Mar

17

microRNA Focused Meeting

Filed Under Events | Leave a Comment

microrna

3/22/10 – 3/24/10  Boston, MA

TOPICS INCLUDE:

microRNA in Cancer
microRNA in Biomarker and Diagnostic Development
microRNA in Therapeutic Development
microRNA in Human Development and Disease
microRNA Pathways and Mechanisms

Don’t miss the Technology Showcase Wed 3/24/10

12:35-12:50 Seq-Array – miRNA Discovery and Profiling Using a Customizable Workflow

Christoph Eicken, Ph.D., Head of Technical Services – Microarrays, LC Sciences
Current miRNA profiling methods rely on the limited sequence information available, hence the focus on a few model species. Seq-Array is a customized solution high-throughput genome-wide miRNA profiling to overcome these limitations. It combines and leverages three technologies: the latest deep sequencing technology, advanced bioinformatics, and μParaflo™ custom microarrays. This talk will present the workflow and a case study with 777 newly discovered miRNAs.

Dec

17

microRNAs Inform Cancer Research

Filed Under miRNA News | Leave a Comment

Alterations in the Expression of miRNA Genes Contribute to Pathogenesis on Broad Basis

Elizabeth Lipp

MicroRNA (miRNA) has a significant role in controlling developmental and cancer processes like cell proliferation, differentiation, cell cycle, apoptosis, and metastasis. This ubiquitousness and their recently revealed role as key regulators of gene expression during development has boosted their use as agents in the fight against cancer. It’s a hot topic “and it’s getting hotter,” said Frank Slack, associate professor of molecular, cellular, and developmental biology at Yale University … (read more)

Oct

30

MicroRNAs as Potential Biomarkers in Cancer and Heart Disease

Filed Under Technical Article | 2 Comments

Heart disease and cancer represent the number one and number two killer diseases in developed countries. Identifying biomarkers to detect these and other diseases at early stages remains an important research goal and researchers are scrambling for ways to identify contributing factors to the pathogenesis of diseased cells in the body.  In recent years, research has turned to the study of microRNA (miRNA) as possible biomarkers due to their extensive role in biological processes and cell functionality in normal vs. diseased cells.  Microarrays combined with quantitative real-time PCR (qRT-PCR) validation are proving to be valuable tools for miRNA expression profiling and are predicted to play a crucial role in biomarker discovery and detection.  Read more