Presented by Christoph Eicken Ph.D. – LC Sciences LLC

An advanced microfluidic biochip system designed to produce high quality data, stay current with the rapidly evolving microRNA field, and perform diverse small RNA discovery experiments is presented. This technology’s unique flexibility allows for miRBase synchronicity and design of customized biochips adapted to each researcher’s specific needs. Applications featuring disease marker discovery, drug treatment, microRNA target screening, and small RNA discovery are highlighted.


Uploaded on authorSTREAM by chebel

LC Sciences’ customers have been publishing raw images of its µParaflo® microfluidic chip data since the company began offering the microRNA microarray service back in 2005.  So we thought we would give you a quick look at some of these images.  (For a more thorough look check out the individual screenshots here)The exceedingly high quality of the data coming from these chips makes the results so clear that it makes sense to illustrate by showing the actual scanned image of the array itself.  “We are continually amazed that our customers choose to publish images of the array in the main text of the articles as a means present research results.  This is not something you typically see with data from a standard microarray and reflects the strength of our advanced technology”.  Chris Hebel, LC Sciences LLC.  Read more

Microsoft PowerPoint - LC Sciences Seminar Flyer [CompatibilityPlease join us in Galveston, TX for an informative seminar describing our µParaflo® microfluidic technology and its use in making significant discoveries in the field of microRNA research.

A platform technology that encompass a new class of microfluidic µParaflo® reaction devices, an advanced digital light synthesizer apparatus, and picoliter scale biochemical processes.  The functionalized µParaflo® chips are particularly suited for applications where small sample consumption, contamination-free, and performance-reproducibility are primary concerns. This technology enables the massively parallel synthesis of high quality DNA and RNA oligonucleotides as well as peptides and peptidomimetics in picoliter-scale reaction chambers. The only platform providing microarrays of oligonucleotide, peptide, and their analog sequences by in situ synthesis using conventional chemistry and a comprehensive list of off-the-shelf synthetic building blocks.

  • High Density – On Chip Parallel Synthesis
  • Customizable – DNA, RNA, Peptides, and Analogs
  • Versatile – Uses Conventional Chemistry
  • Microsoft Word - Tech Bulletin - uParaflo Technology_MM_30_06C.d

    μParaflo® technology consists of a new class of microfluidic reaction devices, an advanced digital light synthesizer apparatus, and picoliter scale biochemical processes. This technology enables the massively parallel synthesis of high quality DNA and RNA oligonucleotides as well as peptides and peptidomimetics in picoliter-scale reaction chambers. (read more)

    LC Sciences provides a genome-wide microRNA (miRNA) expression profiling service using µParaflo®technology and proprietary probe design, which enable highly sensitive and specific direct detection of miRNAs. We have standard arrays for mature miRNA of all species available in the latest version of the miRBase database (Release 14.0). Our service is comprehensive and includes small RNA enrichment from your total RNA sample, single or dual color labeling, hybridization, image data processing and in-depth data analysis. Two-three weeks after receiving your total RNA samples, we send you the analyzed data, representative and original images of the array, and raw data. We offer additional products and services including arrays containing miRNA*, walk/tiling arrays, custom arrays (first 100 probes free of charge), and in-depth analysis for multiple data sets. The in-depth data analysis may include multi-array normalization, t-test, ANOVA, False Discovery Rate calculator, and/or clustering analysis.

    Peptide drug discovery is a huge endeavor—and a huge field. Researchers and tool/technology developers alike traveled to Seoul recently for BIT Life Sciences’ “PepCon” meeting, where advances and trends in peptide and protein research were shared. (read more)