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microRNA Publications

The Latest Customer Publication

MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. 

Proc Natl Acad Sci U S A Feb 16th 2010 - 107(7), 3240-244.

Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, J Li YS, Chien S, Wang N.

Endothelial cells (ECs) respond to changes in mechanical forces, leading to the modulation of signaling networks and cell function; an example is the inhibition of EC proliferation by steady laminar flow. MicroRNAs (miRs) are short noncoding 20-22 nucleotide RNAs that negatively regulate the expression of target genes at the posttranscriptional level. This study demonstrates that miRs are involved in the flow regulation of gene expression in ECs. With the use of microRNA chip array, we found that laminar shear stress (12 dyn/cm(2), 12 h) regulated the EC expression of many miRs, including miR-19a. We further showed that stable transfection of miR-19a significantly decreased the expression of a reporter gene controlled by a conserved 3'-untranslated region of the cyclinD1 gene and also the protein level of cyclin D1, leading to an arrest of cell cycle at G1/S transition. Laminar flow suppressed cyclin D1 protein level, and this suppressive effect was diminished when the endogenous miR-19a was inhibited. In conclusion, we demonstrated that miR-19a plays an important role in the flow regulation of cyclin D1 expression. These results revealed a mechanism by which mechanical forces modulate endothelial gene expression.

