microRNA Microarray Service - Product News

April 16, 2008 - Sanger miRBase microRNA Sequence Database Updated to Release 11.0

The Sanger Institute released the latest version (11.0) of their miRBase sequence database for known miRNAs today ( http://microrna.sanger.ac.uk/sequences/)  The number of verified microRNAs has been increased from 5395 to 6396 hairpin precursor miRNAs expressing 6211 mature miRNA products.  (miRBase release summary).  For the first time, miRNAs are reported from Planarian, Tunicates (or seasquirts) and Slime molds.  There has been a significant increase in the number of miRNAs reported for:

• Human        -     162
• Mouse         -     31
• Drosophila  -     59
• C elegans    -     20
• Rice             -     27
• Dog              -     172

miRNA numbers have also increased for several other primate,  plant and virus species.

This updated probe content is currently available on all of our standard or custom microRNA microarrays.

About miRBase
The miRBase sequence database¹ is a comprehensive database of miRNA sequence data, annotation, and predicted gene targets and is the primary public repository for these data miRBase also provides a gene-naming service for assigning official miRNA names to novel miRNAs before they are published.  miRBase provides a convenient, searchable online database, allowing the user to search by key word or sequence for information about known miRNAs and their targets and is freely available to all at http://microrna.sanger.ac.uk/.

More information about LC Sciences is available at http://www.lcsciences.com.

1. Griffiths-Jones S, Grocock R, van Dongen S, Bateman A, Enright A. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 34(Database issue), D140–D144.  [abstract]

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