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  • Featured Article – MicroRNAome of Porcine Pre- and Postnatal Development
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MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

Researchers at Yale University have discovered that microRNAs play key roles in modulating the expression of genes involved in DNA damage recognition and repair.  They used a combination of microRNA microarrays (for identification of the miRs), bioinformatics (for prediction of the miR targets), and luciferase assays (for confirmation of the miR targets) to make their discoveries. (read more)

Make plans to visit LC Sciences at the upcoming American Society of Human Genetics (ASHG) Meeting in Honolulu, Hawaii next month. (Oct 20-24th).  We will be located in booth #712.

Recent advances in microRNA expression profiling have led to a better understanding of the HNOC pathogenesis. This will lead to the identification of specific microRNA expression patterns that may become powerful biomarkers for diagnosis and prognosis of HNOC. In addition, these microRNAs may also serve as therapeutic targets for novel strategies of HNOC prevention and therapeutics. (read more)

Please join us in Galveston, TX for an informative seminar describing our µParaflo® microfluidic technology and its use in making significant discoveries in the field of microRNA research.

A platform technology that encompass a new class of microfluidic µParaflo^® reaction devices, an advanced digital light synthesizer apparatus, and picoliter scale biochemical processes.  The functionalized µParaflo^® chips are particularly suited for applications where small sample consumption, contamination-free, and performance-reproducibility are primary concerns. This technology enables the massively parallel synthesis of high quality DNA and RNA oligonucleotides as well as peptides and peptidomimetics in picoliter-scale reaction chambers. The only platform providing microarrays of oligonucleotide, peptide, and their analog sequences by in situ synthesis using conventional chemistry and a comprehensive list of off-the-shelf synthetic building blocks.

High Density – On Chip Parallel Synthesis

Customizable – DNA, RNA, Peptides, and Analogs

Versatile – Uses Conventional Chemistry

μParaflo® technology consists of a new class of microfluidic reaction devices, an advanced digital light synthesizer apparatus, and picoliter scale biochemical processes. This technology enables the massively parallel synthesis of high quality DNA and RNA oligonucleotides as well as peptides and peptidomimetics in picoliter-scale reaction chambers. (read more)

 Researchers at the RNA and Cardiovascular Research Laboratory, New Jersey Medical School have studied microRNA in acute myocardial infarction by expression profiling of miRNA in rat hearts with microarray. Their results suggest that miRNAs may play important roles in the phathophysiology of AMI. Some miRNAs may be considered new therapeutic targets or even biomarkers for ischemic heart disease such as AMI. [abstract]

LC Sciences provides a genome-wide microRNA (miRNA) expression profiling service using µParaflo^®technology and proprietary probe design, which enable highly sensitive and specific direct detection of miRNAs. We have standard arrays for mature miRNA of all species available in the latest version of the miRBase database (Release 14.0). Our service is comprehensive and includes small RNA enrichment from your total RNA sample, single or dual color labeling, hybridization, image data processing and in-depth data analysis. Two-three weeks after receiving your total RNA samples, we send you the analyzed data, representative and original images of the array, and raw data. We offer additional products and services including arrays containing miRNA*, walk/tiling arrays, custom arrays (first 100 probes free of charge), and in-depth analysis for multiple data sets. The in-depth data analysis may include multi-array normalization, t-test, ANOVA, False Discovery Rate calculator, and/or clustering analysis.

Peptide drug discovery is a huge endeavor—and a huge field. Researchers and tool/technology developers alike traveled to Seoul recently for BIT Life Sciences’ “PepCon” meeting, where advances and trends in peptide and protein research were shared. (read more)

The current probe content comes from version 14.0 of the miRBase sequence database which was updated on September 15th, 2009.  (See the 14.0 release summary) (See a comparison to previous versions)

• Version 14.0 of the miRBase
• 14.0 release summary
• Comparison to previous versions

We can synthesize microRNA arrays for all species that are listed in the miRBase Sequence Database.  We have listed a subset of our most popular species below. Please call if you don’t see your species of interest.

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  • LC Sciences - microRNA Discovery & Profiling Service - SeqArray ... July 29, 2010
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  • microRNA Discovery&Profiling : LC Sciences Blog » Propeller July 28, 2010

• microRNA News

  • Scientists on path to new treatments for Parkinson's July 30, 2010
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  • Rosetta Genomics Names Genekor S.A Exclusive Distributor for Three ... July 29, 2010
  • Alimta Mesothelioma | Rosetta Genomics Names Genekor S.A Exclusive ... July 29, 2010
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  • Thinking In Genes » Cancer Cells Show Rewired, Fragmented microRNA ... July 29, 2010