Cancer Research

  1. Pacifico F, Crescenzi E, Mellone S, Iannetti A, Porrino N, Liguoro D, Moscato F, Grieco M, Formisano S, Leonardi A. (2010) Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. J Clin Endocrinol Metab 95(3), 1421-30.  [abstract]
  2. Starlard-Davenport A, Tryndyak V, Kosyk O, Ross SR, Rusyn I, Beland FA, Pogribny IP. (2010) Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. World Rev Nutr Diet 101, 123-30.  [abstract]
  3. Greene SB, Gunaratne PH, Hammond SM, Rosen JM. (2010) A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci 123(4), 606-18. [abstract]
  4. Pogribny IP, Filkowski JN, Tryndyak VP, Golubov A, Shpyleva SI, Kovalchuk O. (2010) Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer [Epub ahead of print] [abstract]
  5. Miko E, Czimmerer Z, Csánky E, Boros G, Buslig J, Dezso B, Scholtz B.  (2009)  Differentially expressed microRNAs in small cell lung cancer.  Exp Lung Res 35(8):646-64. [abstract]
  6. Rui W, Bing F, Hai-Zhu S, Wei D, Long-Bang C.  (2009)  Identification of microRNA profiles in docetaxel-resistant human non-small cell lung carcinoma cells (SPC-A1).  J Cell Mol Med (1-2), 206-14. [abstract]
  7. Duan Z, Choy E, Nielsen GP, Rosenberg A,Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ.  (2009)  Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res 28(6), 746-52. [abstract]
  8. Liu W, Gong YH, Chao TF, Peng XZ, Yuan JG, Ma ZY, Jia G, Zhao JZ.  (2009)  Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas.  Chin Med J (Engl) 122(20), 2405-411. [abstract]
  9. Liu S, Goldstein RH, Scepansky EM, Rosenblatt M.  (2009) Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 69(22), 8742-751.   [abstract]
  10. Chow TF, Youssef YM, Lianidou E, Romaschin AD, Honey RJ, Stewart R, Pace KT, Yousef GM. (2009) Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis.  Clin Biochem 43(1-2), 150-58.  [abstract]
  11. Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J.  (2009) miR-200 enhances mouse breast cancer cell colonization to form distant metastases.  PLoS One 4(9), e7181.  [abstract]
  12. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. (2009) MicroRNA regulation of DNA repair gene expression in hypoxic stress.  Cancer Res 69(3), 1221-29.  [abstract]
  13. Wickramasinghe NS, Manavalan TT, Dougherty SM, Riggs KA, Li Y, Klinge CM. (2009) Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids 37(8), 2584-95.[abstract]
  14. Magrelli A, Azzalin G, Salvatore M, Viganotti M, Tosto F, Colombo T, Devito R, Di Masi A, Antoccia A, Lorenzetti S, Maranghi F, Mantovani A, Tanzarella C, Macino G, Taruscio D. (2009)Altered microRNA Expression Patterns in Hepatoblastoma Patients. Transl Oncol 2(3), 157-63. [abstract]
  15. Wang Y, Rathinam R, Walch A, Alahari SK. (2009) ST14 (Suppression of Tumorigenicity 14) Gene Is a Target for miR-27b, and the Inhibitory Effect of ST14 on Cell Growth Is Independent of miR-27b Regulation. J Biol Chem 284(34), 23094-106. [abstract]
  16. Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB. (2009) Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One 4(7), e6377. [abstract]
  17. Saito Y, Suzuki H, Tsugawa H, Nakagawa I, Matsuzaki J, Kanai Y, Hibi T. (2009) Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene 28(30), 2738-44. [abstract]
  18. Hill-Baskin AE, Markiewski MM, Buchner DA, Shao H, DeSantis D, Hsiao G, Subramaniam S, Berger NA, Croniger C, Lambris JD, Nadeau JH. (2009) Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet 18(16), 2975-88. [abstract]
  19. Lukiw WJ, Cui JG, Li YY, Culicchia F. (2008) Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol 91(1), 27-32. [abstract]
  20. Ilnytskyy Y, Koturbash I, Kovalchuk O. (2009) Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner. Environ Mol Mutagen 50(2), 105-13. [abstract]
  21. Guo J, Miao Y, Xiao B, Huan R, Jiang Z, Meng D, Wang Y. (2009) Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. Journal of Gastroenterology and Hepatology 24(4), 652-57. [abstract]
  22. Wang G, Mao W, Zheng S. (2008) MicroRNA-183 regulates Ezrin expression in lung cancer cells. FEBS Lett 582(25-26), 3663-68. [abstract]
  23. Sun Y, Wu J, Wu SH, Thakur A, Bollig A, Huang Y, Joshua Liao D. (2008) Expression profile of microRNAs in c-Myc induced mouse mammary tumors. Breast Cancer Res Treat118(1), 185-96.  [abstract]
  24. Ilnytskyy Y, Zemp FJ, Koturbash I, Kovalchuk O. (2008) Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun 377(1), 41-45. [abstract]
  25. Zhang B, Pan X. (2008) RDX induces aberrant expression of microRNAs in mouse brain and liver. Envir Health Perspect 117(2), 231-40. [abstract] [article]
  26. Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP. (2008)Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther 7(7), 2152-59. [abstract]
  27. Wang X, Tang S, Le SY, Lu R, Rader JS, Meyers C, Zheng ZM. (2008) Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS ONE 3(7), e2557. [abstract]
  28. Koturbash I, Zemp FJ, Kutanzi K, Luzhna L, Loree J, Kolb B, Kovalchuk O. (2008) Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle 7(11), 1658-67. [abstract]
  29. Kort EJ, Farber L, Tretiakova M, Petillo D, Furge KA, Yang XJ, Cornelius A, Teh BT. (2008) The E2F3-Oncomir-1 axis is activated in Wilms' tumor. Cancer Res 68(11), 4034-38. [abstract]
  30. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. (2008)Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451(7175), 147-52.  [abstract]
  31. Sun M, Estrov Z, Ji Y, Coombes KR, Harris DH, Kurzrock R. (2008) Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol Cancer Ther 7(3), 464-73.  [abstract]
  32. Lin SL, Chiang A, Chang D, Ying SY. (2008) Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14(3), 417-24.  [abstract]
  33. Lin SL, Chang DC, Chang-Lin S, Lin CH, Wu DT, Chen DT, Ying SY. (2008) Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 14(10), 2115-24.  [abstract]
  34. Yoshida N, Amanai M, Fukui T, Kajikawa E, Brahmajosyula M, Iwahori A, Nakano Y, Shoji S, Diebold J, Hessel H, Huss R, Perry AC. (2007) Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development & Disease 134(21),3941-52. [abstract]
  35. Weidhaas JB, Babar I, Nallur SM, Trang P, Roush S, Boehm M, Gillespie E, Slack FJ. (2007)MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res 67(23), 11111-16.  [abstract]
  36. Hebert C, Norris K, Scheper MA, Nikitakis N, Sauk JJ. (2007) High mobility group A2 is a target for miRNA-98 in Head and Neck Squamous Cell Carcinoma. Mol Cancer 6(1), 5.  [abstract]  [article]
  37. Pogribny IP, Tryndyak VP, Boyko A, Rodriguez-Juarez R, Beland FA, Kovalchuk O. (2007) Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutat Res 619(1-2), 30-37.  [abstract]
  38. Koturbash I, Boyko A, Rodriguez-Juarez R, McDonald R, Tryndyak V, Kovalchuk I, Pogribny I, Kovalchuk O. (2007) Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis 28(8), 1831-38.  [abstract]
  39. Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. (2007) PPAR{alpha} regulates an miRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol 27(12), 4238-47.  [abstract]
  40. Kovalchuk O, Tryndyak VP, Montgomery B, Boyko A, Kutanzi K, Zemp F, Warbritton AR, Latendresse JR, Kovalchuk I, Beland FA, Pogribny IP. (2007) Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression. Cell Cycle 6(16), 2010-18.  [abstract]
  41. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, Jones PA. (2006) Specific activation of microRNA-127 with downregulation of the protooncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9(6), 435-43.  [abstract]

