In-vivo 1H MR spectra acquired from the striatum of Q111 and wild-type (WT) mice at 13 weeks. STEAM, echo time=2 ms, repetition time (TR)=5 seconds, VOI=8.5 μL, number of transients=240. No water signal removal or baseline corrections were applied. Insets: coronal and sagittal FSE MRI with a typical VOI selection. MR, magnetic resonance; VOI, volumes of interest; FSE MRI, fast spin-echo magnetic resonance imaging; Ala, alanine; Asc, ascorbate; Cr, creatine; GABA, γ-aminobutyric acid; Glu, glutamate; Gln, glutamine; GSH, glutathione; GPC, glycerophosphocholine; Ins, inositol; Lac, lactate; NAA, N-acetylaspartate; PCr, phosphocholine; Tau, taurine.
Bioinformatics Services – Continuing advances in sequencing technologies, increases in the number of installed sequencers, and the decreasing cost of sequencing have all contributed to the generation of vast amounts of raw sequence data. This has led to perhaps the largest challenge faced by scientist performing sequencing experiments, assembly and analysis of the data. [Learn more…]
Tkac I, Henry P, Zacharoff L, Wedel M, Gong W, Deelchand DK, Li T, Dubinsky JM. (2012) Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease. J Cereb Blood Flow Metab 32(11), 1977-88. [article]