT2B11;UGT2B4;UGT2B798472525330.47
ko04916MelanogenesisCALM1;CREBBP;FZD4;GNAI1;GNAI2;GNAO1;GNAS;MAPK1;NRAS;PLCB1108472825330.47
ko05140LeishmaniasisC3;FCGR3A;HLA-DPA1;HLA-DRB1;HLA-DRB5;JUN;MAPK1;MYD88;NFKBIA;PTPN6108472825330.47
ko05416Viral myocarditisCASP3;CD55;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ICAM1;LAMA2;MYH11;MYH9118473125330.47
ko04976Bile secretionABCB1;ABCB4;CA2;GNAS;HMGCR;KCNN2;LDLR;NR1H4;SLC22A1;SLC27A5;SLC4A2;UGT2B4128473425330.47
ko04141Protein processing in endoplasmic reticulumAMFR;ATF6B;BAG2;BAX;CANX;CRYAA;DAD1;DDOST;DNAJB11;DNAJB1;DNAJB2;EDEM1;EIF2AK1;GANAB;HERPUD1;HSP90AA1;HSP90B1;HSPA8;HSPBP1;MAPK8;MBTPS2;MOGS;NFE2L2;PDIA3;PDIA4;PDIA6;RAD23A;RNF5;RPN2;RRBP1;SEC13;SEC23A;SEC24D;SSR1;SSR2;TRAM1;TUSC3;UBE2D2;UBE2G13984711525330.49
ko05164Influenza AAKT3;CREBBP;DDX39B;DNAJB1;EIF2AK1;FDPS;HLA-DPA1;HLA-DRB1;HLA-DRB5;HNRNPUL1;HSPA8;ICAM1;IL33;JUN;KPNA2;MAPK1;MAPK8;MYD88;NFKBIA;NXT1;PIK3CD;RSAD2;TMPRSS2;TRIM25;VDAC1258477425330.52
ko00280Valine, leucine and isoleucine degradationACADS;ALDH1B1;ALDH2;ALDH6A1;ALDH7A1;BCKDHB;ECHS1;EHHADH;HADHA;HADH;PCCA118473225330.52
ko04350TGF-beta signaling pathwayCREBBP;DCN;ID1;MAPK1;PPP2CB;PPP2R1B;RBL2;RPS6KB2;SMAD6;THBS2;THBS4118473225330.52
ko04664Fc epsilon RI signaling pathwayAKT3;FCER1G;GRB2;MAPK1;MAPK8;NRAS;PIK3CD;SYK;VAV198472625330.52
ko05219Bladder cancerCDK4;CDKN1A;CDKN2A;E2F1;FGFR3;MAPK1;MMP2;NRAS;TYMP98472625330.52
ko00500Starch and sucrose metabolismPGM1;PYGB;UGDH;UGT2A3;UGT2B11;UGT2B4;UGT2B7;UXS188472325330.52
ko04971Gastric acid secretionCA2;CALM1;GNAI1;GNAI2;GNAS;PLCB1;SLC4A278472025330.52
ko04975Fat digestion and absorptionABCA1;AGPAT1;CD36;FABP1;GOT2;PPAP2B;SLC27A478472025330.52
ko05340Primary immunodeficiencyCD4;ICOS;PTPRC;RFX548471125330.53
ko04140Regulation of autophagyATG4A;ATG4C;PRKAA2;ULK348471125330.53
ko00740Riboflavin metabolismACP1;ACP5;FLAD13847825330.53

document location: summary/3_2_transcript_differential_expression/*VS*/2_KEGG_Enrichment/*VS*_KEGG_enrichment_Gene.xlsx


Scatterplot of KEGG enrichment:



document location:

summary/3_2_transcript_differential_expression/*VS*/2_KEGG_Enrichment/*VS*_KEGG_enrichment_scatterplot.png

summary/3_2_transcript_differential_expression/*VS*/3_KEGG_Pictures/*.png



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