Neuroscience

  1. Jurkin J, Schichl YM, Koeffel R, Bauer T, Richter S, Konradi S, Gesslbauer B, Strobl H. (2010) miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation. J Immunol 184(9), 4955-65. [abstract]
  2. Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, Hoang T, Xu X, Mi QS, Xin M, Wang F, Appel B, Lu QR. (2010) MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 65(5), 612-26. [abstract]
  3. Pogue AI, Cui JG, Li YY, Zhao Y, Culicchia F, Lukiw WJ. (2010) Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation.  Neurosci Lett  476(1), 18-22. [abstract]
  4. Wibrand K, Panja D, Tiron A, Ofte ML, Skaftnesmo KO, Lee CS, Pena JT, Tuschl T, Bramham CR. (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci (4), 636-45.  [abstract]
  5. Yuan Y, Wang JY, Xu LY, Cai R, Chen Z, Luo BY. (2010)  MicroRNA expression changes in the hippocampi of rats subjected to global ischemia.  J Clin Neurosci 17(6), 774-78.  [abstract]
  6. Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ. (2010)Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation.  PLoS One 5(2), e8898. [abstract]
  7. Williams AH, Valdez G, Moresi V, Qi X, McAnally J, Elliott JL, Bassel-Duby R, Sanes JR, Olson EN.  (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326(5959), 1549-554. [abstract]
  8. Wang X, Liu P, Zhu H, Xu Y, Ma C, Dai X, Huang L, Liu Y, Zhang L, Qin C. (2009) miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation.  Brain Res Bull 80(4-5), 268-73.  [abstract]
  9. Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM. (2009)A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol 11(6), 705-16.  [abstract]
  10. Hill JM, Zhao Y, Clement C, Neumann DM, Lukiw WJ.  (2009)HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling.  Neuroreport20(16), 1500-05.  [abstract]
  11. Nielsen JA, Lau P, Maric D, Barker JL, Hudson LD.  (2009)Integrating microRNA and mRNA expression profiles of neuronal progenitors to identify regulatory networks underlying the onset of cortical neurogenesis.  BMC Neurosci 10(1), 98.  [abstract]
  12. Sethi P, Lukiw WJ.  (2009) Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex.  Neurosci Lett 459(2), 100-04. [abstract]
  13. Dharap A, Bowen K, Place R, Li LC, Vemuganti R. (2009) Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab 29(4), 675-87. [abstract]
  14. Liu NK, Wang XF, Lu QB, Xu XM. (2009) Altered microRNA expression following traumatic spinal cord injury. Exp Neurol219(2), 424-29. [abstract]
  15. Lau P, Verrier JD, Nielsen JA, Johnson KR, Notterpek L, Hudson LD. (2008) Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes.  J Neurosci 28(45), 11720-730. [abstract]
  16. Sehm T, Sachse C, Frenzel C, Echeverri K. (2009) miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events.  Dev Biol334(2), 468-80. [abstract]
  17. Lukiw WJ, Zhao Y, Cui JG.  (2008) An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem 283(46), 31315-22. [abstract]
  18. Redell JB, Liu Y, Dash PK. (2009) Traumatic brain injury alters expression of hippocampal microRNAs: Potential regulators of multiple pathophysiological processes. J Neurosci Res 87(6), 1435-48. [abstract]
  19. Huang W, Li MD. (2008) Nicotine modulates expression of miR-140*, which targets the 3'-untranslated region of dynamin 1 gene (Dnm1). Int J Neuropsychopharmacol 12(4), 537-46. [abstract]
  20. Lau P, Verrier JD, Nielsen JA, Johnson KR, Notterpek L, Hudson LD. (2008) Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes. J Neurosci 28(45), 11720-30. [abstract]
  21. Talebizedah Z, Butler M, Theodoro M. (2008) Feasibility and Relevance of Examining Lymphoblastoid Cell Lines to Study Role of microRNAs in Autism. Autism Research 1(4), 240-50. [abstract]
  22. Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. (2008) A Set of Differentially Expressed miRNAs, including miR-30a-5p, act as Post-transcriptional Inhibitors of BDNF in Prefrontal Cortex. Hum Mol Genet 17(19), 3030-42. [abstract]
  23. Shen J, Yang X, Xie B, Chen Y, Swaim M, Hackett SF, Campochiaro PA. (2008) MicroRNAs Regulate Ocular Neovascularization. Mol Ther 16(7), 1208-16. [abstract]
  24. Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA. (2008) Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6), 751-60. [abstract]
  25. Gillardon F, Mack M, Rist W, Schnack C, Lenter M, Hildebrandt T,  Hengerer B. (2008) MicroRNA and proteome expression profiling in early-symptomatic Æ-synuclein(A30P)-transgenic mice. Proteomics Clin. Appl 2(5), 697-705. [abstract]
  26. Jeyaseelan K, Lim KY, Armugam A. (2008) MicroRNA Expression in the Blood and Brain of Rats Subjected to Transient Focal Ischemia by Middle Cerebral Artery Occlusion. Stroke 39(3), 959-66. [abstract]
  27. Burmistrova OA, Goltsov AY, Abramova LI, Kaleda VG, Orlova VA, Rogaev EI. (2007) MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry (Mosc) 72(5), 578-82.  [abstract]
  28. Lee HJ, Palkovits M, Young WS 3rd. (2006) From the cover: mir-7b, a microRNA upregulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. Proc Natl Acad Sci USA 103, 15669-74.  [abstract]
  29. Rogaev, EI. (2005) Small RNAs in human brain development and disorders. Biochemistry (Mosc) 70, 1404-07. [abstract]

