microRNA

Biomarker

There is clinical potential for miRNA as biomarkers in metabolic disease

miRNAs regulate several metabolic pathways including insulin secretion and lipid/glucose homeostasis. Changes in the metabolic control of these pathways predispose an individual to develop cardiometabolic diseases, such as diabetes and atherosclerosis.

The potential of miRNAs as biomarkers for diagnosis and prognosis has became increasingly apparent, and due to their remarkable tissue specificity, they might even be more versatile markers of disease states than protein-coding mRNAs.

The invasive nature of tissue biopsies, such as from the liver in the case non-alcoholic fatty liver disease, makes diagnosis difficult. Studies aimed at identifying miRNA expression profiles from body fluids, such as serum or urine, that could serve as a novel diagnostic biomarkers of metabolic diseases have met with success recently.

Read more about how LC Sciences is helping clinicians and researchers to demonstrate that:

LC Sciences offers a portfolio of services applicable to metabolic diseases and metabolomic research.
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16S rRNA Gene Sequencing
16S rRNA gene sequencing is commonly used for identification, classification and quantitation of microbes within complex biological mixture such as environmental samples (ex marine water) and gut samples…

VariantPro Mitochondrial Panel
Designed for 100% amplicon coverage (16,569 bp) of the mitochondrial genome, the Mitochondrion Panel offers cost-effective, minimal hands-on, ultra-high resolution…

RNA Sequencing Services

microRNA Profiling Services

microRNAs are small noncoding RNA molecules that function broadly as negative regulators of gene expression to control a wide range of cellular processes. A genome-wide microRNA (miRNA) expression profiling service…