Jul

21

microRNA Discovery & Profiling

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May

26

Seq-Array: microRNA Discovery and Profiling Using a Customizable Workflow

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Seq-ArraySM provides an efficient pathway from an initial broad search to focused biological insights.

Seq-ArraySM offers a customized solution to high-throughput genome-wide microRNA discovery and profiling, especially in species with limited or no microRNA sequence information available. This unique combination of the latest deep sequencing technology, advanced bioinformatics, and our innovative µParaflo® custom microarray platform leverages all these technologies to form a comprehensive service package tailored to your specific research needs.

Jan

20

Seminar – MicroRNA Discovery & Profiling

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Presented by – Dr. Christoph Eicken & Dr. Qi Zhu, LC Sciences
12:00 pm Conference Room 2

as part of – Texas Medical Center BioResearch Product Faire

Houston, TX (Marriott Medical Center) – January 16, 2010

Jan

8

Plant & Animal Genomes Conference

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p&ag_2010_header

Plant & Animal Genomes XVIII Conference
Jan 9 – 13, 2010 – San Diego, CA     Visit LC Sciences at Booth #509

The Premier and Largest Ag-Genomics Meeting in the World

5 Reasons to Select LC Sciences for your microRNA Profiling Studies in Agriculturally Important Species

  • 100% miRBase Coverage – Version 14.0 – 10883 microRNAs – 115 species
  • 100% Plant Database Coverage – Version 1.0 of the Plant microRNA Database – 8433 microRNAs covering 121 plant species
  • Experience – More than 6000 samples processed since 2005 – Over 130 customer publications
  • Custom Microarrays – Expression profiling of any species
  • Deep Sequencing – Discovery or novel small RNAs in any species

Nov

9

MicroRNAs in Dendritic Spine Morphogenesis

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Researchers at Heidelberg University used a combination of expression profiling of miRNAs and subsequent functional inhibitory screening in primary hippocampal neurons to identify miRNAs in the synaptodendritic compartment that function during synaptic development.  MicroRNA microarrays identified ten mature miRNAs that were enriched and four mature miRNAs that were strongly depleted in synaptosomes compared with whole forebrain. Northern blot analysis on selected miRNAs confirmed the microarray results.  Subsequent functional screening identified miR-138 as a negative regulator of dendritic spine size and revealed that mRNA encoding acyl-protein thioesterase 1 (APT1) is a miR-138 target in neurons.

Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM.  (2009) A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.  Nat Cell Biol 11(6), 705-16.  [abstract]

Sep

25

Featured Publication – MicroRNA Profiling and Head and Neck Cancer

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head_and_neck_cancerRecent advances in microRNA expression profiling have led to a better understanding of the HNOC pathogenesis. This will lead to the identification of specific microRNA expression patterns that may become powerful biomarkers for diagnosis and prognosis of HNOC. In addition, these microRNAs may also serve as therapeutic targets for novel strategies of HNOC prevention and therapeutics. (read more)