Cardiovascular Research

  1. Long J, Wang Y, Wang W, Chang BH, Danesh FR. (2010) Identification of MicroRNA-93 as a novel regulator of vascular endothelial growth factor (VEGF) In hyperglycemic conditions. J Biol Chem [Epub ahead of print]. [abstract]
  2. Cheng Y, Zhu P, Yang J, Liu X, Dong S, Wang X, Chun B, Zhuang J, Zhang C. (2010) Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res [Epub ahead of print]. [abstract]
  3. Ye Y, Hu Z, Lin Y, Zhang C, Perez-Polo JR. (2010) Downregulation of microRNA-29 by antisense inhibitors and a PPAR-{gamma} agonist protects against myocardial ischaemia-reperfusion injury. Cardiovasc Res [Epub ahead of print]. [abstract]
  4. Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang N, Shyy JY, Li YS, Chien S. (2010) Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci U S A 107(7), 3234-9.  [abstract]
  5. Small EM, O'Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD, Richardson JA, Olson EN. (2010) Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci U S A 107(9), 4218-223.  [abstract]
  6. Caruso P, Maclean MR, Khanin R, McClure J, Soon E, Southwood M, McDonald RA, Greig JA, Robertson KE, Masson R, Denby L, Dempsie Y, Long L, Morrell NW, Baker AH. (2010)  Dynamic Changes in Lung MicroRNA Profiles During the Development of Pulmonary Hypertension Due to Chronic Hypoxia and Monocrotaline. Arterioscler Thromb Vasc Biol 30(4), 716-23. [abstract]
  7. Divakaran V, Adrogue J, Ishiyama M, Entman ML, Haudek S, Sivasubramanian N, Mann DL. (2009)  Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading. Circ Heart Fail 2(6), 633-42. [abstract]
  8. Sluijter JP, van Mil A, van Vliet P, Metz CH, Liu J, Doevendans PA, Goumans MJ. (2009) MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells. Arterioscler Thromb Vasc Biol 30(4), 859-68. [abstract]
  9. Matkovich SJ, Wang W, Tu Y, Eschenbacher WH, Dorn LE, Condorelli G, Diwan A, Nerbonne JM, Dorn GW 2nd.  (2009) MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts. Circ Res 106(1), 166-75. [abstract]
  10. Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW, Jeyaseelan K.  (2009) Expression profile of MicroRNAs in young stroke patients. PLoS One 4(11), e7689.  [abstract]
  11. Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN.  (2009) MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev 23(18),2166-178. [abstract]
  12. Dong S, Cheng Y, Yang J, Li J, Liu X, Wang X, Wang D, Krall TJ, Delphin ES, Zhang C. (2009)MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction.  J Biol Chem 284(43), 29514-25.  [abstract]
  13. Lin Y, Liu X, Cheng Y, Yang J, Huo Y, Zhang C. (2009) Involvement of MicroRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells.  J Biol Chem 284(12), 7903-13.  [abstract]
  14. Dunn W, Duraine G, Reddi AH. (2009) Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction. Arthritis Rheum 60(8), 2333-39. [abstract]
  15. Ting Chen1, Zhouqing Huang1, Liansheng Wang1, Yue Wang1, Feizhen Wu2, Shu Meng1, Changqian Wang. (2009) MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression inoxLDL-stimulated monocyte/macrophages. Cardiovascular Research 83(1), 131-39. [abstract]
  16. Malumbres R, Sarosiek KA, Cubedo E, Ruiz JW, Jiang X, Gascoyne RD, Tibshirani R, Lossos IS. (2008) Differentiation-stage-specific expression of microRNAs in B-lymphocytes and diffuse large B-cell lymphomas. Blood 113(16), 3754-64. [abstract]
  17. Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. (2008)Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A 105(46), 17824-29. [abstract]
  18. Dai R, Phillips RA, Zhang Y, Khan D, Crasta O, Ahmed SA. (2008) Suppression of LPS-induced IFN{gamma} and nitric oxide in splenic lymphocytes by select estrogen-regulated miRNA: A novel mechanism of immune modulation. Blood 112(12), 4591-97. [abstract]
  19. van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA, Olson EN. (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 105(35), 13027-32. [abstract]
  20. Sucharov C, Bristow MR, Port JD. (2008) miRNA expression in the failing human heart: Functional correlates. J Mol Cell Cardiol 45(2), 185-92. [abstract]
  21. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. (2007) MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy. Circ Res 100(3), 416-24.  [abstract]
  22. Cheng Y, Ji R, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C. (2007) MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart. Do They Play a Role in Cardiac Hypertrophy? Am J Pathol 170(6), 1831-40. [abstract]
  23. Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C. (2007) MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation. Circ Res 100(11), 1579-88.  [abstract]

