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Sept 1, 2008 - Sanger miRBase microRNA Sequence Database Updated to Release 12.0

The Sanger Institute released the latest version (12.0) of their miRBase sequence database for known miRNAs today ( http://microrna.sanger.ac.uk/sequences/)  The number of verified microRNAs has been increased from 6396 to 8619 hairpin precursor miRNAs expressing 8273 mature miRNA products.  (miRBase release summary).  With the addition of 2062 new mature miRNA sequences, the Sanger microRNA Sequence Database (miRBase) has announced it's largest update in miRBase history.

Many sequences have been updated or revised.  For the first time, miRNAs are reported from : 11 new Drosophila species, Platypus, Tomato, Red Flour Bettle, and two Polyomaviruses.  There has been a significant increase in the number of miRNAs reported for Human and model species such as Chimpanzee, Mouse, and Arabidopsis as well as agriculturally important species such as Rice, Soybean, Pig, and Chicken. 

Many of the new sequences, including sequences from a completely new species, were discovered by LC Sciences' customers making use of our unique µParaflo® microarray platform1,2.  Our custom  microarrays have been shown to be an effective approach for uncovering novel ncRNAs experimentally3 and/or to validate predicted candidate ncRNAs4.

This updated probe content is currently available on all of our standard or custom microRNA microarrays.

About miRBase
The miRBase sequence database5 is a comprehensive database of miRNA sequence data, annotation, and predicted gene targets and is the primary public repository for these data miRBase also provides a gene-naming service for assigning official miRNA names to novel miRNAs before they are published.  miRBase provides a convenient, searchable online database, allowing the user to search by key word or sequence for information about known miRNAs and their targets and is freely available to all at http://microrna.sanger.ac.uk/.

More information about LC Sciences is available at http://www.lcsciences.com.

  1. He PA, Nie Z, Chen J, Chen J, Lv Z, Sheng Q, Zhou S, Gao X, Kong L, Wu X, Jin Y, Zhang Y. (2008) Identification and characteristics of microRNAs from Bombyx mori. BMC Genomics 9(1), 248.
  2. Zhang J, Zeng R, Chen J, Liu X, Liao Q. (2008) Identification of conserved microRNAs and their targets from Solanum lycopersicum Mill. Gene [Epub ahead of print].
  3. Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. (2006) A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313(5785), 320-324. 
  4. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz L.A Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, et al. (2006) The colorectal microRNAome. Proc Natl Acad Sci USA 103, 3687-92.
  5. Griffiths-Jones S, Grocock R, van Dongen S, Bateman A, Enright A. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 34(Database issue), D140–D144.  [abstract]

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