Peptide arrays are an exciting and rapidly growing technology with a broad range of applications in the basic and applied life sciences. Peptide arrays have been under development for approximately twenty-five years, and commercial versions have been available for the past decade. The arrays typically comprise hundreds to thousands of distinct peptide sequences and have proven important for determining substrate specificities of enzymes, profiling antibodies, mapping epitopes, studying ligand-receptor interactions, and identifying ligands that mediate cell adhesion. Despite this, peptide arrays still find modest use—particularly when compared to oligonucleotide arrays—and have not yet realized their potential in becoming a standard method in laboratories and in the drug discovery process. In a recent review, investigators provide a discussion of the many approaches that have been developed to prepare and apply peptide arrays, including important advances in the last three years and remaining challenges to making these tools broadly useful.
L. C. Szymczak, HY Kuo, M. Mrksich (2018) Peptide Arrays: Development and Application Anal. Chem. doi: 10.1021/acs.analchem.7b04380 [abstract]