Cell Development & Biology

  1. Sporn P, Wang N, Nair A. (2010) MicroRNA Profile Of Epithelial-Mesenchymal Transition In Normal Human Bronchial Epithelial Cells. Am J Respir Crit Care Med 181, A2488. [abstract]
  2. Cao H, Wang J, Li X, Florez S, Huang Z, Venugopalan SR, Elangovan S, Skobe Z, Margolis HC, Martin JF, Amendt BA. (2010) MicroRNAs Play a Critical Role in Tooth Development. J Dent Res [Epub ahead of print]. [abstract]
  3. Mohamed JS, Lopez MA, Boriek AM. (2010) Mechanical stretch upregulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3{beta}. J Biol Chem [Epub ahead of print]. [abstract]
  4. Mardaryev AN, Ahmed MI, Vlahov NV, Fessing MY, Gill JH, Sharov AA, Botchkareva NV. (2010) Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J [Epub ahead of print]. [abstract]
  5. Zhou B, Liu HL, Shi FX, Wang JY. (2010) MicroRNA expression profiles of porcine skeletal muscle. Anim Genet [Epub ahead of print]. [abstract]
  6. Zeiger U, Khurana TS. (2010)  Distinctive Patterns of MicroRNA Expression in Extraocular Muscles. Physiol Genomics [Epub ahead of print]. [abstract]
  7. van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. (2009)  A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.  Dev Cell 17(5), 662-73. [abstract]
  8. McCarthy JJ, Esser KA, Peterson CA, Dupont-Versteegden EE. (2009) Evidence of MyomiR network regulation of {beta}-myosin heavy chain gene expression during skeletal muscle atrophy. Physiol Genomics 39(3), 219-26. [abstract]
  9. Li Y, Piatigorsky J.  (2009) Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development.  Dev Dyn 38(9), 2388-400.  [abstract]
  10. Lin Q, Gao Z, Alarcon RM, Ye J, Yun Z. (2009) A role of miR-27 in the regulation of adipogenesis.  FEBS J 276(8), 2348-58.  [abstract]

