Extracellular vesicles, including exosomes, are currently being investigated to better understand their biogenesis and biological functions. There is also a rapidly growing interest in utilizing exosomes present in patient biofluids for molecular diagnostics in the clinic. Exosomes are natural shuttles of RNA and protein cargo, making them attractive as potential therapeutic delivery vehicles. In a recent paper, researchers from System Biosciences describe the methods for using the latest tools (including LC Sciences miRNA microarray service and other technologies) to study exosomes to better understand their roles in cell-to-cell communication, for discovery of clinical biomarkers and to engineer exosomes for therapeutic applications.

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miRNA Microarray Service – LC Sciences provides a microRNA (miRNA) expression profiling service using microarrays based on our in-house developed µParaflo® technology platform. We have standard arrays for all mature miRNAs of all species available in the latest version of the miRBase database (Release 21, July 2014). Our service is comprehensive and includes sample labeling, array hybridization, image data processing and in-depth data analysis. Two-three weeks after receiving your total RNA samples, we’ll send you both the raw and fully analyzed data. [Learn more…]


M. F. Peterson, N. Otoc, J. K. Sethi, A. Gupta, T. J. Antes (2015) Integrated systems for exosome investigation Methods doi: 10.1016/j.ymeth.2015.04.015 [article][/panel]

Identifying specific cancer associated proteins and microRNAs contained within exosomes Investigating the role of exosomal communication within the tumor micro-environment