Cumulative evidence has associated microRNA (miRNA) with cancer development, and among those miRNAs, miR-145 has been identified as an anti-oncomiRNA. However, the comprehensive mechanisms of action of miR-145 in breast cancer development have not yet been fully elucidated. In a recent study, investigators performed next-generation sequencing to detect the expression profiles of the transcriptome and conducted cellular function experiments after miR-145 overexpression.

Their results verified the inhibitory effects of miR-145 on breast cancer cell proliferation, colony formation, migration and invasion. Sequencing data revealed that miR-145 triggered the alteration of the whole transcriptome and further led to regulation of the competing endogenous RNA (ceRNA) network. Their study also identified a list of 49 target mRNAs of miR-145 and specific non-coding RNAs, which could be utilized as potential breast cancer biomarkers.

This study might serve as a significant platform for further research on miR-145 along with the ceRNA network in breast cancer.


P. Ye, Y. Shi, N. An, Q. Zhou, J. Guo, X. Long (2018) miR-145 overexpression triggers alteration of the whole transcriptome and inhibits breast cancer development Biomedicine and Pharmacotherapy doi: 10.1016/j.biopha.2018.01.167 [abstract]

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