Stem Cell Research

  1. Chen TS, Lai RC, Lee MM, Choo AB, Lee CN, Lim SK. (2009) Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs.   Nucleic Acids Res  38(1), 215-24. [abstract]
  2. Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC. (2009) MicroRNA Profiling of Human-Induced Pluripotent Stem Cells. Stem Cells Dev 18(5), 749-58. [abstract]
  3. Qian S, Ding JY, Xie R, An JH, Ao XJ, Zhao ZG, Sun JG, Duan YZ, Chen ZT, Zhu B. (2008)MicroRNA expression profile of bronchioalveolar stem cells from mouse lung. Biochem Biophys Res Commun 377(2), 668-73. [abstract]
  4. Lin SL, Chang DC, Chang-Lin S, Lin CH, Wu DT, Chen DT, Ying SY. (2008) Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 14(10), 2115-24. [abstract]
  5. Gu P, Reid JG, Gao X, Shaw CA, Creighton C, Tran PL, Zhou X, Drabek RB, Steffen DL, Hoang DM, Weiss MK, Naghavi AO, El-daye J, Khan MF, Legge GB, Wheeler DA, Gibbs RA, Miller JN, Cooney AJ, Gunaratne PH. (2008) Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells.  PLoS ONE 3(7), e2548. [abstract]
  6. Cao H, Yang CS, Rana TM. (2008) Evolutionary emergence of microRNAs in human embryonic stem cells. PLoS ONE 3(7), e2820. [abstract]
  7. Singh SK, Kagalwala MN, Parker-Thornburg J, Adams H, Majumder S. (2008) REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 453(7192), 223-27.  [abstract]
  8. Tay YM, Tam WL, Ang YS, Gaughwin PM, Yang HH, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B. (2007) MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells where it Causes Post-transcriptional Attenuation of Nanog and LRH1. Stem Cells 26(1), 17-29. [abstract]

Reproductive Biology

  1. Johnston IA, Lee HT, Macqueen DJ, Paranthaman K, Kawashima C, Anwar A, Kinghorn JR, Dalmay T.(2009) Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes.  J Exp Biol 212(Pt 12), 1781-793. [abstract]
  2. Filigheddu N, Gregnanin I, Porporato PE, Surico D, Perego B, Galli L, Patrignani C, Graziani A, Surico N. (2010) Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. J Biomed Biotechnol 2010, 369549.  [abstract]
  3. Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, J Li YS, Chien S, Wang N. (2010)  MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A 107(7), 3240-244. [abstract]
  4. Filkowski J, Ilnytskyy Y, Tamminga J, Koturbash I, Golubov A, Bagnyukova T, Pogribny I, Kovalchuk O. (2009)  Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression.  Carcinogenesis 31(6), 1110-15. [abstract]
  5. Nothnick WB. (2009) Regulation of uterine matrix metalloproteinase-9 and the role of microRNAs. Semin Reprod Med 26(6), 494-99. [abstract]
  6. Zhao H, Rajkovic A. (2008) MicroRNAs and mammalian ovarian development. Semin Reprod Med 26(6), 461-68. [abstract]
  7. Tamminga J, Kathiria P, Koturbash I, Kovalchuk O. (2008) DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle 7(23), 3731-36. [abstract]
  8. Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, Asada N, Kojima K, Yamaguchi Y, Ijiri TW, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H, Nakano T. (2008)DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev 22(7),908-17. [abstract]
  9. Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. (2007) Microarray Analyses of Newborn Mouse Ovaries Lacking Nobox. Biol Reprod 77(2), 312-19.  [abstract]
  10. Marsh EE, Lin Z, Yin P, Milad M, Chakravarti D, Bulun SE. (2007) Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium. Fertil Steril 89(6), 1771-76.  [abstract]
  11. Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. (2006) A Distinct small RNA Pathway Silences Selfish Genetic Elements in the Germline. Science 313(5785), 320-24.
    12.   [abstract]
  12. Amanai M, Brahmajosyula M, Perry AC. (2006) Restricted Role for Sperm-borne MicroRNAs in Mammalian Fertilization. Biol Reprod 75(6), 877-84.  [abstract]

Endocrinology

  1. Klinge CM.  (2009) Estrogen Regulation of MicroRNA Expression. Curr Genomics 10(3), 169-83.  [abstract]
  2. Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G. (2009) MicroRNA Expression Profile in Lieber-DeCarli Diet-Induced Alcoholic and Methionine Choline Deficient Diet-Induced Nonalcoholic Steatohepatitis Models in Mice.  Alcohol Clin Exp Res 33(10), 1704-10. [abstract]
  3. Zhang Z, Peng H, Chen J, Chen X, Han F, Xu X, He X, Yan N. (2009) MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice.  FEBS Lett 583(12), 2009-14.  [abstract]
  4. Xie H, Lim B, Lodish HF. (2009) MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity. Diabetes 58(5), 1050-57. [abstract]
  5. Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R. (2008) Alterations in MicroRNA Expression Contribute to Fatty Acid-Induced Pancreatic -Cell Dysfunction. Diabetes 57(10), 2728-36. [abstract]
  6. Fiedler SD, Carletti MZ, Hong X, Christenson LK. (2008) Hormonal Regulation of MicroRNA Expression in Periovulatory Mouse Mural Granulosa Cells. Biol Reprod 79(6), 1030-37. [abstract]
  7. Cheung O, Puri P, Eicken C, Contos MJ, Mirshahi F, Maher JW, Kellum JM, Min H, Luketic VA, Sanyal AJ (2008) Nonalcoholic Steatohepatitis is associated with altered microRNA expression. Hepatology 48(6), 1810-20.  [abstract]
  8. Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL. (2008) Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun 366(4), 922-26. [abstract]
  9. Cohen A, Shmoish M, Levi L, Cheruti U, Levavi-Sivan B, Lubzens E. (2007) Alterations in microRNA expression profiles reveal a novel pathway for estrogen regulation. Endocrinology 149(4), 1687-96. [abstract]

