Nov

3

OligoMix® Genomics Products

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OligoMix Ad_080310_cmykLC Sciences provides a unique new tool, OligoMix® enabling low cost, multiplex custom oligonucleotides for various applications serving diverse needs in genomics, proteomics, protein/antibody engineering, synthetic biology, drug discovery, and emerging new fields of science such as next-generation sequencing. OligoMix® is a MIXTURE of a large number of DESIGNED synthetic DNA oligonucleotide sequences delivered in a single microtube.

OligoMix® is a product developed in response to the need for pooled oligonucleotides used in multiplexing reactions.  We synthesize thousands of oligonucleotide sequences at once in parallel and then cleave the oligos releasing them into solution in a single microtube.  Synthesis occurs via standard DMT chemistry assuring efficient stepwise yield and high quality final product.  The product is delivered as a pool in a single microtube – ready to use for your experiment.

Sep

16

Putting Synthesis into Biology: A Viral View of Genetic Engineering through De Novo Gene and Genome Synthesis

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S1074552109X00049_cov150hThe rapid improvements in DNA synthesis technology hold the potential to revolutionize biosciences in the near future. Traditional genetic engineering methods are template dependent and make extensive but laborious use of site-directed mutagenesis to explore the impact of small variations on an existing sequence “theme.” De novo gene and genome synthesis frees the investigator from the restrictions of the pre-existing template and allows for the rational design of any conceivable new sequence theme.Viruses, being among the simplest replicating entities, have been at the forefront of the advancing biosciences since the dawn of molecular biology. Viral genomes, especially those of RNA viruses, are relatively short, often less than 10,000 bases long, making them amenable to whole genome synthesis with the currently available technology. For this reason viruses are once again poised to lead the way in the budding field of synthetic biology—for better or worse. (read more)