microRNA Microarray Service - Product News

LC Sciences is proud to announce the recent publication of the 50th peer-reviewed study by one of its customers using the company’s microarray service for analyzing microRNA expression profiles and for discovery of novel small RNAs. These studies, by leading researchers in the field, contribute to a fast growing body of knowledge defining this recently discovered class of regulatory RNAs.

LC Sciences’ microRNA profiling service, powered by its µParaflo® microfluidic technology, provides quick, reliable, fully analyzed data enabling researchers to immediately move forward with innovative research, and publish their results faster. Microarray results require extensive validation prior to publication and the speed with which researchers using this microRNA profiling service have published their discoveries demonstrates the high-quality and reliability of these results.

The 50th study, entitled “Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis” appeared in the September 2nd issue of PNAS. Researchers at the University of Texas Southwestern Medical Center and MiRagen Therapeutics discovered that myocardial infarction in mice and humans results in the dysregulation of specific miRNAs that target a key group of mRNAs that encode proteins involved in cardiac fibrosis. They see at least one of these miRNAs as a potential therapeutic target for tissue fibrosis.

van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA, Olson EN. (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 105(35), 13027-32. [abstract]

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