Virology (HIV, Epstein-Barr)

  1. Sung TL, Rice AP. (2009) miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1. PLoS Pathog 5(1), e1000263. [abstract]
  2. Eletto D, Russo G, Passiatore G, Del Valle L, Giordano A, Khalili K, Gualco E, Peruzzi F. (2008)Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a. J Cell Physiol 216(3), 764-70. [abstract]
  3. Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK. (2008) The Epstein-Barr Virus latent membrane protein 1 (LMP1) induces cellular microRNA-146a, a modulator of lymphocyte signaling pathways. J Virol 82(4), 1946-58. [abstract]
  4. Cameron JE, Fewell C, Yin Q, McBride J, Wang X, Lin Z, Flemington EK. (2008) Epstein-Barr virus growth/latency III program alters cellular microRNA expression. Virology 382(2), 257-66. [abstract]
  5. Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H. (2007) Cellular microRNAs contribute to HIV-1 latency in resting primary CD4(+) T lymphocytes. Nat Med 13(10), 1241-47. [abstract]
  6. Huang J, Liang Z, Yang B, Tian H, Ma J, Zhang H. (2007) Derepression of micro-RNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like3G (APOBEC3G) and its family members. J Biol Chem 282(46), 33632-40. [abstract]

Immunology

  1. Luers AJ, Loudig OD, Berman JW. (2010) MicroRNAs are expressed and processed by human primary macrophages. Cell Immunol 263(1), 1-8. [abstract]
  2. Curtale G, Citarella F, Carissimi C, Goldoni M, Carucci N, Fulci V, Franceschini D, Meloni F, Barnaba V, Macino G. (2009) An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes. Blood 115(2), 265-73. [abstract]
  3. Del Cornò M, Michienzi A, Masotti A, Da Sacco L, Bottazzo GF, Belardelli F, Gessani S. (2009) CC chemokine ligand 2 down-modulation by selected Toll-like receptor agonist combinations contributes to T helper 1 polarization in human dendritic cells. Blood 114(4), 796-806. [abstract]
  4. Hou J, Wang P, Lin L, Liu X, Ma F, An H, Wang Z, Cao X. (2009) MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 183(3), 2150-58. [abstract]
  5. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe BD, McManus MT, Rosenfeld MG, Briata P, Gherzi R. (2009) LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J 23(9), 2898-908. [abstract]

Plant Science

  1. Gundersen-Rindal DE, Pedroni MJ. (2010) Larval stage Lymantria dispar microRNAs differentially expressed in response to parasitization by Glyptapanteles flavicoxis parasitoid. Arch Virol 155(5), 783-87. [abstract]
  2. Buhtz A, Pieritz J, Springer F, Kehr J. (2010) Phloem small RNAs, nutrient stress responses, and systemic mobility. BMC Plant Biol 13(10), 64.  [abstract]
  3. Lv DK, Bai X, Li Y, Ding XD, Ge Y, Cai H, Ji W, Wu N, Zhu YM.(2010)Profiling of cold-stress-responsive miRNAs in rice by microarrays. Gene [Epub ahead of print].  [abstract]
  4. Zhang Z, Yu J, Li D, Zhang Z, Liu F, Zhou X, Wang T, Ling Y, Su Z. (2009) PMRD: plant microRNA database.  Nucleic Acids Res 38(Database issue), D806-13. [abstract]
  5. Dongdong L, Yusheng Zheng, Li Wan, Xiaoming Zhu and Zhekui Wang. (2009) Differentially expressed microRNAs during solid endosperm development in coconut (Cocos nucifera L.). Scientia Horticulturae 122(4), 666-669.
  6. Meng Y, Huang F, Shi Q, Cao J, Chen D, Zhang J, Ni J, Wu P, Chen M. (2009) Genome-wide survey of rice microRNAs and microRNA-target pairs in the root of a novel auxin-resistant mutant. Planta 230(5), 883-98. [abstract]
  7. Ding D, Zhang L, Wang H, Liu Z, Zhang Z, Zheng Y. (2009) Differential expression of miRNAs in response to salt stress in maize roots. Ann Bot (Lond) 103(1), 29-38. [abstract]
  8. Zhang Z, Wei L, Zou X, Tao Y, Liu Z, Zheng Y. (2008) Submergence-responsive MicroRNAs are Potentially Involved in the Regulation of Morphological and Metabolic Adaptations in Maize Root Cells. Ann Bot (Lond) 102(4), 509-19. [abstract]
  9. Pant BD, Buhtz A, Kehr J, Scheible WR. (2008) MicroRNA399 is a Long-Distance Signal for the Regulation of Plant Phosphate Homeostasis. Plant J 53(5), 731-38.  [abstract]
  10. Buhtz A, Springer F, Chappell L, Baulcombe DC, Kehr J. (2007) Identification and characterization of small RNAs from the phloem of Brassica napus. Plant J 53(5), 739-49.  [abstract]
  11. Shiboleth YM, Haronsky E, Leibman D, Arazi T, Wassenegger M, Whitham SA, Gaba V, Gal-On A. (2007) The conserved FRNK box in HC-Pro, a plant viral suppressor of gene silencing, is required for small RNA binding and mediates symptom development. J Virol 81(23), 13135-48.  [abstract]
  12. Pilcher RL, Moxon S, Pakseresht N, Moulton V, Manning K, Seymour G, Dalmay T. (2007) Identification of novel small RNAs in tomato (Solanum lycopersicum). Planta 226(3), 709-17.  [abstract]

