LC Sciences News

Exosomes are 50–90 nm membrane-derived vesicles found in bodily fluids including blood, saliva, and urine. They encapsulate proteins and mRNA as well as miRNA that may be exchanged as a signaling mechanism between cells. Encapsulated mRNA and miRNA are relatively stable because exosomes protect nucleic acids from extracellular degradation. Circulating miRNAs are potential biomarkers of various pathological conditions1 and have been characterized previously in total urine specimens and exosomes from body fluids other than urine2, but have yet to be studied

Oxytocin (Oxt), produced in the hypothalamic paraventricular and supraoptic nuclei for transport to and release from the posterior pituitary, was originally discovered through its role in lactation and parturition. Oxt also plays important roles in the central nervous system by influencing various behaviors. MicroRNAs (miRNAs), endogenous regulators of many genes, are a class of small noncoding RNAs that mediate post-transcriptional gene silencing. Researchers at Kyungpook National University, Korea performed miRNA expression profiling of the mouse hypothalamus by

Jin Y, Tymen Sp, Chen D, Fang ZJ, Zhao Y, Dragas D, Dai Y, Marucha PT, Zhou X. (2013) MicroRNA-99 Family Targets AKT/mTOR Signaling Pathway in Dermal Wound Healing. PLoS ONE 8(5), [abstract] Rao YS, Mott NN, Wang Y, Chung WC, Pak TR. (2013) MicroRNAs in the aging female brain: A putative mechanism for age-specific estrogen effects. Endocrinology [Epub ahead of print]. [abstract] Wei C, Henderson H, Spradley C, Li L, Kim I, Kumar S, Hong N,

LC Sciences will be exhibiting at the upcoming - American Society for Pharmacology and Experimental Therapeutics - Great Lakes Chapter Annual Meeting Friday June 14th, 2013 Rush University Medical Center, The SEARLE Conference Center 1725 W Harrison St., Professional Building, Chicago, IL