Small RNA Discovery, Analysis

  1. Yauk CL, Rowan-Carroll A, Stead JD, Williams A. (2010) Cross-platform analysis of global microRNA expression technologies. BMC Genomics 11(1), 330. [abstract]
  2. Liu G, Fang Y, Zhang H, Li Y, Li X, Yu J, Wang X. (2010)Computational identification and microarray-based validation of microRNAs in Oryctolagus cuniculus. Mol Biol Rep [Epub ahead of print].  [abstract]
  3. Legeai F, Rizk G, Walsh T, Edwards O, Gordon K, Lavenier D, Leterme N, Mereau A, Nicolas J, Tagu D, Jaubert-Possamai S. (2010) Bioinformatic prediction, deep sequencing of microRNAs and expression analysis during phenotypic plasticity in the pea aphid, Acyrthosiphon pisum.  BMC Genomics [Epub ahead of print].  [abstract]
  4. Hayashida Y, Nishibu T, Inoue K, Kurokawa T. (2009) A useful approach to total analysis of RISC-associated RNA. BMC Res Notes 2, 169.  [abstract]
  5. Zhang Y, Zhou X, Ge X, Jian X, Zhao G, Li F, Huang Y. (2009) Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori.  PLoS One 4(3), e4677. [abstract]
  6. Curry E, Ellis SE, Pratt SL. (2009) Detection of porcine sperm microRNAs using a heterologous microRNA microarray and reverse transcriptase polymerase chain reaction. Mol Reprod Dev 76(3), 218-19. [abstract]
  7. He PA, Nie Z, Chen J, Chen J, Lv Z, Sheng Q, Zhou S, Gao X, Kong L, Wu X, Jin Y, Zhang Y. (2008)Identification and characteristics of microRNAs from Bombyx mori BMC Genomics 9(1), 248. [abstract]
  8. Zhang J, Zeng R, Chen J, Liu X, Liao Q. (2008) Identification of conserved microRNAs and their targets from Solanum lycopersicum Mill. Gene 423(1), 1-7. [abstract]
  9. Lee I, Ajay SS, Chen H, Maruyama A, Wang N, McInnis MG, Athey BD. (2008) Discriminating single-base difference miRNA expressions using microarray Probe Design Guru (ProDeG). Nucleic Acids Res 36(5), e27. [abstract]
  10. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad, O, Bentwich Z, Szafranska AE, Labourier E et al. (2006) The colorectal microRNAome. Proc Natl Acad Sci U S A 103, 3687-92.  [abstract]

Mechanism of Action

  1. Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T. (2010) MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev 24(9), 887-92. [abstract]
  2. Hussain M, Asgari S.  (2009) Functional analysis of a cellular microRNA in insect host-ascovirus interaction. J Virol 84(1), 612-20. [abstract]
  3. Song G, Wang L. (2009) Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism.  PLoS One 4(9), e6880.  [abstract]
  4. Song G, Wang L. (2008) Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res 36(18), 5727-35. [abstract] [article]

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